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Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

MT-ND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 2
Gene namesi
Name:MT-ND2
Synonyms:MTND2, NADH2, ND2
Encoded oniMitochondrion
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiHostDB:ENSG00000198763.3
HGNCiHGNC:7456 MT-ND2
MIMi516001 gene
neXtProtiNX_P03891

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Leber hereditary optic neuropathy (LHON)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
See also OMIM:535000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004755150N → D in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs28357980Ensembl.1
Natural variantiVAR_004756259G → S in LHON; rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs199476115Ensembl.1
Alzheimer disease mitochondrial (AD-MT)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionAlzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.
See also OMIM:502500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004758331A → S in AD-MT. 1 Publication1

Keywords - Diseasei

Alzheimer disease, Amyloidosis, Disease mutation, Leber hereditary optic neuropathy, Neurodegeneration, Primary mitochondrial disease

Organism-specific databases

DisGeNETi4536
GeneReviewsiMT-ND2
MalaCardsiMT-ND2
MIMi502500 phenotype
535000 phenotype
OpenTargetsiENSG00000198763
Orphaneti2609 Isolated NADH-CoQ reductase deficiency
104 Leber hereditary optic neuropathy
255210 Maternally-inherited Leigh syndrome
PharmGKBiPA31260

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

DMDMi128676

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001175951 – 347NADH-ubiquinone oxidoreductase chain 2Add BLAST347

Proteomic databases

EPDiP03891
PaxDbiP03891
PeptideAtlasiP03891
PRIDEiP03891
ProteomicsDBi51612

PTM databases

iPTMnetiP03891
PhosphoSitePlusiP03891

Expressioni

Gene expression databases

BgeeiENSG00000198763
ExpressionAtlasiP03891 baseline and differential
GenevisibleiP03891 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110632, 10 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiP03891
IntActiP03891, 5 interactors
MINTiP03891
STRINGi9606.ENSP00000355046

Structurei

3D structure databases

ProteinModelPortaliP03891
SMRiP03891
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4668 Eukaryota
COG1009 LUCA
GeneTreeiENSGT00730000111348
HOGENOMiHOG000113879
HOVERGENiHBG016692
InParanoidiP03891
KOiK03879
OMAiHFWVPEV
OrthoDBiEOG091G0J50
PhylomeDBiP03891

Family and domain databases

InterProiView protein in InterPro
IPR010933 NADH_DH_su2_C
IPR003917 NADH_UbQ_OxRdtase_chain2
IPR001750 ND/Mrp_mem
PfamiView protein in Pfam
PF06444 NADH_dehy_S2_C, 1 hit
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01436 NADHDHGNASE2

Sequencei

Sequence statusi: Complete.

P03891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPLAQPVIY STIFAGTLIT ALSSHWFFTW VGLEMNMLAF IPVLTKKMNP
60 70 80 90 100
RSTEAAIKYF LTQATASMIL LMAILFNNML SGQWTMTNTT NQYSSLMIMM
110 120 130 140 150
AMAMKLGMAP FHFWVPEVTQ GTPLTSGLLL LTWQKLAPIS IMYQISPSLN
160 170 180 190 200
VSLLLTLSIL SIMAGSWGGL NQTQLRKILA YSSITHMGWM MAVLPYNPNM
210 220 230 240 250
TILNLTIYII LTTTAFLLLN LNSSTTTLLL SRTWNKLTWL TPLIPSTLLS
260 270 280 290 300
LGGLPPLTGF LPKWAIIEEF TKNNSLIIPT IMATITLLNL YFYLRLIYST
310 320 330 340
SITLLPMSNN VKMKWQFEHT KPTPFLPTLI ALTTLLLPIS PFMLMIL
Length:347
Mass (Da):38,961
Last modified:December 1, 1992 - v2
Checksum:iC06FD982317C3F2D
GO

