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UniProtKB - P03610 (MATA_BPMS2)
Protein
Maturation protein A
Gene
A
Organism
Escherichia phage MS2 (Bacteriophage MS2)
Status
Functioni
The maturation protein is required for the typical attachment of the phage to the side of the bacterial pili (PubMed:23810697).
Binds to sequences located toward each end of the genome, hence circularizing it (PubMed:26608810).
The RNA genome-maturation protein A complex is released from the capsid upon host receptor binding (PubMed:23810697).
Maturation protein A enters the cell along with the viral RNA (PubMed:4551992).
3 PublicationsGO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
- viral genome circularization Source: UniProtKB-KW
- virion attachment to host cell pilus Source: UniProtKB
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Maturation protein AShort name: MP Alternative name(s): Assembly protein Short name: A protein |
Gene namesi | Name:A |
Organismi | Escherichia phage MS2 (Bacteriophage MS2) |
Taxonomic identifieri | 329852 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Lenarviricota › Allassoviricetes › Levivirales › Leviviridae › Levivirus |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
Subcellular locationi
- Virion Note: A single copy of the maturation protein is present in the virion.1 Publication
Keywords - Cellular componenti
VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164859 | 1 – 393 | Maturation protein AAdd BLAST | 393 |
Post-translational modificationi
During internalization, MP is proteolytically cleaved into two fragments allowing translation and replication to start.1 Publication
Proteomic databases
PRIDEi | P03610 |
Interactioni
Subunit structurei
Interacts with the host pilus.
1 PublicationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 233 | Viral RNA-binding1 PublicationAdd BLAST | 208 |
Sequence similaritiesi
Belongs to the Levivirus maturation protein family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR005563, A_protein |
Pfami | View protein in Pfam PF03863, Phage_mat-A, 1 hit |
i Sequence
Sequence statusi: Complete.
P03610-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAFSTLDRE NETFVPSVRV YADGETEDNS FSLKYRSNWT PGRFNSTGAK
60 70 80 90 100
TKQWHYPSPY SRGALSVTSI DQGAYKRSGS SWGRPYEEKA GFGFSLDARS
110 120 130 140 150
CYSLFPVSQN LTYIEVPQNV ANRASTEVLQ KVTQGNFNLG VALAEARSTA
160 170 180 190 200
SQLATQTIAL VKAYTAARRG NWRQALRYLA LNEDRKFRSK HVAGRWLELQ
210 220 230 240 250
FGWLPLMSDI QGAYEMLTKV HLQEFLPMRA VRQVGTNIKL DGRLSYPAAN
260 270 280 290 300
FQTTCNISRR IVIWFYINDA RLAWLSSLGI LNPLGIVWEK VPFSFVVDWL
310 320 330 340 350
LPVGNMLEGL TAPVGCSYMS GTVTDVITGE SIISVDAPYG WTVERQGTAK
360 370 380 390
AQISAMHRGV QSVWPTTGAY VKSPFSMVHT LDALALIRQR LSR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00642 mRNA Translation: CAA23988.1 M25187 Genomic RNA Translation: AAA32257.1 |
PIRi | A93176, ACBPMS |
RefSeqi | NP_040647.1, NC_001417.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00642 mRNA Translation: CAA23988.1 M25187 Genomic RNA Translation: AAA32257.1 |
PIRi | A93176, ACBPMS |
RefSeqi | NP_040647.1, NC_001417.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5TC1 | electron microscopy | 3.60 | M | 1-393 | [»] | |
6NM5 | electron microscopy | 6.20 | M | 1-393 | [»] | |
SMRi | P03610 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | P03610 |
Family and domain databases
InterProi | View protein in InterPro IPR005563, A_protein |
Pfami | View protein in Pfam PF03863, Phage_mat-A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MATA_BPMS2 | |
Accessioni | P03610Primary (citable) accession number: P03610 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | September 29, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families