UniProtKB - P02916 (MALF_ECOLI)

BLAST

>sp|P02916|MALF_ECOLI Maltose/maltodextrin transport system permease protein MalF OS=Escherichia coli (strain K12) OX=83333 GN=malF PE=1 SV=1
MDVIKKKHWWQSDALKWSVLGLLGLLVGYLVVLMYAQGEYLFAITTLILSSAGLYIFANR
KAYAWRYVYPGMAGMGLFVLFPLVCTIAIAFTNYSSTNQLTFERAQEVLLDRSWQAGKTY
NFGLYPAGDEWQLALSDGETGKNYLSDAFKFGGEQKLQLKETTAQPEGERANLRVITQNR
QALSDITAILPDGNKVMMSSLRQFSGTQPLYTLDGDGTLTNNQSGVKYRPNNQIGFYQSI
TADGNWGDEKLSPGYTVTTGWKNFTRVFTDEGIQKPFLAIFVWTVVFSLITVFLTVAVGM
VLACLVQWEALRGKAVYRVLLILPYAVPSFISILIFKGLFNQSFGEINMMLSALFGVKPA
WFSDPTTARTMLIIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFKITLP
LLIKPLTPLMIASFAFNFNNFVLIQLLTNGGPDRLGTTTPAGYTDLLVNYTYRIAFEGGG
GQDFGLAAAIATLIFLLVGALAIVNLKATRMKFD

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History
Entry version 161 (20 Jun 2018)
Sequence version 1 (21 Jul 1986)
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Protein

Maltose/maltodextrin transport system permease protein MalF

Gene

malF

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.2 Publications

Miscellaneous

When MalF EAA loop mutations are made concomitantly with MalG EAA loop mutations, a complete loss of transport and complex formation is observed, except for the Gly-407. This suggests that the MalF-MalG interaction may be important for the proper assembly and also for the correct function of the transporter.

GO - Molecular functionⁱ

maltose-transporting ATPase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 2026607

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: EcoliWiki
Inferred from expression patternⁱ
- 11967071
maltodextrin transport
Source: EcoCyc
Inferred from direct assayⁱ
- 6997044
maltose transport
Source: EcoCyc
Inferred from direct assayⁱ
- 2026607

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Sugar transport, Transport

Biological process

Sugar transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:MALF-MONOMER MetaCyc:MALF-MONOMER

BioCycⁱ

EcoCyc:MALF-MONOMER
MetaCyc:MALF-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.1.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.1.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Maltose/maltodextrin transport system permease protein MalFCurated
Gene namesⁱ	Name:malF1 Publication Ordered Locus Names:b4033, JW3993
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10555 malF

EcoGeneⁱ

EG10555 malF

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.16
  "Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC."
  Wagner S., Pop O.I., Haan G.J., Baars L., Koningstein G., Klepsch M.M., Genevaux P., Luirink J., de Gier J.W.
  J. Biol. Chem. 283:17881-17890(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBUNIT, SUBCELLULAR LOCATION, REQUIREMENT FOR YIDC FOR PROTEIN AND COMPLEX FORMATION.
; Multi-pass membrane protein
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00441
1 Publication
Manual assertion based on experiment inⁱ
- Ref.16
  "Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC."
  Wagner S., Pop O.I., Haan G.J., Baars L., Koningstein G., Klepsch M.M., Genevaux P., Luirink J., de Gier J.W.
  J. Biol. Chem. 283:17881-17890(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBUNIT, SUBCELLULAR LOCATION, REQUIREMENT FOR YIDC FOR PROTEIN AND COMPLEX FORMATION.
; Periplasmic side
1 Publication
Manual assertion based on experiment inⁱ
- Ref.16
  "Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC."
  Wagner S., Pop O.I., Haan G.J., Baars L., Koningstein G., Klepsch M.M., Genevaux P., Luirink J., de Gier J.W.
  J. Biol. Chem. 283:17881-17890(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBUNIT, SUBCELLULAR LOCATION, REQUIREMENT FOR YIDC FOR PROTEIN AND COMPLEX FORMATION.