Sequence cautioni

The sequence AAA65502 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00859042P → L1 Publication1
Natural variantiVAR_01134843V → I1 PublicationCorresponds to variant dbSNP:rs1117207Ensembl.1
Natural variantiVAR_00859157I → T1 PublicationCorresponds to variant dbSNP:rs41510547Ensembl.1
Natural variantiVAR_00859263Q → R1 Publication1
Natural variantiVAR_01134969I → V1 Publication1
Natural variantiVAR_01135088N → S1 PublicationCorresponds to variant dbSNP:rs201854167Ensembl.1
Natural variantiVAR_008593119T → A1 Publication1
Natural variantiVAR_008594148S → P1 Publication1
Natural variantiVAR_004755150N → D in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs28357980Ensembl.1
Natural variantiVAR_008595150N → S1 PublicationCorresponds to variant dbSNP:rs879058895Ensembl.1
Natural variantiVAR_008596159I → T1 Publication1
Natural variantiVAR_008597185T → A1 Publication1
Natural variantiVAR_011351237L → M1 PublicationCorresponds to variant dbSNP:rs28357984Ensembl.1
Natural variantiVAR_004756259G → S in LHON; rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs199476115Ensembl.1
Natural variantiVAR_011352265A → T1 PublicationCorresponds to variant dbSNP:rs370378529Ensembl.1
Natural variantiVAR_011353265A → V1 PublicationCorresponds to variant dbSNP:rs41320049Ensembl.1
Natural variantiVAR_011354278I → T1 PublicationCorresponds to variant dbSNP:rs878853115Ensembl.1
Natural variantiVAR_011355325F → L1 PublicationCorresponds to variant dbSNP:rs3020601Ensembl.1
Natural variantiVAR_004758331A → S in AD-MT. 1 Publication1
Natural variantiVAR_004757331A → T1 PublicationCorresponds to variant dbSNP:rs3021088Ensembl.1
Natural variantiVAR_011356333T → A1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01415 Genomic DNA Translation: AAB58944.1
V00662 Genomic DNA Translation: CAA24027.1
M10546 Genomic DNA Translation: AAA65502.1 Different initiation.
D38112 Genomic DNA Translation: BAA07291.1
AF014882 Genomic DNA Translation: AAC25441.1
AF014884 Genomic DNA Translation: AAC25443.1
AF014885 Genomic DNA Translation: AAC25444.1
AF014887 Genomic DNA Translation: AAC25446.1
AF014889 Genomic DNA Translation: AAC25448.1
AF014890 Genomic DNA Translation: AAC25449.1
AF014891 Genomic DNA Translation: AAC25450.1
AF014892 Genomic DNA Translation: AAC25451.1
AF014895 Genomic DNA Translation: AAC25454.1
AF014896 Genomic DNA Translation: AAC25455.2
AF014897 Genomic DNA Translation: AAC25456.1
AF014898 Genomic DNA Translation: AAC25457.1
AF014899 Genomic DNA Translation: AAC25458.2
AF014900 Genomic DNA Translation: AAC25459.1
AF014901 Genomic DNA Translation: AAC25460.1
AY339402 Genomic DNA Translation: AAP89037.1
AY339403 Genomic DNA Translation: AAP89050.1
AY339404 Genomic DNA Translation: AAP89063.1
AY339405 Genomic DNA Translation: AAP89076.1
AY339406 Genomic DNA Translation: AAP89089.1
AY339407 Genomic DNA Translation: AAP89102.1
AY339408 Genomic DNA Translation: AAP89115.1
AY339409 Genomic DNA Translation: AAP89128.1
AY339410 Genomic DNA Translation: AAP89141.1
AY339411 Genomic DNA Translation: AAP89154.1
AY339412 Genomic DNA Translation: AAP89167.1
AY339413 Genomic DNA Translation: AAP89180.1
AY339414 Genomic DNA Translation: AAP89193.1
AY339415 Genomic DNA Translation: AAP89206.1
AY339416 Genomic DNA Translation: AAP89219.1
