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Protein

Outer membrane pore protein E

Gene

phoE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Stress response, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-282
MetaCyc:MONOMER0-282

Protein family/group databases

TCDBi1.B.1.1.2 the general bacterial porin (gbp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane pore protein E
Gene namesi
Name:phoE
Synonyms:ompE
Ordered Locus Names:b0241, JW0231
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10729 phoE

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: UniProtKB-SubCell
  • pore complex Source: CACAO

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi351F → Y, N, S or V: Less resistant to trypsin. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002524222 – 351Outer membrane pore protein EAdd BLAST330

Proteomic databases

PaxDbiP02932
PRIDEiP02932

2D gel databases

SWISS-2DPAGEiP02932

Expressioni

Inductioni

By phosphate starvation.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

BioGridi4259766, 264 interactors
DIPiDIP-10498N
IntActiP02932, 4 interactors
STRINGi316385.ECDH10B_0223

Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02932
SMRiP02932
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02932

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105FCK Bacteria
COG3203 LUCA
HOGENOMiHOG000272406
InParanoidiP02932
KOiK11929
PhylomeDBiP02932

Family and domain databases

CDDicd00342 gram_neg_porins, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR033900 Gram_neg_porin_domain
IPR023614 Porin_dom_sf
IPR001897 Porin_gammaproteobac
IPR001702 Porin_Gram-ve
IPR013793 Porin_Gram-ve_CS
PfamiView protein in Pfam
PF00267 Porin_1, 1 hit
PRINTSiPR00183 ECOLIPORIN
PR00182 ECOLNEIPORIN
PROSITEiView protein in PROSITE
PS00576 GRAM_NEG_PORIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKSTLALVV MGIVASASVQ AAEIYNKDGN KLDVYGKVKA MHYMSDNASK
60 70 80 90 100
DGDQSYIRFG FKGETQINDQ LTGYGRWEAE FAGNKAESDT AQQKTRLAFA
110 120 130 140 150
GLKYKDLGSF DYGRNLGALY DVEAWTDMFP EFGGDSSAQT DNFMTKRASG
160 170 180 190 200
LATYRNTDFF GVIDGLNLTL QYQGKNENRD VKKQNGDGFG TSLTYDFGGS
210 220 230 240 250
DFAISGAYTN SDRTNEQNLQ SRGTGKRAEA WATGLKYDAN NIYLATFYSE
260 270 280 290 300
TRKMTPITGG FANKTQNFEA VAQYQFDFGL RPSLGYVLSK GKDIEGIGDE
310 320 330 340 350
DLVNYIDVGA TYYFNKNMSA FVDYKINQLD SDNKLNINND DIVAVGMTYQ

F
Length:351
Mass (Da):38,922
Last modified:July 21, 1986 - v1
Checksum:i249E2E362C030C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00316 Genomic DNA Translation: CAA23605.1
U70214 Genomic DNA Translation: AAB08661.1
U00096 Genomic DNA Translation: AAC73345.1
AP009048 Genomic DNA Translation: BAA77910.1
X00786 Genomic DNA Translation: CAA25362.1
PIRiA03432 MMECPE
RefSeqiNP_414776.1, NC_000913.3
WP_000749863.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73345; AAC73345; b0241
BAA77910; BAA77910; BAA77910
GeneIDi944926
KEGGiecj:JW0231
eco:b0241
PATRICifig|1411691.4.peg.2042

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00316 Genomic DNA Translation: CAA23605.1
U70214 Genomic DNA Translation: AAB08661.1
U00096 Genomic DNA Translation: AAC73345.1
AP009048 Genomic DNA Translation: BAA77910.1
X00786 Genomic DNA Translation: CAA25362.1
PIRiA03432 MMECPE
RefSeqiNP_414776.1, NC_000913.3
WP_000749863.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PHOX-ray3.00A22-351[»]
ProteinModelPortaliP02932
SMRiP02932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259766, 264 interactors
DIPiDIP-10498N
IntActiP02932, 4 interactors
STRINGi316385.ECDH10B_0223

Protein family/group databases

TCDBi1.B.1.1.2 the general bacterial porin (gbp) family

2D gel databases

SWISS-2DPAGEiP02932

Proteomic databases

PaxDbiP02932
PRIDEiP02932

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73345; AAC73345; b0241
BAA77910; BAA77910; BAA77910
GeneIDi944926
KEGGiecj:JW0231
eco:b0241
PATRICifig|1411691.4.peg.2042

Organism-specific databases

EchoBASEiEB0722
EcoGeneiEG10729 phoE

Phylogenomic databases

eggNOGiENOG4105FCK Bacteria
COG3203 LUCA
HOGENOMiHOG000272406
InParanoidiP02932
KOiK11929
PhylomeDBiP02932

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-282
MetaCyc:MONOMER0-282

Miscellaneous databases

EvolutionaryTraceiP02932
PROiPR:P02932

Family and domain databases

CDDicd00342 gram_neg_porins, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR033900 Gram_neg_porin_domain
IPR023614 Porin_dom_sf
IPR001897 Porin_gammaproteobac
IPR001702 Porin_Gram-ve
IPR013793 Porin_Gram-ve_CS
PfamiView protein in Pfam
PF00267 Porin_1, 1 hit
PRINTSiPR00183 ECOLIPORIN
PR00182 ECOLNEIPORIN
PROSITEiView protein in PROSITE
PS00576 GRAM_NEG_PORIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHOE_ECOLI
AccessioniPrimary (citable) accession number: P02932
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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