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Entry version 100 (25 May 2022)
Sequence version 2 (01 Nov 1995)
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Protein

Envelopment polyprotein

Gene

GP

Organism
Rift valley fever virus (RVFV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the virion that interacts with glycoprotein C (By similarity).

It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity).

The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635).

They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity).

Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (By similarity).

By similarity2 Publications

Structural component of the virion that interacts with glycoprotein N (By similarity).

Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (PubMed:23319635, PubMed:29097548).

The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635).

They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity).

By similarity3 Publications

Plays a role for virus dissemination in the mosquito.

By similarity1 Publication

Plays a role for virus dissemination in mosquitoes.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral attachment to host entry receptor, Viral penetration into host cytoplasm, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
NSm-Gn proteinBy similarity
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G1
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRift valley fever virus (RVFV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11588 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPhenuiviridaePhlebovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 130CytoplasmicSequence analysisAdd BLAST114
Topological domaini154 – 582LumenalSequence analysisAdd BLAST429
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 673CytoplasmicSequence analysisAdd BLAST70
Topological domaini691 – 1159LumenalSequence analysisAdd BLAST469
Transmembranei1160 – 1180HelicalSequence analysisAdd BLAST21
Topological domaini1181 – 1206CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Host mitochondrion, Host mitochondrion outer membrane, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024700917 – 1206Envelopment polyproteinAdd BLAST1190
ChainiPRO_000003684717 – 153NSm-Gn proteinAdd BLAST137
ChainiPRO_0000036848154 – 690Glycoprotein NSequence analysisAdd BLAST537
ChainiPRO_0000036849691 – 1206Glycoprotein CSequence analysisAdd BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi179 ↔ 1881 Publication
Disulfide bondi229 ↔ 2391 Publication
Disulfide bondi250 ↔ 2811 Publication
Disulfide bondi271 ↔ 2841 Publication
Disulfide bondi304 ↔ 4561 Publication
Disulfide bondi322 ↔ 3321 Publication
Disulfide bondi374 ↔ 4341 Publication
Disulfide bondi402 ↔ 4131 Publication
Disulfide bondi420 ↔ 4251 Publication
Disulfide bondi479 ↔ 4821 Publication
Disulfide bondi486 ↔ 5561 Publication
Disulfide bondi506 ↔ 5111 Publication
Disulfide bondi691 ↔ 731By similarity
Disulfide bondi704 ↔ 713By similarity
Disulfide bondi756 ↔ 852By similarity
Disulfide bondi771 ↔ 965By similarity
Disulfide bondi777 ↔ 825By similarity
Disulfide bondi783 ↔ 832By similarity
Disulfide bondi788 ↔ 814By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi794N-linked (GlcNAc...) asparagine; by host1 Publication1
Disulfide bondi818 ↔ 823By similarity
Disulfide bondi934 ↔ 947By similarity
Disulfide bondi1029 ↔ 1101By similarity
Glycosylationi1035N-linked (GlcNAc...) asparagine; by host1 Publication1
Disulfide bondi1039 ↔ 1042By similarity
Disulfide bondi1049 ↔ 1083By similarity
Glycosylationi1077N-linked (GlcNAc...) asparagine; by hostSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including NSm protein, Glycoprotein C, and Glycoprotein N.By similarity
Glycosylated (By similarity). The glycans can attach to host CD209/DC-SIGN, and may play a role in virus entry into dendritic cells (By similarity).By similarity
Glycosylated (By similarity). The glycans can attach to host CD209/DC-SIGN, and may play a role in virus entry into dendritic cells (By similarity).By similarity
Palmitoylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei153 – 154Cleavage; by host signal peptidaseBy similarity2
Sitei690 – 691Cleavage; by host signal peptidaseBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with glycoprotein C (PubMed:19193794, PubMed:28827346).

Interacts with nucleocapsid protein N and with the polymerase L in order to package them into virus particles (By similarity).

By similarity2 Publications

Heterodimer with glycoprotein C (PubMed:19193794, PubMed:28827346). Homotrimer (postfusion) (PubMed:29097548).

Interacts with nucleocapsid protein N and with the polymerase L in order to package them into virus particles (By similarity).

Interacts with host E3 ubiquitin-protein ligase UBR4; this interaction is important for viral RNA production (By similarity).

By similarity3 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P03518

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni131 – 153Internal signal sequence for glycoprotein NBy similarityAdd BLAST23
Regioni608 – 650Golgi retention signalBy similarityAdd BLAST43
Regioni646 – 650Important for correct targeting of the glycoproteins to the Golgi complex but not for heterodimerizationBy similarity5
Regioni675 – 690Internal signal sequence for glycoprotein CBy similarityAdd BLAST16
Regioni777 – 783Fusion loopBy similarity7
Regioni819 – 830Fusion loopBy similarityAdd BLAST12

