ESR1

Functionⁱ

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032).

20 Publications

Isoform 3:

Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726).

Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861).

Binds to ERE and inhibits isoform 1 (PubMed:10970861).

2 Publications

Miscellaneous

Selective estrogen receptor modulators (SERMs), such as tamoxifen, raloxifene, toremifene, lasofoxifene, clomifene, femarelle and ormeloxifene, have tissue selective agonistic and antagonistic effects on the estrogen receptor (ER). They interfere with the ER association with coactivators or corepressors, mainly involving the AF-2 domain.

Caution

Was reported to be activated by DDX5. However, this study has been retracted due to concerns of image manipulation.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	185 – 250	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	66
Zinc fingerⁱ	185 – 205	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	221 – 245	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	P03372
Reactomeⁱ	R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-5689896, Ovarian tumor domain proteases R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8931987, RUNX1 regulates estrogen receptor mediated transcription R-HSA-8939211, ESR-mediated signaling R-HSA-8939256, RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9018519, Estrogen-dependent gene expression
SignaLinkⁱ	P03372
SIGNORⁱ	P03372

Protein family/group databases

MoonDBⁱ	P03372, Predicted

MoonDBⁱ

P03372, Predicted

Chemistry databases

SwissLipidsⁱ	SLP:000001568

SwissLipidsⁱ

SLP:000001568

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Estrogen receptor Short name: ER Alternative name(s): ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1
Gene namesⁱ	Name:ESR1 Synonyms:ESR, NR3A1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3467, ESR1
MIMⁱ	133430, gene
neXtProtⁱ	NX_P03372
VEuPathDBⁱ	HostDB:ENSG00000091831

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Estrogen resistance (ESTRR)2 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA disorder characterized by partial or complete resistance to estrogens, in the presence of elevated estrogen serum levels. Clinical features include absence of the pubertal growth spurt, delayed bone maturation, unfused epiphyses, reduced bone mineral density, osteoporosis, continued growth into adulthood and very tall adult stature. Glucose intolerance, hyperinsulinemia and lipid abnormalities may also be present.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070072	375	Q → H in ESTRR; results in highly reduced activity. 1 PublicationCorresponds to variant dbSNP:rs397509428EnsemblClinVar.		1
Natural variantⁱVAR_078516	394	R → H in ESTRR; highly decreased estrogen receptor activity. 1 PublicationCorresponds to variant dbSNP:rs1131692059EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	39	L → P: Impairs AF-1 transactivation. 1 Publication	1
Mutagenesisⁱ	43	Y → P: Impairs AF-1 transactivation. 1 Publication	1
Mutagenesisⁱ	104	S → A: Loss of cyclin A-dependent induction of transcriptional activation. 1 Publication	1
Mutagenesisⁱ	106	S → A: Loss of cyclin A-dependent induction of transcriptional activation. 1 Publication	1
Mutagenesisⁱ	118	S → A: Decreases phosphorylation and transactivation activity. Abolishes AF-1 transactivation. Insensitive to PPP5C inhibition of transactivation activity. 2 Publications	1
Mutagenesisⁱ	118	S → E: Enhances transactivation activity. Insensitive to PPP5C inhibition of transactivation activity. 1 Publication	1
Mutagenesisⁱ	260	R → A or K: Loss of methylation. 1 Publication	1
Mutagenesisⁱ	364	V → E: Has higher transcriptional activity in the absence of wild type ER. Inhibits transcriptional activity when coexpressed with the wild type receptor. 1 Publication	1
Mutagenesisⁱ	386	I → C: Loss of transmembrane localization, no effect on peripheral membrane localization. Impairs activation of estrogen-induced activation of NOS3 and production of nitric oxide. No effect on binding to ERES. 1 Publication	1
Mutagenesisⁱ	447	C → A: Loss of hormone binding capacity and temperature-sensitive loss in DNA-binding. 1 Publication	1
Mutagenesisⁱ	537	Y → A: Reduces PELP1-mediated activation of transcriptional activity. 1 Publication	1
Mutagenesisⁱ	539	L → A: Abolishes interaction with NCOA1, NCOA2 and NCOA3. 1 Publication	1

Keywords - Diseaseⁱ

Disease variant

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2099
MalaCards human disease database More...MalaCardsⁱ	ESR1
MIMⁱ	615363, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000091831
Orphanetⁱ	785, Estrogen resistance syndrome
PharmGKBⁱ	PA156

Miscellaneous databases

Pharosⁱ	P03372, Tclin

Pharosⁱ

P03372, Tclin

Chemistry databases

ChEMBLⁱ	CHEMBL206
Drug and drug target database More...DrugBankⁱ	DB07567, (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL DB07638, (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB08737, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL DB08020, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB07678, (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL DB07707, (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL DB03802, 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol DB06871, 17-METHYL-17-ALPHA-DIHYDROEQUILENIN DB08773, 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol DB08398, 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine DB13869, 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol DB04471, 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol DB07708, 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB07712, 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB06898, 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol DB08048, 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DB08595, 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07195, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07086, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07087, 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB08047, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE DB04468, Afimoxifene DB01431, Allylestrenol DB05233, AP1081 DB06249, Arzoxifene DB06401, Bazedoxifene DB01878, Benzophenone DB06732, beta-Naphthoflavone DB05882, CHF 4227 DB00269, Chlorotrianisene DB00882, Clomifene DB02715, Compound 18 DB02615, Compound 19 DB03742, Compound 4-D DB00286, Conjugated estrogens DB05487, Custirsen DB01406, Danazol DB00304, Desogestrel DB00890, Dienestrol DB08320, DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE DB00255, Diethylstilbestrol DB07932, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate DB00841, Dobutamine DB06374, Elacestrant DB11219, Enzacamene DB02187, Equilin DB07933, Erteberel DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01196, Estramustine DB04573, Estriol DB14641, Estriol tripropionate DB00655, Estrone DB04574, Estrone sulfate DB00977, Ethinylestradiol DB00823, Ethynodiol diacetate DB09086, Eugenol DB15690, Fluoroestradiol F-18 DB01185, Fluoxymesterone DB00947, Fulvestrant DB01645, Genistein DB11619, Gestrinone DB00756, Hexachlorophene DB07931, Hexestrol DB11064, Homosalate DB06202, Lasofoxifene DB00367, Levonorgestrel DB00431, Lindane DB00603, Medroxyprogesterone acetate DB01065, Melatonin DB01357, Mestranol DB06710, Methyltestosterone DB00648, Mitotane DB07991, N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE DB01183, Naloxone DB03467, Naringenin DB09371, Norethynodrel DB00957, Norgestimate DB05662, NP-50301 DB09535, Octocrylene DB04938, Ospemifene DB01428, Oxybenzone DB04930, Permethrin DB04824, Phenolphthalein DB02746, Phthalic Acid DB09369, Polyestradiol phosphate DB01708, Prasterone DB00396, Progesterone DB12450, Propyl Gallate DB02757, Pyrazole DB04216, Quercetin DB04575, Quinestrol DB11541, Ractopamine DB00481, Raloxifene DB02709, Resveratrol DB02901, Stanolone DB13951, Stanolone acetate DB09317, Synthetic Conjugated Estrogens, A DB09318, Synthetic Conjugated Estrogens, B DB00675, Tamoxifen DB05966, TAS-108 DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB09070, Tibolone DB00539, Toremifene DB01108, Trilostane DB11478, Zeranol DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form
DrugCentral More...DrugCentralⁱ	P03372
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	620

Genetic variation databases

BioMutaⁱ	ESR1
DMDMⁱ	544257

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053618	1 – 595	Estrogen receptorAdd BLAST		595

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	10	O-linked (GlcNAc) serineBy similarity	1
Modified residueⁱ	104	Phosphoserine; by CDK21 Publication	1
Modified residueⁱ	106	Phosphoserine; by CDK21 Publication	1
Modified residueⁱ	118	Phosphoserine1 Publication	1
Modified residueⁱ	167	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	260	Asymmetric dimethylarginine; by PRMT12 Publications	1
Lipidationⁱ	447	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	537	Phosphotyrosine; by Tyr-kinases1 Publication	1

Post-translational modificationⁱ

Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro.7 Publications

Glycosylated; contains N-acetylglucosamine, probably O-linked.1 Publication

Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation (PubMed:21602804, PubMed:28068668). Deubiquitinated by OTUB1 (PubMed:19383985).3 Publications

Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization (PubMed:18657504, PubMed:24498420). Demethylated by JMJD6 at Arg-260 (PubMed:24498420).2 Publications

Palmitoylated (isoform 3). Not biotinylated (isoform 3).1 Publication

Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor.1 Publication

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-1241 CPTAC-145
EPDⁱ	P03372
jPOSTⁱ	P03372
MassIVEⁱ	P03372
PaxDbⁱ	P03372
PeptideAtlas More...PeptideAtlasⁱ	P03372
PRIDEⁱ	P03372
ProteomicsDBⁱ	51607 [P03372-1] 51608 [P03372-2] 51609 [P03372-3] 51610 [P03372-4]

PTM databases

GlyConnectⁱ	144, 1 O-Linked glycan
GlyGenⁱ	P03372, 2 sites, 1 O-linked glycan (1 site)
iPTMnetⁱ	P03372
PhosphoSitePlusⁱ	P03372
SwissPalmⁱ	P03372

Expressionⁱ

Tissue specificityⁱ

Widely expressed (PubMed:10970861). Not expressed in the pituitary gland (PubMed:10970861).1 Publication

Isoform 3:

Widely expressed, however not expressed in the pituitary gland.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000091831, Expressed in endometrium and 168 other tissues
ExpressionAtlasⁱ	P03372, baseline and differential
Genevisibleⁱ	P03372, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000091831, Tissue enhanced (cervix, endometrium, fallopian tube)

HPAⁱ

ENSG00000091831, Tissue enhanced (cervix, endometrium, fallopian tube)

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer. Can form a heterodimer with ESR2.

Interacts with FOXC2, MAP1S, SLC30A9, UBE1C and NCOA3 coactivator (By similarity).

Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol, the interaction increases ESR1 transcriptional activity (PubMed:11481323, PubMed:14963108).

Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1.

Interacts with CITED1; the interaction is estrogen-dependent.

Interacts with NCOA5 and NCOA6 coactivators.

Interacts with NCOA7; the interaction is a ligand-inducible.

Interacts with PHB2, and UBE1C.

Interacts with AKAP13.

Interacts with CUEDC2.

Interacts with KDM5A.

Interacts with SMARD1.

Interacts with HEXIM1.

Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription.

Interacts with DNTTIP2, FAM120B and UIMC1.

Interacts with isoform 4 of TXNRD1.

Interacts with KMT2D/MLL2.

Interacts with ATAD2 and this interaction is enhanced by estradiol.

Interacts with KIF18A and LDB1.

Interacts with RLIM (via C-terminus).

Interacts with MACROD1.

Interacts with SH2D4A and PLCG. Interaction with SH2D4A blocks binding to PLCG and inhibits estrogen-induced cell proliferation.

Interacts with DYNLL1.

Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes.

Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth.

Interacts with DNAAF4.

Interacts with PRMT2.

Interacts with RBFOX2.

Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D.

Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy.

Interacts with DDX5 (PubMed:11682626).

Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions.

Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3.

Interacts with NRIP1 (By similarity).

Interacts with GPER1; the interaction occurs in an estrogen-dependent manner.

Interacts with CLOCK and the interaction is stimulated by estrogen.

Interacts with BCAS3.

Interacts with TRIP4 (ufmylated); estrogen dependent.

Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation.

Interacts with CCAR2 (via N-terminus) in a ligand-independent manner.

Interacts with ZFHX3.

Interacts with SFR1 in a ligand-dependent and -independent manner (PubMed:23874500).

Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:28068668).

Interacts (via DNA-binding domain) with POU4F2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner (By similarity).

Interacts with ESRRB isoform 1 (PubMed:19755138).

Interacts with UBE3A and WBP2 (PubMed:16772533).

Interacts with GTF2B (PubMed:1517211).

Interacts with RBM39 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (PubMed:20078863).

Interacts with PI3KR1 or PI3KR2 and PTK2/FAK1 (PubMed:18657504).

Interacts with SRC (PubMed:14963108, PubMed:18657504).

By similarity61 Publications

Isoform 3:

Probably homodimerizes or heterodimerizes with isoform 1 and ESR2.

1 Publication

Binary interactionsⁱ

P03372

With	#Exp.	IntAct
AKAP13 [Q12802]	3	EBI-78473,EBI-1373806
ARID5A [Q03989]	9	EBI-78473,EBI-948603
ASCL4 [Q6XD76]	3	EBI-78473,EBI-10254793
ASF1A [Q9Y294]	4	EBI-78473,EBI-749553
ASXL1 [Q8IXJ9]	2	EBI-78473,EBI-1646500
ATAD2 [Q6PL18]	5	EBI-78473,EBI-6598454
ATF1 [P18846]	3	EBI-78473,EBI-852794
BLCAP [P62952]	2	EBI-78473,EBI-3895726
BRCA1 [P38398]	14	EBI-78473,EBI-349905
BTF3 - isoform 2 [P20290-2]	5	EBI-78473,EBI-1054703
CACUL1 [Q86Y37]	5	EBI-78473,EBI-8168227
CCN2 [P29279]	7	EBI-78473,EBI-2835375
CEBPB [P17676]	2	EBI-78473,EBI-969696
CITED1 [Q99966]	3	EBI-78473,EBI-2624951
CUEDC2 [Q9H467]	2	EBI-78473,EBI-1248228
DCAF13 [Q9NV06]	2	EBI-78473,EBI-7402939
DNM1L [O00429]	2	EBI-78473,EBI-724571
EDF1 [O60869]	3	EBI-78473,EBI-781301
EGFR [P00533]	2	EBI-78473,EBI-297353
itself	11	EBI-78473,EBI-78473
FOXO1 [Q12778]	2	EBI-78473,EBI-1108782
FOXO3 [O43524]	7	EBI-78473,EBI-1644164
GRIP1 [Q9Y3R0]	2	EBI-78473,EBI-5349621
HAX1 [O00165]	2	EBI-78473,EBI-357001
JMJD6 [Q6NYC1]	8	EBI-78473,EBI-8464037
KDM6B [O15054]	2	EBI-78473,EBI-2831260
KMT2D [O14686]	3	EBI-78473,EBI-996065
LATS1 [O95835]	2	EBI-78473,EBI-444209
LIAT1 - isoform 4 [Q6ZQX7-4]	3	EBI-78473,EBI-25830459
LMTK3 [Q96Q04]	3	EBI-78473,EBI-720814
MACROD1 [Q9BQ69]	6	EBI-78473,EBI-5324932
MDM2 [Q00987]	2	EBI-78473,EBI-389668
MED1 [Q15648]	3	EBI-78473,EBI-394459
MYL6 [P60660]	3	EBI-78473,EBI-300817
NCOA1 [Q15788]	8	EBI-78473,EBI-455189
NCOA2 [Q15596]	5	EBI-78473,EBI-81236
NCOA3 [Q9Y6Q9]	4	EBI-78473,EBI-81196
NDRG2 [Q9UN36]	2	EBI-78473,EBI-3895741
Nuclear factor NF-kappa-B p50 subunit (PRO_0000030311)	3	EBI-78473,EBI-697771
NR1H4 - isoform 1 [Q96RI1-3]	2	EBI-78473,EBI-10921781
NSD3 [Q9BZ95]	3	EBI-78473,EBI-3390132
PAGR1 [Q9BTK6]	5	EBI-78473,EBI-2372223
PBXIP1 - isoform 1 [Q96AQ6-1]	3	EBI-78473,EBI-15606280
PGR [P06401]	20	EBI-78473,EBI-78539
PGR - isoform B [P06401-1]	4	EBI-78473,EBI-12590474
PHB2 [Q99623]	4	EBI-78473,EBI-358348
PPP1CC [P36873]	3	EBI-78473,EBI-356283
PPP5C [P53041]	4	EBI-78473,EBI-716663
PRMT2 [P55345]	9	EBI-78473,EBI-78458
RAC3 [P60763]	5	EBI-78473,EBI-767084
RBFOX2 [O43251]	4	EBI-78473,EBI-746056
RELA [Q04206]	9	EBI-78473,EBI-73886
SAFB2 [Q14151]	2	EBI-78473,EBI-352869
SENP5 [Q96HI0]	2	EBI-78473,EBI-3895753
SP1 [P08047]	2	EBI-78473,EBI-298336
SP3 [Q02447]	4	EBI-78473,EBI-348158
SRC [P12931]	12	EBI-78473,EBI-621482
TRIM24 [O15164]	3	EBI-78473,EBI-2130378
TXNRD1 - isoform 4 [Q16881-4]	4	EBI-78473,EBI-9080335
UXT [Q9UBK9]	2	EBI-78473,EBI-357355
WFS1 [O76024]	3	EBI-78473,EBI-720609
ZNF366 [Q8N895]	6	EBI-78473,EBI-2813661
Asxl1 [P59598] from Mus musculus.	2	EBI-78473,EBI-5743705
Jun [P05627] from Mus musculus.	6	EBI-78473,EBI-764369
Ncoa6 [Q9JLI4] from Rattus norvegicus.	2	EBI-78473,EBI-286271
Ncor1 [Q60974] from Mus musculus.	2	EBI-78473,EBI-349004
Pfn1 [P62962] from Mus musculus.	3	EBI-78473,EBI-647096
SRC [P00523] from Gallus gallus.	2	EBI-78473,EBI-848039

