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Entry version 189 (07 Oct 2020)
Sequence version 2 (01 Nov 1991)
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Protein

Glutathione-regulated potassium-efflux system protein KefC

Gene

kefC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K+/H+ antiport. Can also export rubidium, lithium and sodium.UniRule annotation3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by glutathione. This inhibition is increased by NADH. Activated by adducts between glutathione and electrophiles.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei412Glutathione; shared with dimeric partner1
Binding sitei434AMP1 Publication1
Binding sitei472AMP1 Publication1
Binding sitei496AMP1 Publication1
Binding sitei516Glutathione1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi408 – 410AMP1 Publication3
Nucleotide bindingi429 – 430AMP1 Publication2
Nucleotide bindingi449 – 450AMP1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Potassium transport, Transport
LigandNucleotide-binding, Potassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:KEFC-MONOMER
MetaCyc:KEFC-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.37.1.1, the monovalent cation:proton antiporter-2 (cpa2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione-regulated potassium-efflux system protein KefCUniRule annotation
Alternative name(s):
K(+)/H(+) antiporterUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kefCUniRule annotation
Synonyms:trkC
Ordered Locus Names:b0047, JW0046
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3PeriplasmicSequence analysis3
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Topological domaini25CytoplasmicSequence analysis1
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Topological domaini47 – 53PeriplasmicSequence analysis7
Transmembranei54 – 74HelicalUniRule annotationAdd BLAST21
Topological domaini75 – 89CytoplasmicSequence analysisAdd BLAST15
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Topological domaini111 – 113PeriplasmicSequence analysis3
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Topological domaini135 – 148CytoplasmicSequence analysisAdd BLAST14
Transmembranei149 – 169HelicalUniRule annotationAdd BLAST21
Topological domaini170 – 177PeriplasmicSequence analysis8
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Topological domaini199 – 213CytoplasmicSequence analysisAdd BLAST15
Transmembranei214 – 233HelicalUniRule annotationAdd BLAST20
Topological domaini234 – 236PeriplasmicSequence analysis3
Transmembranei237 – 254HelicalUniRule annotationAdd BLAST18
Topological domaini255 – 269CytoplasmicSequence analysisAdd BLAST15
Transmembranei270 – 290HelicalUniRule annotationAdd BLAST21
Topological domaini291 – 293PeriplasmicSequence analysis3
Transmembranei294 – 314HelicalUniRule annotationAdd BLAST21
Topological domaini315 – 326CytoplasmicSequence analysisAdd BLAST12
Transmembranei327 – 347HelicalUniRule annotationAdd BLAST21
Topological domaini348 – 358PeriplasmicSequence analysisAdd BLAST11
Transmembranei359 – 379HelicalUniRule annotationAdd BLAST21
Topological domaini380 – 620Cytoplasmic1 PublicationAdd BLAST241