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a Golgi retention signal on its C-terminus (By similarity). The cytoplasmic tail specifically interacts with the ribonucleoproteins and is critical for genome packaging (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016404, M_polyprot_prcur_phlebovir
IPR043603, Phlebo_G2_C
IPR010826, Phlebovirus_G1
IPR009878, Phlebovirus_G2_fusion
IPR009879, Phlebovirus_NSM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19019, Phlebo_G2_C, 1 hit
PF07243, Phlebovirus_G1, 1 hit
PF07245, Phlebovirus_G2, 1 hit
PF07246, Phlebovirus_NSM, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003961, M_poly_PhleboV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1 (identifier: P03518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYVLLTILIS VLVCEAVIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE
60 70 80 90 100
EMPEELSCSI SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI
110 120 130 140 150
SLIKGPPHKK RVGIVRCERR RDAKQIGRET MAGIAMTVLP ALAVFALAPV
160 170 180 190 200
VFAEDPHLRN RPGKGHNYID GMTQEDATCK PVTYAGACSS FDVLLEKGKF
210 220 230 240 250
PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LQSAHGNPCM KEKLVMKTHC
260 270 280 290 300
PNDYQSAHYL NNDGKMASVK CPPKYGLTED CNFCRQMTGA SLKKGSYPLQ
310 320 330 340 350
DLFCQSSEDD GSKLKTKMKG VCEVGVQAHK KCDGQLSTAH EVVPFAVFKN
360 370 380 390 400
SKKVYLDKLD LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS
410 420 430 440 450
QCPKIGGHGS KKCTGDAAFC SAYECTAQYA NAYCSHANGS GIVQIQVSGV
460 470 480 490 500
WKKPLCVGYE RVVVKRELSA KPIQRVEPCT TCITKCEPHG LVVRSTGFKI
510 520 530 540 550
SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH MAHDDQSVSS
560 570 580 590 600
KIVAHCPPQD PCLVHGCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL
610 620 630 640 650
AVLYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA HNINQVNREI
660 670 680 690 700
GWMEGGQLVL GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR
710 720 730 740 750
ITTCSTEGVN TKCRLSGTAL IRAGSVGAEA CLMLKGVKED QTKFLKIKTV
760 770 780 790 800
SSELSCREGQ SYWTGSISPK CLSSRRCHLV GECHVNRCLS WRDNETSAEF
810 820 830 840 850
SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ SVRKEALRVF
860 870 880 890 900
NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS
910 920 930 940 950
NSFSFIESPS KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA
960 970 980 990 1000
PNLISYKPMI DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ
1010 1020 1030 1040 1050
AFSKGSVQAD LTLMFDNFEV DFVGAAVSCD AAFLNLTGCY SCNAGARVCL
1060 1070 1080 1090 1100
SITSTGTGSL SAHNKDGSLH IVLPSENGTK DQCQILHFTV PEVEEEFMYS
1110 1120 1130 1140 1150
CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW NFFDWFSGLM
1160 1170 1180 1190 1200
SWFGGPLKLY SSFACMLHYQ LGSFSSLYIL EEQASLKCGL LPLRRPHRSV

RVKVIC
Length:1,206
Mass (Da):132,053
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2E8017179285924
GO
Isoform NSm proteinBy similarity (identifier: P03518-2) [UniParc]FASTAAdd to basket
Also known as: P14

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     154-1197: Missing.

Show »
Length:124
Mass (Da):13,657
Checksum:iE20CCDB67F1AD7DC
GO
Isoform NSm' proteinBy similarity (identifier: P03518-3) [UniParc]FASTAAdd to basket
Also known as: P13

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     154-1197: Missing.

Show »
Length:111
Mass (Da):12,110
Checksum:iF6418D10C3EC8F6D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0579851 – 51Missing in isoform NSm' protein. Add BLAST51
Alternative sequenceiVSP_0579861 – 38Missing in isoform NSm protein. Add BLAST38
Alternative sequenceiVSP_057987154 – 1197Missing in isoform NSm protein and isoform NSm' protein. Add BLAST1044

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M11157 Genomic RNA Translation: AAA47450.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A04110, VGVURV

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11157 Genomic RNA Translation: AAA47450.1
PIRiA04110, VGVURV

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HJ1X-ray1.90A/B/C/D691-1119[»]
4HJCX-ray4.15A691-1118[»]
5Y0WX-ray2.50A154-469[»]
5Y0YX-ray3.40A154-469[»]
6EGTX-ray2.50A/B/C691-1158[»]
6EGUX-ray2.30A/B/C691-1158[»]
6IEAX-ray2.00A154-469[»]
6IEBX-ray2.41A/B154-469[»]
6IECX-ray3.20A/B/E/I154-469[»]
6IEKX-ray2.70A/D154-469[»]
SMRiP03518
ModBaseiSearch...
PDBe-KBiSearch...

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P03518, 10 sequenced antibodies

Family and domain databases

InterProiView protein in InterPro
IPR016404, M_polyprot_prcur_phlebovir
IPR043603, Phlebo_G2_C
IPR010826, Phlebovirus_G1
IPR009878, Phlebovirus_G2_fusion
IPR009879, Phlebovirus_NSM
PfamiView protein in Pfam
PF19019, Phlebo_G2_C, 1 hit
PF07243, Phlebovirus_G1, 1 hit
PF07245, Phlebovirus_G2, 1 hit
PF07246, Phlebovirus_NSM, 2 hits
PIRSFiPIRSF003961, M_poly_PhleboV, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP_RVFV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03518
Secondary accession number(s): Q86494, Q86495
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: May 25, 2022
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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