AY339417 Genomic DNA Translation: AAP89232.1
AY339418 Genomic DNA Translation: AAP89245.1
AY339419 Genomic DNA Translation: AAP89258.1
AY339420 Genomic DNA Translation: AAP89271.1
AY339421 Genomic DNA Translation: AAP89284.1
AY339422 Genomic DNA Translation: AAP89297.1
AY339423 Genomic DNA Translation: AAP89310.1
AY339424 Genomic DNA Translation: AAP89323.1
AY339425 Genomic DNA Translation: AAP89336.1
AY339426 Genomic DNA Translation: AAP89349.1
AY339427 Genomic DNA Translation: AAP89362.1
AY339428 Genomic DNA Translation: AAP89375.1
AY339429 Genomic DNA Translation: AAP89388.1
AY339430 Genomic DNA Translation: AAP89401.1
AY339431 Genomic DNA Translation: AAP89414.1
AY339432 Genomic DNA Translation: AAP89427.1
AY339433 Genomic DNA Translation: AAP89440.1
AY339446 Genomic DNA Translation: AAP89609.1
AY339447 Genomic DNA Translation: AAP89622.1
AY339448 Genomic DNA Translation: AAP89635.1
AY339449 Genomic DNA Translation: AAP89648.1
AY339450 Genomic DNA Translation: AAP89661.1
AY339451 Genomic DNA Translation: AAP89674.1
AY339452 Genomic DNA Translation: AAP89687.1
AY339453 Genomic DNA Translation: AAP89700.1
AY339454 Genomic DNA Translation: AAP89713.1
AY339455 Genomic DNA Translation: AAP89726.1
AY339456 Genomic DNA Translation: AAP89739.1
AY339457 Genomic DNA Translation: AAP89752.1
AY339458 Genomic DNA Translation: AAP89765.1
AY339459 Genomic DNA Translation: AAP89778.1
AY339497 Genomic DNA Translation: AAP90272.1
AY339498 Genomic DNA Translation: AAP90285.1
AY339499 Genomic DNA Translation: AAP90298.1
AY339500 Genomic DNA Translation: AAP90311.1
AY339501 Genomic DNA Translation: AAP90324.1
AY339502 Genomic DNA Translation: AAP90337.1
AY339503 Genomic DNA Translation: AAP90350.1
AY339504 Genomic DNA Translation: AAP90363.1
AY339505 Genomic DNA Translation: AAP90376.1
AY339506 Genomic DNA Translation: AAP90389.1
AY339507 Genomic DNA Translation: AAP90402.1
AY339508 Genomic DNA Translation: AAP90415.1
AY339509 Genomic DNA Translation: AAP90428.1
AY339510 Genomic DNA Translation: AAP90441.1
AY339511 Genomic DNA Translation: AAP90454.1
AY339512 Genomic DNA Translation: AAP90467.1
AY339513 Genomic DNA Translation: AAP90480.1
AY339514 Genomic DNA Translation: AAP90493.1
AY339515 Genomic DNA Translation: AAP90506.1
AY339516 Genomic DNA Translation: AAP90519.1
AY339517 Genomic DNA Translation: AAP90532.1
AY339518 Genomic DNA Translation: AAP90545.1
AY339519 Genomic DNA Translation: AAP90558.1
AY339520 Genomic DNA Translation: AAP90571.1
AY339521 Genomic DNA Translation: AAP90584.1
AY339522 Genomic DNA Translation: AAP90597.1
AY339523 Genomic DNA Translation: AAP90610.1
AY339524 Genomic DNA Translation: AAP90623.1
AY339525 Genomic DNA Translation: AAP90636.1
AY339526 Genomic DNA Translation: AAP90649.1
AY339527 Genomic DNA Translation: AAP90662.1
AY339528 Genomic DNA Translation: AAP90675.1
AY339529 Genomic DNA Translation: AAP90688.1
AY339530 Genomic DNA Translation: AAP90701.1
AY339531 Genomic DNA Translation: AAP90714.1
AY339532 Genomic DNA Translation: AAP90727.1
AY339533 Genomic DNA Translation: AAP90740.1
AY339534 Genomic DNA Translation: AAP90753.1
AY339535 Genomic DNA Translation: AAP90766.1
AY339536 Genomic DNA Translation: AAP90779.1
AY339537 Genomic DNA Translation: AAP90792.1