ESR1 - isoform 1 [P03372-1]

With	#Exp.	IntAct
itself	4	EBI-15606245,EBI-15606245
ESR2 [Q92731]	5	EBI-15606245,EBI-78505
KAT5 [Q92993]	3	EBI-15606245,EBI-399080
PBXIP1 - isoform 1 [Q96AQ6-1]	5	EBI-15606245,EBI-15606280

Isoform 4 [P03372-4]

With	#Exp.	IntAct
EGFR [P00533]	4	EBI-4309277,EBI-297353
SHC1 [P29353]	2	EBI-4309277,EBI-78835
SRC [P12931]	2	EBI-4309277,EBI-621482

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	108403, 2158 interactors
ComplexPortalⁱ	CPX-5156, ERalpha-NCOA2 activated estrogen receptor complex
CORUMⁱ	P03372
Database of interacting proteins More...DIPⁱ	DIP-5965N
ELMⁱ	P03372
IntActⁱ	P03372, 1904 interactors
Molecular INTeraction database More...MINTⁱ	P03372
STRINGⁱ	9606.ENSP00000405330

Chemistry databases

BindingDBⁱ

P03372

Miscellaneous databases

RNActⁱ	P03372, protein

RNActⁱ

P03372, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	186 – 188	Combined sources	3
Beta strandⁱ	189 – 191	Combined sources	3
Beta strandⁱ	194 – 196	Combined sources	3
Beta strandⁱ	199 – 201	Combined sources	3
Helixⁱ	203 – 213	Combined sources	11
Beta strandⁱ	222 – 225	Combined sources	4
Turnⁱ	231 – 236	Combined sources	6
Helixⁱ	238 – 248	Combined sources	11
Helixⁱ	288 – 291	Combined sources	4
Helixⁱ	302 – 304	Combined sources	3
Helixⁱ	307 – 309	Combined sources	3
Helixⁱ	312 – 321	Combined sources	10
Beta strandⁱ	330 – 332	Combined sources	3
Beta strandⁱ	334 – 336	Combined sources	3
Helixⁱ	339 – 341	Combined sources	3
Helixⁱ	342 – 361	Combined sources	20
Helixⁱ	367 – 369	Combined sources	3
Helixⁱ	372 – 393	Combined sources	22
Turnⁱ	394 – 397	Combined sources	4
Beta strandⁱ	401 – 405	Combined sources	5
Beta strandⁱ	408 – 411	Combined sources	4
Helixⁱ	412 – 415	Combined sources	4
Turnⁱ	416 – 418	Combined sources	3
Turnⁱ	419 – 421	Combined sources	3
Helixⁱ	424 – 438	Combined sources	15
Helixⁱ	442 – 455	Combined sources	14
Turnⁱ	456 – 459	Combined sources	4
Helixⁱ	466 – 492	Combined sources	27
Helixⁱ	497 – 527	Combined sources	31
Beta strandⁱ	528 – 530	Combined sources	3
Beta strandⁱ	531 – 533	Combined sources	3
Helixⁱ	537 – 544	Combined sources	8
Helixⁱ	547 – 549	Combined sources	3
Helixⁱ	588 – 590	Combined sources	3

Show more details

3D structure databases

SASBDBⁱ	P03372
SMRⁱ	P03372
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P03372

EvolutionaryTraceⁱ

P03372

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	311 – 547	NR LBDPROSITE-ProRule annotationAdd BLAST		237

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 184	Modulating (transactivation AF-1); mediates interaction with MACROD11 PublicationAdd BLAST	184
Regionⁱ	35 – 174	Interaction with DDX5; self-association1 PublicationAdd BLAST	140
Regionⁱ	35 – 47	Required for interaction with NCOA11 PublicationAdd BLAST	13
Regionⁱ	147 – 174	DisorderedSequence analysisAdd BLAST	28
Regionⁱ	185 – 310	Mediates interaction with DNTTIP21 PublicationAdd BLAST	126
Regionⁱ	251 – 310	HingeAdd BLAST	60
Regionⁱ	259 – 282	DisorderedSequence analysisAdd BLAST	24
Regionⁱ	262 – 595	Interaction with AKAP131 PublicationAdd BLAST	334
Regionⁱ	264 – 595	Self-associationAdd BLAST	332
Regionⁱ	311 – 595	Transactivation AF-2Add BLAST	285
Regionⁱ	553 – 573	DisorderedSequence analysisAdd BLAST	21

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	558 – 573	Polar residuesSequence analysisAdd BLAST		16

Domainⁱ

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner. AF-1 seems to provide the major transactivation function in differentiated cells.

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	185 – 205	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	221 – 245	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Transmembrane, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158133
InParanoidⁱ	P03372
OMAⁱ	NRPYTEV
Database of Orthologous Groups More...OrthoDBⁱ	487299at2759
PhylomeDBⁱ	P03372
TreeFamⁱ	TF323751

Family and domain databases

Database of protein disorder More...DisProtⁱ	DP00074
Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
IDEALⁱ	IID00013
InterProⁱ	View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR001292, Estr_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit
PIRSFⁱ	PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit
PRINTSⁱ	PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P03372-1) [UniParc]FASTA Add to basket

Also known as: Long, hER-alpha66, ER66

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA 
        60         70         80         90        100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL 
       110        120        130        140        150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY 
       160        170        180        190        200
RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW 
       210        220        230        240        250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM 
       260        270        280        290        300
MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR 
       310        320        330        340        350
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA 
       360        370        380        390        400
DRELVHMINW AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG 
       410        420        430        440        450
KLLFAPNLLL DRNQGKCVEG MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS 
       460        470        480        490        500
IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KITDTLIHLM AKAGLTLQQQ 
       510        520        530        540        550
HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL LEMLDAHRLH 
       560        570        580        590 
APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV

Length:595

Mass (Da):66,216

Last modified:June 1, 1994 - v2

Checksum:ⁱ5455C57AB0CCCAA7

GO

Isoform 2 (identifier: P03372-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
255-366: Missing.

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA 
        60         70         80         90        100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL 
       110        120        130        140        150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY 
       160        170        180        190        200
RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW 
       210        220        230        240        250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM 
       260        270        280        290        300
MKGGFVDLTL HDQVHLLECA WLEILMIGLV WRSMEHPGKL LFAPNLLLDR 
       310        320        330        340        350
NQGKCVEGMV EIFDMLLATS SRFRMMNLQG EEFVCLKSII LLNSGVYTFL 
       360        370        380        390        400
SSTLKSLEEK DHIHRVLDKI TDTLIHLMAK AGLTLQQQHQ RLAQLLLILS 
       410        420        430        440        450
HIRHMSNKGM EHLYSMKCKN VVPLYDLLLE MLDAHRLHAP TSRGGASVEE 
       460        470        480 
TDQSHLATAG STSSHSLQKY YITGEAEGFP ATV

Show »

Length:483

Mass (Da):53,687

Checksum:ⁱ449BC03EF22E80A5

GO

Isoform 3 (identifier: P03372-3) [UniParc]FASTA Add to basket

Also known as: hER-alpha46, ER46

The sequence of this isoform differs from the canonical sequence as follows:
1-173: Missing.

