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Protein

Protein Tax-2

Gene

tax

Organism
Human T-cell leukemia virus 2 (HTLV-2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Induces T-cell transformation, although much less efficiently than HTLV-1. Required for viral replication (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 49Sequence analysisAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processG0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell cycle by virus, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tax-2
Alternative name(s):
Trans-activating transcriptional regulatory protein of HTLV-2
Gene namesi
Name:tax
OrganismiHuman T-cell leukemia virus 2 (HTLV-2)
Taxonomic identifieri11909 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeDeltaretrovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009254 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000854961 – 331Protein Tax-2Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48Phosphothreonine; by hostBy similarity1
Modified residuei184Phosphothreonine; by hostBy similarity1
Modified residuei215Phosphothreonine; by hostBy similarity1
Modified residuei300Phosphoserine; by hostBy similarity1
Modified residuei301Phosphoserine; by hostBy similarity1

Post-translational modificationi

Phosphorylation at Thr-48 results in the loss of NF-kappa-B activation function. Phosphorylation at Thr-215 results in loss of CREB and NF-B responsive promoters activation. Phosphorylation at Thr-184 has no effect on these Tax functions. Phosphorylation of either Ser-300 or Ser-301 is necessary for localization to nuclear bodies. Thr-48, Thr-184 and Thr-215 are highly phosphorylated, whereas Ser-300 or Ser-301 are only rarely phosphorylated (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP03410

Interactioni

Subunit structurei

Homodimer. Interacts with host CREB1, CREBBP and EP300 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiP03410, 48 interactors
MINTiP03410

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 58Interaction with CREB1By similarityAdd BLAST57
Regioni81 – 95Interaction with CREBBP/P300By similarityAdd BLAST15
Regioni106 – 111Interaction with IKBKGBy similarity6
Regioni116 – 145HomodimerizationBy similarityAdd BLAST30
Regioni213 – 248HomodimerizationBy similarityAdd BLAST36
Regioni289 – 322TransactivationBy similarityAdd BLAST34
Regioni312 – 319Interaction with CREBBP C-terminusBy similarity8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi73 – 80SH3-bindingSequence analysis8
Motifi188 – 202Nuclear export signalBy similarityAdd BLAST15

Domaini

The 48 N-terminal residues contain a non-canonical functional nuclear localization signal (NLS).By similarity

Sequence similaritiesi

Belongs to the deltaretrovirus Tax protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 49Sequence analysisAdd BLAST27

Keywords - Domaini

SH3-binding, Zinc-finger

Phylogenomic databases

KOiK21857
OrthoDBiVOG090000CJ

Family and domain databases

InterProiView protein in InterPro
IPR036922 Rieske_2Fe-2S_sf
IPR004120 Tax
PfamiView protein in Pfam
PF02959 Tax, 1 hit
SUPFAMiSSF50022 SSF50022, 1 hit

Sequencei

Sequence statusi: Complete.

P03410-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHFPGFGQS LLYGYPVYVF GDCVQADWCP VSGGLCSTRL HRHALLATCP
60 70 80 90 100
EHQLTWDPID GRVVSSPLQY LIPRLPSFPT QRTSRTLKVL TPPTTPVSPK
110 120 130 140 150
VPPAFFQSMR KHTPYRNGCL EPTLGDQLPS LAFPEPGLRP QNIYTTWGKT
160 170 180 190 200
VVCLYLYQLS PPMTWPLIPH VIFCHPRQLG AFLTKVPLKR LEELLYKMFL
210 220 230 240 250
HTGTVIVLPE DDLPTTMFQP VRAPCIQTAW CTGLLPYHSI LTTPGLIWTF
260 270 280 290 300
NDGSPMISGP YPKAGQPSLV VQSSLLIFEK FETKAFHPSY LLSHQLIQYS
310 320 330
SFHNLHLLFD EYTNIPVSIL FNKEEADDNG D
Length:331
Mass (Da):37,318
Last modified:May 16, 2006 - v2
Checksum:iA13F590EB6075101
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5P → L (PubMed:6330894).Curated1
Sequence conflicti22D → N (PubMed:6330894).Curated1
Sequence conflicti204T → A (PubMed:6330894).Curated1
Sequence conflicti261Y → C (PubMed:6330894).Curated1
Sequence conflicti282E → Q (PubMed:6330894).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10060 Genomic DNA Translation: AAB59888.1
K02532 Genomic RNA No translation available.
PIRiA04012 TNLJH2
A04013 TNLJT2
A48751
RefSeqiNP_041005.1, NC_001488.1

Genome annotation databases

GeneIDi1491946
KEGGivg:1491946

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10060 Genomic DNA Translation: AAB59888.1
K02532 Genomic RNA No translation available.
PIRiA04012 TNLJH2
A04013 TNLJT2
A48751
RefSeqiNP_041005.1, NC_001488.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03410, 48 interactors
MINTiP03410

Proteomic databases

PRIDEiP03410

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1491946
KEGGivg:1491946

Phylogenomic databases

KOiK21857
OrthoDBiVOG090000CJ

Family and domain databases

InterProiView protein in InterPro
IPR036922 Rieske_2Fe-2S_sf
IPR004120 Tax
PfamiView protein in Pfam
PF02959 Tax, 1 hit
SUPFAMiSSF50022 SSF50022, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAX_HTLV2
AccessioniPrimary (citable) accession number: P03410
Secondary accession number(s): P03411, Q85602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 16, 2006
Last modified: June 20, 2018
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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