AY339538 Genomic DNA Translation: AAP90805.1
AY339539 Genomic DNA Translation: AAP90818.1
AY339540 Genomic DNA Translation: AAP90831.1
AY339541 Genomic DNA Translation: AAP90844.1
AY339542 Genomic DNA Translation: AAP90857.1
AY339543 Genomic DNA Translation: AAP90870.1
AY339545 Genomic DNA Translation: AAP90896.1
AY339546 Genomic DNA Translation: AAP90909.1
AY339547 Genomic DNA Translation: AAP90922.1
AY339548 Genomic DNA Translation: AAP90935.1
AY339549 Genomic DNA Translation: AAP90948.1
AY339550 Genomic DNA Translation: AAP90961.1
AY339551 Genomic DNA Translation: AAP90974.1
AY339552 Genomic DNA Translation: AAP90987.1
AY339553 Genomic DNA Translation: AAP91000.1
AY339554 Genomic DNA Translation: AAP91013.1
AY339555 Genomic DNA Translation: AAP91026.1
AY339556 Genomic DNA Translation: AAP91039.1
AY339557 Genomic DNA Translation: AAP91052.1
AY339558 Genomic DNA Translation: AAP91065.1
AY339559 Genomic DNA Translation: AAP91078.1
AY339560 Genomic DNA Translation: AAP91091.1
AY339561 Genomic DNA Translation: AAP91104.1
AY339562 Genomic DNA Translation: AAP91117.1
AY339563 Genomic DNA Translation: AAP91130.1
AY339564 Genomic DNA Translation: AAP91143.1
AY339565 Genomic DNA Translation: AAP91156.1
AY339577 Genomic DNA Translation: AAP91312.1
AY339578 Genomic DNA Translation: AAP91325.1
AY339579 Genomic DNA Translation: AAP91338.1
AY339580 Genomic DNA Translation: AAP91351.1
AY339583 Genomic DNA Translation: AAP91390.1
AY339584 Genomic DNA Translation: AAP91403.1
AY339585 Genomic DNA Translation: AAP91416.1
AY339586 Genomic DNA Translation: AAP91429.1
AY339587 Genomic DNA Translation: AAP91442.1
AY339588 Genomic DNA Translation: AAP91455.1
AY339589 Genomic DNA Translation: AAP91468.1
AY339590 Genomic DNA Translation: AAP91481.1
AY339591 Genomic DNA Translation: AAP91494.1
AY339592 Genomic DNA Translation: AAP91507.1
AY339593 Genomic DNA Translation: AAP91520.1
AF346963 Genomic DNA Translation: AAK17208.1
AF346964 Genomic DNA Translation: AAK17221.1
AF346965 Genomic DNA Translation: AAK17234.1
AF346968 Genomic DNA Translation: AAK17273.1
AF346970 Genomic DNA Translation: AAK17299.1
AF346974 Genomic DNA Translation: AAK17351.1
AF346975 Genomic DNA Translation: AAK17364.1
AF346976 Genomic DNA Translation: AAK17377.1
AF346977 Genomic DNA Translation: AAK17390.1
AF346978 Genomic DNA Translation: AAK17403.1
AF346979 Genomic DNA Translation: AAK17416.1
AF346980 Genomic DNA Translation: AAK17429.1
AF346981 Genomic DNA Translation: AAK17442.1
AF346983 Genomic DNA Translation: AAK17468.1
AF346988 Genomic DNA Translation: AAK17533.1
AF346991 Genomic DNA Translation: AAK17572.1
AF346992 Genomic DNA Translation: AAK17585.1
AF346994 Genomic DNA Translation: AAK17611.1
AF346995 Genomic DNA Translation: AAK17624.1
AF346997 Genomic DNA Translation: AAK17650.1
AF347000 Genomic DNA Translation: AAK17689.1
AF347001 Genomic DNA Translation: AAK17702.1
AF347002 Genomic DNA Translation: AAK17715.1
AF347004 Genomic DNA Translation: AAK17741.1
AF347005 Genomic DNA Translation: AAK17754.1
AF347006 Genomic DNA Translation: AAK17767.1
AF347007 Genomic DNA Translation: AAK17780.1
AF347011 Genomic DNA Translation: AAK17832.1
AF347012 Genomic DNA Translation: AAK17845.1
AF347013 Genomic DNA Translation: AAK17858.1
AF347014 Genomic DNA Translation: AAK17871.1
