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UniProtKB - P02981 (TCR3_ECOLX)
Protein
Tetracycline resistance protein, class C
Gene
tetA
Organism
Escherichia coli
Status
Functioni
Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H+ antiporter.
GO - Molecular functioni
- antiporter activity Source: UniProtKB-KW
GO - Biological processi
- ion transport Source: UniProtKB-KW
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic resistance, Antiport, Hydrogen ion transport, Ion transport, Transport |
Protein family/group databases
TCDBi | 2.A.1.2.102, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Tetracycline resistance protein, class CShort name: TetA(C) |
Gene namesi | Name:tetA |
Encoded oni | Plasmid pSC101 |
Organismi | Escherichia coli |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | Cytoplasmic1 Publication | 6 | |
Transmembranei | 7 – 27 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 28 – 45 | Periplasmic1 PublicationAdd BLAST | 18 | |
Transmembranei | 46 – 66 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 67 – 79 | Cytoplasmic1 PublicationAdd BLAST | 13 | |
Transmembranei | 80 – 100 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 101 – 103 | Periplasmic1 Publication | 3 | |
Transmembranei | 104 – 124 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 125 – 138 | Cytoplasmic1 PublicationAdd BLAST | 14 | |
Transmembranei | 139 – 159 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 160 | Periplasmic1 Publication | 1 | |
Transmembranei | 161 – 181 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 182 – 210 | Cytoplasmic1 PublicationAdd BLAST | 29 | |
Transmembranei | 211 – 231 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 232 – 246 | Periplasmic1 PublicationAdd BLAST | 15 | |
Transmembranei | 247 – 267 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 268 – 277 | Cytoplasmic1 Publication | 10 | |
Transmembranei | 278 – 298 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 299 | Periplasmic1 Publication | 1 | |
Transmembranei | 300 – 320 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 321 – 339 | Cytoplasmic1 PublicationAdd BLAST | 19 | |
Transmembranei | 340 – 360 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 361 – 364 | Periplasmic1 Publication | 4 | |
Transmembranei | 365 – 385 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 386 – 396 | Cytoplasmic1 PublicationAdd BLAST | 11 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Biotechnological usei
This protein is used as a marker in many commonly used cloning vectors, such as pBR322 and pACYC184.
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173394 | 1 – 396 | Tetracycline resistance protein, class CAdd BLAST | 396 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P02981-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSNNALIVI LGTVTLDAVG IGLVMPVLPG LLRDIVHSDS IASHYGVLLA
60 70 80 90 100
LYALMQFLCA PVLGALSDRF GRRPVLLASL LGATIDYAIM ATTPVLWILY
110 120 130 140 150
AGRIVAGITG ATGAVAGAYI ADITDGEDRA RHFGLMSACF GVGMVAGPVA
160 170 180 190 200
GGLLGAISLH APFLAAAVLN GLNLLLGCFL MQESHKGERR PMPLRAFNPV
210 220 230 240 250
SSFRWARGMT IVAALMTVFF IMQLVGQVPA ALWVIFGEDR FRWSATMIGL
260 270 280 290 300
SLAVFGILHA LAQAFVTGPA TKRFGEKQAI IAGMAADALG YVLLAFATRG
310 320 330 340 350
WMAFPIMILL ASGGIGMPAL QAMLSRQVDD DHQGQLQGSL AALTSLTSIT
360 370 380 390
GPLIVTAIYA ASASTWNGLA WIVGAALYLV CLPALRRGAW SRATST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01749 Genomic DNA Translation: AAB59735.1 |
PIRi | B90923, YTEC32 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01749 Genomic DNA Translation: AAB59735.1 |
PIRi | B90923, YTEC32 |
3D structure databases
SMRi | P02981 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 2.A.1.2.102, the major facilitator superfamily (mfs) |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCR3_ECOLX | |
Accessioni | P02981Primary (citable) accession number: P02981 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
PlasmidDocuments
- SIMILARITY comments
Index of protein domains and families