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Protein

Epstein-Barr nuclear antigen 6

Gene

EBNA6

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex. Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell apoptosis by virus, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral latency, Viral latency initiation and maintenance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epstein-Barr nuclear antigen 6
Short name:
EBNA-6
Short name:
EBV nuclear antigen 6
Alternative name(s):
Epstein-Barr nuclear antigen 3C
Short name:
EBNA-3C
Short name:
EBV nuclear antigen 3C
Epstein-Barr nuclear antigen 4B
Short name:
EBNA-4B
Short name:
EBV nuclear antigen 4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EBNA6
ORF Names:BERF3-BERF4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000153037 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001161791 – 992Epstein-Barr nuclear antigen 6Add BLAST992

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P03204

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host CTPB1; this interaction seems important for EBNA6-mediated transcriptional repression. Interacts with host MYC; this interaction enhances MYC stability. Interacts (via N-terminus) with host RBPJ. Interacts (via N-terminus) with host histone H2AX; this interaction facilitates H2AX proteasomal degradation. Interacts with host TP73; this interaction inhibits TP73-mediated apoptotic pathway.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
3509134, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-29893N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P03204

Protein interaction database and analysis system

More...
IntActi
P03204, 7 interactors

Molecular INTeraction database

More...
MINTi
P03204

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CG9X-ray2.70C98-106[»]
2BSRX-ray2.30C258-266[»]
3DX6X-ray1.70C281-290[»]
3DX7X-ray1.60C281-290[»]
3DX8X-ray2.10C281-290[»]
3DXAX-ray3.50C/H/M281-290[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P03204

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P03204

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati551 – 5551-1; approximate5
Repeati556 – 5602-1; approximate5
Repeati561 – 5653-1; approximate5
Repeati566 – 5704-15
Repeati571 – 5755-15
Repeati576 – 5806-15
Repeati581 – 5857-15
Repeati586 – 5908-15
Repeati591 – 5959-15
Repeati596 – 60010-1; approximate5
Repeati601 – 60511-1; approximate5
Repeati606 – 61012-15
Repeati741 – 7531-2Add BLAST13
Repeati754 – 7662-2Add BLAST13
Repeati767 – 7793-2Add BLAST13

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni551 – 61012 X 5 AA approximate tandem repeats of P-P-A-A-GAdd BLAST60
Regioni741 – 7793 X 13 AA tandem repeats of P-[AP]-P-Q-A-P-Y-Q-G-Y-Q-E-PAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi74 – 80Poly-Arg7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae EBNA-6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K21856

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007706 EBNA-3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05009 EBV-NA3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P03204-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFEGQGDS RQSPDNERGD NVQTTGEHDQ DPGPGPPSSG ASERLVPEES
60 70 80 90 100
YSRDQQPWGQ SRGDENRGWM QRIRRRRRRR AALSGHLLDT EDNVPPWLPP
110 120 130 140 150
HDITPYTARN IRDAACRAVK QSHLQALSNL ILDSGLDTQH ILCFVMAARQ
160 170 180 190 200
RLQDIRRGPL VAEGGVGWRH WLLTSPSQSW PMGYRTATLR TLTPVPNRVG
210 220 230 240 250
ADSIMLTATF GCQNAARTLN TFSATVWTPP HAGPREQERY AREAEVRFLR
260 270 280 290 300
GKWQRRYRRI YDLIELCGSL HHIWQNLLQT EENLLDFVRF MGVMSSCNNP
310 320 330 340 350
AVNYWFHKTI GNFKPYYPWN APPNENPYHA RRGIKEHVIQ NAFRKAQIQG
360 370 380 390 400
LSMLATGGEP RGDATSETSS DEDTGRQGSD VELESSDDEL PYIDPNMEPV
410 420 430 440 450
QQRPVMFVSR VPAKKPRKLP WPTPKTHPVK RTNVKTSDRS DKAEAQSTPE
460 470 480 490 500
RPGPSEQSSV TVEPAHPTPV EMPMVILHQP PPVPKPVPVK PTPPPSRRRR
510 520 530 540 550
GACVVYDDDV IEVIDVETTE DSSSVSQPNK PHRKHQDGFQ RSGRRQKRAA
560 570 580 590 600
PPTVSPSDTG PPAVGPPAAG PPAAGPPAAG PPAAGPPAAG PPAAGPRILA
610 620 630 640 650
PLSAGPPAAG PHIVTPPSAR PRIMAPPVVR MFMRERQLPQ STGRKPQCFW
660 670 680 690 700
EMRAGREITQ MQQEPSSHLQ SATQPTTPRP SWAPSVCALS VMDAGKAQPI
710 720 730 740 750
ESSHLSSMSP TQPISHEEQP RYEDPDAPLD LSLHPDVAAQ PAPQAPYQGY
760 770 780 790 800
QEPPAPQAPY QGYQEPPPPQ APYQGYQEPP AHGLQSSSYP GYAGPWTPRS
810 820 830 840 850
QHPCYRHPWA PWSQDPVHGH TQGPWDPRAP HLPPQWDGSA GHGQDQVSQF
860 870 880 890 900
PHLQSETGPP RLQLSLVPLV SSSAPSWSSP QPRAPIRPIP TRFPPPPMPL
910 920 930 940 950
QDSMAVGCDS SGTACPSMPF ASDYSQGAFT PLDINATTPK RPRVEESSHG
960 970 980 990
PARCSQATAE AQEILSDNSE ISVFPKDAKQ TDYDASTESE LD
Length:992
Mass (Da):109,129
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39BEAB9BC515BD84
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24859.1
AJ507799 Genomic DNA Translation: CAD53421.1

NCBI Reference Sequences

More...
RefSeqi
YP_401671.1, NC_007605.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3783763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3783763

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24859.1
AJ507799 Genomic DNA Translation: CAD53421.1
RefSeqiYP_401671.1, NC_007605.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CG9X-ray2.70C98-106[»]
2BSRX-ray2.30C258-266[»]
3DX6X-ray1.70C281-290[»]
3DX7X-ray1.60C281-290[»]
3DX8X-ray2.10C281-290[»]
3DXAX-ray3.50C/H/M281-290[»]
SMRiP03204
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3509134, 1 interactor
DIPiDIP-29893N
ELMiP03204
IntActiP03204, 7 interactors
MINTiP03204

Proteomic databases

PRIDEiP03204

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783763
KEGGivg:3783763

Phylogenomic databases

KOiK21856

Miscellaneous databases

EvolutionaryTraceiP03204

Family and domain databases

InterProiView protein in InterPro
IPR007706 EBNA-3
PfamiView protein in Pfam
PF05009 EBV-NA3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEBNA6_EBVB9
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03204
Secondary accession number(s): Q777E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1988
Last modified: January 16, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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