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UniProtKB - P02942 (MCP1_ECOLI)

Entry version 187 (02 Dec 2020)
Sequence version 2 (01 Jul 1993)
Previous versions | rss
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Protein

Methyl-accepting chemotaxis protein I

Gene

tsr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer
Biological processChemotaxis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:TSR-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein I
Short name:
MCP-I
Alternative name(s):
Serine chemoreceptor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tsr
Synonyms:cheD
Ordered Locus Names:b4355, JW4318
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 30HelicalSequence analysisAdd BLAST24
Topological domaini31 – 190PeriplasmicSequence analysisAdd BLAST160
Transmembranei191 – 210HelicalSequence analysisAdd BLAST20
Topological domaini211 – 551CytoplasmicSequence analysisAdd BLAST341

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001105371 – 551Methyl-accepting chemotaxis protein IAdd BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei297Glutamate methyl ester (Gln)2 Publications1
Modified residuei304Glutamate methyl ester (Glu)2 Publications1
Modified residuei311Glutamate methyl ester (Gln)2 Publications1
Modified residuei493Glutamate methyl ester (Glu)2 Publications1
Modified residuei502Glutamate methyl ester (Glu)1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02942

PRoteomics IDEntifications database

More...PRIDEi		P02942

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261744, 203 interactors
853162, 1 interactor

Database of interacting proteins

More...DIPi		DIP-11046N

Protein interaction database and analysis system

More...IntActi		P02942, 4 interactors

Molecular INTeraction database

More...MINTi		P02942

STRING: functional protein association networks

More...STRINGi		511145.b4355

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1551
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02942

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P02942

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini216 – 268HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini273 – 502Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST230

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 73The 3 Arg may form a positively charged pocket, which binds the alpha-carboxyl group of the attractant AA10

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0840, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000445_107_16_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02942

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02942

Family and domain databases

Conserved Domains Database

More...CDDi		cd06225, HAMP, 1 hit
cd00181, Tar_Tsr_LBD, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035440, 4HB_MCP_dom_sf
IPR004090, Chemotax_Me-accpt_rcpt
IPR004091, Chemotax_Me-accpt_rcpt_Me-site
IPR003660, HAMP_dom
IPR004089, MCPsignal_dom
IPR003122, Tar_rcpt_lig-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00672, HAMP, 1 hit
PF00015, MCPsignal, 1 hit
PF02203, TarH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00260, CHEMTRNSDUCR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00304, HAMP, 1 hit
SM00283, MA, 1 hit
SM00319, TarH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47170, SSF47170, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00538, CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885, HAMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P02942-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKRIKIVTS LLLVLAVFGL LQLTSGGLFF NALKNDKENF TVLQTIRQQQ 
        60         70         80         90        100
STLNGSWVAL LQTRNTLNRA GIRYMMDQNN IGSGSTVAEL MESASISLKQ 
       110        120        130        140        150
AEKNWADYEA LPRDPRQSTA AAAEIKRNYD IYHNALAELI QLLGAGKINE 
       160        170        180        190        200
FFDQPTQGYQ DGFEKQYVAY MEQNDRLHDI AVSDNNASYS QAMWILVGVM 
       210        220        230        240        250
IVVLAVIFAV WFGIKASLVA PMNRLIDSIR HIAGGDLVKP IEVDGSNEMG 
       260        270        280        290        300
QLAESLRHMQ GELMRTVGDV RNGANAIYSG ASEIATGNND LSSRTEQQAA 
       310        320        330        340        350
SLEETAASME QLTATVKQNA ENARQASHLA LSASETAQRG GKVVDNVVQT 
       360        370        380        390        400
MRDISTSSQK IADIISVIDG IAFQTNILAL NAAVEAARAG EQGRGFAVVA 
       410        420        430        440        450
GEVRNLAQRS AQAAREIKSL IEDSVGKVDV GSTLVESAGE TMAEIVSAVT 
       460        470        480        490        500
RVTDIMGEIA SASDEQSRGI DQVGLAVAEM DRVTQQNAAL VEESAAAAAA 
       510        520        530        540        550
LEEQASRLTE AVAVFRIQQQ QRETSAVVKT VTPAAPRKMA VADSEENWET 