Note:

A substantial portion of it protrudes into the periplasmic space; inserts in an SRP- and Sec-dependent, YidC-independent fashion into the membrane.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 16	CytoplasmicCuratedAdd BLAST	16
Transmembraneⁱ	17 – 36	HelicalCuratedAdd BLAST	20
Topological domainⁱ	37 – 39	PeriplasmicCurated	3
Transmembraneⁱ	40 – 58	HelicalCuratedAdd BLAST	19
Topological domainⁱ	59 – 66	CytoplasmicCurated	8
Transmembraneⁱ	67 – 92	HelicalCuratedAdd BLAST	26
Topological domainⁱ	93 – 275	PeriplasmicCuratedAdd BLAST	183
Transmembraneⁱ	276 – 306	HelicalCuratedAdd BLAST	31
Topological domainⁱ	307 – 318	CytoplasmicCuratedAdd BLAST	12
Transmembraneⁱ	319 – 336	HelicalCuratedAdd BLAST	18
Topological domainⁱ	337 – 369	PeriplasmicCuratedAdd BLAST	33
Transmembraneⁱ	370 – 392	HelicalCuratedAdd BLAST	23
Topological domainⁱ	393 – 425	CytoplasmicCuratedAdd BLAST	33
Transmembraneⁱ	426 – 452	HelicalCuratedAdd BLAST	27
Topological domainⁱ	453 – 483	PeriplasmicCuratedAdd BLAST	31
Transmembraneⁱ	484 – 505	HelicalCuratedAdd BLAST	22
Topological domainⁱ	506 – 514	CytoplasmicCurated	9

GO - Cellular componentⁱ

ATP-binding cassette (ABC) transporter complex
Source: EcoCyc
Inferred from direct assayⁱ
- 2026607
integral component of plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 3317413
- 6088520
maltose transport complex
Source: EcoCyc
Inferred from direct assayⁱ
- 18033289
- 2026607
membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 18456666
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	334	L → W: Ability to transport lactose in a saturable manner. 1 Publication	1
Mutagenesisⁱ	372	L → W: Growth on maltose but not on media containing either maltoheptaose or maltoheptaose plus maltose. 1 Publication	1
Mutagenesisⁱ	376	N → K or H: No growth on maltose. 1 Publication	1
Mutagenesisⁱ	380	G → C or S: No growth on maltose. 1 Publication	1
Mutagenesisⁱ	401	E → A, C, K or L: Reduction of transport rate. 2 Publications	1
Mutagenesisⁱ	403	S → C, D, K or L: Reduction of transport rate. 2 Publications	1
Mutagenesisⁱ	407	G → A or P: No effect. 1 Publication	1
Mutagenesisⁱ	420	P → A: No effect. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000060068	1 – 514	Maltose/maltodextrin transport system permease protein MalFAdd BLAST		514

Proteomic databases

PaxDbⁱ	P02916
PRIDEⁱ	P02916

Interactionⁱ

Subunit structureⁱ

The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). Protein stability and stable complex formation require YidC.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
malE	P0AEX9	5	EBI-1118919,EBI-369910

With

Entry

#Exp.

IntAct

Notes

malE

P0AEX9

EBI-1118919,EBI-369910

Protein-protein interaction databases

BioGridⁱ	4261701, 15 interactors
ComplexPortalⁱ	CPX-1932 Maltose transport complex CPX-1978 Enzyme IIA-maltose transporter complex CPX-2103 MalFGK2 maltose transport complex
Database of interacting proteins More...DIPⁱ	DIP-10142N
IntActⁱ	P02916, 7 interactors
STRINGⁱ	316385.ECDH10B_4222

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	14 – 29	Combined sources	16
Helixⁱ	31 – 35	Combined sources	5
Turnⁱ	36 – 38	Combined sources	3
Helixⁱ	40 – 58	Combined sources	19
Helixⁱ	60 – 62	Combined sources	3
Helixⁱ	65 – 78	Combined sources	14
Helixⁱ	80 – 89	Combined sources	10
Beta strandⁱ	95 – 98	Combined sources	4
Helixⁱ	102 – 111	Combined sources	10
Beta strandⁱ	113 – 127	Combined sources	15
Beta strandⁱ	130 – 137	Combined sources	8
Turnⁱ	138 – 141	Combined sources	4
Beta strandⁱ	142 – 146	Combined sources	5
Beta strandⁱ	153 – 164	Combined sources	12
Helixⁱ	173 – 178	Combined sources	6
Helixⁱ	180 – 183	Combined sources	4
Beta strandⁱ	186 – 189	Combined sources	4
Beta strandⁱ	191 – 193	Combined sources	3
Beta strandⁱ	195 – 198	Combined sources	4
Beta strandⁱ	200 – 213	Combined sources	14
Beta strandⁱ	215 – 217	Combined sources	3
Beta strandⁱ	219 – 221	Combined sources	3
Turnⁱ	222 – 224	Combined sources	3
Beta strandⁱ	227 – 231	Combined sources	5
Turnⁱ	232 – 235	Combined sources	4
Beta strandⁱ	236 – 239	Combined sources	4
Beta strandⁱ	250 – 253	Combined sources	4
Helixⁱ	262 – 269	Combined sources	8
Turnⁱ	272 – 276	Combined sources	5
Helixⁱ	277 – 306	Combined sources	30
Beta strandⁱ	309 – 311	Combined sources	3
Helixⁱ	314 – 322	Combined sources	9
Helixⁱ	323 – 325	Combined sources	3
Helixⁱ	329 – 339	Combined sources	11
Beta strandⁱ	342 – 345	Combined sources	4
Helixⁱ	346 – 353	Combined sources	8
Beta strandⁱ	354 – 356	Combined sources	3
Turnⁱ	361 – 363	Combined sources	3
Helixⁱ	365 – 391	Combined sources	27
Helixⁱ	392 – 394	Combined sources	3
Helixⁱ	397 – 405	Combined sources	9
Helixⁱ	410 – 416	Combined sources	7
Helixⁱ	418 – 438	Combined sources	21
Helixⁱ	441 – 447	Combined sources	7
Turnⁱ	448 – 450	Combined sources	3
Beta strandⁱ	452 – 454	Combined sources	3
Beta strandⁱ	462 – 464	Combined sources	3
Helixⁱ	467 – 475	Combined sources	9
Beta strandⁱ	477 – 480	Combined sources	4
Helixⁱ	484 – 501	Combined sources	18
Turnⁱ	502 – 504	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P02916
SMRⁱ	P02916
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P02916

