UniProtKB - P03170 (ICP47_HHV11)

BLAST

>sp|P03170|ICP47_HHV11 ICP47 protein OS=Human herpesvirus 1 (strain 17) OX=10299 GN=US12 PE=1 SV=2
MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPE
IAPNASLGVAHRRTGGTVTDSPRNPVTR

Align
Format
Add to basket Added to basket
History
Entry version 91 (12 Sep 2018)
Sequence version 2 (01 Mar 2004)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

ICP47 protein

Gene

US12

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.4 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	22	Binding to TAP1 subunitBy similarity		1

GO - Biological processⁱ

suppression by virus of host adaptive immune response Source: UniProtKB-KW
suppression by virus of host antigen processing and presentation Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host TAP by virus, Viral immunoevasion

Biological process

Host-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host TAP by virus, Viral immunoevasion

Protein family/group databases

TCDBⁱ	8.A.72.1.1 the immune evasion protein, icp47 (icp47) family

TCDBⁱ

8.A.72.1.1 the immune evasion protein, icp47 (icp47) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ICP47 protein Alternative name(s): Immediate-early protein IE12 Immediate-early-5 Infected cell protein 47 US12 protein Vmw12
Gene namesⁱ	Name:US12
Organismⁱ	Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10299 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000009294 Componentⁱ: Genome

Subcellular locationⁱ

GO - Cellular componentⁱ

host cell cytoplasm Source: UniProtKB-SubCell
host cell nucleus Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cytoplasm, Host nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	24	D → G: Reduced ability to inhibit peptide-binding to TAP. 1 Publication	1
Mutagenesisⁱ	31	K → G: Reduced ability to inhibit peptide-binding to TAP. 1 Publication	1
Mutagenesisⁱ	32	R → G: Reduced ability to inhibit peptide-binding to TAP. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000115810	1 – 88	ICP47 proteinAdd BLAST		88

Proteomic databases

PRIDEⁱ	P03170

PRIDEⁱ

P03170

Expressionⁱ

Keywords - Developmental stageⁱ

Early protein

Interactionⁱ

Subunit structureⁱ

Interacts with host TAP1 and TAP2; these interactions inhibit the loading of peptides onto MHC class I molecules.1 Publication

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-61932N
IntActⁱ	P03170, 2 interactors

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 13	Combined sources	9
Beta strandⁱ	16 – 18	Combined sources	3
Helixⁱ	22 – 31	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P03170
SMRⁱ	P03170
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P03170

EvolutionaryTraceⁱ

P03170

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 35	Active domainBy similarityAdd BLAST		34

Domainⁱ

The N-terminal active domain blocks peptide binding to and peptide transport by TAP.By similarity

Sequence similaritiesⁱ

Belongs to the herpesviridae US12 family.Curated

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K19446
Database of Orthologous Groups More...OrthoDBⁱ	VOG090003BB

Family and domain databases

InterProⁱ	View protein in InterPro IPR008026 Herpes_ICP47
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05363 Herpes_US12, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P03170-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSWALEMADT FLDTMRVGPR TYADVRDEIN KRGREDREAA RTAVHDPERP 
        60         70         80 
LLRSPGLLPE IAPNASLGVA HRRTGGTVTD SPRNPVTR

Length:88

Mass (Da):9,793

Last modified:March 1, 2004 - v2

Checksum:ⁱC5D2EA8C35006612

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	14	T → N (PubMed:6278443).Curated		1
Sequence conflictⁱ	14	T → N (PubMed:11117552).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02220 Genomic DNA Translation: AAA45795.1 L00036 Genomic DNA Translation: AAA96676.1 X00428 Genomic RNA Translation: CAA25124.1 X02138 Genomic DNA Translation: CAA26066.1 X14112 Genomic DNA Translation: CAA32277.1 V00462 Genomic DNA Translation: CAA23737.1 AF290017 Genomic DNA Translation: AAG33133.1 AF290018 Genomic DNA Translation: AAG33134.1 AF324428 Genomic DNA Translation: AAK12110.1
PIRⁱ	A93454 EDBE51
NCBI Reference Sequences More...RefSeqⁱ	YP_009137148.1, NC_001806.2

Genome annotation databases

GeneIDⁱ	2703441
KEGGⁱ	vg:2703441

Protein	Similar proteins		Species	Score	Length	Source
P03170	TAP transporter inhibitor ICP47		HHV1		88	UniRef100_P03170

Protein	Similar proteins		Species	Score	Length	Source
P03170	TAP transporter inhibitor ICP47		HHV1		88	UniRef90_P03170
TAP transporter inhibitor ICP47		Human alphaherpesvirus 1 strain RH2		88
US12		HHV1		88
TAP transporter inhibitor ICP47		HHV1		88
TAP transporter inhibitor ICP47		HHV1		88
+12

Protein	Similar proteins		Species	Score	Length	Source
P03170	TAP transporter inhibitor ICP47		HHV1		88	UniRef50_P03170
TAP transporter inhibitor ICP47		Human alphaherpesvirus 1 strain RH2		88
TAP transporter inhibitor ICP47		HHV1		88
US12		HHV1		88
US12		HHV1		88
+12

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02220 Genomic DNA Translation: AAA45795.1 L00036 Genomic DNA Translation: AAA96676.1 X00428 Genomic RNA Translation: CAA25124.1 X02138 Genomic DNA Translation: CAA26066.1 X14112 Genomic DNA Translation: CAA32277.1 V00462 Genomic DNA Translation: CAA23737.1 AF290017 Genomic DNA Translation: AAG33133.1 AF290018 Genomic DNA Translation: AAG33134.1 AF324428 Genomic DNA Translation: AAK12110.1
PIRⁱ	A93454 EDBE51
RefSeqⁱ	YP_009137148.1, NC_001806.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1QLO	NMR	-	A	1-34	[»]
ProteinModelPortalⁱ	P03170
SMRⁱ	P03170
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-61932N
IntActⁱ	P03170, 2 interactors

Protein family/group databases

TCDBⁱ	8.A.72.1.1 the immune evasion protein, icp47 (icp47) family

TCDBⁱ

8.A.72.1.1 the immune evasion protein, icp47 (icp47) family

Proteomic databases

PRIDEⁱ	P03170

PRIDEⁱ

P03170

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2703441
KEGGⁱ	vg:2703441

Phylogenomic databases

KOⁱ	K19446
OrthoDBⁱ	VOG090003BB

Miscellaneous databases

EvolutionaryTraceⁱ	P03170

EvolutionaryTraceⁱ

P03170

Family and domain databases

InterProⁱ	View protein in InterPro IPR008026 Herpes_ICP47
Pfamⁱ	View protein in Pfam PF05363 Herpes_US12, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ICP47_HHV11
Accessionⁱ	P03170Primary (citable) accession number: P03170 Secondary accession number(s): Q99BW2, Q9E0N0, Q9E0N1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	March 1, 2004
	Last modified:	September 12, 2018
	This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P03170 (ICP47_HHV11)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

ICP47 protein

US12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Keywords - Developmental stageⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