AF347015 Genomic DNA Translation: AAK17884.1
AY289051 Genomic DNA Translation: AAP47881.1
AY289053 Genomic DNA Translation: AAP47907.1
AY289054 Genomic DNA Translation: AAP47920.1
AY289055 Genomic DNA Translation: AAP47933.1
AY289057 Genomic DNA Translation: AAP47959.1
AY289061 Genomic DNA Translation: AAP48011.1
AY289062 Genomic DNA Translation: AAP48024.1
AY289063 Genomic DNA Translation: AAP48037.1
AY289065 Genomic DNA Translation: AAP48063.1
AY289068 Genomic DNA Translation: AAP48102.1
AY289069 Genomic DNA Translation: AAP48115.1
AY289071 Genomic DNA Translation: AAP48141.1
AY289072 Genomic DNA Translation: AAP48154.1
AY289073 Genomic DNA Translation: AAP48167.1
AY289074 Genomic DNA Translation: AAP48180.1
AY289076 Genomic DNA Translation: AAP48206.1
AY289077 Genomic DNA Translation: AAP48219.1
AY289079 Genomic DNA Translation: AAP48245.1
AY289083 Genomic DNA Translation: AAP48297.1
AY289084 Genomic DNA Translation: AAP48310.1
AY289086 Genomic DNA Translation: AAP48336.1
AY289087 Genomic DNA Translation: AAP48349.1
AY289088 Genomic DNA Translation: AAP48362.1
AY289089 Genomic DNA Translation: AAP48375.1
AY289091 Genomic DNA Translation: AAP48401.1
AY289092 Genomic DNA Translation: AAP48414.1
AY289094 Genomic DNA Translation: AAP48439.1
AY289099 Genomic DNA Translation: AAP48504.1
AY289100 Genomic DNA Translation: AAP48517.1
AY289101 Genomic DNA Translation: AAP48530.1
AY289102 Genomic DNA Translation: AAP48543.1
AY495090 Genomic DNA Translation: AAR92497.1
AY495091 Genomic DNA Translation: AAR92510.1
AY495092 Genomic DNA Translation: AAR92523.1
AY495093 Genomic DNA Translation: AAR92536.1
AY495095 Genomic DNA Translation: AAR92562.1
AY495096 Genomic DNA Translation: AAR92575.1
AY495097 Genomic DNA Translation: AAR92588.1
AY495098 Genomic DNA Translation: AAR92601.1
AY495099 Genomic DNA Translation: AAR92614.1
AY495100 Genomic DNA Translation: AAR92627.1
AY495101 Genomic DNA Translation: AAR92640.1
AY495102 Genomic DNA Translation: AAR92653.1
AY495103 Genomic DNA Translation: AAR92666.1
AY495104 Genomic DNA Translation: AAR92679.1
AY495105 Genomic DNA Translation: AAR92692.1
AY495106 Genomic DNA Translation: AAR92705.1
AY495107 Genomic DNA Translation: AAR92718.1
AY495108 Genomic DNA Translation: AAR92731.1
AY495109 Genomic DNA Translation: AAR92744.1
AY495110 Genomic DNA Translation: AAR92757.1
AY495111 Genomic DNA Translation: AAR92770.1
AY495113 Genomic DNA Translation: AAR92796.1
AY495114 Genomic DNA Translation: AAR92809.1
AY495115 Genomic DNA Translation: AAR92822.1
AY495116 Genomic DNA Translation: AAR92835.1
AY495117 Genomic DNA Translation: AAR92848.1
AY495118 Genomic DNA Translation: AAR92861.1
AY495119 Genomic DNA Translation: AAR92874.1
AY495120 Genomic DNA Translation: AAR92887.1
AY495121 Genomic DNA Translation: AAR92900.1
AY495122 Genomic DNA Translation: AAR92913.1
AY495123 Genomic DNA Translation: AAR92926.1
AY495124 Genomic DNA Translation: AAR92939.1
AY495125 Genomic DNA Translation: AAR92952.1
AY495126 Genomic DNA Translation: AAR92965.1
AY495127 Genomic DNA Translation: AAR92978.1
AY495128 Genomic DNA Translation: AAR92991.1
AY495129 Genomic DNA Translation: AAR93004.1
AY495130 Genomic DNA Translation: AAR93017.1
AY495131 Genomic DNA Translation: AAR93030.1
AY495132 Genomic DNA Translation: AAR93043.1
