UniProtKB - P03130 (VE7_CRPVK)
Protein E7
E7
Functioni
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
UniRule annotationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 56 – 92 | UniRule annotationAdd BLAST | 37 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-UniRule
- protein domain specific binding Source: UniProtKB-UniRule
GO - Biological processi
- modulation by virus of host G1/S transition checkpoint Source: UniProtKB-UniRule
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-UniRule
- transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Protein E7UniRule annotation |
Gene namesi | Name:E7UniRule annotation |
Organismi | Cottontail rabbit papillomavirus (strain Kansas) (CRPV) (Papillomavirus sylvilagi) |
Taxonomic identifieri | 31553 [NCBI] |
Taxonomic lineagei | Viruses › Monodnaviria › Shotokuvirae › Cossaviricota › Papovaviricetes › Zurhausenvirales › Papillomaviridae › Firstpapillomavirinae › Kappapapillomavirus › |
Virus hosti | Sylvilagus floridanus (Cottontail rabbit) [TaxID: 9988] |
Proteomesi |
|
Subcellular locationi
- Host cytoplasm UniRule annotation
- Host nucleus UniRule annotation Note: Predominantly found in the host nucleus.UniRule annotation
Keywords - Cellular componenti
Host cytoplasm, Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000133466 | 1 – 94 | Protein E7Add BLAST | 94 |
Post-translational modificationi
Interactioni
Subunit structurei
Homodimer. Homooligomer.
Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity.
Interacts with host EP300; this interaction represses EP300 transcriptional activity.
Interacts with protein E2; this interaction inhibits E7 oncogenic activity.
Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
UniRule annotationGO - Molecular functioni
- protein domain specific binding Source: UniProtKB-UniRule
Protein-protein interaction databases
DIPi | DIP-1091N |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | E7 terminal domainUniRule annotationAdd BLAST | 42 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 22 – 26 | LXCXE motif; interaction with host RB1 and TMEM173/STINGUniRule annotation | 5 | |
Motifi | 74 – 82 | Nuclear export signalUniRule annotation | 9 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 56 – 92 | UniRule annotationAdd BLAST | 37 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
HAMAPi | MF_04004, PPV_E7, 1 hit |
InterProi | View protein in InterPro IPR000148, Papilloma_E7 |
Pfami | View protein in Pfam PF00527, E7, 1 hit |
PIRSFi | PIRSF003407, Papvi_E7, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MIGRTPKLSE LVLGETAEAL SLHCDEALEN LSDDDEEDHQ DRQVFIERPY
60 70 80 90
AVSVPCKRCR QTISFVCVCA PEAIRTLNRL LSASLSLVCP ECCN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02708 Genomic DNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02708 Genomic DNA No translation available. |
3D structure databases
SMRi | P03130 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-1091N |
Family and domain databases
HAMAPi | MF_04004, PPV_E7, 1 hit |
InterProi | View protein in InterPro IPR000148, Papilloma_E7 |
Pfami | View protein in Pfam PF00527, E7, 1 hit |
PIRSFi | PIRSF003407, Papvi_E7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VE7_CRPVK | |
Accessioni | P03130Primary (citable) accession number: P03130 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | June 2, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families