UniProtKB - P03888 (NU1M_MOUSE)
Protein
NADH-ubiquinone oxidoreductase chain 1
Gene
Mtnd1
Organism
Mus musculus (Mouse)
Status
Functioni
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity
Catalytic activityi
- EC:7.1.1.2
GO - Biological processi
- aerobic respiration Source: GO_Central
- response to drug Source: Ensembl
- response to hydroperoxide Source: MGI
- response to organic cyclic compound Source: Ensembl
Keywordsi
Molecular function | Translocase |
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | NAD, Ubiquinone |
Enzyme and pathway databases
Reactomei | R-MMU-611105 Respiratory electron transport R-MMU-6799198 Complex I biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-ubiquinone oxidoreductase chain 1 (EC:7.1.1.2)Alternative name(s): NADH dehydrogenase subunit 1 |
Gene namesi | Name:Mtnd1 Synonyms:mt-Nd1, Nd1 |
Encoded oni | Mitochondrion |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101787 mt-Nd1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial membrane Source: MGI
- mitochondrial respiratory chain complex I Source: MGI
- mitochondrion Source: MGI
Other locations
- dendrite Source: MGI
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2 – 22 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 70 – 90 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 253 – 273 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 293 – 313 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000117431 | 1 – 318 | NADH-ubiquinone oxidoreductase chain 1Add BLAST | 318 |
Proteomic databases
EPDi | P03888 |
jPOSTi | P03888 |
PaxDbi | P03888 |
PRIDEi | P03888 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000064341 Expressed in 20 organ(s), highest expression level in female gonad |
ExpressionAtlasi | P03888 baseline and differential |
Interactioni
Protein-protein interaction databases
BioGridi | 201547, 2 interactors |
ComplexPortali | CPX-266 Mitochondrial respiratory chain complex I |
CORUMi | P03888 |
DIPi | DIP-61655N |
IntActi | P03888, 3 interactors |
STRINGi | 10090.ENSMUSP00000080991 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6G2J | electron microscopy | 3.30 | H | 1-318 | [»] | |
6G72 | electron microscopy | 3.90 | H | 1-318 | [»] | |
ProteinModelPortali | P03888 | |||||
SMRi | P03888 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I subunit 1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4770 Eukaryota COG1005 LUCA |
GeneTreei | ENSGT00390000006621 |
HOGENOMi | HOG000228276 |
HOVERGENi | HBG016682 |
InParanoidi | P03888 |
KOi | K03878 |
OMAi | MKFALFY |
OrthoDBi | 1214989at2759 |
PhylomeDBi | P03888 |
Family and domain databases
HAMAPi | MF_01350 NDH1_NuoH, 1 hit |
InterProi | View protein in InterPro IPR001694 NADH_UbQ_OxRdtase_su1/FPO IPR018086 NADH_UbQ_OxRdtase_su1_CS |
PANTHERi | PTHR11432 PTHR11432, 1 hit |
Pfami | View protein in Pfam PF00146 NADHdh, 1 hit |
PROSITEi | View protein in PROSITE PS00667 COMPLEX1_ND1_1, 1 hit PS00668 COMPLEX1_ND1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P03888-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA
60 70 80 90 100
DAMKLFMKEP MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL
110 120 130 140 150
GILFILATSS LSVYSILWSG WASNSKYSLF GALRAVAQTI SYEVTMAIIL
160 170 180 190 200
LSVLLMNGSY SLQTLITTQE HMWLLLPAWP MAMMWFISTL AETNRAPFDL
210 220 230 240 250
TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI IFLGPLYYIN
260 270 280 290 300
LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
310
CMWHISLPIF TAGVPPYM
Sequence cautioni
