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Protein

Nuclear shuttle protein

Gene

BR1

Organism
Tomato golden mosaic virus (strain Yellow vein) (TGMV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus. Begomoviruses use 2 proteins to transport their DNA from cell to cell. The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear shuttle protein
Short name:
NSP
Alternative name(s):
Protein BR1
Protein BV1
Gene namesi
ORF Names:BR1, BV1
OrganismiTomato golden mosaic virus (strain Yellow vein) (TGMV)
Taxonomic identifieri223341 [NCBI]
Taxonomic lineageiVirusesssDNA virusesGeminiviridaeBegomovirus
Virus hostiSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Proteomesi
  • UP000007405 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell cytosol Source: CAFA
  • host cell nucleus Source: CAFA
  • host cell plasma membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-KW
  • viral capsid Source: InterPro

Keywords - Cellular componenti

Host cell membrane, Host cytoplasm, Host membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002222681 – 256Nuclear shuttle proteinAdd BLAST256

Proteomic databases

PRIDEiP03564

Interactioni

Subunit structurei

Binds to single-stranded and double-stranded viral DNA. Interacts with the host nuclear shuttle interacting (NSI) protein. This interaction may allow NSP to recruit NSI monomers to the viral genome and thus regulate nuclear export of viral genome by NSP (By similarity).By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 187Interaction with Arabidopsis thaliana NSI proteinBy similarityAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 42Bipartite nuclear localization signalBy similarityAdd BLAST22
Motifi81 – 96Nuclear localization signalBy similarityAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000LH

Family and domain databases

InterProiView protein in InterPro
IPR001530 Gemini_BR1
IPR000263 GV_A/BR1_coat
PfamiView protein in Pfam
PF00844 Gemini_coat, 1 hit
PRINTSiPR00223 GEMCOATARBR1
PR00225 GEMCOATBR1

Sequencei

Sequence statusi: Complete.

P03564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSTKYRRGF LANQGRGYPR HSTGKRSRNV SRIDFKRRSS KYVHGNDDSK
60 70 80 90 100
MANQRIHENQ FGPEFVMVHN TAISTFITFP SLGKTEPSRS RSYIKLKRLR
110 120 130 140 150
FKGTVKIERV HVDLSMDGPS PKIEGVFSLV VVVDRQPHLS PTGCLHTFDE
160 170 180 190 200
LFGARIHSHG NLAVSSALKD RFYIRHVFKR VISVEKDSTM IDLEGMTSFT
210 220 230 240 250
NRRFNCWSAF KDFDRQACNG VYGNISKNAI LVYYCWMSDI VSKASTFVSF

DLDYVG
Length:256
Mass (Da):29,375
Last modified:July 21, 1986 - v1
Checksum:i4DB486E0C396F949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02030 Genomic DNA No translation available.
PIRiA04167 QQCVRG

Similar proteinsi

Entry informationi

Entry nameiNSP_TGMVY
AccessioniPrimary (citable) accession number: P03564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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