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Protein

Host-nuclease inhibitor protein gam

Gene

gam

Organism
Escherichia phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to host RecBCD nuclease and inhibits it thereby protecting the viral DNA against recBCD mediated degradation.1 Publication

Caution

Originally (PubMed:6458018) the gam gene product was assigned to the sequence shown and it was suggested that the gene kil protein is encoded from within this gene and corresponds to residues 41-138. For an alternative assignment of this gene see the entry for the kil gene protein of lambda.1 Publication

GO - Molecular functioni

  • deoxyribonuclease inhibitor activity Source: CACAO

GO - Biological processi

Keywordsi

Biological processDNA end degradation evasion by virus, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Host-nuclease inhibitor protein gam
Gene namesi
Name:gam
Synonyms:gamma
OrganismiEscherichia phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdavirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000776411 – 138Host-nuclease inhibitor protein gamAdd BLAST138

Interactioni

Subunit structurei

Interacts with host RecBCD; this interaction prevents RecBCD from binding to DNA.1 Publication

Protein-protein interaction databases

DIPiDIP-572N

Structurei

Secondary structure

1138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03702
SMRiP03702
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03702

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG09000123

Family and domain databases

InterProiView protein in InterPro
IPR009274 Gam
PfamiView protein in Pfam
PF06064 Gam, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD084412 Gam, 1 hit

Sequencei

Sequence statusi: Complete.

P03702-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDINTETEIK QKHSLTPFPV FLISPAFRGR YFHSYFRSSA MNAYYIQDRL
60 70 80 90 100
EAQSWARHYQ QLAREEKEAE LADDMEKGLP QHLFESLCID HLQRHGASKK
110 120 130
SITRAFDDDV EFQERMAEHI RYMVETIAHH QVDIDSEV
Length:138
Mass (Da):16,346
Last modified:July 21, 1986 - v1
Checksum:i19479118D37F576C
GO

Sequence cautioni

The sequence CAA23977 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79L → I in AAB23852 (PubMed:1327972).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00638 Genomic DNA Translation: CAA23978.1
V00638 Genomic DNA Translation: CAA23977.1 Different initiation.
J02459 Genomic DNA Translation: AAA96571.1
S46756 Genomic DNA Translation: AAB23852.2
PIRiD93737 QGBPL
RefSeqiNP_040618.1, NC_001416.1

Genome annotation databases

GeneIDi2703509
KEGGivg:2703509

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00638 Genomic DNA Translation: CAA23978.1
V00638 Genomic DNA Translation: CAA23977.1 Different initiation.
J02459 Genomic DNA Translation: AAA96571.1
S46756 Genomic DNA Translation: AAB23852.2
PIRiD93737 QGBPL
RefSeqiNP_040618.1, NC_001416.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UUZX-ray2.30A/B40-138[»]
2UV1X-ray2.60A/B40-138[»]
5MBVelectron microscopy3.80A/E41-138[»]
ProteinModelPortaliP03702
SMRiP03702
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-572N

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703509
KEGGivg:2703509

Phylogenomic databases

OrthoDBiVOG09000123

Miscellaneous databases

EvolutionaryTraceiP03702

Family and domain databases

InterProiView protein in InterPro
IPR009274 Gam
PfamiView protein in Pfam
PF06064 Gam, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD084412 Gam, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAM_LAMBD
AccessioniPrimary (citable) accession number: P03702
Secondary accession number(s): Q53285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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