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UniProtKB - P02915 (HISP_SALTY)
Protein
Histidine transport ATP-binding protein HisP
Gene
hisP
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Functioni
Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system.
3 PublicationsActivity regulationi
ATPase activity is slightly increased in the presence of HisM and HisQ, and strongly increased when HisJ is also present.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 39 – 46 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type amino acid transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
TCDBi | 3.A.1.3.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Histidine transport ATP-binding protein HisP |
Gene namesi | Name:hisP Ordered Locus Names:STM2351 |
Organismi | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
Taxonomic identifieri | 99287 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Binds much more tightly to the membrane in the presence of HisQ and HisM.
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092342 | 1 – 258 | Histidine transport ATP-binding protein HisPAdd BLAST | 258 |
Proteomic databases
PaxDbi | P02915 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).
4 PublicationsProtein-protein interaction databases
STRINGi | 99287.STM2351 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02915 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02915 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 253 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 247 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily.Curated
Phylogenomic databases
HOGENOMi | CLU_000604_1_22_6 |
OMAi | EVFCLIG |
PhylomeDBi | P02915 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR030679, ABC_ATPase_HisP-typ IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
PIRSFi | PIRSF039085, ABC_ATPase_HisP, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P02915-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSENKLHVI DLHKRYGGHE VLKGVSLQAR AGDVISIIGS SGSGKSTFLR
60 70 80 90 100
CINFLEKPSE GAIIVNGQNI NLVRDKDGQL KVADKNQLRL LRTRLTMVFQ
110 120 130 140 150
HFNLWSHMTV LENVMEAPIQ VLGLSKHDAR ERALKYLAKV GIDERAQGKY
160 170 180 190 200
PVHLSGGQQQ RVSIARALAM EPDVLLFDEP TSALDPELVG EVLRIMQQLA
210 220 230 240 250
EEGKTMVVVT HEMGFARHVS SHVIFLHQGK IEEEGDPEQV FGNPQSPRLQ
QFLKGSLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01373 Genomic DNA Translation: CAA24662.1 J01805 Genomic DNA Translation: AAA75581.1 AE006468 Genomic DNA Translation: AAL21252.1 |
PIRi | A03412, QREBPT |
RefSeqi | NP_461293.1, NC_003197.2 WP_000986775.1, NC_003197.2 |
Genome annotation databases
EnsemblBacteriai | AAL21252; AAL21252; STM2351 |
GeneIDi | 1253873 |
KEGGi | stm:STM2351 |
PATRICi | fig|99287.12.peg.2488 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01373 Genomic DNA Translation: CAA24662.1 J01805 Genomic DNA Translation: AAA75581.1 AE006468 Genomic DNA Translation: AAL21252.1 |
PIRi | A03412, QREBPT |
RefSeqi | NP_461293.1, NC_003197.2 WP_000986775.1, NC_003197.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B0U | X-ray | 1.50 | A | 1-258 | [»] | |
SMRi | P02915 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 99287.STM2351 |
Protein family/group databases
TCDBi | 3.A.1.3.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P02915 |
Genome annotation databases
EnsemblBacteriai | AAL21252; AAL21252; STM2351 |
GeneIDi | 1253873 |
KEGGi | stm:STM2351 |
PATRICi | fig|99287.12.peg.2488 |
Phylogenomic databases
HOGENOMi | CLU_000604_1_22_6 |
OMAi | EVFCLIG |
PhylomeDBi | P02915 |
Miscellaneous databases
EvolutionaryTracei | P02915 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR030679, ABC_ATPase_HisP-typ IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
PIRSFi | PIRSF039085, ABC_ATPase_HisP, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HISP_SALTY | |
Accessioni | P02915Primary (citable) accession number: P02915 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families