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi262E → K: Increases potassium efflux in the absence of glutathione, but not in the presence of glutathione. Increases constitutive potassium efflux; when associated with D-551. 1
Mutagenesisi264D → A: Increases constitutive potassium efflux. 1 Publication1
Mutagenesisi412Q → A: Increases constitutive potassium efflux and reduces glutathione-mediated inhibition of potassium efflux. 1 Publication1
Mutagenesisi412Q → K: Increases constitutive potassium efflux and abolishes regulation of potassium efflux by glutathione and glutathione adducts. 1 Publication1
Mutagenesisi416R → A: Increases constitutive potassium efflux and abolishes regulation of potassium efflux by glutathione and glutathione adducts; when associated with A-516 and A-551. 2 Publications1
Mutagenesisi416R → S: Increased constitutive potassium efflux. 2 Publications1
Mutagenesisi441F → D or L: Reduced activation of potassium efflux by glutathione adducts. 1 Publication1
Mutagenesisi441F → W or Y: No effect on activation of potassium efflux by glutathione adducts. 1 Publication1
Mutagenesisi499D → A: Strongly reduced activation of potassium efflux by glutathione adducts. 1 Publication1
Mutagenesisi499D → G: Mildly reduced activation of potassium efflux by glutathione adducts. 1 Publication1
Mutagenesisi499D → S: No effect on potassium efflux. 1 Publication1
Mutagenesisi516R → A: Increases constitutive potassium efflux and abolishes regulation of potassium efflux by glutathione and glutathione adducts; when associated with A-416 and A-551. 1 Publication1
Mutagenesisi520E → G: Strongly reduced potassium efflux. 1 Publication1
Mutagenesisi522A → V: Strongly reduced potassium efflux. 1 Publication1
Mutagenesisi526G → V: Strongly reduced potassium efflux. 1 Publication1
Mutagenesisi551N → A: Increases constitutive potassium efflux and abolishes regulation of potassium efflux by glutathione and glutathione adducts; when associated with A-416 and A-516. 2 Publications1
Mutagenesisi551N → D: Increases constitutive potassium efflux; when associated with K-262. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001966061 – 620Glutathione-regulated potassium-efflux system protein KefCAdd BLAST620

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P03819

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P03819

PRoteomics IDEntifications database

More...
PRIDEi
P03819

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the regulatory subunit KefF, forming a heterotetramer with 2:2 stoichiometry. Interaction with KefF is required for optimal activity. The active antiporter may be formed by the heterotetramer, or by an octamer.

UniRule annotation3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4262200, 8 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2543, Glutathione-regulated potassium-efflux system KefC-KefF complex

Database of interacting proteins

More...
DIPi
DIP-10072N

Protein interaction database and analysis system

More...
IntActi
P03819, 3 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0047

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1620
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P03819

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P03819

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini401 – 523RCK N-terminalUniRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni259 – 267Important for the regulation of potassium conductance9
Regioni498 – 500Glutathione binding3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic RCK N-terminal domain regulates channel activity. It binds glutathione, resulting in inhibition of potassium efflux. In contrast, binding of the adducts formed between glutathione and electrophiles leads to activation of potassium efflux. Is expected to bind NADH, but X-ray crystallography shows bound AMP, and it would be difficult to accommodate NADH in this binding site (PubMed:21041667).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0475, Bacteria
COG1226, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005126_9_3_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P03819

KEGG Orthology (KO)

More...
KOi
K11745

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P03819

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1530.20, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01413, K_H_efflux_KefC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153, Cation/H_exchanger
IPR004771, K/H_exchanger
IPR023941, K_H_efflux_KefC
IPR006036, K_uptake_TrkA
IPR038770, Na+/solute_symporter_sf
IPR036291, NAD(P)-bd_dom_sf
IPR003148, RCK_N