AY495133 Genomic DNA Translation: AAR93056.1
AY495135 Genomic DNA Translation: AAR93082.1
AY495136 Genomic DNA Translation: AAR93095.1
AY495137 Genomic DNA Translation: AAR93108.1
AY495138 Genomic DNA Translation: AAR93121.1
AY495139 Genomic DNA Translation: AAR93134.1
AY495140 Genomic DNA Translation: AAR93147.1
AY495141 Genomic DNA Translation: AAR93160.1
AY495142 Genomic DNA Translation: AAR93173.1
AY495143 Genomic DNA Translation: AAR93186.1
AY495144 Genomic DNA Translation: AAR93199.1
AY495145 Genomic DNA Translation: AAR93212.1
AY495146 Genomic DNA Translation: AAR93225.1
AY495147 Genomic DNA Translation: AAR93238.1
AY495148 Genomic DNA Translation: AAR93251.1
AY495149 Genomic DNA Translation: AAR93264.1
AY495150 Genomic DNA Translation: AAR93277.1
AY495151 Genomic DNA Translation: AAR93290.1
AY495152 Genomic DNA Translation: AAR93303.1
AY495153 Genomic DNA Translation: AAR93316.1
AY495154 Genomic DNA Translation: AAR93329.1
AY495155 Genomic DNA Translation: AAR93342.1
AY495156 Genomic DNA Translation: AAR93355.1
AY495157 Genomic DNA Translation: AAR93368.1
AY495158 Genomic DNA Translation: AAR93381.1
AY495159 Genomic DNA Translation: AAR93394.1
AY495160 Genomic DNA Translation: AAR93407.1
AY495161 Genomic DNA Translation: AAR93420.1
AY495162 Genomic DNA Translation: AAR93433.1
AY495163 Genomic DNA Translation: AAR93446.1
AY495164 Genomic DNA Translation: AAR93459.1
AY495165 Genomic DNA Translation: AAR93472.1
AY495166 Genomic DNA Translation: AAR93485.1
AY495167 Genomic DNA Translation: AAR93498.1
AY495168 Genomic DNA Translation: AAR93511.1
AY495169 Genomic DNA Translation: AAR93524.1
AY495170 Genomic DNA Translation: AAR93537.1
AY495171 Genomic DNA Translation: AAR93550.1
AY495172 Genomic DNA Translation: AAR93563.1
AY495173 Genomic DNA Translation: AAR93576.1
AY495174 Genomic DNA Translation: AAR93589.1
AY495175 Genomic DNA Translation: AAR93602.1
AY495176 Genomic DNA Translation: AAR93615.1
AY495177 Genomic DNA Translation: AAR93628.1
AY495178 Genomic DNA Translation: AAR93641.1
AY495179 Genomic DNA Translation: AAR93654.1
AY495180 Genomic DNA Translation: AAR93667.1
AY495181 Genomic DNA Translation: AAR93680.1
AY495182 Genomic DNA Translation: AAR93693.1
AY495183 Genomic DNA Translation: AAR93706.1
AY495184 Genomic DNA Translation: AAR93719.1
AY495185 Genomic DNA Translation: AAR93732.1
AY495186 Genomic DNA Translation: AAR93745.1
AY495187 Genomic DNA Translation: AAR93758.1
AY495188 Genomic DNA Translation: AAR93771.1
AY495190 Genomic DNA Translation: AAR93797.1
AY495191 Genomic DNA Translation: AAR93810.1
AY495192 Genomic DNA Translation: AAR93823.1
AY495194 Genomic DNA Translation: AAR93849.1
AY495195 Genomic DNA Translation: AAR93862.1
AY495196 Genomic DNA Translation: AAR93875.1
AY495197 Genomic DNA Translation: AAR93888.1
AY495198 Genomic DNA Translation: AAR93901.1
AY495199 Genomic DNA Translation: AAR93914.1
AY495200 Genomic DNA Translation: AAR93927.1
AY495201 Genomic DNA Translation: AAR93940.1
AY495202 Genomic DNA Translation: AAR93953.1
AY495203 Genomic DNA Translation: AAR93966.1
AY495204 Genomic DNA Translation: AAR93979.1
AY495205 Genomic DNA Translation: AAR93992.1
AY495206 Genomic DNA Translation: AAR94005.1
AY495207 Genomic DNA Translation: AAR94018.1
AY495208 Genomic DNA Translation: AAR94031.1