« Hide

        10         20         30         40         50
MAMESAKETR YCAVCNDYAS GYHYGVWSCE GCKAFFKRSI QGHNDYMCPA 
        60         70         80         90        100
TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR MLKHKRQRDD 
       110        120        130        140        150
GEGRGEVGSA GDMRAANLWP SPLMIKRSKK NSLALSLTAD QMVSALLDAE 
       160        170        180        190        200
PPILYSEYDP TRPFSEASMM GLLTNLADRE LVHMINWAKR VPGFVDLTLH 
       210        220        230        240        250
DQVHLLECAW LEILMIGLVW RSMEHPGKLL FAPNLLLDRN QGKCVEGMVE 
       260        270        280        290        300
IFDMLLATSS RFRMMNLQGE EFVCLKSIIL LNSGVYTFLS STLKSLEEKD 
       310        320        330        340        350
HIHRVLDKIT DTLIHLMAKA GLTLQQQHQR LAQLLLILSH IRHMSNKGME 
       360        370        380        390        400
HLYSMKCKNV VPLYDLLLEM LDAHRLHAPT SRGGASVEET DQSHLATAGS 
       410        420 
TSSHSLQKYY ITGEAEGFPA TV

Note: Produced by alternative promoter usage.Curated

Show »

Length:422

Mass (Da):47,629

Checksum:ⁱC51DF9A9644127C0

GO

Isoform 4 (identifier: P03372-4) [UniParc]FASTA Add to basket

Also known as: hER-alpha36, ER36

The sequence of this isoform differs from the canonical sequence as follows:
1-173: Missing.
458-595: VYTFLSSTLK...GEAEGFPATV → FTISHVEAKKRILNLHPKIFGNKWFPRV

« Hide

        10         20         30         40         50
MAMESAKETR YCAVCNDYAS GYHYGVWSCE GCKAFFKRSI QGHNDYMCPA 
        60         70         80         90        100
TNQCTIDKNR RKSCQACRLR KCYEVGMMKG GIRKDRRGGR MLKHKRQRDD 
       110        120        130        140        150
GEGRGEVGSA GDMRAANLWP SPLMIKRSKK NSLALSLTAD QMVSALLDAE 
       160        170        180        190        200
PPILYSEYDP TRPFSEASMM GLLTNLADRE LVHMINWAKR VPGFVDLTLH 
       210        220        230        240        250
DQVHLLECAW LEILMIGLVW RSMEHPGKLL FAPNLLLDRN QGKCVEGMVE 
       260        270        280        290        300
IFDMLLATSS RFRMMNLQGE EFVCLKSIIL LNSGFTISHV EAKKRILNLH 
       310 
PKIFGNKWFP RV

Note: Produced by alternative splicing of isoform 3.Curated

Show »

Length:312

Mass (Da):35,547

Checksum:ⁱ85C8DEAD873F9AEC

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9H2M1	Q9H2M1_HUMAN	ER-alpha ER-alpha (Estradiol receptor) (Estrogen receptor) (Nuclear receptor subfamily 3 group A member 1)	ESR1	334	Annotation score:
H0Y4W6	H0Y4W6_HUMAN	Estrogen receptor Estrogen receptor	ESR1	310	Annotation score:
Q9UE35	Q9UE35_HUMAN	Estrogen receptor Estrogen receptor (Estrogen receptor protein)	ESR1 estrogen receptor	115	Annotation score:
Q5T5H8	Q5T5H8_HUMAN	Estrogen receptor Estrogen receptor	ESR1	84	Annotation score:
Q9H2M2	Q9H2M2_HUMAN	Estrogen receptor Estrogen receptor (Estrogen receptor alpha)	ESR1	152	Annotation score:
B0QYW7	B0QYW7_HUMAN	Estrogen receptor Estrogen receptor	ESR1	107	Annotation score:
A0A1W2PP92	A0A1W2PP92_HUMAN	Estrogen receptor Estrogen receptor	ESR1	44	Annotation score:

Sequence cautionⁱ

The sequence AAB00115 differs from that shown. contains an in-frame duplication of exons 6 and 7.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	452	I → L in CAE45969 (PubMed:17974005).Curated		1

Polymorphismⁱ

Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033028	6	H → Y in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs139960913EnsemblClinVar.	1
Natural variantⁱVAR_018905	77	G → S. Corresponds to variant dbSNP:rs9340773EnsemblClinVar.	1
Natural variantⁱVAR_004671	160	G → C1 PublicationCorresponds to variant dbSNP:rs149308960EnsemblClinVar.	1
Natural variantⁱVAR_033029	264	M → I in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_070072	375	Q → H in ESTRR; results in highly reduced activity. 1 PublicationCorresponds to variant dbSNP:rs397509428EnsemblClinVar.	1
Natural variantⁱVAR_078516	394	R → H in ESTRR; highly decreased estrogen receptor activity. 1 PublicationCorresponds to variant dbSNP:rs1131692059EnsemblClinVar.	1
Natural variantⁱVAR_004673	400	G → V Destabilizes the receptor and decreases its affinity for estradiol at 25 degrees Celsius, but not at 4 degrees Celsius. 3 Publications	1
Natural variantⁱVAR_010143	411	D → RNQGKCVEGMVEIFDMLLAT SSRFRMMNLQGEEFVCLKSI ILLNSGVYTFLSSTLKSLEE KDHIHRVLDKITDTLIHLMA KAGLTLQQQHQRLAQLLLIL SHIRHM in a 80 kDa form found in a breast cancer line; contains an in-frame duplication of exons 6 and 7.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_042460	1 – 173	Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST	173
Alternative sequenceⁱVSP_003680	255 – 366	Missing in isoform 2. 1 PublicationAdd BLAST	112
Alternative sequenceⁱVSP_042461	458 – 595	VYTFL…FPATV → FTISHVEAKKRILNLHPKIF GNKWFPRV in isoform 4. 2 PublicationsAdd BLAST	138

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03635 mRNA Translation: CAA27284.1 M12674 mRNA Translation: AAA52399.1 U47678 mRNA Translation: AAB00115.1 Sequence problems. AY425004 Genomic DNA Translation: AAQ91815.1 BX640939 mRNA Translation: CAE45969.1 AL049821 Genomic DNA No translation available. AL078582 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47740.1 BC128573 mRNA Translation: AAI28574.1 BC128574 mRNA Translation: AAI28575.1 AH008151 Genomic DNA Translation: AAD52984.1 X73067 mRNA Translation: CAA51528.1 Z75126 mRNA Translation: CAA99436.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5234.1 [P03372-1]
PIRⁱ	S64737
NCBI Reference Sequences More...RefSeqⁱ	NP_000116.2, NM_000125.3 [P03372-1] NP_001116212.1, NM_001122740.1 [P03372-1] NP_001116213.1, NM_001122741.1 [P03372-1] NP_001116214.1, NM_001122742.1 [P03372-1] NP_001278159.1, NM_001291230.1 NP_001278170.1, NM_001291241.1 NP_001315029.1, NM_001328100.1 XP_006715438.1, XM_006715375.3 [P03372-3] XP_011533845.1, XM_011535543.2 [P03372-1] XP_011533846.1, XM_011535544.2 [P03372-1] XP_011533847.1, XM_011535545.2 [P03372-1] XP_016865865.1, XM_017010376.1 [P03372-1] XP_016865866.1, XM_017010377.1 [P03372-1] XP_016865867.1, XM_017010378.1 [P03372-1] XP_016865868.1, XM_017010379.1 [P03372-1] XP_016865869.1, XM_017010380.1 [P03372-1] XP_016865870.1, XM_017010381.1 [P03372-1]

Genome annotation databases

Ensemblⁱ	ENST00000206249; ENSP00000206249; ENSG00000091831 ENST00000338799; ENSP00000342630; ENSG00000091831 ENST00000440973; ENSP00000405330; ENSG00000091831 ENST00000443427; ENSP00000387500; ENSG00000091831
GeneIDⁱ	2099
KEGGⁱ	hsa:2099
MANE-Selectⁱ	ENST00000206249.8; ENSP00000206249.3; NM_000125.4; NP_000116.2
UCSC genome browser More...UCSCⁱ	uc003qom.5, human [P03372-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P03372	Estrogen receptor		HUMAN		595	UniRef100_P03372
Isoform 3 of Estrogen receptor		HUMAN		422

Protein	Similar proteins		Species	Score	Length	Source
P03372	Estrogen receptor		HUMAN		595	UniRef90_P03372
Estrogen receptor		PROCO		599
Estrogen receptor		OTOGA		598
Estrogen receptor		NOMLE		595
Estrogen receptor		ATEPA		595
+59
P03372-2	Estrogen receptor		HUMAN		594	UniRef90_P03372-2
ER-alpha		AOTNA		482
ER-alpha		HUMAN		483
Estrogen receptor alpha E1-1-2 variant (Fragment)		HUMAN		192
Estrogen receptor alpha (Fragment)		HUMAN		190
+18
P03372-4	Estrogen receptor 1		AOTNA		320	UniRef90_P03372-4
Estrogen receptor 1		CERAT		310
Uncharacterized protein		RHIBE		310
Uncharacterized protein		CALJA		310
Uncharacterized protein		NOMLE		310
+18

Protein	Similar proteins		Species	Score	Length	Source
P03372	Estrogen receptor		XENLA		586	UniRef50_P03372
Estrogen receptor		BOVIN		596
Estrogen receptor		FELCA		595
Estrogen receptor		PIG		595
Estrogen receptor		HUMAN		595
+418
P03372-2	Estrogen receptor		CHICK		589	UniRef50_P03372-2
Estrogen receptor		TAEGU		587
Estrogen receptor		HUMAN		594
ER-alpha		AOTNA		482
ER-alpha (Fragment)		greater painted-snipe		589
+395
P03372-4	Estrogen receptor 1		AOTNA		320	UniRef50_P03372-4
Estrogen receptor 1		CEBIM		310
ESR1 isoform 1		PANTR		310
Estrogen receptor 1		PANPA		310
Estrogen receptor 1		GORGO		310
+40

