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Entry version 221 (07 Apr 2021)
Sequence version 1 (21 Jul 1986)
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Protein

General control transcription factor GCN4

Gene

GCN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Master transcriptional regulator that mediates the response to amino acid starvation (PubMed:11390663, PubMed:29628310). Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' in canonical nucleosome-depleted 5'-positioned promoters, and also within coding sequences and 3' non-coding regions (PubMed:29628310, PubMed:11390663, PubMed:1473154, PubMed:2277632, PubMed:1939099, PubMed:7664107, PubMed:2204805, PubMed:3678204, PubMed:3532321, PubMed:3530496). During nutrient starvation (low or poor amino acid, carbon or purine sources), it activates genes required for amino acid biosynthesis and transport, autophagy, cofactor biosynthesis and transport, mitochondrial transport, and additional downstream transcription factors (PubMed:11390663, PubMed:29628310, PubMed:8336737, PubMed:1939099, PubMed:10733573, PubMed:7862116). Activates transcription by recruiting multiple coactivators, including the mediator complex, the SAGA complex, and the SWI/SNF complex, to enable assembly of the pre-initiation complex at core promoters (PubMed:19940160, PubMed:9488488, PubMed:10549298).16 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processAmino-acid biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-2559580, Oxidative Stress Induced Senescence
R-SCE-2871796, FCERI mediated MAPK activation
R-SCE-450341, Activation of the AP-1 family of transcription factors

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
P03069

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General control transcription factor GCN4
Alternative name(s):
Amino acid biosynthesis regulatory protein
General control protein GCN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCN41 PublicationImported
Synonyms:AAS1011 PublicationImported, AAS3Imported, ARG9Imported
Ordered Locus Names:YEL009C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000735, GCN4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YEL009C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abolishes recruitment of the mediator complex to the upstream activating sequence (UAS) of amino-acid starvation responsive genes (PubMed:19940160). Decreases RNA level of genes involved in amino acid biosynthesis and cofactor biosynthesis during amino acid starvation or methyl methanesulfonate stress (PubMed:11390663, PubMed:8336737, PubMed:29628310). Growth dependent on amino acid supplementation (PubMed:10733573). Sensitive to amino acid starvation (PubMed:10549298). Sensitive to purine starvation (PubMed:8336737). Decreases cellular glycogen levels during glucose starvation (PubMed:10733573).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi97 – 98FF → AA: Reduces transcriptional activation activity; when associated with A-107; A-110; A-113; A-120; A-123 and A-124. 1 Publication2
Mutagenesisi107M → A: Reduces transcriptional activation activity; when associated with A-97; A-98; A-110; A-113; A-120; A-123 and A-124. 1 Publication1
Mutagenesisi110Y → A: Reduces transcriptional activation activity; when associated with A-97; A-98; A-107; A-113; A-120; A-123 and A-124. 1 Publication1
Mutagenesisi113L → A: Reduces transcriptional activation activity; when associated with A-97; A-98; A-107; A-110; A-120; A-123 and A-124. 1 Publication1
Mutagenesisi120 – 124WTSLF → ATSAA: Reduces transcriptional activation activity; when associated with A-97; A-98; A-107; A-110 and A-113. 1 Publication5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000764901 – 281General control transcription factor GCN4Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
Modified residuei165Phosphothreonine; by PHO851 Publication1
Modified residuei218PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by the cyclin-CDK PCL5-PHO85. Phosphorylation of Thr-165 induces degradation of GCN4 by the E3 ubiquitin ligase complex SCF(Cdc4).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P03069

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P03069

PRoteomics IDEntifications database

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PRIDEi
P03069

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P03069

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Translation is induced by amino acid or purine starvation, or during growth in low or poor carbon sources (PubMed:6387704, PubMed:6433345, PubMed:8336737, PubMed:10733573, PubMed:9582292). Translational repression during nutrient-rich conditions is dependent on four uORFs (upstream open reading frames) present in the 5'-UTR of the mRNA; these promote ribosome dissociation (PubMed:6387704, PubMed:6433345, PubMed:3516411, PubMed:2676723, PubMed:8336737, PubMed:9582292). Translational induction occurs in conditions reducing translation machinery efficiency, leading to ribosomes scanning over the uORFs, and increased translation of the mRNA (PubMed:1986242). The rapid translational induction is followed by transcriptional induction at later time-points, independently of the uORF sequences (PubMed:9582292).8 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:1473154, PubMed:3678204). Each subunit binds overlapping and non-identical half-sites that flank the central CG base-pair in the pseudo-palindromic motif 5'-ATGA[CG]TCAT-3' (PubMed:1473154, PubMed:7664107, PubMed:2204805, PubMed:3678204).

Interacts with the mediator tail; the interaction with GAL11/MED15 is direct (PubMed:19940160, PubMed:9488488, PubMed:10549298).

Interacts with the SAGA histone acetyltransferase complex (PubMed:19940160, PubMed:9488488, PubMed:10549298).

Interacts with the SWI/SNF chromatin remodeling complex (PubMed:19940160, PubMed:10549298).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
36723, 288 interactors

Database of interacting proteins

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DIPi
DIP-591N

Protein interaction database and analysis system

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IntActi
P03069, 17 interactors

Molecular INTeraction database

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MINTi
P03069

STRING: functional protein association networks

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STRINGi
4932.YEL009C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P03069, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
P03069

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P03069

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P03069

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini225 – 281bZIPPROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni89 – 100Required for transcriptional activation1 PublicationAdd BLAST12
Regioni106 – 125Required for transcriptional activation1 PublicationAdd BLAST20
Regioni231 – 251Basic motifPROSITE-ProRule annotation1 PublicationAdd BLAST21
Regioni253 – 274Leucine-zipperPROSITE-ProRule annotation1 PublicationAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi167 – 200Nuclear localization signal1 PublicationAdd BLAST34
Motifi231 – 249Nuclear localization signal1 PublicationAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Residues 89 to 100 and 106 to 125 define the N-terminal activation domain (NTAD) and the central acidic activation domain (CAAD) respectively, which can function independently to promote high-level transcription of the target genes.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. GCN4 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0837, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_068501_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P03069

Identification of Orthologs from Complete Genome Data

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OMAi
PMFEYEN

Family and domain databases

Database of protein disorder

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DisProti
DP00083

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004827, bZIP

Pfam protein domain database

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Pfami
View protein in Pfam
PF07716, bZIP_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00338, BRLZ, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P03069-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEYQPSLFA LNPMGFSPLD GSKSTNENVS ASTSTAKPMV GQLIFDKFIK
60 70 80 90 100
TEEDPIIKQD TPSNLDFDFA LPQTATAPDA KTVLPIPELD DAVVESFFSS
110 120 130 140 150
STDSTPMFEY ENLEDNSKEW TSLFDNDIPV TTDDVSLADK AIESTEEVSL
160 170 180 190 200
VPSNLEVSTT SFLPTPVLED AKLTQTRKVK KPNSVVKKSH HVGKDDESRL
210 220 230 240 250
DHLGVVAYNR KQRSIPLSPI VPESSDPAAL KRARNTEAAR RSRARKLQRM
260 270 280
KQLEDKVEEL LSKNYHLENE VARLKKLVGE R
Length:281
Mass (Da):31,310
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ED1B8E35D509578
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239 – 281ARRSR…LVGER → PGVLVRESCKE in AAA65521 (PubMed:6433345).CuratedAdd BLAST43

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti24S → P in strain: CLIB 219. 1 Publication1
Natural varianti62P → S in strain: CLIB 630 haplotype Ha2. 1 Publication1
Natural varianti82T → A in strain: CLIB 556 haplotype Ha1. 1 Publication1
Natural varianti91D → A in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13 haplotype Ha2, Sigma 1278B haplotype Ha1, YIIc12 and YIIc17. 1 Publication1
Natural varianti125D → A in strain: CLIB 556 haplotype Ha1. 1 Publication1
Natural varianti196D → E in strain: CLIB 388, CLIB 410, CLIB 413, CLIB 630 haplotype Ha1, K1, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K02205 Genomic DNA Translation: AAA34640.1
K02649 Genomic DNA Translation: AAA65521.1
AJ585686 Genomic DNA Translation: CAE52206.1
AJ585687 Genomic DNA Translation: CAE52207.1
AJ585688 Genomic DNA Translation: CAE52208.1
AJ585689 Genomic DNA Translation: CAE52209.1
AJ585690 Genomic DNA Translation: CAE52210.1
AJ585691 Genomic DNA Translation: CAE52211.1
AJ585692 Genomic DNA Translation: CAE52212.1
AJ585693 Genomic DNA Translation: CAE52213.1
AJ585694 Genomic DNA Translation: CAE52214.1
AJ585695 Genomic DNA Translation: CAE52215.1
AJ585696 Genomic DNA Translation: CAE52216.1
AJ585697 Genomic DNA Translation: CAE52217.1
AJ585698 Genomic DNA Translation: CAE52218.1
AJ585699 Genomic DNA Translation: CAE52219.1
AJ585700 Genomic DNA Translation: CAE52220.1
AJ585701 Genomic DNA Translation: CAE52221.1
AJ585702 Genomic DNA Translation: CAE52222.1
AJ585703 Genomic DNA Translation: CAE52223.1
AJ585704 Genomic DNA Translation: CAE52224.1
AF416613 mRNA Translation: AAL09032.1
U18530 Genomic DNA Translation: AAB64486.1
BK006939 Genomic DNA Translation: DAA07643.1

Protein sequence database of the Protein Information Resource

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PIRi
A03605, RGBYA2

NCBI Reference Sequences

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RefSeqi
NP_010907.3, NM_001178824.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YEL009C_mRNA; YEL009C; YEL009C

