Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

Mtnd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 2
Gene namesi
Name:Mtnd2
Synonyms:mt-Nd2, Nd2
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102500 mt-Nd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei92 – 114HelicalSequence analysisAdd BLAST23
Transmembranei149 – 171HelicalSequence analysisAdd BLAST23
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001176071 – 345NADH-ubiquinone oxidoreductase chain 2Add BLAST345

Proteomic databases

PaxDbiP03893
PRIDEiP03893

PTM databases

PhosphoSitePlusiP03893

Expressioni

Gene expression databases

BgeeiENSMUSG00000064345
ExpressionAtlasiP03893 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
IntActiP03893, 1 interactor
STRINGi10090.ENSMUSP00000080992

Structurei

3D structure databases

ProteinModelPortaliP03893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPMV Eukaryota
COG1007 LUCA
GeneTreeiENSGT00730000111348
HOGENOMiHOG000113879
HOVERGENiHBG016692
InParanoidiP03893
KOiK03879
OMAiHFWVPEV
OrthoDBiEOG091G0J50

Family and domain databases

InterProiView protein in InterPro
IPR010933 NADH_DH_su2_C
IPR003917 NADH_UbQ_OxRdtase_chain2
IPR001750 ND/Mrp_mem
PfamiView protein in Pfam
PF06444 NADH_dehy_S2_C, 1 hit
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01436 NADHDHGNASE2

Sequencei

Sequence statusi: Complete.

P03893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPITLAIIY FTIFLGPVIT MSSTNLMLMW VGLEFSLLAI IPMLINKKNP
60 70 80 90 100
RSTEAATKYF VTQATASMII LLAIVLNYKQ LGTWMFQQQT NGLILNMTLM
110 120 130 140 150
ALSMKLGLAP FHFWLPEVTQ GIPLHMGLIL LTWQKIAPLS ILIQIYPLLN
160 170 180 190 200
STIILMLAIT SIFMGAWGGL NQTQMRKIMA YSSIAHMGWM LAILPYNPSL
210 220 230 240 250
TLLNLMIYII LTAPMFMALM LNNSMTINSI SLLWNKTPAM LTMISLMLLS
260 270 280 290 300
LGGLPPLTGF LPKWIIITEL MKNNCLIMAT LMAMMALLNL FFYTRLIYST
310 320 330 340
SLTMFPTNNN SKMMTHQTKT KPNLMFSTLA IMSTMTLPLA PQLIT
Length:345
Mass (Da):38,752
Last modified:April 1, 2015 - v2
Checksum:iF6855CA2CA3F2E59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti294T → I in AAB48645 (PubMed:7332926).Curated1
Sequence conflicti294T → I in CAA24081 (PubMed:7332926).Curated1
Sequence conflicti294T → I in AAP89024 (PubMed:12954771).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48645.1
V00711 Genomic DNA Translation: CAA24081.1
AY172335 Genomic DNA Translation: AAN85123.1
AY339599 Genomic DNA Translation: AAP89024.1
PIRiA00416 QXMS2M
RefSeqiNP_904329.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000082396; ENSMUSP00000080992; ENSMUSG00000064345
GeneIDi17717
KEGGimmu:17717

Similar proteinsi

Entry informationi

Entry nameiNU2M_MOUSE
AccessioniPrimary (citable) accession number: P03893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 2015
Last modified: July 18, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health