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Estrogen receptor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03635 mRNA Translation: CAA27284.1 M12674 mRNA Translation: AAA52399.1 U47678 mRNA Translation: AAB00115.1 Sequence problems. AY425004 Genomic DNA Translation: AAQ91815.1 BX640939 mRNA Translation: CAE45969.1 AL049821 Genomic DNA No translation available. AL078582 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47740.1 BC128573 mRNA Translation: AAI28574.1 BC128574 mRNA Translation: AAI28575.1 AH008151 Genomic DNA Translation: AAD52984.1 X73067 mRNA Translation: CAA51528.1 Z75126 mRNA Translation: CAA99436.1
CCDSⁱ	CCDS5234.1 [P03372-1]
PIRⁱ	S64737
RefSeqⁱ	NP_000116.2, NM_000125.3 [P03372-1] NP_001116212.1, NM_001122740.1 [P03372-1] NP_001116213.1, NM_001122741.1 [P03372-1] NP_001116214.1, NM_001122742.1 [P03372-1] NP_001278159.1, NM_001291230.1 NP_001278170.1, NM_001291241.1 NP_001315029.1, NM_001328100.1 XP_006715438.1, XM_006715375.3 [P03372-3] XP_011533845.1, XM_011535543.2 [P03372-1] XP_011533846.1, XM_011535544.2 [P03372-1] XP_011533847.1, XM_011535545.2 [P03372-1] XP_016865865.1, XM_017010376.1 [P03372-1] XP_016865866.1, XM_017010377.1 [P03372-1] XP_016865867.1, XM_017010378.1 [P03372-1] XP_016865868.1, XM_017010379.1 [P03372-1] XP_016865869.1, XM_017010380.1 [P03372-1] XP_016865870.1, XM_017010381.1 [P03372-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A52	X-ray	2.80	A/B	297-554	[»]
	1ERE	X-ray	3.10	A/B/C/D/E/F	301-553	[»]
	1ERR	X-ray	2.60	A/B	301-553	[»]
	1G50	X-ray	2.90	A/B/C	304-550	[»]
	1GWQ	X-ray	2.45	A/B	301-548	[»]
	1GWR	X-ray	2.40	A/B	305-549	[»]
	1HCP	NMR	-	A	180-254	[»]
	1HCQ	X-ray	2.40	A/B/E/F	180-262	[»]
	1L2I	X-ray	1.95	A/B	297-554	[»]
	1PCG	X-ray	2.70	A/B	304-547	[»]
	1QKT	X-ray	2.20	A	304-551	[»]
	1QKU	X-ray	3.20	A/B/C	301-550	[»]
	1R5K	X-ray	2.70	A/B/C	297-554	[»]
	1SJ0	X-ray	1.90	A	307-554	[»]
	1UOM	X-ray	2.28	A	301-553	[»]
	1X7E	X-ray	2.80	A/B	305-549	[»]
	1X7R	X-ray	2.00	A	305-549	[»]
	1XP1	X-ray	1.80	A	307-554	[»]
	1XP6	X-ray	1.70	A	307-554	[»]
	1XP9	X-ray	1.80	A	307-554	[»]
	1XPC	X-ray	1.60	A	307-554	[»]
	1XQC	X-ray	2.05	A/B/C/D	301-553	[»]
	1YIM	X-ray	1.90	A	307-554	[»]
	1YIN	X-ray	2.20	A	307-554	[»]
	1ZKY	X-ray	2.25	A/B	298-554	[»]
	2AYR	X-ray	1.90	A	304-551	[»]
	2B1V	X-ray	1.80	A/B	298-554	[»]
	2B1Z	X-ray	1.78	A/B	298-554	[»]
	2B23	X-ray	2.10	A/B	298-554	[»]
	2BJ4	X-ray	2.00	A/B	305-533	[»]
	2FAI	X-ray	2.10	A/B	298-554	[»]
	2G44	X-ray	2.65	A/B	298-554	[»]
	2G5O	X-ray	2.30	A/B	298-554	[»]
	2I0J	X-ray	2.90	A/B/C/D	304-547	[»]
	2IOG	X-ray	1.60	A	309-554	[»]
	2IOK	X-ray	2.40	A/B	301-554	[»]
	2JF9	X-ray	2.10	A/B/C	304-533	[»]
	2JFA	X-ray	2.55	A/B	304-533	[»]
	2LLO	NMR	-	B	287-305	[»]
	2LLQ	NMR	-	B	287-305	[»]
	2OCF	X-ray	2.95	A	298-595	[»]
	2OUZ	X-ray	2.00	A	301-553	[»]
	2P15	X-ray	1.94	A/B	298-554	[»]
	2POG	X-ray	1.84	A/B	304-551	[»]
	2Q6J	X-ray	2.70	A/B	298-554	[»]
	2Q70	X-ray	1.95	A/B	304-551	[»]
	2QA6	X-ray	2.60	A/B	298-554	[»]
	2QA8	X-ray	1.85	A/B	298-554	[»]
	2QAB	X-ray	1.89	A/B	298-554	[»]
	2QE4	X-ray	2.40	A/B	304-551	[»]
	2QGT	X-ray	2.15	A/B	298-554	[»]
	2QGW	X-ray	2.39	A/B	298-554	[»]
	2QH6	X-ray	2.70	A/B	298-554	[»]
	2QR9	X-ray	2.00	A/B	298-554	[»]
	2QSE	X-ray	1.85	A/B	298-554	[»]
	2QXM	X-ray	2.30	A/B	298-554	[»]
	2QXS	X-ray	1.70	A/B	298-554	[»]
	2QZO	X-ray	1.72	A/B	298-554	[»]
	2R6W	X-ray	2.00	A/B	304-551	[»]
	2R6Y	X-ray	2.00	A/B	304-551	[»]
	2YAT	X-ray	2.60	A	301-551	[»]
	2YJA	X-ray	1.82	B	299-551	[»]
	3CBM	X-ray	1.69	B	298-307	[»]
3CBO	X-ray	1.65	B	298-307	[»]
3CBP	X-ray	1.42	B	298-307	[»]
3DT3	X-ray	2.40	A/B	299-551	[»]
3ERD	X-ray	2.03	A/B	297-554	[»]
3ERT	X-ray	1.90	A	297-554	[»]
3HLV	X-ray	3.00	A/B	298-550	[»]
3HM1	X-ray	2.33	A/B	298-550	[»]
3L03	X-ray	1.90	A/B	298-550	[»]
3OS8	X-ray	2.03	A/B/C/D	299-553	[»]
3OS9	X-ray	2.30	A/B/C/D	299-553	[»]
3OSA	X-ray	2.30	A/B/C/D	299-553	[»]
3Q95	X-ray	2.05	A/B	298-554	[»]
3UU7	X-ray	2.20	A/B	302-552	[»]
3UUA	X-ray	2.05	A/B	302-552	[»]
3UUC	X-ray	2.10	A/B/C/D	302-552	[»]
3UUD	X-ray	1.60	A/B	302-552	[»]
4AA6	X-ray	2.60	A/B/E/F	182-252	[»]
4DMA	X-ray	2.30	A/B	303-549	[»]
4IU7	X-ray	2.29	A/B	303-549	[»]
4IUI	X-ray	2.30	A/B	303-549	[»]
4IV2	X-ray	2.14	A/B	303-549	[»]
4IV4	X-ray	2.30	A/B	303-549	[»]
4IVW	X-ray	2.06	A/B	303-549	[»]
4IVY	X-ray	1.95	A/B	303-549	[»]
4IW6	X-ray	1.98	A/B	303-549	[»]
4IW8	X-ray	2.04	A/B	303-549	[»]
4IWC	X-ray	2.24	A/B	303-549	[»]
4IWF	X-ray	1.93	A/B	303-549	[»]
4JC3	X-ray	2.05	B	585-595	[»]
4JDD	X-ray	2.10	B	585-595	[»]
4MG5	X-ray	2.05	A/B	302-552	[»]
4MG6	X-ray	2.10	A/B	302-552	[»]
4MG7	X-ray	2.15	A/B	302-552	[»]
4MG8	X-ray	1.85	A/B	302-552	[»]
4MG9	X-ray	2.00	A/B	302-552	[»]
4MGA	X-ray	1.80	A/B	302-552	[»]
4MGB	X-ray	1.85	A/B	302-552	[»]
4MGC	X-ray	2.15	A/B	302-552	[»]
4MGD	X-ray	1.90	A/B	302-552	[»]
4O6F	X-ray	2.82	B	261-271	[»]
4PP6	X-ray	2.20	A/B	305-548	[»]
4PPP	X-ray	2.69	A/B	305-548	[»]
4PPS	X-ray	1.93	A/B	305-548	[»]
4PXM	X-ray	1.90	A/B	299-554	[»]
4Q13	X-ray	2.24	A/B	299-554	[»]
4Q50	X-ray	3.07	A/B/C/D/E/F/G/H	299-554	[»]
4TUZ	X-ray	1.90	A/B	302-552	[»]
4TV1	X-ray	1.85	A/B	302-552	[»]
4XI3	X-ray	2.49	A/B/C/D	306-548	[»]
4ZN7	X-ray	1.93	A/B	301-559	[»]
4ZN9	X-ray	2.21	A/B	301-559	[»]
4ZNH	X-ray	1.93	A/B	301-559	[»]
4ZNS	X-ray	1.86	A/B	301-559	[»]
4ZNT	X-ray	1.90	A/B	301-559	[»]
4ZNU	X-ray	2.40	A/B	301-559	[»]
4ZNV	X-ray	1.77	A/B	301-559	[»]
4ZNW	X-ray	2.31	A/B	301-559	[»]
5AAU	X-ray	1.90	A/B	307-554	[»]
5AAV	X-ray	1.95	A	307-554	[»]
			B	306-554	[»]
5ACC	X-ray	1.88	A	307-554	[»]
5AK2	X-ray	2.19	A/B	307-554	[»]
5DI7	X-ray	2.24	A/B	298-554	[»]
5DID	X-ray	2.24	A/B	298-554	[»]
5DIE	X-ray	2.24	A/B	298-554	[»]
5DIG	X-ray	2.24	A/B	298-554	[»]
5DK9	X-ray	2.28	A/B	298-554	[»]
5DKB	X-ray	2.40	A/B	298-554	[»]
5DKE	X-ray	2.60	A/B	298-554	[»]
5DKG	X-ray	2.15	A/B	298-554	[»]
5DKS	X-ray	2.60	A/B	298-554	[»]
5DL4	X-ray	2.10	A/B	298-554	[»]
5DLR	X-ray	2.26	A/B	298-554	[»]
5DMC	X-ray	2.40	A/B	298-554	[»]
5DMF	X-ray	2.40	A/B	298-554	[»]
5DP0	X-ray	2.38	A/B	298-554	[»]
5DRJ	X-ray	2.07	A/B	298-554	[»]
5DRM	X-ray	2.24	A/B	298-554	[»]
5DTV	X-ray	2.29	A/B	298-554	[»]
5DU5	X-ray	2.19	A/B	298-554	[»]
5DUE	X-ray	2.09	A/B	298-554	[»]
5DUG	X-ray	2.25	A/B	298-554	[»]
5DUH	X-ray	2.24	A/B	298-554	[»]
5DVS	X-ray	2.28	A/B	298-554	[»]
5DVV	X-ray	2.50	A/B	298-554	[»]
5DWE	X-ray	1.92	A/B	298-554	[»]
5DWG	X-ray	2.30	A/B	298-554	[»]
