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Entry version 156 (02 Jun 2021)
Sequence version 1 (21 Jul 1986)
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Protein

DNA helicase/primase

Gene

4

Organism
Escherichia phage T7 (Bacteriophage T7)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent DNA helicase and primase essential for viral DNA replication and recombination (PubMed:21606333, PubMed:22977246, PubMed:32009150).

The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis (PubMed:21606333, PubMed:22977246, PubMed:32009150).

ATP or dTTP hydrolysis propels each helicase domain to translocate 2 nt per step sequentially along DNA (PubMed:30679383, PubMed:17604719).

Mediates strand transfer when a joint molecule is available and participates in recombinational DNA repair through its role in strand exchange (PubMed:9096333, PubMed:8617248).

Primase activity synthesizes short RNA primers at the sequence 5'-GTC-3' on the lagging strand that the polymerase elongates using dNTPs and providing the primase is still present (PubMed:6454135, PubMed:9139692).

UniRule annotation9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation1 PublicationNote: Binds 2 Mg2+, one of which is catalytic.UniRule annotation2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi17ZincUniRule annotation1 Publication1
Metal bindingi20ZincUniRule annotation1 Publication1
Metal bindingi36ZincUniRule annotation1 Publication1
Metal bindingi39ZincUniRule annotation1 Publication1
Metal bindingi157Magnesium 1; catalyticUniRule annotation1 Publication1
Metal bindingi207Magnesium 1; catalyticUniRule annotation1 Publication1
Metal bindingi237Magnesium 2UniRule annotation1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei361dTTP/dATP bindingUniRule annotation1 Publication1
Sitei465dTTP/dATP bindingUniRule annotation1 Publication1
Sitei504dTTP/dATP bindingUniRule annotation2 Publications1
Sitei522dTTP/dATP bindingUniRule annotation2 Publications1
Sitei535dTTP/dATP bindingUniRule annotation2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri17 – 39C4-like; zinc ribbon foldUniRule annotation1 Publication2 PublicationsAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi312 – 319ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase, Multifunctional enzyme, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA helicase/primaseUniRule annotation (EC:2.7.7.-UniRule annotation1 Publication, EC:3.6.4.12UniRule annotation2 Publications)
Alternative name(s):
Gene product 4UniRule annotation
Short name:
Gp4UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia phage T7 (Bacteriophage T7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10760 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraeUroviricotaCaudoviricetesCaudoviralesAutographiviridaeStudiervirinaeTeseptimavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiEscherichia coli [TaxID: 562]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000840 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Primosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03222, dATP
DB02452, Thymidine 5'-triphosphate

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000033551 – 566DNA helicase/primaseAdd BLAST566

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer (PubMed:16777142, PubMed:10880454, PubMed:30679383, PubMed:10535735, PubMed:10892646, PubMed:14636571). Assembles as a hexamer onto linear or circular ssDNA in the presence of ATP or dTTP (PubMed:10880454). Present in a mixture of heptamers and hexamers in the absence of DNA (PubMed:16777142, PubMed:14636571).

Interacts (via C-terminus) with the viral DNA polymerase that is bound to DNA; this interaction is essential to initiate leading-strand DNA synthesis (PubMed:15795374, PubMed:22977246, PubMed:23675753, PubMed:26620561). The priming complex consists of 2 DNA polymerases and 1 helicase-primase hexamer that assemble on the DNA template (PubMed:23675753).

Interacts with the single-stranded DNA-binding protein (PubMed:1634539). Part of the replicase complex that includes the DNA polymerase, thioredoxin, the primase/helicase and the single-stranded DNA binding protein (PubMed:22977246).

UniRule annotation11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P03692, 1 interactor

Molecular INTeraction database

More...
MINTi
P03692

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1566
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P03692

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P03692

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini151 – 238ToprimPROSITE-ProRule annotationAdd BLAST88
Domaini281 – 548SF4 helicaseUniRule annotationAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni543 – 566DisorderedSequence analysisAdd BLAST24
Regioni550 – 566Binding to viral DNA polymeraseUniRule annotation1 PublicationAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi549 – 566Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus zinc finger domain is essential for delivering the primed DNA template to the DNA polymerase (PubMed:12769857, PubMed:10200256). The central core domain contains the primase activity (PubMed:2829184). The C-terminus region is responsible for the helicase activity and binds 1 Mg2+-dTTP (PubMed:2829184, PubMed:9185573, PubMed:30679383).UniRule annotation5 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Teseptimavirus DNA helicase/primase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 39C4-like; zinc ribbon foldUniRule annotation1 Publication2 PublicationsAdd BLAST23

