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UniProtKB - P03697 (EXO_LAMBD)
Protein
Exonuclease
Gene
exo
Organism
Escherichia phage lambda (Bacteriophage lambda)
Status
Functioni
Facilitates phage DNA recombination through the double-strand break repair (DSBR) and single-strand annealing pathways. Also important for the late, rolling-circle mode of lambda DNA replication.
Catalytic activityi
- Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates. EC:3.1.11.3
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 119 | Magnesium | 1 | |
Metal bindingi | 129 | Magnesium | 1 |
GO - Molecular functioni
- exonuclease activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Exonuclease, Hydrolase, Nuclease |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:exo Synonyms:red-alpha, redX |
Organismi | Escherichia phage lambda (Bacteriophage lambda) |
Taxonomic identifieri | 10710 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Siphoviridae › Lambdavirus |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077574 | 1 – 226 | ExonucleaseAdd BLAST | 226 |
Interactioni
Subunit structurei
Trimer of three subunits that form a toroid, with a tapered channel passing through the middle.
Protein-protein interaction databases
DIPi | DIP-59695N |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P03697 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P03697 |
Family & Domainsi
Family and domain databases
Gene3Di | 3.90.320.10, 1 hit |
InterProi | View protein in InterPro IPR011604, PDDEXK-like_dom_sf IPR011335, Restrct_endonuc-II-like IPR019080, YqaJ_viral_recombinase |
Pfami | View protein in Pfam PF09588, YqaJ, 1 hit |
SUPFAMi | SSF52980, SSF52980, 1 hit |
i Sequence
Sequence statusi: Complete.
P03697-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPDIILQRT GIDVRAVEQG DDAWHKLRLG VITASEVHNV IAKPRSGKKW
60 70 80 90 100
PDMKMSYFHT LLAEVCTGVA PEVNAKALAW GKQYENDART LFEFTSGVNV
110 120 130 140 150
TESPIIYRDE SMRTACSPDG LCSDGNGLEL KCPFTSRDFM KFRLGGFEAI
160 170 180 190 200
KSAYMAQVQY SMWVTRKNAW YFANYDPRMK REGLHYVVIE RDEKYMASFD
210 220
EIVPEFIEKM DEALAEIGFV FGEQWR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02459 Genomic DNA Translation: AAA96569.1 |
PIRi | H94614, NDBPXL |
RefSeqi | NP_040616.1, NC_001416.1 |
Genome annotation databases
GeneIDi | 2703469 2703502 |
KEGGi | vg:2703522 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02459 Genomic DNA Translation: AAA96569.1 |
PIRi | H94614, NDBPXL |
RefSeqi | NP_040616.1, NC_001416.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AVQ | X-ray | 2.40 | A/B/C | 1-226 | [»] | |
3SLP | X-ray | 2.30 | A/B/C | 1-226 | [»] | |
3SM4 | X-ray | 1.88 | A/B/C | 1-226 | [»] | |
4WUZ | X-ray | 2.38 | A/B/C | 1-226 | [»] | |
6M9K | X-ray | 2.30 | A/B/C | 1-226 | [»] | |
SMRi | P03697 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-59695N |
Genome annotation databases
GeneIDi | 2703469 2703502 |
KEGGi | vg:2703522 |
Miscellaneous databases
EvolutionaryTracei | P03697 |
Family and domain databases
Gene3Di | 3.90.320.10, 1 hit |
InterProi | View protein in InterPro IPR011604, PDDEXK-like_dom_sf IPR011335, Restrct_endonuc-II-like IPR019080, YqaJ_viral_recombinase |
Pfami | View protein in Pfam PF09588, YqaJ, 1 hit |
SUPFAMi | SSF52980, SSF52980, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EXO_LAMBD | |
Accessioni | P03697Primary (citable) accession number: P03697 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references