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Protein

ICP47 protein

Gene

US12

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei22Binding to TAP1 subunitBy similarity1

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host TAP by virus, Viral immunoevasion

Protein family/group databases

TCDBi8.A.72.1.1 the immune evasion protein, icp47 (icp47) family

Names & Taxonomyi

Protein namesi
Recommended name:
ICP47 protein
Alternative name(s):
Immediate-early protein IE12
Immediate-early-5
Infected cell protein 47
US12 protein
Vmw12
Gene namesi
Name:US12
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24D → G: Reduced ability to inhibit peptide-binding to TAP. 1 Publication1
Mutagenesisi31K → G: Reduced ability to inhibit peptide-binding to TAP. 1 Publication1
Mutagenesisi32R → G: Reduced ability to inhibit peptide-binding to TAP. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001158101 – 88ICP47 proteinAdd BLAST88

Proteomic databases

PRIDEiP03170

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with host TAP1 and TAP2; these interactions inhibit the loading of peptides onto MHC class I molecules.1 Publication

Protein-protein interaction databases

DIPiDIP-61932N
IntActiP03170, 2 interactors

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03170
SMRiP03170
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03170

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 35Active domainBy similarityAdd BLAST34

Domaini

The N-terminal active domain blocks peptide binding to and peptide transport by TAP.By similarity

Sequence similaritiesi

Belongs to the herpesviridae US12 family.Curated

Phylogenomic databases

KOiK19446
OrthoDBiVOG090003BB

Family and domain databases

InterProiView protein in InterPro
IPR008026 Herpes_ICP47
PfamiView protein in Pfam
PF05363 Herpes_US12, 1 hit

Sequencei

Sequence statusi: Complete.

P03170-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWALEMADT FLDTMRVGPR TYADVRDEIN KRGREDREAA RTAVHDPERP
60 70 80
LLRSPGLLPE IAPNASLGVA HRRTGGTVTD SPRNPVTR
Length:88
Mass (Da):9,793
Last modified:March 1, 2004 - v2
Checksum:iC5D2EA8C35006612
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14T → N (PubMed:6278443).Curated1
Sequence conflicti14T → N (PubMed:11117552).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02220 Genomic DNA Translation: AAA45795.1
L00036 Genomic DNA Translation: AAA96676.1
X00428 Genomic RNA Translation: CAA25124.1
X02138 Genomic DNA Translation: CAA26066.1
X14112 Genomic DNA Translation: CAA32277.1
V00462 Genomic DNA Translation: CAA23737.1
AF290017 Genomic DNA Translation: AAG33133.1
AF290018 Genomic DNA Translation: AAG33134.1
AF324428 Genomic DNA Translation: AAK12110.1
PIRiA93454 EDBE51
RefSeqiYP_009137148.1, NC_001806.2

Genome annotation databases

GeneIDi2703441
KEGGivg:2703441

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02220 Genomic DNA Translation: AAA45795.1
L00036 Genomic DNA Translation: AAA96676.1
X00428 Genomic RNA Translation: CAA25124.1
X02138 Genomic DNA Translation: CAA26066.1
X14112 Genomic DNA Translation: CAA32277.1
V00462 Genomic DNA Translation: CAA23737.1
AF290017 Genomic DNA Translation: AAG33133.1
AF290018 Genomic DNA Translation: AAG33134.1
AF324428 Genomic DNA Translation: AAK12110.1
PIRiA93454 EDBE51
RefSeqiYP_009137148.1, NC_001806.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QLONMR-A1-34[»]
ProteinModelPortaliP03170
SMRiP03170
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61932N
IntActiP03170, 2 interactors

Protein family/group databases

TCDBi8.A.72.1.1 the immune evasion protein, icp47 (icp47) family

Proteomic databases

PRIDEiP03170

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703441
KEGGivg:2703441

Phylogenomic databases

KOiK19446
OrthoDBiVOG090003BB

Miscellaneous databases

EvolutionaryTraceiP03170

Family and domain databases

InterProiView protein in InterPro
IPR008026 Herpes_ICP47
PfamiView protein in Pfam
PF05363 Herpes_US12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiICP47_HHV11
AccessioniPrimary (citable) accession number: P03170
Secondary accession number(s): Q99BW2, Q9E0N0, Q9E0N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 2004
Last modified: September 12, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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