Database of genes from NCBI RefSeq genomes

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GeneIDi
856709

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YEL009C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02205 Genomic DNA Translation: AAA34640.1
K02649 Genomic DNA Translation: AAA65521.1
AJ585686 Genomic DNA Translation: CAE52206.1
AJ585687 Genomic DNA Translation: CAE52207.1
AJ585688 Genomic DNA Translation: CAE52208.1
AJ585689 Genomic DNA Translation: CAE52209.1
AJ585690 Genomic DNA Translation: CAE52210.1
AJ585691 Genomic DNA Translation: CAE52211.1
AJ585692 Genomic DNA Translation: CAE52212.1
AJ585693 Genomic DNA Translation: CAE52213.1
AJ585694 Genomic DNA Translation: CAE52214.1
AJ585695 Genomic DNA Translation: CAE52215.1
AJ585696 Genomic DNA Translation: CAE52216.1
AJ585697 Genomic DNA Translation: CAE52217.1
AJ585698 Genomic DNA Translation: CAE52218.1
AJ585699 Genomic DNA Translation: CAE52219.1
AJ585700 Genomic DNA Translation: CAE52220.1
AJ585701 Genomic DNA Translation: CAE52221.1
AJ585702 Genomic DNA Translation: CAE52222.1
AJ585703 Genomic DNA Translation: CAE52223.1
AJ585704 Genomic DNA Translation: CAE52224.1
AF416613 mRNA Translation: AAL09032.1
U18530 Genomic DNA Translation: AAB64486.1
BK006939 Genomic DNA Translation: DAA07643.1
PIRiA03605, RGBYA2
RefSeqiNP_010907.3, NM_001178824.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CE9X-ray1.80A/B/C/D251-281[»]
1DGCX-ray3.00A220-281[»]
1ENVX-ray2.60A252-280[»]
1FAVX-ray3.00A252-280[»]
1FMHNMR-A/B249-279[»]
1GCLX-ray2.10A/B/C/D249-281[»]
1GCMX-ray1.80A/B/C249-281[»]
1GK6X-ray1.90A/B249-279[»]
1GZLX-ray1.80A/B249-276[»]
1IHQNMR-A/B264-281[»]
1IJ0X-ray1.86A/B/C249-281[»]
1IJ1X-ray1.86A/B/C249-281[»]
1IJ2X-ray1.70A/B/C249-281[»]
1IJ3X-ray1.80A/B/C249-281[»]
1KQLX-ray2.70A/B255-278[»]
1LD4electron microscopy11.40E/F/G/H/I/J/K/L225-281[»]
1LLMX-ray1.50C/D253-281[»]
1NKNX-ray2.50A/B/C/D250-281[»]
1PIQX-ray1.80A249-279[»]
1RB4X-ray1.90A/B/C249-281[»]
1RB5X-ray1.90A/B/C249-281[»]
1RB6X-ray1.90A/B/C249-281[»]
1SWIX-ray2.60A/B/C249-281[»]
1TMZNMR-A/B264-281[»]
1UNTX-ray2.07A/B249-281[»]
1UNUX-ray2.07A/B249-281[»]
1UNVX-ray2.14A/B249-281[»]
1UNWX-ray2.20A/B249-281[»]
1UNXX-ray2.40A/B249-281[»]
1UNYX-ray2.30A/B249-281[»]
1UNZX-ray2.30A/B249-281[»]
1UO0X-ray2.40A/B249-281[»]
1UO1X-ray2.50A/B249-281[»]
1UO2X-ray1.99A/B249-281[»]
1UO3X-ray1.92A/B249-281[»]
1UO4X-ray1.70A/B249-281[»]
1UO5X-ray2.07A/B249-281[»]
1W5GX-ray2.16A/B249-281[»]
1W5HX-ray2.50A/B249-281[»]
1W5IX-ray2.30A/B249-281[»]
1W5JX-ray2.20A/B/C/D249-281[»]
1W5KX-ray1.92A/B/C/D249-281[»]
1W5LX-ray2.17A/B249-281[»]
1YSAX-ray2.90C/D226-281[»]
1ZIIX-ray1.80A/B249-281[»]
1ZIJX-ray2.00A/B/C249-281[»]
1ZIKX-ray1.80A/B249-281[»]
1ZILX-ray2.25A/B249-281[»]
1ZIMX-ray2.00A/B/C249-281[»]
1ZTANMR-A247-281[»]
2AHPX-ray2.00A/B249-281[»]
2B1FX-ray1.50A/B/C/D251-281[»]
2B22X-ray2.00A251-281[»]
2BNIX-ray1.50A/B/C/D249-281[»]
2CCEX-ray1.90A/B249-281[»]
2CCFX-ray1.70A/B249-281[»]
2CCNX-ray1.60A/B249-281[»]
2D3EX-ray2.60A/B/C/D254-277[»]
2DGCX-ray2.20A220-281[»]
2EFRX-ray1.80A/B/C/D249-277[»]
2EFSX-ray2.00A/B/C/D249-277[»]
2G9JNMR-A/B264-281[»]
2HY6X-ray1.25A/B/C/D/E/F/G251-281[»]
2IPZX-ray1.35A/B/C/D251-281[»]
2K8XNMR-A/B264-281[»]
2LPBNMR-B101-134[»]
2N9BNMR-A/B253-280[»]
2NRNX-ray1.40A/B/C/D251-281[»]
2O7HX-ray1.86A/B/C/D/E/F249-281[»]
2OVNNMR-A264-280[»]
2VKYX-ray2.05B256-280[»]
2VNLX-ray1.80A252-280[»]
2WG5X-ray2.10A/B/C/D/E/F/G/H/I/J/K/L249-272[»]
2WG6X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L249-272[»]
2WPYX-ray1.75A249-281[»]
2WPZX-ray1.25A/B/C249-281[»]
2WQ0X-ray1.12A249-281[»]
2WQ1X-ray1.08A249-281[»]
2WQ2X-ray1.36A249-281[»]
2WQ3X-ray1.22A249-281[»]
2YNYX-ray1.35A/B/C250-278[»]
2YNZX-ray1.40A/B/C250-278[»]
2YO0X-ray2.80A250-278[»]
2YO1X-ray3.10A/B/C250-278[»]
2YO2X-ray2.00A250-278[»]
2YO3X-ray2.00A/B/C250-278[»]
2Z5HX-ray2.89A/B/C/D/E/F/G/H259-278[»]
I267-278[»]
2Z5IX-ray2.10A/B/C/D/E/F/G/H259-278[»]
I/J267-278[»]
2ZTAX-ray1.80A/B249-281[»]
3AZDX-ray0.98A/B264-281[»]
3BASX-ray2.30A/B250-281[»]
3BATX-ray2.30A/B/C/D250-281[»]
3CK4X-ray1.70A/B/C/D/E/F/G/H/I/J/K/L251-281[»]
3CRPX-ray1.70A/B/C/D/E251-281[»]
3G9RX-ray2.00A/B/C/D/E/F258-276[»]
3GJPX-ray2.00A/B/C249-281[»]
3I1GX-ray1.60A249-281[»]
3I5CX-ray1.94A/B249-278[»]
3K7ZX-ray1.90A/B/C249-281[»]
3M48X-ray1.45A249-281[»]
3P8MX-ray2.90C/D250-281[»]
3ZMFX-ray1.85A/B/C250-278[»]
4C46X-ray1.95A/B/C250-278[»]
4DMDX-ray2.00A/B249-281[»]
4G2KX-ray1.90A/B/C250-279[»]
4HU5X-ray2.30A/B249-281[»]
4HU6X-ray2.30A/B/C/D260-281[»]
4NIZX-ray2.00A/B249-281[»]
4NJ0X-ray1.90A/B249-281[»]
4NJ1X-ray2.00A/B249-281[»]
4NJ2X-ray2.20A/B249-281[»]
4OWIX-ray1.20A/B249-278[»]
4TL1X-ray1.80A/B249-281[»]
5APPX-ray2.30A/B/C250-276[»]
5APQX-ray2.10A/B/C250-281[»]
5APSX-ray1.37A250-281[»]
5APTX-ray1.80A/B/C250-281[»]
5APUX-ray1.35A/B/C250-281[»]
5APVX-ray2.00A/B/C/D/E/F250-281[»]
5APWX-ray1.60A/B/C250-281[»]
5APXX-ray1.80A/B/C250-281[»]
5APYX-ray2.00A/B/C250-281[»]
5APZX-ray1.60A250-279[»]
5IEWNMR-A/B250-280[»]
5IIRNMR-A/B250-280[»]
5IIVNMR-A/B250-280[»]
5KHTX-ray1.50A/B/C/D264-281[»]
6E52X-ray1.93A/B250-275[»]
6E95X-ray2.25A/B250-275[»]
6H9MX-ray2.10A/B/C251-281[»]
6HN4electron microscopy4.20E/F249-281[»]
6HN5electron microscopy3.20E/F249-281[»]
6O2EX-ray1.90A249-279[»]
6O2FX-ray1.80A249-279[»]
6PSAX-ray1.30A249-277[»]
6UT2NMR-B/C264-281[»]
6VWGelectron microscopy3.21A/B249-281[»]
6VWHelectron microscopy4.26A/B249-281[»]
6VWIelectron microscopy3.70A/B249-281[»]
6VWJelectron microscopy4.21A/B249-281[»]
BMRBiP03069
SMRiP03069
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36723, 288 interactors
DIPiDIP-591N
IntActiP03069, 17 interactors
MINTiP03069
STRINGi4932.YEL009C