F
Length:551
Mass (Da):59,443
Last modified:July 1, 1993 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8DB026029989B0F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
V00373 Genomic DNA Translation: CAA23676.1 Sequence problems.
U14003 Genomic DNA Translation: AAA97252.1
U00096 Genomic DNA Translation: AAC77311.1
AP009048 Genomic DNA Translation: BAE78345.1
S56952 Genomic DNA Translation: AAB25802.1

Protein sequence database of the Protein Information Resource

More...PIRi		E65250, QRECS

NCBI Reference Sequences

More...RefSeqi		NP_418775.1, NC_000913.3
WP_000919536.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77311; AAC77311; b4355
BAE78345; BAE78345; BAE78345

Database of genes from NCBI RefSeq genomes

More...GeneIDi		49586240
948884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4318
eco:b4355

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2331

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00373 Genomic DNA Translation: CAA23676.1 Sequence problems.
U14003 Genomic DNA Translation: AAA97252.1
U00096 Genomic DNA Translation: AAC77311.1
AP009048 Genomic DNA Translation: BAE78345.1
S56952 Genomic DNA Translation: AAB25802.1
PIRiE65250, QRECS
RefSeqiNP_418775.1, NC_000913.3
WP_000919536.1, NZ_LN832404.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QU7X-ray2.60A/B294-520[»]
2D4UX-ray1.95A/B25-190[»]
3ATPX-ray2.50A/B25-190[»]
3ZX6X-ray2.65A/B264-551[»]
6S1Kelectron microscopy8.38E/F/G/H/I/J/K/L/M/N/O/P1-551[»]
SMRiP02942
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4261744, 203 interactors
853162, 1 interactor
DIPiDIP-11046N
IntActiP02942, 4 interactors
MINTiP02942
STRINGi511145.b4355

Proteomic databases

PaxDbiP02942
PRIDEiP02942

Genome annotation databases

EnsemblBacteriaiAAC77311; AAC77311; b4355
BAE78345; BAE78345; BAE78345
GeneIDi49586240
948884
KEGGiecj:JW4318
eco:b4355
PATRICifig|1411691.4.peg.2331

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1027

Phylogenomic databases

eggNOGiCOG0840, Bacteria
HOGENOMiCLU_000445_107_16_6
InParanoidiP02942
PhylomeDBiP02942

Enzyme and pathway databases

BioCyciEcoCyc:TSR-MONOMER

Miscellaneous databases

EvolutionaryTraceiP02942

Protein Ontology

More...PROi		PR:P02942

Family and domain databases

CDDicd06225, HAMP, 1 hit
cd00181, Tar_Tsr_LBD, 1 hit
InterProiView protein in InterPro
IPR035440, 4HB_MCP_dom_sf
IPR004090, Chemotax_Me-accpt_rcpt
IPR004091, Chemotax_Me-accpt_rcpt_Me-site
IPR003660, HAMP_dom
IPR004089, MCPsignal_dom
IPR003122, Tar_rcpt_lig-bd
PfamiView protein in Pfam
PF00672, HAMP, 1 hit
PF00015, MCPsignal, 1 hit
PF02203, TarH, 1 hit
PRINTSiPR00260, CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304, HAMP, 1 hit
SM00283, MA, 1 hit
SM00319, TarH, 1 hit
SUPFAMiSSF47170, SSF47170, 1 hit
PROSITEiView protein in PROSITE
PS00538, CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885, HAMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCP1_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02942
Secondary accession number(s): P76817, Q2M5W1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1993
Last modified: December 2, 2020
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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