Keywords - Domaini

Zinc-finger

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01029, TOPRIM_primases, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_04154, Helic_Prim_T7, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007694, DNA_helicase_DnaB-like_C
IPR027417, P-loop_NTPase
IPR013237, Phage_T7_Gp4_N
IPR034154, TOPRIM_DnaG/twinkle
IPR006171, TOPRIM_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03796, DnaB_C, 1 hit
PF08273, Prim_Zn_Ribbon, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00778, Prim_Zn_Ribbon, 1 hit
SM00493, TOPRIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51199, SF4_HELICASE, 1 hit
PS50880, TOPRIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Note: Isoform 4A contains the primase/helicase region, whereas isoform 4B contains only the helicase region (PubMed:7310871). Isoform 4A and 4B are present in a molar ratio of 1:8 (PubMed:2829184).2 Publications
Isoform 4A (identifier: P03692-1) [UniParc]FASTAAdd to basket
Also known as: 63-kDa protein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNSHDSDSV FLYHIPCDNC GSSDGNSLFS DGHTFCYVCE KWTAGNEDTK
60 70 80 90 100
ERASKRKPSG GKPMTYNVWN FGESNGRYSA LTARGISKET CQKAGYWIAK
110 120 130 140 150
VDGVMYQVAD YRDQNGNIVS QKVRDKDKNF KTTGSHKSDA LFGKHLWNGG
160 170 180 190 200
KKIVVTEGEI DMLTVMELQD CKYPVVSLGH GASAAKKTCA ANYEYFDQFE
210 220 230 240 250
QIILMFDMDE AGRKAVEEAA QVLPAGKVRV AVLPCKDANE CHLNGHDREI
260 270 280 290 300
MEQVWNAGPW IPDGVVSALS LRERIREHLS SEESVGLLFS GCTGINDKTL
310 320 330 340 350
GARGGEVIMV TSGSGMGKST FVRQQALQWG TAMGKKVGLA MLEESVEETA
360 370 380 390 400
EDLIGLHNRV RLRQSDSLKR EIIENGKFDQ WFDELFGNDT FHLYDSFAEA
410 420 430 440 450
ETDRLLAKLA YMRSGLGCDV IILDHISIVV SASGESDERK MIDNLMTKLK
460 470 480 490 500
GFAKSTGVVL VVICHLKNPD KGKAHEEGRP VSITDLRGSG ALRQLSDTII
510 520 530 540 550
ALERNQQGDM PNLVLVRILK CRFTGDTGIA GYMEYNKETG WLEPSSYSGE
560
EESHSESTDW SNDTDF
Length:566
Mass (Da):62,655
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC808C3663FEBE5AA
GO
Isoform 4B (identifier: P03692-2) [UniParc]FASTAAdd to basket
Also known as: 56-kDa protein

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Show »
Length:503
Mass (Da):55,743
Checksum:i402AD68B32328F71
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0186831 – 63Missing in isoform 4B. CuratedAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V01127 Genomic DNA Translation: CAA24348.1
V01146 Genomic DNA Translation: CAA24405.1
V01146 Genomic DNA Translation: CAA24407.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A04314, YDBPA7

NCBI Reference Sequences

More...
RefSeqi
NP_041975.1, NC_001604.1 [P03692-1]
NP_041977.1, NC_001604.1 [P03692-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1261046
1261048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1261046
vg:1261048

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01127 Genomic DNA Translation: CAA24348.1
V01146 Genomic DNA Translation: CAA24405.1
V01146 Genomic DNA Translation: CAA24407.1
PIRiA04314, YDBPA7
RefSeqiNP_041975.1, NC_001604.1 [P03692-1]
NP_041977.1, NC_001604.1 [P03692-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CR0X-ray2.30A271-566[»]
1CR1X-ray2.30A271-566[»]
1CR2X-ray2.30A271-566[»]
1CR4X-ray2.50A271-566[»]
1E0JX-ray3.00A/B/C/D/E/F261-549[»]
1E0KX-ray3.30A/B/C/D/E/F261-549[»]
1NUIX-ray2.90A/B1-255[»]
1Q57X-ray3.45A/B/C/D/E/F/G64-566[»]
5IKNX-ray4.80D/E/F/G/H/I/J64-549[»]
6N7Ielectron microscopy3.20A/B/C/D/E/F1-566[»]
6N7Nelectron microscopy3.50A/B/C/D/E/F1-566[»]
6N7Selectron microscopy4.60A/B/C/D/E/F1-566[»]
6N7Telectron microscopy3.90A/B/C/D/E/F1-566[»]
6N7Velectron microscopy3.80A/B/C/D/E/F1-566[»]
6N9Uelectron microscopy3.70E/F1-566[»]
6N9Velectron microscopy4.00A/B/C/D/E/F1-566[»]
6N9Welectron microscopy4.00A/B/C/D/E/F1-566[»]
6N9Xelectron microscopy4.10A/B/C/D/E/F1-566[»]
SMRiP03692
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP03692, 1 interactor
MINTiP03692

Chemistry databases

DrugBankiDB03222, dATP
DB02452, Thymidine 5'-triphosphate

Genome annotation databases

GeneIDi1261046
1261048
KEGGivg:1261046
vg:1261048

Miscellaneous databases

EvolutionaryTraceiP03692

Family and domain databases

CDDicd01029, TOPRIM_primases, 1 hit
HAMAPiMF_04154, Helic_Prim_T7, 1 hit
InterProiView protein in InterPro
IPR007694, DNA_helicase_DnaB-like_C
IPR027417, P-loop_NTPase
IPR013237, Phage_T7_Gp4_N
IPR034154, TOPRIM_DnaG/twinkle
IPR006171, TOPRIM_domain
PfamiView protein in Pfam
PF03796, DnaB_C, 1 hit
PF08273, Prim_Zn_Ribbon, 1 hit
SMARTiView protein in SMART
SM00778, Prim_Zn_Ribbon, 1 hit
SM00493, TOPRIM, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51199, SF4_HELICASE, 1 hit
PS50880, TOPRIM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHELIC_BPT7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03692
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 2, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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