The sequence AAB48644 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA24080 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00711 Genomic DNA Translation: CAA24080.1 Different initiation. J01420 Genomic DNA Translation: AAB48644.1 Different initiation. AB042523 Genomic DNA Translation: BAA95653.2 AB042524 Genomic DNA Translation: BAA95640.2 AB042809 Genomic DNA Translation: BAA95795.2 AB049357 Genomic DNA Translation: BAB13801.2 AJ512208 Genomic DNA Translation: CAD54432.1 AY172335 Genomic DNA Translation: AAN85122.1 AY339599 Genomic DNA Translation: AAP89023.2 AJ489607 Genomic DNA Translation: CAD33907.1 AY533105 Genomic DNA Translation: AAS01439.1 AY533106 Genomic DNA Translation: AAS01452.1 AY533107 Genomic DNA Translation: AAS01465.1 AY533108 Genomic DNA Translation: AAS01478.1 |
PIRi | A00409 QXMS1M |
RefSeqi | NP_904328.1, NC_005089.1 YP_220550.1, NC_006914.1 |
Genome annotation databases
Ensembli | ENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341 |
GeneIDi | 17716 3338902 |
KEGGi | mmu:17716 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00711 Genomic DNA Translation: CAA24080.1 Different initiation. J01420 Genomic DNA Translation: AAB48644.1 Different initiation. AB042523 Genomic DNA Translation: BAA95653.2 AB042524 Genomic DNA Translation: BAA95640.2 AB042809 Genomic DNA Translation: BAA95795.2 AB049357 Genomic DNA Translation: BAB13801.2 AJ512208 Genomic DNA Translation: CAD54432.1 AY172335 Genomic DNA Translation: AAN85122.1 AY339599 Genomic DNA Translation: AAP89023.2 AJ489607 Genomic DNA Translation: CAD33907.1 AY533105 Genomic DNA Translation: AAS01439.1 AY533106 Genomic DNA Translation: AAS01452.1 AY533107 Genomic DNA Translation: AAS01465.1 AY533108 Genomic DNA Translation: AAS01478.1 |
PIRi | A00409 QXMS1M |
RefSeqi | NP_904328.1, NC_005089.1 YP_220550.1, NC_006914.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6G2J | electron microscopy | 3.30 | H | 1-318 | [»] | |
6G72 | electron microscopy | 3.90 | H | 1-318 | [»] | |
ProteinModelPortali | P03888 | |||||
SMRi | P03888 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 201547, 2 interactors |
ComplexPortali | CPX-266 Mitochondrial respiratory chain complex I |
CORUMi | P03888 |
DIPi | DIP-61655N |
IntActi | P03888, 3 interactors |
STRINGi | 10090.ENSMUSP00000080991 |
Proteomic databases
EPDi | P03888 |
jPOSTi | P03888 |
PaxDbi | P03888 |
PRIDEi | P03888 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341 |
GeneIDi | 17716 3338902 |
KEGGi | mmu:17716 |
Organism-specific databases
CTDi | 4535 |
MGIi | MGI:101787 mt-Nd1 |
Phylogenomic databases
eggNOGi | KOG4770 Eukaryota COG1005 LUCA |
GeneTreei | ENSGT00390000006621 |
HOGENOMi | HOG000228276 |
HOVERGENi | HBG016682 |
InParanoidi | P03888 |
KOi | K03878 |
OMAi | MKFALFY |
OrthoDBi | 1214989at2759 |
PhylomeDBi | P03888 |
Enzyme and pathway databases
Reactomei | R-MMU-611105 Respiratory electron transport R-MMU-6799198 Complex I biogenesis |
Miscellaneous databases
PROi | PR:P03888 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000064341 Expressed in 20 organ(s), highest expression level in female gonad |
ExpressionAtlasi | P03888 baseline and differential |
Family and domain databases
HAMAPi | MF_01350 NDH1_NuoH, 1 hit |
InterProi | View protein in InterPro IPR001694 NADH_UbQ_OxRdtase_su1/FPO IPR018086 NADH_UbQ_OxRdtase_su1_CS |
PANTHERi | PTHR11432 PTHR11432, 1 hit |
Pfami | View protein in Pfam PF00146 NADHdh, 1 hit |
PROSITEi | View protein in PROSITE PS00667 COMPLEX1_ND1_1, 1 hit PS00668 COMPLEX1_ND1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | NU1M_MOUSE | |
Accessioni | P03888Primary (citable) accession number: P03888 Secondary accession number(s): Q9G0S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 4, 2005 | |
Last modified: | January 16, 2019 | |
This is version 137 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot