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Protein

Replication and transcription activator

Gene

BRLF1

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation, Viral latency, Viral reactivation from latency

Names & Taxonomyi

Protein namesi
Recommended name:
Replication and transcription activator
Short name:
Rta
Alternative name(s):
Immediate-early protein Rta
Gene namesi
ORF Names:BRLF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001162011 – 605Replication and transcription activatorAdd BLAST605

Proteomic databases

PRIDEiP03209

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human ATF7IP protein, leading to promote and regulate host genes in virus-infected cells.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LF2Q3KSP52EBI-2621080,EBI-2621084From Epstein-Barr virus (strain GD1).

Protein-protein interaction databases

BioGridi971769, 4 interactors
IntActiP03209, 15 interactors
MINTiP03209

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi327 – 334Poly-Ser8
Compositional biasi445 – 499Pro-richAdd BLAST55

Sequence similaritiesi

Belongs to the herpesviridae Rta family.Curated

Phylogenomic databases

OrthoDBiVOG090001ZK

Family and domain databases

InterProiView protein in InterPro
IPR004998 Herpes_TAF50
PfamiView protein in Pfam
PF03326 Herpes_TAF50, 2 hits

Sequencei

Sequence statusi: Complete.

P03209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPKKDGLED FLRLTPEIKK QLGSLVSDYC NVLNKEFTAG SVEITLRSYK
60 70 80 90 100
ICKAFINEAK AHGREWGGLM ATLNICNFWA ILRNNRVRRR AENAGNDACS
110 120 130 140 150
IACPIVMRYV LDHLIVVTDR FFIQAPSNRV MIPATIGTAM YKLLKHSRVR
160 170 180 190 200
AYTYSKVLGV DRAAIMASGK QVVEHLNRME KEGLLSSKFK AFCKWVFTYP
210 220 230 240 250
VLEEMFQTMV SSKTGHLTDD VKDVRALIKT LPRASYSSHA GQRSYVSGVL
260 270 280 290 300
PACLLSTKSK AVETPILVSG ADRMDEELMG NDGGASHTEA RYSESGQFHA
310 320 330 340 350
FTDELESLPS PTMPLKPGAQ SADCGDSSSS SSDSGNSDTE QSEREEARAE
360 370 380 390 400
APRLRAPKSR RTSRPNRGQT PCPSNAAEPE QPWIAAVHQE SDERPIFPHP
410 420 430 440 450
SKPTFLPPVK RKKGLRDSRE GMFLPKPEAG SAISDVFEGR EVCQPKRIRP
460 470 480 490 500
FHPPGSPWAN RPLPASLAPT PTGPVHEPVG SLTPAPVPQP LDPAPAVTPE
510 520 530 540 550
ASHLLEDPDE ETSQAVKALR EMADTVIPQK EEAAICGQMD LSHPPPRGHL
560 570 580 590 600
DELTTTLESM TEDLNLDSPL TPELNEILDT FLNDECLLHA MHISTGLSIF

DTSLF
Length:605
Mass (Da):66,595
Last modified:July 21, 1986 - v1
Checksum:iB5B7DF0593FADB08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24814.1
AJ507799 Genomic DNA Translation: CAD53424.1
PIRiA43043 QQBE29
RefSeqiYP_401674.1, NC_007605.1

Genome annotation databases

GeneIDi3783727
KEGGivg:3783727

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24814.1
AJ507799 Genomic DNA Translation: CAD53424.1
PIRiA43043 QQBE29
RefSeqiYP_401674.1, NC_007605.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971769, 4 interactors
IntActiP03209, 15 interactors
MINTiP03209

Proteomic databases

PRIDEiP03209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783727
KEGGivg:3783727

Phylogenomic databases

OrthoDBiVOG090001ZK

Family and domain databases

InterProiView protein in InterPro
IPR004998 Herpes_TAF50
PfamiView protein in Pfam
PF03326 Herpes_TAF50, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRTA_EBVB9
AccessioniPrimary (citable) accession number: P03209
Secondary accession number(s): Q777E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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