5DWI	X-ray	2.43	A/B	298-554	[»]
5DWJ	X-ray	2.00	A/B	298-554	[»]
5DX3	X-ray	2.09	A/B	297-554	[»]
5DXB	X-ray	2.08	A/B	297-554	[»]
5DXE	X-ray	1.50	A/B	297-554	[»]
5DXG	X-ray	1.86	A/B	297-554	[»]
5DXK	X-ray	2.23	A/B	298-554	[»]
5DXM	X-ray	2.37	A/B	298-554	[»]
5DXP	X-ray	2.20	A/B	298-554	[»]
5DXQ	X-ray	2.40	A/B	298-554	[»]
5DXR	X-ray	2.28	A/B	298-554	[»]
5DY8	X-ray	2.03	A/B	298-554	[»]
5DYB	X-ray	2.27	A/B	298-554	[»]
5DYD	X-ray	2.48	A/B	298-554	[»]
5DZ0	X-ray	2.24	A/B	298-554	[»]
5DZ1	X-ray	2.20	A/B	298-554	[»]
5DZ3	X-ray	2.15	A/B	298-554	[»]
5DZH	X-ray	2.11	A/B	298-554	[»]
5DZI	X-ray	1.90	A/B	298-554	[»]
5E0W	X-ray	2.00	A/B	298-554	[»]
5E0X	X-ray	2.01	A/B	298-554	[»]
5E14	X-ray	2.22	A/B	298-554	[»]
5E15	X-ray	2.10	A/B	298-554	[»]
5E19	X-ray	2.24	A/B	298-554	[»]
5E1C	X-ray	1.98	A/B	298-554	[»]
5EGV	X-ray	2.86	A/B	298-554	[»]
5EHJ	X-ray	2.50	A/B	298-554	[»]
5EI1	X-ray	2.40	A/B	298-554	[»]
5EIT	X-ray	2.68	A/B	298-554	[»]
5FQP	X-ray	1.88	A	307-554	[»]
5FQR	X-ray	1.88	A	307-554	[»]
5FQS	X-ray	1.94	A	307-554	[»]
5FQT	X-ray	1.99	A	307-554	[»]
5FQV	X-ray	1.74	A	307-554	[»]
5GS4	X-ray	2.40	A	305-547	[»]
5GTR	X-ray	2.80	A	305-547	[»]
5HYR	X-ray	2.27	A/B	302-559	[»]
5JMM	X-ray	2.10	A/B	302-552	[»]
5KCC	X-ray	2.39	A/B	298-554	[»]
			A/B	304-549	[»]
5KCD	X-ray	1.82	A/B	298-554	[»]
			A/B	305-549	[»]
5KCE	X-ray	1.85	A/B	298-554	[»]
			A/B	303-549	[»]
5KCF	X-ray	2.07	A/B	298-554	[»]
			A/B	303-549	[»]
5KCT	X-ray	1.60	A/B	298-554	[»]
			A/B	303-548	[»]
5KCU	X-ray	2.03	A/B	298-554	[»]
			A/B	303-548	[»]
5KCW	X-ray	1.91	A/B	303-549	[»]
			A/B	298-554	[»]
5KD9	X-ray	1.78	A/B	298-554	[»]
			A/B	303-549	[»]
5KR9	X-ray	2.25	A/B	298-554	[»]
5KRA	X-ray	2.40	A/B/E/F	298-554	[»]
5KRC	X-ray	2.40	A/B	298-554	[»]
5KRF	X-ray	2.19	A/B	298-554	[»]
5KRH	X-ray	2.24	A/B	298-554	[»]
5KRI	X-ray	2.25	A/B	298-554	[»]
5KRJ	X-ray	2.70	A/B	298-554	[»]
5KRK	X-ray	2.39	A/B	298-554	[»]
5KRL	X-ray	2.40	A/B	298-554	[»]
5KRM	X-ray	2.24	A/B	298-554	[»]
5KRO	X-ray	2.10	A/B	298-554	[»]
5N10	X-ray	1.60	C/D/F	584-595	[»]
5T0X	NMR	-	B/C	287-305	[»]
5T1Z	X-ray	2.10	A/B	298-554	[»]
5T92	X-ray	2.22	A/B	301-553	[»]
5T97	X-ray	3.00	A/B	301-553	[»]
5TLD	X-ray	2.38	A/B	298-554	[»]
5TLF	X-ray	2.20	A/B	298-554	[»]
5TLG	X-ray	2.23	A/B	298-554	[»]
5TLL	X-ray	2.42	A/B	298-554	[»]
5TLM	X-ray	2.50	A/B	298-554	[»]
5TLO	X-ray	2.28	A/B	298-554	[»]
5TLP	X-ray	2.08	A/B	298-554	[»]
5TLT	X-ray	1.90	A/B	298-554	[»]
5TLU	X-ray	2.22	A/B	298-554	[»]
5TLV	X-ray	2.32	A/B	298-554	[»]
5TLX	X-ray	2.10	A/B	298-554	[»]
5TLY	X-ray	2.14	A/B	298-554	[»]
5TM1	X-ray	2.23	A/B	298-554	[»]
5TM2	X-ray	2.60	A/B	298-554	[»]
5TM3	X-ray	2.19	A/B	298-554	[»]
5TM4	X-ray	2.25	A/B	298-554	[»]
5TM5	X-ray	2.24	A/B	298-554	[»]
5TM6	X-ray	2.54	A/B	298-554	[»]
5TM7	X-ray	2.40	A/B	298-554	[»]
5TM8	X-ray	1.99	A/B	298-554	[»]
5TM9	X-ray	2.50	A/B	298-554	[»]
5TML	X-ray	2.25	A/B	298-554	[»]
5TMM	X-ray	2.20	A/B	298-554	[»]
5TMO	X-ray	2.17	A/B	298-554	[»]
5TMQ	X-ray	2.24	A/B	298-554	[»]
5TMR	X-ray	2.30	A/B	298-554	[»]
5TMS	X-ray	2.24	A/B	298-554	[»]
5TMT	X-ray	2.05	A/B	298-554	[»]
5TMU	X-ray	2.43	A/B	298-554	[»]
5TMV	X-ray	2.38	A/B	298-554	[»]
5TMW	X-ray	2.29	A/B	298-554	[»]
5TMZ	X-ray	2.21	A/B	298-554	[»]
5TN1	X-ray	2.06	A/B	298-554	[»]
5TN3	X-ray	2.54	A/B	298-554	[»]
5TN4	X-ray	1.86	A/B	298-554	[»]
5TN5	X-ray	1.89	A/B	298-554	[»]
5TN6	X-ray	2.09	A/B	298-554	[»]
5TN7	X-ray	2.24	A/B	298-554	[»]
5TN8	X-ray	2.65	A/B	298-554	[»]
5TN9	X-ray	2.25	A/B/C/D	298-554	[»]
5TNB	X-ray	2.08	A/B/C/D	298-554	[»]
5U2B	X-ray	2.22	A/B/C/D/E/F	298-554	[»]
5U2D	X-ray	1.86	A/B	298-554	[»]
5UFW	X-ray	1.58	A/B	306-554	[»]
5UFX	X-ray	1.55	A/B	306-554	[»]
5W9C	X-ray	1.80	A/B/C/D	306-554	[»]
5W9D	X-ray	1.65	A/B	306-554	[»]
5WGD	X-ray	1.80	A/B	297-554	[»]
5WGQ	X-ray	2.30	A/B	297-554	[»]
6B0F	X-ray	2.86	A/B	301-553	[»]
6C42	X-ray	2.00	A/B	307-554	[»]
6CBZ	X-ray	1.65	A/B	305-554	[»]
6CHW	X-ray	1.89	A	306-551	[»]
6CHZ	X-ray	1.68	A	307-554	[»]
6CZN	X-ray	2.50	A/B	298-554	[»]
6D0F	X-ray	2.50	A/B	305-554	[»]
6DF6	X-ray	2.50	A/B/C/D	298-553	[»]
6DFN	X-ray	2.10	A/B/C/D	298-553	[»]
6HHP	X-ray	1.80	B	588-595	[»]
6HKB	X-ray	1.70	B	588-595	[»]
6HKF	X-ray	1.80	B	588-595	[»]
6HMU	X-ray	1.20	B	588-595	[»]
6IAR	X-ray	1.84	A	307-547	[»]
6OWC	X-ray	1.85	A/B	298-554	[»]
6PET	X-ray	2.20	A/B/C/D	298-553	[»]
6PFM	X-ray	2.84	A/D	298-553	[»]
6PIT	X-ray	2.25	A/B	297-554	[»]
6PSJ	X-ray	1.80	A/B	307-554	[»]
6SBO	X-ray	1.48	A/B	297-554	[»]
6SQ0	X-ray	1.77	A/B	307-554	[»]
6SUO	X-ray	1.74	A/B	307-554	[»]
6TJM	X-ray	1.85	B	588-595	[»]
6TL3	X-ray	2.46	B	588-595	[»]
6V87	X-ray	2.40	A/B	307-554	[»]
6V8T	X-ray	2.10	A/B	307-554	[»]
6VGH	X-ray	2.10	A/B	307-554	[»]
6VIG	X-ray	1.45	A/B/C/D	306-554	[»]
6VJ1	X-ray	1.68	A/B/D/E	306-554	[»]
6VJD	X-ray	1.80	A/B/C/D	307-554	[»]
6VMU	X-ray	1.70	A/B/C/D	307-554	[»]
6VPF	X-ray	1.60	A/B/C/D	306-554	[»]
6VPK	X-ray	1.70	A/B/C/D	306-554	[»]
6VVP	X-ray	2.60	A/B/C/D	306-554	[»]
6WOK	X-ray	2.31	A/B/C/D	298-553	[»]
6ZOQ	X-ray	1.80	A/B	307-554	[»]
6ZOR	X-ray	1.97	A/B	307-554	[»]
6ZOS	X-ray	2.00	A/B	307-554	[»]
7B9M	X-ray	1.70	B	588-595	[»]
7B9R	X-ray	1.15	B	588-595	[»]
7B9T	X-ray	1.15	B	588-595	[»]
7BA3	X-ray	1.40	B	588-595	[»]
7BA5	X-ray	1.45	B	588-595	[»]
7BA6	X-ray	1.40	B	588-595	[»]
7BA7	X-ray	1.45	B	588-595	[»]
7BA8	X-ray	1.20	B	588-595	[»]
7BA9	X-ray	1.48	B	588-595	[»]
7BAA	X-ray	1.10	B	588-595	[»]
7BAB	X-ray	1.30	B	588-595	[»]
7JHD	X-ray	2.40	A/B	305-554	[»]
7KBS	X-ray	1.83	A/B	307-554	[»]
7KCA	X-ray	1.78	A/B	306-554	[»]
7KCD	X-ray	1.80	A/B/C/D	307-554	[»]
7MSA	X-ray	2.24	A/B/C/D	298-553	[»]
7NDO	X-ray	1.60	A/B	304-548	[»]
7NEL	X-ray	1.45	A/B	304-548	[»]
7NFB	X-ray	1.33	A/B	304-548	[»]
7NFW	X-ray	1.19	B	588-595	[»]
7RRX	X-ray	1.78	A/B/C/D	298-554	[»]
7RRY	X-ray	1.87	A/B/C/D	298-554	[»]
7RRZ	X-ray	1.83	A/B/C/D	298-554	[»]
7RS0	X-ray	1.67	A/B/C/D	298-554	[»]
7RS1	X-ray	1.59	A/B/C/D	298-554	[»]
7RS2	X-ray	1.72	A/B/C/D	298-554	[»]
7RS3	X-ray	1.84	A/B/C/D	298-554	[»]
7RS4	X-ray	1.78	A/B/C/D	298-554	[»]
7RS7	X-ray	1.58	A/B/C/D	298-554	[»]
7RS8	X-ray	1.64	A/B/C/D	298-554	[»]
7RS9	X-ray	1.70	A/B/C/D	298-554	[»]
SASBDBⁱ	P03372
SMRⁱ	P03372
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	108403, 2158 interactors
ComplexPortalⁱ	CPX-5156, ERalpha-NCOA2 activated estrogen receptor complex
CORUMⁱ	P03372
DIPⁱ	DIP-5965N
ELMⁱ	P03372
IntActⁱ	P03372, 1904 interactors
MINTⁱ	P03372
STRINGⁱ	9606.ENSP00000405330

