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Entry version 141 (23 Feb 2022)
Sequence version 1 (21 Jul 1986)
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Protein

Tetracycline resistance protein, class B

Gene

tetA

Organism
Escherichia coli
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H+ antiporter.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntibiotic resistance, Antiport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.2.68, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetracycline resistance protein, class B
Short name:
TetA(B)
Alternative name(s):
Metal-tetracycline/H(+) antiporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tetA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6Cytoplasmic1 Publication6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 30HelicalCuratedAdd BLAST24
Topological domaini31 – 42Periplasmic1 PublicationAdd BLAST12
Transmembranei43 – 61HelicalCuratedAdd BLAST19
Topological domaini62 – 71Cytoplasmic1 Publication10
Transmembranei72 – 91HelicalCuratedAdd BLAST20
Topological domaini92 – 98Periplasmic1 Publication7
Transmembranei99 – 119HelicalCuratedAdd BLAST21
Topological domaini120 – 129Cytoplasmic1 Publication10
Transmembranei130 – 152HelicalCuratedAdd BLAST23
Topological domaini153 – 158Periplasmic1 Publication6
Transmembranei159 – 178HelicalCuratedAdd BLAST20
Topological domaini179 – 211Cytoplasmic1 PublicationAdd BLAST33
Transmembranei212 – 232HelicalCuratedAdd BLAST21
Topological domaini233 – 243Periplasmic1 PublicationAdd BLAST11
Transmembranei244 – 265HelicalCuratedAdd BLAST22
Topological domaini266 – 275Cytoplasmic1 Publication10
Transmembranei276 – 295HelicalCuratedAdd BLAST20
Topological domaini296 – 298Periplasmic1 Publication3
Transmembranei299 – 322HelicalCuratedAdd BLAST24
Topological domaini323 – 332Cytoplasmic1 Publication10
Transmembranei333 – 356HelicalCuratedAdd BLAST24
Topological domaini357 – 365Periplasmic1 Publication9
Transmembranei366 – 387HelicalCuratedAdd BLAST22
Topological domaini388 – 401Cytoplasmic1 PublicationAdd BLAST14

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi65S → A: No change in activity. 1 Publication1
Mutagenesisi65S → C: Almost no change in activity. 1 Publication1
Mutagenesisi66D → E: Moderate resistance to tetracycline. 1 Publication1
Mutagenesisi66D → N: Unable to extrude tetracycline. 1 Publication1
Mutagenesisi257H → D: No H(+) translocation. 1 Publication1
Mutagenesisi257H → E: No H(+) translocation. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5821

DrugCentral

More...
DrugCentrali
P02980

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001733931 – 401Tetracycline resistance protein, class BAdd BLAST401

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-16933N

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02980

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR005829, Sugar_transporter_CS
IPR001958, Tet-R_TetA/multi-R_MdtG

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01035, TCRTETA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P02980-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSSTKIALV ITLLDAMGIG LIMPVLPTLL REFIASEDIA NHFGVLLALY
60 70 80 90 100
ALMQVIFAPW LGKMSDRFGR RPVLLLSLIG ASLDYLLLAF SSALWMLYLG
110 120 130 140 150
RLLSGITGAT GAVAASVIAD TTSASQRVKW FGWLGASFGL GLIAGPIIGG
160 170 180 190 200
FAGEISPHSP FFIAALLNIV TFLVVMFWFR ETKNTRDNTD TEVGVETQSN
210 220 230 240 250
SVYITLFKTM PILLIIYFSA QLIGQIPATV WVLFTENRFG WNSMMVGFSL
260 270 280 290 300
AGLGLLHSVF QAFVAGRIAT KWGEKTAVLL GFIADSSAFA FLAFISEGWL
310 320 330 340 350
VFPVLILLAG GGIALPALQG VMSIQTKSHQ QGALQGLLVS LTNATGVIGP
360 370 380 390 400
LLFAVIYNHS LPIWDGWIWI IGLAFYCIII LLSMTFMLTP QAQGSKQETS

A
Length:401
Mass (Da):43,267
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3995FBE6297F22EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti281G → E in CAA23880 (PubMed:6298728).Curated1
Sequence conflicti281G → E in AAB59094 (PubMed:6298728).Curated1
Sequence conflicti301V → D in CAA23880 (PubMed:6298728).Curated1
Sequence conflicti301V → D in AAB59094 (PubMed:6298728).Curated1
Sequence conflicti330Q → E in CAA23880 (PubMed:6298728).Curated1
Sequence conflicti330Q → E in AAB59094 (PubMed:6298728).Curated1
Sequence conflicti354A → T in CAA23880 (PubMed:6298728).Curated1
Sequence conflicti354A → T in AAB59094 (PubMed:6298728).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00611 Genomic DNA Translation: CAA23880.1
J01830 Genomic DNA Translation: AAB59094.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A91505, YTECT0

NCBI Reference Sequences

More...
RefSeqi
WP_001089072.1, NZ_WSIP01000050.1
WP_031942563.1, NC_025021.1
YP_001096450.1, NC_009133.1
YP_009060383.1, NC_024960.1
YP_009062970.1, NC_025021.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59693417
66257065

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00611 Genomic DNA Translation: CAA23880.1
J01830 Genomic DNA Translation: AAB59094.1
PIRiA91505, YTECT0
RefSeqiWP_001089072.1, NZ_WSIP01000050.1
WP_031942563.1, NC_025021.1
YP_001096450.1, NC_009133.1
YP_009060383.1, NC_024960.1
YP_009062970.1, NC_025021.1

3D structure databases

SMRiP02980
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-16933N

Chemistry databases

ChEMBLiCHEMBL5821
DrugCentraliP02980

Protein family/group databases

TCDBi2.A.1.2.68, the major facilitator superfamily (mfs)

Genome annotation databases

GeneIDi59693417
66257065

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P02980

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR005829, Sugar_transporter_CS
IPR001958, Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
PRINTSiPR01035, TCRTETA
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCR2_ECOLX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02980
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 23, 2022
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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