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	281 – 505	ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST		225

Sequence similaritiesⁱ

Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105D56 Bacteria COG1175 LUCA
HOGENOMⁱ	HOG000239267
InParanoidⁱ	P02916
KEGG Orthology (KO) More...KOⁱ	K10109
OMAⁱ	NQNFGEI
PhylomeDBⁱ	P02916

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06261 TM_PBP2, 1 hit
Gene3Dⁱ	1.10.3720.10, 1 hit 1.20.58.370, 1 hit
InterProⁱ	View protein in InterPro IPR030156 MalF IPR035277 MalF_N IPR029345 MalF_P2 IPR000515 MetI-like IPR035906 MetI-like_sf
PANTHERⁱ	PTHR30193:SF22 PTHR30193:SF22, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00528 BPD_transp_1, 1 hit PF14785 MalF_P2, 1 hit
SUPFAMⁱ	SSF161098 SSF161098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50928 ABC_TM1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P02916-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDVIKKKHWW QSDALKWSVL GLLGLLVGYL VVLMYAQGEY LFAITTLILS 
        60         70         80         90        100
SAGLYIFANR KAYAWRYVYP GMAGMGLFVL FPLVCTIAIA FTNYSSTNQL 
       110        120        130        140        150
TFERAQEVLL DRSWQAGKTY NFGLYPAGDE WQLALSDGET GKNYLSDAFK 
       160        170        180        190        200
FGGEQKLQLK ETTAQPEGER ANLRVITQNR QALSDITAIL PDGNKVMMSS 
       210        220        230        240        250
LRQFSGTQPL YTLDGDGTLT NNQSGVKYRP NNQIGFYQSI TADGNWGDEK 
       260        270        280        290        300
LSPGYTVTTG WKNFTRVFTD EGIQKPFLAI FVWTVVFSLI TVFLTVAVGM 
       310        320        330        340        350
VLACLVQWEA LRGKAVYRVL LILPYAVPSF ISILIFKGLF NQSFGEINMM 
       360        370        380        390        400
LSALFGVKPA WFSDPTTART MLIIVNTWLG YPYMMILCMG LLKAIPDDLY 
       410        420        430        440        450
EASAMDGAGP FQNFFKITLP LLIKPLTPLM IASFAFNFNN FVLIQLLTNG 
       460        470        480        490        500
GPDRLGTTTP AGYTDLLVNY TYRIAFEGGG GQDFGLAAAI ATLIFLLVGA 
       510 
LAIVNLKATR MKFD

Length:514

Mass (Da):57,013

Last modified:July 21, 1986 - v1

Checksum:ⁱ895CEA1986CE5C0B

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J01648 Genomic DNA Translation: AAB59055.1 U00006 Genomic DNA Translation: AAC43127.1 U00096 Genomic DNA Translation: AAC77003.1 AP009048 Genomic DNA Translation: BAE78035.1 X02871 Genomic DNA Translation: CAA26627.1
PIRⁱ	A03414 MMECMF
NCBI Reference Sequences More...RefSeqⁱ	NP_418457.1, NC_000913.3 WP_001297290.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC77003; AAC77003; b4033 BAE78035; BAE78035; BAE78035
GeneIDⁱ	948532
KEGGⁱ	ecj:JW3993 eco:b4033
PATRICⁱ	fig\|511145.12.peg.4148

Protein	Similar proteins		Species	Score	Length	Source
P02916	Maltose transport system permease protein MalF		ECOLX		519	UniRef100_P02916
Maltose transport system permease protein MalF		Escherichia coli MS 145-7		519
Maltose transport system permease protein MalF		Escherichia coli 110957		519
Maltose transport system permease protein MalF		Escherichia coli MS 124-1		519
Maltose transport system permease protein MalF		Escherichia coli MS 115-1		519
+62

