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Protein

Protein E7

Gene

E7

Organism
Human papillomavirus type 16
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).UniRule annotation3 Publications

Miscellaneous

HPV16, in comparison to HPV types 6 and 11, is more often associated with malignant genital cancers in humans.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri58 – 94UniRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E7UniRule annotation
Gene namesi
Name:E7UniRule annotation
OrganismiHuman papillomavirus type 16
Taxonomic identifieri333760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeFirstpapillomavirinaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000115181 Componenti: Genome
  • UP000106302 Componenti: Genome
  • UP000009251 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67L → R: Complete loss of interaction with HDAC1 and transformation ability. 1 Publication1
Mutagenesisi82 – 83LL → RR: Complete loss of interaction with HDAC1 and transformation ability. 1 Publication2
Mutagenesisi91C → G: Complete loss of interaction with HDAC1 and transformation ability. 1 Publication1

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001334141 – 98Protein E7Add BLAST98

Post-translational modificationi

Highly phosphorylated.UniRule annotation1 Publication

PTM databases

iPTMnetiP03129

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer (PubMed:11123931). Homooligomer (PubMed:15035602). Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity (PubMed:1316611). Interacts with host EP300; this interaction represses EP300 transcriptional activity (PubMed:12970734). Forms a complex with CHD4 and HDAC1, thereby altering the action of host histone deacetylation. A similar complex involving E7, CHD4 and HDAC2 may also form (PubMed:10228159). Interacts with protein E2; this interaction inhibits E7 oncogenic activity (PubMed:16439535).UniRule annotation6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4263558, 7 interactors
DIPiDIP-1090N
IntActiP03129, 81 interactors
MINTiP03129

Structurei

3D structure databases

DisProtiDP00024
ProteinModelPortaliP03129
SMRiP03129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 40DisorderedUniRule annotation1 PublicationAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 26LXCXE motif; interaction with host RB1 and TMEM173/STINGUniRule annotation5
Motifi76 – 84Nuclear export signalUniRule annotation1 Publication9

Sequence similaritiesi

Belongs to the papillomaviridae E7 protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri58 – 94UniRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

KOiK21809
OrthoDBiVOG090001L5

Family and domain databases

HAMAPiMF_04004 PPV_E7, 1 hit
InterProiView protein in InterPro
IPR000148 Papilloma_E7
PfamiView protein in Pfam
PF00527 E7, 1 hit
PIRSFiPIRSF003407 Papvi_E7, 1 hit

Sequencei

Sequence statusi: Complete.

P03129-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHGDTPTLHE YMLDLQPETT DLYCYEQLND SSEEEDEIDG PAGQAEPDRA
60 70 80 90
HYNIVTFCCK CDSTLRLCVQ STHVDIRTLE DLLMGTLGIV CPICSQKP
Length:98
Mass (Da):11,022
Last modified:July 21, 1986 - v1
Checksum:i9BD612534CD2C9EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02718 Genomic DNA Translation: AAA46940.1
D00735 Genomic DNA Translation: BAA00633.1
AF003020 Genomic DNA Translation: AAB70737.1
AF003023 Genomic DNA Translation: AAB70740.1
AF003024 Genomic DNA Translation: AAB70741.1
AF003025 Genomic DNA Translation: AAB70742.1
AF003026 Genomic DNA Translation: AAB70743.1
U76411 Genomic DNA Translation: AAB18962.1
U76412 Genomic DNA Translation: AAB18963.1
U76413 Genomic DNA Translation: AAB18964.1
AF536179 Genomic DNA Translation: AAQ10713.1
AF536180 Genomic DNA Translation: AAQ10721.1
PIRiA03688 W7WLHS
RefSeqiNP_041326.1, NC_001526.4

Genome annotation databases

GeneIDi1489079
KEGGivg:1489079

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02718 Genomic DNA Translation: AAA46940.1
D00735 Genomic DNA Translation: BAA00633.1
AF003020 Genomic DNA Translation: AAB70737.1
AF003023 Genomic DNA Translation: AAB70740.1
AF003024 Genomic DNA Translation: AAB70741.1
AF003025 Genomic DNA Translation: AAB70742.1
AF003026 Genomic DNA Translation: AAB70743.1
U76411 Genomic DNA Translation: AAB18962.1
U76412 Genomic DNA Translation: AAB18963.1
U76413 Genomic DNA Translation: AAB18964.1
AF536179 Genomic DNA Translation: AAQ10713.1
AF536180 Genomic DNA Translation: AAQ10721.1
PIRiA03688 W7WLHS
RefSeqiNP_041326.1, NC_001526.4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YOZX-ray2.25B21-29[»]
DisProtiDP00024
ProteinModelPortaliP03129
SMRiP03129
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263558, 7 interactors
DIPiDIP-1090N
IntActiP03129, 81 interactors
MINTiP03129

PTM databases

iPTMnetiP03129

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489079
KEGGivg:1489079

Phylogenomic databases

KOiK21809
OrthoDBiVOG090001L5

Family and domain databases

HAMAPiMF_04004 PPV_E7, 1 hit
InterProiView protein in InterPro
IPR000148 Papilloma_E7
PfamiView protein in Pfam
PF00527 E7, 1 hit
PIRSFiPIRSF003407 Papvi_E7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVE7_HPV16
AccessioniPrimary (citable) accession number: P03129
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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