UniProtKB - P03230 (LMP1_EBVB9)
Protein
Latent membrane protein 1
Gene
LMP1
Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Functioni
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.3 Publications
GO - Biological processi
- activation by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
- suppression by virus of host TRAF activity Source: UniProtKB-KW
- suppression by virus of host TYK2 activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- transformation of host cell by virus Source: InterPro
Keywordsi
Protein family/group databases
TCDBi | 9.B.387.1.1, the viral latent membrane protein (vlmp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Latent membrane protein 1Short name: LMP-1 Alternative name(s): Protein p63 Cleaved into the following chain: |
Gene namesi | Name:LMP1 ORF Names:BNLF1 |
Organismi | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) |
Taxonomic identifieri | 10377 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Lymphocryptovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | CytoplasmicAdd BLAST | 23 | |
Transmembranei | 24 – 44 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 51 | Extracellular | 7 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 75 | Cytoplasmic | 3 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 106 | Extracellular | 10 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 139 | CytoplasmicAdd BLAST | 12 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 163 | Extracellular | 3 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 386 | CytoplasmicAdd BLAST | 202 |
GO - Cellular componenti
- host cell membrane Source: CACAO
- host cell plasma membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cell membrane, Host membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 330 | K → R: No effect on ubiquitination and proteasomal degradation. 1 Publication | 1 |
Keywords - Diseasei
OncogeneChemistry databases
ChEMBLi | CHEMBL1795089 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000038310 | 1 – 386 | Latent membrane protein 1Add BLAST | 386 | |
ChainiPRO_0000038311 | 242 – 386 | Protein p25Add BLAST | 145 |
Post-translational modificationi
Ubiquitinated on the N-terminus.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PRIDEi | P03230 |
PTM databases
SwissPalmi | P03230 |
Interactioni
Subunit structurei
Interacts (via PXQXT motif) with host tumor necrosis factor receptor-associated factor (TRAF) proteins TRAF1, TRAF2, TRAF3 and TRAF5.
Interacts with human protein ZMYND11; leading to negatively regulate NF-kappa-B activation.
Interacts with host UBE2I; this interaction induces the sumoylation of various cellular proteins.
Interacts with host IRF7.
5 PublicationsBinary interactionsi
Hide detailsP03230
Protein-protein interaction databases
BioGRIDi | 971792, 12 interactors |
DIPi | DIP-29603N DIP-43767N |
ELMi | P03230 |
IntActi | P03230, 14 interactors |
MINTi | P03230 |
Structurei
3D structure databases
SMRi | P03230 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P03230 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 194 – 232 | CTAR1Add BLAST | 39 | |
Regioni | 351 – 386 | CTAR2Add BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 204 – 208 | Interaction with host TRAF proteins | 5 |
Domaini
Two regions, C-terminal-activating region 1 (CTAR1) and CTAR2, have been identified within the cytoplasmic carboxy terminal domain that activates NF-kappa-B.1 Publication
Sequence similaritiesi
Belongs to the herpesviridae LMP-1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR007961, Herpes_LMP1 |
Pfami | View protein in Pfam PF05297, Herpes_LMP1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P03230-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHDLERGPP GPRRPPRGPP LSSSLGLALL LLLLALLFWL YIVMSDWTGG
60 70 80 90 100
ALLVLYSFAL MLIIIILIIF IFRRDLLCPL GALCILLLMI TLLLIALWNL
110 120 130 140 150
HGQALFLGIV LFIFGCLLVL GIWIYLLEML WRLGATIWQL LAFFLAFFLD
160 170 180 190 200
LILLIIALYL QQNWWTLLVD LLWLLLFLAI LIWMYYHGQR HSDEHHHDDS
210 220 230 240 250
LPHPQQATDD SGHESDSNSN EGRHHLLVSG AGDGPPLCSQ NLGAPGGGPD
260 270 280 290 300
NGPQDPDNTD DNGPQDPDNT DDNGPHDPLP QDPDNTDDNG PQDPDNTDDN
310 320 330 340 350
GPHDPLPHSP SDSAGNDGGP PQLTEEVENK GGDQGPPLMT DGGGGHSHDS
360 370 380
GHGGGDPHLP TLLLGSSGSG GDDDDPHGPV QLSYYD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01995 Genomic DNA Translation: CAA26023.1 K02165 Genomic DNA Translation: AAA45888.1 V01555 Genomic DNA No translation available. AJ507799 Genomic DNA Translation: CAD53472.1 |
PIRi | D43045, QQBE50 |
RefSeqi | YP_401722.1, NC_007605.1 |
Genome annotation databases
GeneIDi | 3783750 |
KEGGi | vg:3783750 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01995 Genomic DNA Translation: CAA26023.1 K02165 Genomic DNA Translation: AAA45888.1 V01555 Genomic DNA No translation available. AJ507799 Genomic DNA Translation: CAD53472.1 |
PIRi | D43045, QQBE50 |
RefSeqi | YP_401722.1, NC_007605.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CZY | X-ray | 2.00 | D/E | 204-210 | [»] | |
SMRi | P03230 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 971792, 12 interactors |
DIPi | DIP-29603N DIP-43767N |
ELMi | P03230 |
IntActi | P03230, 14 interactors |
MINTi | P03230 |
Chemistry databases
ChEMBLi | CHEMBL1795089 |
Protein family/group databases
TCDBi | 9.B.387.1.1, the viral latent membrane protein (vlmp) family |
PTM databases
SwissPalmi | P03230 |
Proteomic databases
PRIDEi | P03230 |
Protocols and materials databases
ABCDi | P03230, 11 sequenced antibodies |
Genome annotation databases
GeneIDi | 3783750 |
KEGGi | vg:3783750 |
Miscellaneous databases
EvolutionaryTracei | P03230 |
PROi | PR:P03230 |
Family and domain databases
InterProi | View protein in InterPro IPR007961, Herpes_LMP1 |
Pfami | View protein in Pfam PF05297, Herpes_LMP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LMP1_EBVB9 | |
Accessioni | P03230Primary (citable) accession number: P03230 Secondary accession number(s): Q777A4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families