Protein	Similar proteins		Species	Score	Length	Source
P02916	Maltose/maltodextrin transport system permease protein MalF		ECOL6		519	UniRef90_P02916
Maltose/maltodextrin transport system permease protein MalF		SHIFL		514
Maltose/maltodextrin transport system permease protein MalF		SALTY		514
Maltose/maltodextrin transport system permease protein MalF		ECO57		514
Maltose transport system permease protein MalF		ECOLX		519
+948

Protein	Similar proteins		Species	Score	Length	Source
P02916	Maltose/maltodextrin transport system permease protein MalF		ECOL6		519	UniRef50_P02916
Maltose/maltodextrin transport system permease protein MalF		SHIFL		514
Maltose/maltodextrin transport system permease protein MalF		ECO57		514
Maltose/maltodextrin transport system permease protein MalF		SALTY		514
Maltose/maltodextrin transport system permease protein MalF		KLEAE		514
+2722

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J01648 Genomic DNA Translation: AAB59055.1 U00006 Genomic DNA Translation: AAC43127.1 U00096 Genomic DNA Translation: AAC77003.1 AP009048 Genomic DNA Translation: BAE78035.1 X02871 Genomic DNA Translation: CAA26627.1
PIRⁱ	A03414 MMECMF
RefSeqⁱ	NP_418457.1, NC_000913.3 WP_001297290.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2R6G	X-ray	2.80	F	1-514	[»]
	3FH6	X-ray	4.50	F/H	36-514	[»]
	3PUV	X-ray	2.40	F	1-514	[»]
	3PUW	X-ray	2.30	F	1-514	[»]
	3PUX	X-ray	2.30	F	1-514	[»]
	3PUY	X-ray	3.10	F	1-514	[»]
	3PUZ	X-ray	2.90	F	1-514	[»]
	3PV0	X-ray	3.10	F	1-514	[»]
	3RLF	X-ray	2.20	F	1-514	[»]
	4JBW	X-ray	3.91	F/H	1-514	[»]
	4KHZ	X-ray	2.90	F	1-514	[»]
	4KI0	X-ray	2.38	F	1-514	[»]
ProteinModelPortalⁱ	P02916
SMRⁱ	P02916
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261701, 15 interactors
ComplexPortalⁱ	CPX-1932 Maltose transport complex CPX-1978 Enzyme IIA-maltose transporter complex CPX-2103 MalFGK2 maltose transport complex
DIPⁱ	DIP-10142N
IntActⁱ	P02916, 7 interactors
STRINGⁱ	316385.ECDH10B_4222

Protein family/group databases

TCDBⁱ	3.A.1.1.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.1.1 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P02916
PRIDEⁱ	P02916

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC77003; AAC77003; b4033 BAE78035; BAE78035; BAE78035
GeneIDⁱ	948532
KEGGⁱ	ecj:JW3993 eco:b4033
PATRICⁱ	fig\|511145.12.peg.4148

Organism-specific databases

EchoBASEⁱ	EB0550
EcoGeneⁱ	EG10555 malF

Phylogenomic databases

eggNOGⁱ	ENOG4105D56 Bacteria COG1175 LUCA
HOGENOMⁱ	HOG000239267
InParanoidⁱ	P02916
KOⁱ	K10109
OMAⁱ	NQNFGEI
PhylomeDBⁱ	P02916

Enzyme and pathway databases

BioCycⁱ	EcoCyc:MALF-MONOMER MetaCyc:MALF-MONOMER

BioCycⁱ

EcoCyc:MALF-MONOMER
MetaCyc:MALF-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P02916
Protein Ontology More...PROⁱ	PR:P02916

Family and domain databases

CDDⁱ	cd06261 TM_PBP2, 1 hit
Gene3Dⁱ	1.10.3720.10, 1 hit 1.20.58.370, 1 hit
InterProⁱ	View protein in InterPro IPR030156 MalF IPR035277 MalF_N IPR029345 MalF_P2 IPR000515 MetI-like IPR035906 MetI-like_sf
PANTHERⁱ	PTHR30193:SF22 PTHR30193:SF22, 1 hit
Pfamⁱ	View protein in Pfam PF00528 BPD_transp_1, 1 hit PF14785 MalF_P2, 1 hit
SUPFAMⁱ	SSF161098 SSF161098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50928 ABC_TM1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MALF_ECOLI
Accessionⁱ	P02916Primary (citable) accession number: P02916 Secondary accession number(s): Q2M6S1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	June 20, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02916 (MALF_ECOLI)

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Maltose/maltodextrin transport system permease protein MalF

malF

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