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Entry version 132 (23 Feb 2022)
Sequence version 3 (31 Aug 2004)
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Protein

Tetracycline resistance protein

Gene

tet

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H+ antiporter.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntibiotic resistance, Antiport, Hydrogen ion transport, Ion transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.3.6, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetracycline resistance protein
Alternative name(s):
Tetracycline efflux protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tet
Synonyms:tet(K)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pT1813 Publications
Plasmid pTP51 Publication
Plasmid pKH61 Publication
Plasmid pKH12 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Transmembranei49 – 68HelicalSequence analysisAdd BLAST20
Transmembranei81 – 100HelicalSequence analysisAdd BLAST20
Transmembranei105 – 127HelicalSequence analysisAdd BLAST23
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Transmembranei166 – 188HelicalSequence analysisAdd BLAST23
Transmembranei201 – 218HelicalSequence analysisAdd BLAST18
Transmembranei223 – 240HelicalSequence analysisAdd BLAST18
Transmembranei261 – 283HelicalSequence analysisAdd BLAST23
Transmembranei293 – 315HelicalSequence analysisAdd BLAST23
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei348 – 370HelicalSequence analysisAdd BLAST23
Transmembranei391 – 413HelicalSequence analysisAdd BLAST23
Transmembranei428 – 450HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001733841 – 459Tetracycline resistance proteinAdd BLAST459

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02983

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P02983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSLYKKFKG LFYSVLFWLC ILSFFSVLNE MVLNVSLPDI ANHFNTTPGI
60 70 80 90 100
TNWVNTAYML TFSIGTAVYG KLSDYINIKK LLIIGISLSC LGSLIAFIGH
110 120 130 140 150
NHFFILIFGR LVQGVGSAAF PSLIMVVVAR NITRKKQGKA FGFIGSIVAL
160 170 180 190 200
GEGLGPSIGG IIAHYIHWSY LLILPMITIV TIPFLIKVMV PGKSTKNTLD
210 220 230 240 250
IVGIVLMSIS IICFMLFTTN YNWTFLILFT IFFVIFIKHI SRVSNPFINP
260 270 280 290 300
KLGKNIPFML GLFSGGLIFS IVAGFISMVP YMMKTIYHVN VATIGNSVIF
310 320 330 340 350
PGTMSVIVFG YFGGFLVDRK GSLFVFILGS LSISISFLTI AFFVEFSMWL
360 370 380 390 400
TTFMFIFVMG GLSFTKTVIS KIVSSSLSEE EVASGMSLLN FTSFLSEGTG
410 420 430 440 450
IAIVGGLLSL QLINRKLVLE FINYSSGVYS NILVAMAILI ILCCLLTIIV

FKRSEKQFE
Length:459
Mass (Da):50,695
Last modified:August 31, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE53C55535372B41
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA26034 differs from that shown. Reason: Frameshift.Curated
The sequence AAA26035 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti361G → E in AAA26034 (PubMed:6657777).Curated1
Sequence conflicti438I → N in AAA26034 (PubMed:6657777).Curated1
Sequence conflicti443C → S in AAA26034 (PubMed:6657777).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01764 Genomic DNA Translation: AAA26034.1 Sequence problems.
J01764 Genomic DNA Translation: AAA26035.1 Different initiation.
M23644 Genomic DNA Translation: AAA98301.1
M16217 Unassigned DNA Translation: AAA19179.1
U38428 Genomic DNA Translation: AAB07712.1
S67449 Genomic DNA Translation: AAB28795.1
U38656 Genomic DNA Translation: AAB09660.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A04492, QQSACT
S42238

NCBI Reference Sequences

More...
RefSeqi
NP_040465.1, NC_001391.1
NP_040470.1, NC_001393.1
NP_040471.1, NC_001393.1
NP_044360.1, NC_001763.1
NP_053795.1, NC_001767.1
WP_000492283.1, NZ_WTUM01000069.1
WP_010889938.1, NC_001763.1
WP_010889939.1, NC_001393.1
YP_001649337.1, NC_010262.1
YP_006937482.1, NC_013307.1
YP_006937490.1, NC_013309.1
YP_006937494.1, NC_013311.1
YP_006937498.1, NC_013312.1
YP_006937647.1, NC_013320.1
YP_006937988.1, NC_013328.1
YP_006938259.1, NC_013336.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50019748
61682012
64117985

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01764 Genomic DNA Translation: AAA26034.1 Sequence problems.
J01764 Genomic DNA Translation: AAA26035.1 Different initiation.
M23644 Genomic DNA Translation: AAA98301.1
M16217 Unassigned DNA Translation: AAA19179.1
U38428 Genomic DNA Translation: AAB07712.1
S67449 Genomic DNA Translation: AAB28795.1
U38656 Genomic DNA Translation: AAB09660.1
PIRiA04492, QQSACT
S42238
RefSeqiNP_040465.1, NC_001391.1
NP_040470.1, NC_001393.1
NP_040471.1, NC_001393.1
NP_044360.1, NC_001763.1
NP_053795.1, NC_001767.1
WP_000492283.1, NZ_WTUM01000069.1
WP_010889938.1, NC_001763.1
WP_010889939.1, NC_001393.1
YP_001649337.1, NC_010262.1
YP_006937482.1, NC_013307.1
YP_006937490.1, NC_013309.1
YP_006937494.1, NC_013311.1
YP_006937498.1, NC_013312.1
YP_006937647.1, NC_013320.1
YP_006937988.1, NC_013328.1
YP_006938259.1, NC_013336.1

3D structure databases

SMRiP02983
ModBaseiSearch...

Protein family/group databases

TCDBi2.A.1.3.6, the major facilitator superfamily (mfs)

Genome annotation databases

GeneIDi50019748
61682012
64117985

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCR_STAAU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02983
Secondary accession number(s): P03863, P14512, Q79CG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 31, 2004
Last modified: February 23, 2022
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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