Chemistry databases

BindingDBⁱ	P03372
ChEMBLⁱ	CHEMBL206
DrugBankⁱ	DB07567, (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL DB07638, (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB08737, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL DB08020, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB07678, (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL DB07707, (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL DB03802, 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol DB06871, 17-METHYL-17-ALPHA-DIHYDROEQUILENIN DB08773, 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol DB08398, 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine DB13869, 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol DB04471, 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol DB07708, 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB07712, 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DB06898, 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol DB08048, 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DB08595, 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07195, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07086, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB07087, 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL DB08047, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE DB04468, Afimoxifene DB01431, Allylestrenol DB05233, AP1081 DB06249, Arzoxifene DB06401, Bazedoxifene DB01878, Benzophenone DB06732, beta-Naphthoflavone DB05882, CHF 4227 DB00269, Chlorotrianisene DB00882, Clomifene DB02715, Compound 18 DB02615, Compound 19 DB03742, Compound 4-D DB00286, Conjugated estrogens DB05487, Custirsen DB01406, Danazol DB00304, Desogestrel DB00890, Dienestrol DB08320, DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE DB00255, Diethylstilbestrol DB07932, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate DB00841, Dobutamine DB06374, Elacestrant DB11219, Enzacamene DB02187, Equilin DB07933, Erteberel DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01196, Estramustine DB04573, Estriol DB14641, Estriol tripropionate DB00655, Estrone DB04574, Estrone sulfate DB00977, Ethinylestradiol DB00823, Ethynodiol diacetate DB09086, Eugenol DB15690, Fluoroestradiol F-18 DB01185, Fluoxymesterone DB00947, Fulvestrant DB01645, Genistein DB11619, Gestrinone DB00756, Hexachlorophene DB07931, Hexestrol DB11064, Homosalate DB06202, Lasofoxifene DB00367, Levonorgestrel DB00431, Lindane DB00603, Medroxyprogesterone acetate DB01065, Melatonin DB01357, Mestranol DB06710, Methyltestosterone DB00648, Mitotane DB07991, N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE DB01183, Naloxone DB03467, Naringenin DB09371, Norethynodrel DB00957, Norgestimate DB05662, NP-50301 DB09535, Octocrylene DB04938, Ospemifene DB01428, Oxybenzone DB04930, Permethrin DB04824, Phenolphthalein DB02746, Phthalic Acid DB09369, Polyestradiol phosphate DB01708, Prasterone DB00396, Progesterone DB12450, Propyl Gallate DB02757, Pyrazole DB04216, Quercetin DB04575, Quinestrol DB11541, Ractopamine DB00481, Raloxifene DB02709, Resveratrol DB02901, Stanolone DB13951, Stanolone acetate DB09317, Synthetic Conjugated Estrogens, A DB09318, Synthetic Conjugated Estrogens, B DB00675, Tamoxifen DB05966, TAS-108 DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB09070, Tibolone DB00539, Toremifene DB01108, Trilostane DB11478, Zeranol DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form
DrugCentralⁱ	P03372
GuidetoPHARMACOLOGYⁱ	620
SwissLipidsⁱ	SLP:000001568

Protein family/group databases

MoonDBⁱ	P03372, Predicted

MoonDBⁱ

P03372, Predicted

PTM databases

GlyConnectⁱ	144, 1 O-Linked glycan
GlyGenⁱ	P03372, 2 sites, 1 O-linked glycan (1 site)
iPTMnetⁱ	P03372
PhosphoSitePlusⁱ	P03372
SwissPalmⁱ	P03372

Genetic variation databases

BioMutaⁱ	ESR1
DMDMⁱ	544257

Proteomic databases

CPTACⁱ	CPTAC-1241 CPTAC-145
EPDⁱ	P03372
jPOSTⁱ	P03372
MassIVEⁱ	P03372
PaxDbⁱ	P03372
PeptideAtlasⁱ	P03372
PRIDEⁱ	P03372
ProteomicsDBⁱ	51607 [P03372-1] 51608 [P03372-2] 51609 [P03372-3] 51610 [P03372-4]

Protocols and materials databases

ABCDⁱ	P03372, 5 sequenced antibodies
Antibodypediaⁱ	739, 4120 antibodies from 53 providers
The DNASU plasmid repository More...DNASUⁱ	2099

Genome annotation databases

Ensemblⁱ	ENST00000206249; ENSP00000206249; ENSG00000091831 ENST00000338799; ENSP00000342630; ENSG00000091831 ENST00000440973; ENSP00000405330; ENSG00000091831 ENST00000443427; ENSP00000387500; ENSG00000091831
GeneIDⁱ	2099
KEGGⁱ	hsa:2099
MANE-Selectⁱ	ENST00000206249.8; ENSP00000206249.3; NM_000125.4; NP_000116.2
UCSCⁱ	uc003qom.5, human [P03372-1]

Organism-specific databases

CTDⁱ	2099
DisGeNETⁱ	2099
GeneCardsⁱ	ESR1
HGNCⁱ	HGNC:3467, ESR1
HPAⁱ	ENSG00000091831, Tissue enhanced (cervix, endometrium, fallopian tube)
MalaCardsⁱ	ESR1
MIMⁱ	133430, gene 615363, phenotype
neXtProtⁱ	NX_P03372
OpenTargetsⁱ	ENSG00000091831
Orphanetⁱ	785, Estrogen resistance syndrome
PharmGKBⁱ	PA156
VEuPathDBⁱ	HostDB:ENSG00000091831
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
GeneTreeⁱ	ENSGT00940000158133
InParanoidⁱ	P03372
OMAⁱ	NRPYTEV
OrthoDBⁱ	487299at2759
PhylomeDBⁱ	P03372
TreeFamⁱ	TF323751

Enzyme and pathway databases

PathwayCommonsⁱ	P03372
Reactomeⁱ	R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-5689896, Ovarian tumor domain proteases R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8931987, RUNX1 regulates estrogen receptor mediated transcription R-HSA-8939211, ESR-mediated signaling R-HSA-8939256, RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9018519, Estrogen-dependent gene expression
SignaLinkⁱ	P03372
SIGNORⁱ	P03372

Miscellaneous databases

BioGRID-ORCSⁱ	2099, 23 hits in 1063 CRISPR screens
ChiTaRSⁱ	ESR1, human
EvolutionaryTraceⁱ	P03372
GeneWikiⁱ	Estrogen_receptor_alpha
GenomeRNAiⁱ	2099
Pharosⁱ	P03372, Tclin
Protein Ontology More...PROⁱ	PR:P03372
RNActⁱ	P03372, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000091831, Expressed in endometrium and 168 other tissues
ExpressionAtlasⁱ	P03372, baseline and differential
Genevisibleⁱ	P03372, HS

Family and domain databases

DisProtⁱ	DP00074
Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
IDEALⁱ	IID00013
InterProⁱ	View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR001292, Estr_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit
PIRSFⁱ	PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit
PRINTSⁱ	PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ESR1_HUMAN
Accessionⁱ	P03372Primary (citable) accession number: P03372 Secondary accession number(s): Q13511 Q9UIS7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	June 1, 1994
	Last modified:	February 23, 2022
	This is version 280 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

Annotation systems

Supporting data

UniProtKB - P03372 (ESR1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Estrogen receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Plasma membrane

Nucleus

Cytoplasm and Cytosol

Plasma membrane

Nucleus

Golgi apparatus

Plasma membrane

Nucleus

Cytosol

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