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Entry version 167 (07 Oct 2020)
Sequence version 3 (23 Jan 2002)
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Protein

Methyl-accepting chemotaxis protein II

Gene

tar

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel. Unlike in E.coli tar, it does not mediates maltose taxis.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer
Biological processChemotaxis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein II
Short name:
MCP-II
Alternative name(s):
Aspartate chemoreceptor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tar
Synonyms:cheM
Ordered Locus Names:STM1919
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 33HelicalSequence analysisAdd BLAST27
Topological domaini34 – 190PeriplasmicSequence analysisAdd BLAST157
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 553CytoplasmicSequence analysisAdd BLAST342

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:6983

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02365, 1,10-Phenanthroline

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001105391 – 553Methyl-accepting chemotaxis protein IIAdd BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295Glutamate methyl ester (Gln)By similarity1
Modified residuei302Glutamate methyl ester (Glu)By similarity1
Modified residuei309Glutamate methyl ester (Gln)By similarity1
Modified residuei491Glutamate methyl ester (Glu)By similarity1
Modified residuei500Glutamate methyl ester (Glu)By similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02941

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61268N

Protein interaction database and analysis system

More...
IntActi
P02941, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1553
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02941

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02941

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini214 – 266HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini271 – 500Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST230

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 73The 3 Arg may form a positively charged pocket, which binds the alpha-carboxyl group of the attractant AA10

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000445_107_16_6

KEGG Orthology (KO)

More...
KOi
K05875

Identification of Orthologs from Complete Genome Data

More...
OMAi
SARMMMD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02941

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06225, HAMP, 1 hit
cd00181, Tar_Tsr_LBD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035440, 4HB_MCP_dom_sf
IPR004090, Chemotax_Me-accpt_rcpt
IPR004091, Chemotax_Me-accpt_rcpt_Me-site
IPR003660, HAMP_dom
IPR004089, MCPsignal_dom
IPR003122, Tar_rcpt_lig-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00672, HAMP, 1 hit
PF00015, MCPsignal, 1 hit
PF02203, TarH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00260, CHEMTRNSDUCR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00304, HAMP, 1 hit
SM00283, MA, 1 hit
SM00319, TarH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47170, SSF47170, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00538, CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885, HAMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P02941-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNRIRVVTM LMMVLGVFAL LQLVSGGLLF SSLQHNQQGF VISNELRQQQ
60 70 80 90 100
SELTSTWDLM LQTRINLSRS AARMMMDASN QQSSAKTDLL QNAKTTLAQA
110 120 130 140 150
AAHYANFKNM TPLPAMAEAS ANVDEKYQRY QAALAELIQF LDNGNMDAYF
160 170 180 190 200
AQPTQGMQNA LGEALGNYAR VSENLYRQTF DQSAHDYRFA QWQLGVLAVV
210 220 230 240 250
LVLILMVVWF GIRHALLNPL ARVITHIREI ASGDLTKTLT VSGRNEIGEL
260 270 280 290 300
AGTVEHMQRS LIDTVTQVRE GSDAIYSGTS EIAAGNTDLS SRTEQQASAL
310 320 330 340 350
EETAASMEQL TATVKQNADN ARQASQLAQS ASETARHGGK VVDGVVNTMH
360 370 380 390 400
EIADSSKKIA DIISVIDGIA FQTNILALNA AVEAARAGEQ GRGFAVVAGE
410 420 430 440 450
VRNLASRSAQ AAKEIKALIE DSVSRVDTGS VLVESAGETM TDIVNAVTRV
460 470 480 490 500
TDIMGEIASA SDEQSRGIDQ VALAVSEMDR VTQQNASLVQ ESAAAAAALE
510 520 530 540 550
EQASRLTQAV SAFRLASRPL AVNKPEMRLS VNAQSGNTPQ SLAARDDANW

ETF
Length:553
Mass (Da):59,614
Last modified:January 23, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CEC8E707452760D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246E → G (PubMed:6302843).Curated1
Sequence conflicti451T → A (PubMed:6302843).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01809 Genomic DNA No translation available.
AE006468 Genomic DNA Translation: AAL20835.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A03441, QREBDT

NCBI Reference Sequences

More...
RefSeqi
NP_460876.1, NC_003197.2
WP_000483274.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL20835; AAL20835; STM1919

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1253440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stm:STM1919

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|99287.12.peg.2035

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01809 Genomic DNA No translation available.
AE006468 Genomic DNA Translation: AAL20835.1
PIRiA03441, QREBDT
RefSeqiNP_460876.1, NC_003197.2
WP_000483274.1, NC_003197.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMWX-ray1.90A36-180[»]
1LIHX-ray2.20A26-188[»]
1VLSX-ray1.85A36-180[»]
1VLTX-ray2.20A/B36-180[»]
1WASX-ray2.70A36-180[»]
1WATX-ray3.00A/B36-180[»]
2LIGX-ray2.00A/B26-188[»]
SMRiP02941
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61268N
IntActiP02941, 1 interactor

Chemistry databases

DrugBankiDB02365, 1,10-Phenanthroline

Proteomic databases

PaxDbiP02941

Genome annotation databases

EnsemblBacteriaiAAL20835; AAL20835; STM1919
GeneIDi1253440
KEGGistm:STM1919
PATRICifig|99287.12.peg.2035

Phylogenomic databases

HOGENOMiCLU_000445_107_16_6
KOiK05875
OMAiSARMMMD
PhylomeDBiP02941

Miscellaneous databases

EvolutionaryTraceiP02941
PHI-baseiPHI:6983

Family and domain databases

CDDicd06225, HAMP, 1 hit
cd00181, Tar_Tsr_LBD, 1 hit
InterProiView protein in InterPro
IPR035440, 4HB_MCP_dom_sf
IPR004090, Chemotax_Me-accpt_rcpt
IPR004091, Chemotax_Me-accpt_rcpt_Me-site
IPR003660, HAMP_dom
IPR004089, MCPsignal_dom
IPR003122, Tar_rcpt_lig-bd
PfamiView protein in Pfam
PF00672, HAMP, 1 hit
PF00015, MCPsignal, 1 hit
PF02203, TarH, 1 hit
PRINTSiPR00260, CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304, HAMP, 1 hit
SM00283, MA, 1 hit
SM00319, TarH, 1 hit
SUPFAMiSSF47170, SSF47170, 1 hit
PROSITEiView protein in PROSITE
PS00538, CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885, HAMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCP2_SALTY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02941
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2002
Last modified: October 7, 2020
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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