AY495209 Genomic DNA Translation: AAR94044.1
AY495210 Genomic DNA Translation: AAR94057.1
AY495211 Genomic DNA Translation: AAR94070.1
AY495212 Genomic DNA Translation: AAR94083.1
AY495213 Genomic DNA Translation: AAR94096.1
AY495215 Genomic DNA Translation: AAR94122.1
AY495216 Genomic DNA Translation: AAR94135.1
AY495217 Genomic DNA Translation: AAR94148.1
AY495218 Genomic DNA Translation: AAR94161.1
AY495219 Genomic DNA Translation: AAR94174.1
AY495220 Genomic DNA Translation: AAR94187.1
AY495221 Genomic DNA Translation: AAR94200.1
AY495222 Genomic DNA Translation: AAR94213.1
AY495223 Genomic DNA Translation: AAR94226.1
AY495224 Genomic DNA Translation: AAR94239.1
AY495225 Genomic DNA Translation: AAR94252.1
AY495226 Genomic DNA Translation: AAR94265.1
AY495227 Genomic DNA Translation: AAR94278.1
AY495228 Genomic DNA Translation: AAR94291.1
AY495229 Genomic DNA Translation: AAR94304.1
AY495230 Genomic DNA Translation: AAR94317.1
AY495243 Genomic DNA Translation: AAR94486.1
AY495245 Genomic DNA Translation: AAR94512.1
AY495250 Genomic DNA Translation: AAR94577.1
AY495251 Genomic DNA Translation: AAR94590.1
AY495253 Genomic DNA Translation: AAR94616.1
AY495254 Genomic DNA Translation: AAR94629.1
AY495255 Genomic DNA Translation: AAR94642.1
AY495256 Genomic DNA Translation: AAR94655.1
AY495258 Genomic DNA Translation: AAR94681.1
AY495259 Genomic DNA Translation: AAR94694.1
AY495260 Genomic DNA Translation: AAR94707.1
AY495261 Genomic DNA Translation: AAR94720.1
AY495262 Genomic DNA Translation: AAR94733.1
AY495263 Genomic DNA Translation: AAR94746.1
AY495264 Genomic DNA Translation: AAR94759.1
AY495265 Genomic DNA Translation: AAR94772.1
AY495266 Genomic DNA Translation: AAR94785.1
AY495306 Genomic DNA Translation: AAR95305.1
AY495307 Genomic DNA Translation: AAR95318.1
AY495308 Genomic DNA Translation: AAR95331.1
AY495309 Genomic DNA Translation: AAR95344.1
AY495310 Genomic DNA Translation: AAR95357.1
AY495311 Genomic DNA Translation: AAR95370.1
AY495312 Genomic DNA Translation: AAR95383.1
AY495313 Genomic DNA Translation: AAR95396.1
AY495314 Genomic DNA Translation: AAR95409.1
AY495315 Genomic DNA Translation: AAR95422.1
AY495316 Genomic DNA Translation: AAR95435.1
AY495317 Genomic DNA Translation: AAR95448.1
AY495318 Genomic DNA Translation: AAR95461.1
AY495319 Genomic DNA Translation: AAR95474.1
AY495320 Genomic DNA Translation: AAR95487.1
AY495321 Genomic DNA Translation: AAR95500.1
AY495322 Genomic DNA Translation: AAR95513.1
AY495323 Genomic DNA Translation: AAR95526.1
AY495326 Genomic DNA Translation: AAR95565.1
AY495327 Genomic DNA Translation: AAR95578.1
AY495328 Genomic DNA Translation: AAR95591.1
AY495329 Genomic DNA Translation: AAR95604.1
AY495330 Genomic DNA Translation: AAR95617.1
AY495302 Genomic DNA Translation: AAR95253.1
PIRiA00414 DNHUN2
RefSeqiYP_003024027.1, NC_012920.1

Genome annotation databases

EnsembliENST00000361453; ENSP00000355046; ENSG00000198763
GeneIDi4536
KEGGihsa:4536

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiNU2M_HUMAN
AccessioniPrimary (citable) accession number: P03891
Secondary accession number(s): Q34769
, Q9TGI0, Q9TGI1, Q9TGI2, Q9TGI3, Q9TGI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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