UniProtKB - P03030 (LYSR_ECOLI)
Protein
Transcriptional activator protein LysR
Gene
lysR
Organism
Escherichia coli (strain K12)
Status
Functioni
This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 21 – 40 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- lysine biosynthetic process via diaminopimelate Source: EcoCyc
- positive regulation of gene expression Source: EcoCyc
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00360 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional activator protein LysR |
Gene namesi | Name:lysR Ordered Locus Names:b2839, JW2807 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105669 | 1 – 311 | Transcriptional activator protein LysRAdd BLAST | 311 |
Proteomic databases
PaxDbi | P03030 |
PRIDEi | P03030 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262309, 10 interactors 851638, 2 interactors |
DIPi | DIP-10135N |
IntActi | P03030, 6 interactors |
STRINGi | 511145.b2839 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 61 | HTH lysR-typePROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the LysR transcriptional regulatory family.Curated
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_6_3_6 |
InParanoidi | P03030 |
PhylomeDBi | P03030 |
Family and domain databases
CDDi | cd08456, PBP2_LysR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR037414, LysR_PBP2 IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
i Sequence
Sequence statusi: Complete.
P03030-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVNLRHIE IFHAVMTAGS LTEAAHLLHT SQPTVSRELA RFEKVIGLKL
60 70 80 90 100
FERVRGRLHP TVQGLRLFEE VQRSWYGLDR IVSAAESLRE FRQGELSIAC
110 120 130 140 150
LPVFSQSFLP QLLQPFLARY PDVSLNIVPQ ESPLLEEWLS AQRHDLGLTE
160 170 180 190 200
TLHTPAGTER TELLSLDEVC VLPPGHPLAV KKVLTPDDFQ GENYISLSRT
210 220 230 240 250
DSYRQLLDQL FTEHQVKRRM IVETHSAASV CAMVRAGVGI SVVNPLTALD
260 270 280 290 300
YAASGLVVRR FSIAVPFTVS LIRPLHRPSS ALVQAFSGHL QAGLPKLVTS
310
LDAILSSATT A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01614 Genomic DNA Translation: AAA83862.1 U29581 Genomic DNA Translation: AAB40486.1 U00096 Genomic DNA Translation: AAC75878.1 AP009048 Genomic DNA Translation: BAE76908.1 J03732 Genomic DNA Translation: AAA23471.1 |
PIRi | A03565, RGECK |
RefSeqi | NP_417316.1, NC_000913.3 WP_000741825.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75878; AAC75878; b2839 BAE76908; BAE76908; BAE76908 |
GeneIDi | 947311 |
KEGGi | ecj:JW2807 eco:b2839 |
PATRICi | fig|1411691.4.peg.3895 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01614 Genomic DNA Translation: AAA83862.1 U29581 Genomic DNA Translation: AAB40486.1 U00096 Genomic DNA Translation: AAC75878.1 AP009048 Genomic DNA Translation: BAE76908.1 J03732 Genomic DNA Translation: AAA23471.1 |
PIRi | A03565, RGECK |
RefSeqi | NP_417316.1, NC_000913.3 WP_000741825.1, NZ_LN832404.1 |
3D structure databases
SMRi | P03030 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262309, 10 interactors 851638, 2 interactors |
DIPi | DIP-10135N |
IntActi | P03030, 6 interactors |
STRINGi | 511145.b2839 |
Proteomic databases
PaxDbi | P03030 |
PRIDEi | P03030 |
Genome annotation databases
EnsemblBacteriai | AAC75878; AAC75878; b2839 BAE76908; BAE76908; BAE76908 |
GeneIDi | 947311 |
KEGGi | ecj:JW2807 eco:b2839 |
PATRICi | fig|1411691.4.peg.3895 |
Organism-specific databases
EchoBASEi | EB0546 |
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_6_3_6 |
InParanoidi | P03030 |
PhylomeDBi | P03030 |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00360 |
Miscellaneous databases
PROi | PR:P03030 |
Family and domain databases
CDDi | cd08456, PBP2_LysR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR037414, LysR_PBP2 IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYSR_ECOLI | |
Accessioni | P03030Primary (citable) accession number: P03030 Secondary accession number(s): Q2M9Z8, Q46936 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | October 7, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families