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Protein

Regulatory protein rop

Gene

rop

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates plasmid DNA replication by modulating the initiation of transcription of the primer RNA precursor. Processing of the precursor of the primer, RNAII, is inhibited by hydrogen bonding of RNAII to its complementary sequence in RNAI. ROP increases the affinity of RNAI for RNAII and thus decreases the rate of replication initiation events.

GO - Molecular functioni

  • identical protein binding Source: IntAct

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein rop
Alternative name(s):
RNA one modulator
Short name:
ROM
Gene namesi
Name:rop
Encoded oniPlasmid ColE12 Publications
Plasmid pMB11 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000684391 – 63Regulatory protein ropAdd BLAST63

Interactioni

Subunit structurei

Antiparallel homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15786748,EBI-15786748

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48900N

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03051
SMRiP03051
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03051

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR000769 Regulatory_Rop
IPR035962 Rop-like_sf
PfamiView protein in Pfam
PF01815 Rop, 1 hit
PIRSFiPIRSF003229 Rop_reg, 1 hit
PRINTSiPR00835 ROPREGULATRY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012167 Rop_reg, 1 hit
SUPFAMiSSF47380 SSF47380, 1 hit

Sequencei

Sequence statusi: Complete.

P03051-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKQEKTALN MARFIRSQTL TLLEKLNELD ADEQADICES LHDHADELYR
60
SCLARFGDDG ENL
Length:63
Mass (Da):7,228
Last modified:July 21, 1986 - v1
Checksum:i0A1986BD29CF6FE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01749 Genomic DNA Translation: AAB59736.1
J01564 Genomic DNA Translation: AAA87380.1
PIRiA03587 RGECRE
RefSeqiNP_040367.1, NC_001371.1
NP_863575.1, NC_005019.1
WP_000165985.1, NZ_UIMT01000044.1
YP_006940171.1, NC_018997.1
YP_006953570.1, NC_019076.1
YP_007316613.1, NC_019982.1
YP_009071085.1, NC_025178.1
YP_794132.1, NC_008488.1

Genome annotation databases

GeneIDi13877151
13906508
14401266
1446623
20493156
2693963
4397513

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01749 Genomic DNA Translation: AAB59736.1
J01564 Genomic DNA Translation: AAA87380.1
PIRiA03587 RGECRE
RefSeqiNP_040367.1, NC_001371.1
NP_863575.1, NC_005019.1
WP_000165985.1, NZ_UIMT01000044.1
YP_006940171.1, NC_018997.1
YP_006953570.1, NC_019076.1
YP_007316613.1, NC_019982.1
YP_009071085.1, NC_025178.1
YP_794132.1, NC_008488.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6QX-ray1.80A1-63[»]
1F4MX-ray2.25A/B/C/D/E/F1-63[»]
1F4NX-ray1.90A/B1-63[»]
1GMGX-ray1.90A/B1-63[»]
1GTOX-ray1.82A/B/C2-62[»]
1NKDX-ray1.09A1-63[»]
1QX8X-ray2.02A/B1-63[»]
1ROPX-ray1.70A1-63[»]
1RPOX-ray1.40A1-63[»]
1RPRNMR-A/B1-63[»]
1YO7X-ray2.80A/B1-63[»]
2GHYX-ray2.50A/B1-63[»]
2IJHX-ray1.80A/B/C1-63[»]
2IJIX-ray2.30A1-63[»]
2IJJX-ray1.90A/B/C1-63[»]
2IJKX-ray1.55A/B1-63[»]
3K79X-ray1.96A2-63[»]
4DO2X-ray1.40A/B1-63[»]
ProteinModelPortaliP03051
SMRiP03051
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48900N

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13877151
13906508
14401266
1446623
20493156
2693963
4397513

Miscellaneous databases

EvolutionaryTraceiP03051

Family and domain databases

InterProiView protein in InterPro
IPR000769 Regulatory_Rop
IPR035962 Rop-like_sf
PfamiView protein in Pfam
PF01815 Rop, 1 hit
PIRSFiPIRSF003229 Rop_reg, 1 hit
PRINTSiPR00835 ROPREGULATRY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012167 Rop_reg, 1 hit
SUPFAMiSSF47380 SSF47380, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiROP_ECOLX
AccessioniPrimary (citable) accession number: P03051
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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