Protein family/group databases

MoonProtiP03069

PTM databases

iPTMnetiP03069

Proteomic databases

MaxQBiP03069
PaxDbiP03069
PRIDEiP03069

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P03069, 2 sequenced antibodies

Genome annotation databases

EnsemblFungiiYEL009C_mRNA; YEL009C; YEL009C
GeneIDi856709
KEGGisce:YEL009C

Organism-specific databases

SGDiS000000735, GCN4
VEuPathDBiFungiDB:YEL009C

Phylogenomic databases

eggNOGiKOG0837, Eukaryota
HOGENOMiCLU_068501_1_0_1
InParanoidiP03069
OMAiPMFEYEN

Enzyme and pathway databases

ReactomeiR-SCE-2559580, Oxidative Stress Induced Senescence
R-SCE-2871796, FCERI mediated MAPK activation
R-SCE-450341, Activation of the AP-1 family of transcription factors

Miscellaneous databases

EvolutionaryTraceiP03069

Protein Ontology

More...
PROi
PR:P03069
RNActiP03069, protein

Family and domain databases

DisProtiDP00083
InterProiView protein in InterPro
IPR004827, bZIP
PfamiView protein in Pfam
PF07716, bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCN4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03069
Secondary accession number(s): D3DLN9
, P03068, Q70D88, Q70D91, Q70D96, Q70D99, Q70DA0, Q96UT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 7, 2021
This is version 221 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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