UniProtKB - P03733 (TUBE_LAMBD)
Tail tube protein
V
Functioni
Forms the phage's tail tube composed of 32 hexameric disks. When it encounters the appropriate initiation complex gpM and gpL, it assembles in hexameric rings that stack on top of each others. Multimerization ceases when the correct tail length is achieved through a mechanism dependent on tail terminator protein.
2 PublicationsGO - Biological processi
- viral genome ejection through host cell envelope, long flexible tail mechanism Source: UniProtKB-KW
- viral tail assembly Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Tail tube proteinShort name: TTP Alternative name(s): Gene product V Short name: gpV Major tail protein V |
Gene namesi | Name:V Ordered Locus Names:lambdap13 |
Organismi | Escherichia phage lambda (Bacteriophage lambda) |
Taxonomic identifieri | 10710 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Siphoviridae › Lambdavirus |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
Subcellular locationi
- Virion 1 Publication
- Host cytoplasm 1 Publication
Keywords - Cellular componenti
Host cytoplasm, Viral tail protein, Viral tail tube protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077671 | 1 – 246 | Tail tube proteinAdd BLAST | 246 |
Interactioni
Subunit structurei
Multimerizes into a structure formed by 32 hexameric rings stacked on phage baseplate gpM and gpL. Does not multimerize in solution without the tail initiation complex. Soluble major tail protein interacts with tail assembly protein GT during tail assembly.
2 PublicationsProtein-protein interaction databases
IntActi | P03733, 6 interactors |
Structurei
Secondary structure
3D structure databases
BMRBi | P03733 |
SMRi | P03733 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P03733 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 161 – 239 | BIG2Sequence analysisAdd BLAST | 79 | |
Domaini | 204 – 246 | Big-1; incompletePROSITE-ProRule annotationAdd BLAST | 43 |
Family and domain databases
InterProi | View protein in InterPro IPR003343, Big_2 IPR032494, Phage_TTP_12 |
Pfami | View protein in Pfam PF02368, Big_2, 1 hit PF16461, Phage_TTP_12, 1 hit |
SMARTi | View protein in SMART SM00635, BID_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPVPNPTMPV KGAGTTLWVY KGSGDPYANP LSDVDWSRLA KVKDLTPGEL
60 70 80 90 100
TAESYDDSYL DDEDADWTAT GQGQKSAGDT SFTLAWMPGE QGQQALLAWF
110 120 130 140 150
NEGDTRAYKI RFPNGTVDVF RGWVSSIGKA VTAKEVITRT VKVTNVGRPS
160 170 180 190 200
MAEDRSTVTA ATGMTVTPAS TSVVKGQSTT LTVAFQPEGV TDKSFRAVSA
210 220 230 240
DKTKATVSVS GMTITVNGVA AGKVNIPVVS GNGEFAAVAE ITVTAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02459 Genomic DNA Translation: AAA96545.1 |
PIRi | D43008, TLBPVL |
RefSeqi | NP_040592.1, NC_001416.1 |
Genome annotation databases
GeneIDi | 2703487 |
KEGGi | vg:2703487 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02459 Genomic DNA Translation: AAA96545.1 |
PIRi | D43008, TLBPVL |
RefSeqi | NP_040592.1, NC_001416.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K4Q | NMR | - | A | 1-153 | [»] | |
2L04 | NMR | - | A | 160-246 | [»] | |
6P3E | electron microscopy | 5.40 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R | 1-246 | [»] | |
BMRBi | P03733 | |||||
SMRi | P03733 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P03733, 6 interactors |
Genome annotation databases
GeneIDi | 2703487 |
KEGGi | vg:2703487 |
Miscellaneous databases
EvolutionaryTracei | P03733 |
Family and domain databases
InterProi | View protein in InterPro IPR003343, Big_2 IPR032494, Phage_TTP_12 |
Pfami | View protein in Pfam PF02368, Big_2, 1 hit PF16461, Phage_TTP_12, 1 hit |
SMARTi | View protein in SMART SM00635, BID_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TUBE_LAMBD | |
Accessioni | P03733Primary (citable) accession number: P03733 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | June 2, 2021 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references