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Protein

Trans-activator protein BZLF1

Gene

BZLF1

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processG0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral immunoevasion, Viral latency, Viral reactivation from latency

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-activator protein BZLF1
Short name:
EB1
Alternative name(s):
Zebra
Gene namesi
ORF Names:BZLF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1293280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765411 – 245Trans-activator protein BZLF1Add BLAST245

Proteomic databases

PRIDEiP03206

PTM databases

iPTMnetiP03206

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human UBN1, CRTC2 and RACK1.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi971786, 3 interactors
IntActiP03206, 10 interactors
MINTiP03206

Chemistry databases

BindingDBiP03206

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03206
SMRiP03206
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03206

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 228bZIPAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 195Basic motifBy similarityAdd BLAST18
Regioni196 – 228Leucine-zipperBy similarityAdd BLAST33

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

KOiK19462
OrthoDBiVOG090000MA

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR017339 Trans-activator_BZLF1_HHV-4
PIRSFiPIRSF037966 BZLF1, 1 hit
PROSITEiView protein in PROSITE
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P03206-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDPNSTSED VKFTPDPYQV PFVQAFDQAT RVYQDLGGPS QAPLPCVLWP
60 70 80 90 100
VLPEPLPQGQ LTAYHVSTAP TGSWFSAPQP APENAYQAYA APQLFPVSDI
110 120 130 140 150
TQNQQTNQAG GEAPQPGDNS TVQTAAAVVF ACPGANQGQQ LADIGVPQPA
160 170 180 190 200
PVAAPARRTR KPQQPESLEE CDSELEIKRY KNRVASRKCR AKFKQLLQHY
210 220 230 240
REVAAAKSSE NDRLRLLLKQ MCPSLDVDSI IPRTPDVLHE DLLNF
Length:245
Mass (Da):26,860
Last modified:July 1, 1989 - v2
Checksum:i7F3D55D79F1F0196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24861.1
AJ507799 Genomic DNA Translation: CAD53423.1
M17547 mRNA Translation: AAA66529.1
RefSeqiYP_401673.1, NC_007605.1

Genome annotation databases

GeneIDi3783744
KEGGivg:3783744

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24861.1
AJ507799 Genomic DNA Translation: CAD53423.1
M17547 mRNA Translation: AAA66529.1
RefSeqiYP_401673.1, NC_007605.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZSDX-ray1.70C54-64[»]
2AK4X-ray2.50C/H/M/S52-64[»]
2AXFX-ray1.80C77-86[»]
2AXGX-ray2.00C77-86[»]
2C9LX-ray2.25Y/Z175-236[»]
2C9NX-ray3.30Y/Z175-236[»]
2NX5X-ray2.70C/H/M/S54-64[»]
3KWWX-ray2.18C52-64[»]
3KXFX-ray3.10Q/R/S/T52-64[»]
3SPVX-ray1.30C190-197[»]
3VFNX-ray1.50C52-64[»]
3VFOX-ray1.70C52-64[»]
3VFPX-ray1.85C52-64[»]
3VFRX-ray1.85C52-64[»]
5SZXX-ray2.25A/B175-236[»]
ProteinModelPortaliP03206
SMRiP03206
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971786, 3 interactors
IntActiP03206, 10 interactors
MINTiP03206

Chemistry databases

BindingDBiP03206
ChEMBLiCHEMBL1293280

PTM databases

iPTMnetiP03206

Proteomic databases

PRIDEiP03206

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783744
KEGGivg:3783744

Phylogenomic databases

KOiK19462
OrthoDBiVOG090000MA

Miscellaneous databases

EvolutionaryTraceiP03206
PROiPR:P03206

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR017339 Trans-activator_BZLF1_HHV-4
PIRSFiPIRSF037966 BZLF1, 1 hit
PROSITEiView protein in PROSITE
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBZLF1_EBVB9
AccessioniPrimary (citable) accession number: P03206
Secondary accession number(s): Q69127, Q777E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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