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UniProtKB - P02921 (MELB_ECOLI)

Entry version 164 (02 Dec 2020)
Sequence version 2 (19 Oct 2011)
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Protein

Melibiose carrier protein

Gene

melB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Symport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:MELB-MONOMER
MetaCyc:MELB-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melibiose carrier protein
Alternative name(s):
Melibiose permease
Melibiose transporter
Na+ (Li+)/melibiose symporter
Thiomethylgalactoside permease II
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:melB
Synonyms:mel-4
Ordered Locus Names:b4120, JW4081
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini5 – 19CytoplasmicCuratedAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalCuratedAdd BLAST21
Topological domaini41 – 42PeriplasmicCurated2
Transmembranei43 – 63HelicalCuratedAdd BLAST21
Topological domaini64 – 80CytoplasmicCuratedAdd BLAST17
Transmembranei81 – 101HelicalCuratedAdd BLAST21
Topological domaini102 – 108PeriplasmicCurated7
Transmembranei109 – 129HelicalCuratedAdd BLAST21
Topological domaini130 – 153CytoplasmicCuratedAdd BLAST24
Transmembranei154 – 174HelicalCuratedAdd BLAST21
Topological domaini175 – 186PeriplasmicCuratedAdd BLAST12
Transmembranei187 – 207HelicalCuratedAdd BLAST21
Topological domaini208 – 235CytoplasmicCuratedAdd BLAST28
Transmembranei236 – 256HelicalCuratedAdd BLAST21
Topological domaini257 – 269PeriplasmicCuratedAdd BLAST13
Transmembranei270 – 290HelicalCuratedAdd BLAST21
Topological domaini291 – 299CytoplasmicCurated9
Transmembranei300 – 320HelicalCuratedAdd BLAST21
Topological domaini321 – 328PeriplasmicCurated8
Transmembranei329 – 349HelicalCuratedAdd BLAST21
Topological domaini350 – 381CytoplasmicCuratedAdd BLAST32
Transmembranei382 – 402HelicalCuratedAdd BLAST21
Topological domaini403 – 410PeriplasmicCurated8
Transmembranei411 – 431HelicalCuratedAdd BLAST21
Topological domaini432 – 473CytoplasmicCuratedAdd BLAST42

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59D → C: Loses ability to catalyze Na(+) or H(+)-coupled melibiose transport against a concentration gradient. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001707522 – 473Melibiose carrier proteinAdd BLAST472

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02921

PRoteomics IDEntifications database

More...PRIDEi		P02921

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263176, 14 interactors

Database of interacting proteins

More...DIPi		DIP-10180N

Protein interaction database and analysis system

More...IntActi		P02921, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b4120

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:galactoside symporter (TC 2.A.2) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2211, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027408_0_3_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02921

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039672, MFS_2
IPR036259, MFS_trans_sf
IPR001927, Na/Gal_symport
IPR018043, Na/Gal_symport_CS

The PANTHER Classification System

More...PANTHERi		PTHR11328, PTHR11328, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00792, gph, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00872, NA_GALACTOSIDE_SYMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02921-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSISMTTKLS YGFGAFGKDF AIGIVYMYLM YYYTDVVGLS VGLVGTLFLV 
        60         70         80         90        100
ARIWDAINDP IMGWIVNATR SRWGKFKPWI LIGTLANSVI LFLLFSAHLF 
       110        120        130        140        150
EGTTQIVFVC VTYILWGMTY TIMDIPFWSL VPTITLDKRE REQLVPYPRF 
       160        170        180        190        200
FASLAGFVTA GVTLPFVNYV GGGDRGFGFQ MFTLVLIAFF IVSTIITLRN 
       210        220        230        240        250
VHEVFSSDNQ PSAEGSHLTL KAIVALIYKN DQLSCLLGMA LAYNVASNII 
       260        270        280        290        300
TGFAIYYFSY VIGDADLFPY YLSYAGAANL VTLVFFPRLV KSLSRRILWA 
       310        320        330        340        350
GASILPVLSC GVLLLMALMS YHNVVLIVIA GILLNVGTAL FWVLQVIMVA 
       360        370        380        390        400
DIVDYGEYKL HVRCESIAYS VQTMVVKGGS AFAAFFIAVV LGMIGYVPNV 
       410        420        430        440        450
EQSTQALLGM QFIMIALPTL FFMVTLILYF RFYRLNGDTL RRIQIHLLDK 
       460        470 
YRKVPPEPVH ADIPVGAVSD VKA
Length:473
Mass (Da):52,636
Last modified:October 19, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE05FAA436F4CA70C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA24148 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA97020 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAE78122 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
K01991 Genomic DNA Translation: AAA24148.1 Different initiation.
U14003 Genomic DNA Translation: AAA97020.1 Different initiation.
U00096 Genomic DNA Translation: AAC77081.2
AP009048 Genomic DNA Translation: BAE78122.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		A03421, BDEC

NCBI Reference Sequences

More...RefSeqi		NP_418544.2, NC_000913.3
WP_000028111.1, NZ_SSZK01000018.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77081; AAC77081; b4120
BAE78122; BAE78122; BAE78122

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4081
eco:b4120

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.4251

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01991 Genomic DNA Translation: AAA24148.1 Different initiation.
U14003 Genomic DNA Translation: AAA97020.1 Different initiation.
U00096 Genomic DNA Translation: AAC77081.2
AP009048 Genomic DNA Translation: BAE78122.1 Different initiation.
PIRiA03421, BDEC
RefSeqiNP_418544.2, NC_000913.3
WP_000028111.1, NZ_SSZK01000018.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4263176, 14 interactors
DIPiDIP-10180N
IntActiP02921, 1 interactor
STRINGi511145.b4120

Proteomic databases

PaxDbiP02921
PRIDEiP02921

Genome annotation databases

EnsemblBacteriaiAAC77081; AAC77081; b4120
BAE78122; BAE78122; BAE78122
GeneIDi948635
KEGGiecj:JW4081
eco:b4120
PATRICifig|511145.12.peg.4251

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0573

Phylogenomic databases

eggNOGiCOG2211, Bacteria
HOGENOMiCLU_027408_0_3_6
InParanoidiP02921

Enzyme and pathway databases

BioCyciEcoCyc:MELB-MONOMER
MetaCyc:MELB-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P02921

Family and domain databases

InterProiView protein in InterPro
IPR039672, MFS_2
IPR036259, MFS_trans_sf
IPR001927, Na/Gal_symport
IPR018043, Na/Gal_symport_CS
PANTHERiPTHR11328, PTHR11328, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00792, gph, 1 hit
PROSITEiView protein in PROSITE
PS00872, NA_GALACTOSIDE_SYMP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMELB_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02921
Secondary accession number(s): Q2M6I4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 19, 2011
Last modified: December 2, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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