The PANTHER Classification System

More...
PANTHERi
PTHR46157:SF3, PTHR46157:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF02254, TrkA_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00335, KUPTAKETRKA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00932, 2a37, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51201, RCK_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P03819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSHTLIQAL IYLGSAALIV PIAVRLGLGS VLGYLIAGCI IGPWGLRLVT
60 70 80 90 100
DAESILHFAE IGVVLMLFII GLELDPQRLW KLRAAVFGCG ALQMVICGGL
110 120 130 140 150
LGLFCMLLGL RWQVAELIGM TLALSSTAIA MQAMNERNLM VTQMGRSAFA
160 170 180 190 200
VLLFQDIAAI PLVAMIPLLA TSSASTTMGA FALSALKVAG ALVLVVLLGR
210 220 230 240 250
YVTRPALRFV ARSGLREVFS AVALFLVFGF GLLLEEVGLS MAMGAFLAGV
260 270 280 290 300
LLASSEYRHA LESDIEPFKG LLLGLFFIGV GMSIDFGTLL ENPLRIVILL
310 320 330 340 350
LGFLIIKIAM LWLIARPLQV PNKQRRWFAV LLGQGSEFAF VVFGAAQMAN
360 370 380 390 400
VLEPEWAKSL TLAVALSMAA TPILLVILNR LEQSSTEEAR EADEIDEEQP
410 420 430 440 450
RVIIAGFGRF GQITGRLLLS SGVKMVVLDH DPDHIETLRK FGMKVFYGDA
460 470 480 490 500
TRMDLLESAG AAKAEVLINA IDDPQTNLQL TEMVKEHFPH LQIIARARDV
510 520 530 540 550
DHYIRLRQAG VEKPERETFE GALKTGRLAL ESLGLGPYEA RERADVFRRF
560 570 580 590 600
NIQMVEEMAM VENDTKARAA VYKRTSAMLS EIITEDREHL SLIQRHGWQG
610 620
TEEGKHTGNM ADEPETKPSS
Length:620
Mass (Da):67,796
Last modified:November 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9995B2E8E3C1DCE3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56742 Genomic DNA Translation: CAA40066.1
U00096 Genomic DNA Translation: AAC73158.1
AP009048 Genomic DNA Translation: BAB96615.1
J01609 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
S40568, QQECRD

NCBI Reference Sequences

More...
RefSeqi
NP_414589.1, NC_000913.3
WP_000377098.1, NZ_STEB01000010.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73158; AAC73158; b0047
BAB96615; BAB96615; BAB96615

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
944773

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0046
eco:b0047

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2236

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56742 Genomic DNA Translation: CAA40066.1
U00096 Genomic DNA Translation: AAC73158.1
AP009048 Genomic DNA Translation: BAB96615.1
J01609 Genomic DNA No translation available.
PIRiS40568, QQECRD
RefSeqiNP_414589.1, NC_000913.3
WP_000377098.1, NZ_STEB01000010.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EYWX-ray2.40A/B401-620[»]
3L9WX-ray1.75A/B401-620[»]
3L9XX-ray2.10A/B401-620[»]
SMRiP03819
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4262200, 8 interactors
ComplexPortaliCPX-2543, Glutathione-regulated potassium-efflux system KefC-KefF complex
DIPiDIP-10072N
IntActiP03819, 3 interactors
STRINGi511145.b0047

Protein family/group databases

TCDBi2.A.37.1.1, the monovalent cation:proton antiporter-2 (cpa2) family

Proteomic databases

jPOSTiP03819
PaxDbiP03819
PRIDEiP03819

Genome annotation databases

EnsemblBacteriaiAAC73158; AAC73158; b0047
BAB96615; BAB96615; BAB96615
GeneIDi944773
KEGGiecj:JW0046
eco:b0047
PATRICifig|1411691.4.peg.2236

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0516

Phylogenomic databases

eggNOGiCOG0475, Bacteria
COG1226, Bacteria
HOGENOMiCLU_005126_9_3_6
InParanoidiP03819
KOiK11745
PhylomeDBiP03819

Enzyme and pathway databases

BioCyciEcoCyc:KEFC-MONOMER
MetaCyc:KEFC-MONOMER

Miscellaneous databases

EvolutionaryTraceiP03819

Protein Ontology

More...
PROi
PR:P03819

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
HAMAPiMF_01413, K_H_efflux_KefC, 1 hit
InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR004771, K/H_exchanger
IPR023941, K_H_efflux_KefC
IPR006036, K_uptake_TrkA
IPR038770, Na+/solute_symporter_sf
IPR036291, NAD(P)-bd_dom_sf
IPR003148, RCK_N
PANTHERiPTHR46157:SF3, PTHR46157:SF3, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF02254, TrkA_N, 1 hit
PRINTSiPR00335, KUPTAKETRKA
SUPFAMiSSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR00932, 2a37, 1 hit
PROSITEiView protein in PROSITE
PS51201, RCK_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKEFC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03819
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: October 7, 2020
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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