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Protein

Triplex capsid protein 1

Gene

TRX1

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 1UniRule annotation
Gene namesi
Name:TRX1UniRule annotation
ORF Names:BORF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157231 – 364Triplex capsid protein 1Add BLAST364

Proteomic databases

PRIDEiP03187

Interactioni

Subunit structurei

Interacts with TRX2, MCP and capsid vertex component 2/CVC2.UniRule annotation

Structurei

3D structure databases

SMRiP03187
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000FJ

Family and domain databases

HAMAPiMF_04018 HSV_TRX1, 1 hit
InterProiView protein in InterPro
IPR004999 Herpes_1
PfamiView protein in Pfam
PF03327 Herpes_VP19C, 1 hit

Sequencei

Sequence statusi: Complete.

P03187-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVQGSVDRR RLQRRIAGLL PPPARRLNIS RGSEFTRDVR GLVEEHAQAS
60 70 80 90 100
SLSAAAVWRA GLLAPGEVAV AGGGSGGGSF SWSGWRPPVF GDFLIHASSF
110 120 130 140 150
NNAEATGTPL FQFKQSDPFS GVDAVFTPLS LFILMNHGRG VAARVEAGGG
160 170 180 190 200
LTRMANLLYD SPATLADLVP DFGRLVADRR FHNFITPVGP LVENIKSTYL
210 220 230 240 250
NKITTVVHGP VVSKAIPRST VKVTVPQEAF VDLDAWLSGG AGGGGGVCFV
260 270 280 290 300
GGLGLQPCPA DARLYVALTY EEAGPRFTFF QSSRGHCQIM NILRIYYSPS
310 320 330 340 350
IMHRYAVVQP LHIEELTFGA VACLGTFSAT DGWRRSAFNY RGSSLPVVEI
360
DSFYSNVSDW EVIL
Length:364
Mass (Da):39,191
Last modified:July 21, 1986 - v1
Checksum:i6843A9A0A0CDD794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24840.1
AJ507799 Genomic DNA Translation: CAD53404.1
PIRiH93065 QQBE9
RefSeqiYP_401654.1, NC_007605.1

Genome annotation databases

GeneIDi3783724
KEGGivg:3783724

Similar proteinsi

Entry informationi

Entry nameiTRX1_EBVB9
AccessioniPrimary (citable) accession number: P03187
Secondary accession number(s): Q777G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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