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Protein

Middle T antigen

Gene
N/A
Organism
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor. Recruits upon association with Ppp2/PP2A the Src tyrosine kinase component Fyn, thereby activating its kinase activity. In turn, MT becomes phosphorylated and mediates signal transduction pathways leading to cell cycle progression and cell division. MT plays also a role in regulation of early and late gene expression as well as viral DNA replication (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Middle T antigen
Short name:
MT
Short name:
MT-AG
OrganismiHamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1)
Taxonomic identifieri1891729 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolyomaviridae
Virus hostiMesocricetus auratus (Golden hamster) [TaxID: 10036]
Proteomesi
  • UP000008477 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 374CytoplasmicSequence analysisAdd BLAST374
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 401ExtracellularSequence analysis6

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi324Y → F: 70% loss of interaction with host Fyn. 1 Publication1

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001150471 – 401Middle T antigenAdd BLAST401

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP03079

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with host Ppp2/PP2A A and C subunits; this interaction alters PP2A substrate specificity and localization (By similarity). Interacts with host Fyn.By similarity1 Publication

Protein-protein interaction databases

ELMiP03079
IntActiP03079, 1 interactor
MINTiP03079

Structurei

3D structure databases

ProteinModelPortaliP03079
SMRiP03079
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03079

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 75JPROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR003354 Papo_T_antigen
IPR036092 Papo_T_antigensf
PfamiView protein in Pfam
PF02380 Papo_T_antigen, 1 hit
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF161240 SSF161240, 1 hit
SSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Middle T antigen (identifier: P03079-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRILTKEEK QALISLLDLE PQYWGDYGRM QKCYKKKCLQ LHPDKGGNEE
60 70 80 90 100
LMQQLNTLWT KLKDGLYRVR LLLGPSQVRR LGKDQWNLSL QQTFSGTYFR
110 120 130 140 150
RLCRLPITCL RNKGISTCNC ILCLLRKQHF LLKKSWRVPC LVLGECYCID
160 170 180 190 200
CFALWFGLPV TNMLVPLYAQ FLAPIPVDWL DLNVHEVYNP ASGMTLMLPP
210 220 230 240 250
PPADPESSTI LTQEDTGPTL MGQQDTLTSR RNTGKSFSLS GMLMRTSPAK
260 270 280 290 300
KSYHHQKMNS PPGIPIPPPP LFLFPVTAPV PPVTRNTQET QAERENEYMP
310 320 330 340 350
MAPQIHLYSQ IREPTHQEEE EPQYEEIPIY LELLPENPNQ HLALTSTARR
360 370 380 390 400
SLRRKYHKHN SHIITQRQRN RLRRLVLMIF LLSLGGFFLT LFFLIKRKMH

L
Length:401
Mass (Da):46,562
Last modified:July 21, 1986 - v1
Checksum:i91B6172F4293F448
GO
Isoform Small t antigen (identifier: P03080-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P03080.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:194
Mass (Da):22,625
GO
Isoform Large T antigen (identifier: P03075-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P03075.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:751
Mass (Da):85,988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26281 Genomic DNA Translation: AAA67117.1
X02449 Genomic DNA Translation: CAB59362.1
PIRiA03615 TVVPMH
RefSeqiYP_009111408.1, NC_001663.2 [P03079-1]

Genome annotation databases

GeneIDi29030998
KEGGivg:29030998

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26281 Genomic DNA Translation: AAA67117.1
X02449 Genomic DNA Translation: CAB59362.1
PIRiA03615 TVVPMH
RefSeqiYP_009111408.1, NC_001663.2 [P03079-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOTNMR-P321-331[»]
1AOUNMR-P321-331[»]
1LCJX-ray1.80B321-331[»]
1SPSX-ray2.70D/E/F321-331[»]
4U1PX-ray1.40B321-331[»]
ProteinModelPortaliP03079
SMRiP03079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP03079
IntActiP03079, 1 interactor
MINTiP03079

PTM databases

iPTMnetiP03079

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29030998
KEGGivg:29030998

Miscellaneous databases

EvolutionaryTraceiP03079

Family and domain databases

Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR003354 Papo_T_antigen
IPR036092 Papo_T_antigensf
PfamiView protein in Pfam
PF02380 Papo_T_antigen, 1 hit
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF161240 SSF161240, 1 hit
SSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT_POVHA
AccessioniPrimary (citable) accession number: P03079
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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