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Entry version 55 (22 Apr 2020)
Sequence version 2 (01 Jul 1989)
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Protein

Glycophorin-binding protein

Gene

GBP

Organism
Plasmodium falciparum (isolate FCR-3 / Gambia)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in erythrocyte invasion.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycophorin-binding protein
Alternative name(s):
GBP-130
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate FCR-3 / Gambia)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5838 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Note: Erythrocyte cytoplasm of schizonts. Released into the culture supernatant at the time of schizont rupture. Only a minor fraction of GBP was found to be loosely associated with merozoites.

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Malaria

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002171861 – 774Glycophorin-binding proteinAdd BLAST774

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P02895

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Synthesized at the trophozoite and schizont stages.

Keywords - Developmental stagei

Merozoite

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host glycophorin.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02895

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati226 – 275GBP 1Add BLAST50
Repeati276 – 325GBP 2Add BLAST50
Repeati326 – 375GBP 3Add BLAST50
Repeati376 – 425GBP 4Add BLAST50
Repeati426 – 474GBP 5Add BLAST49
Repeati475 – 524GBP 6Add BLAST50
Repeati525 – 574GBP 7Add BLAST50
Repeati575 – 624GBP 8Add BLAST50
Repeati625 – 674GBP 9Add BLAST50
Repeati675 – 724GBP 10Add BLAST50
Repeati725 – 774GBP 11Add BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 204Lys-richAdd BLAST109

Keywords - Domaini

Repeat

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003681, Glycophorin-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02526, GBP_repeat, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51069, GBP, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P02895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSKVSDIK STGVSNYKNF NSKNSSKYSL MEVSKKNEKK NSLGAFHSKK
60 70 80 90 100
ILLIFGIIYV VLLNAYICGD KYEKAVDYGF RESRILAEGE DTCARKEKTT
110 120 130 140 150
LRKSKQKTST RTVATQTKKD EENKSVVTEE QKVESDSEKQ KRTKKVVKKQ
160 170 180 190 200
INIGDTENQK EGKNVKKVIK KEKKKEESGK PEENKHANEA SKKKEPKASK
210 220 230 240 250
VSQKPSTSTR SNNEVKIRAA SNQETLTSAD PEGQIMREYA ADPEYRKHLE
260 270 280 290 300
IFYKILTNTD PNDEVERRNA DNKEDLTSAD PEGQIMREYA SDPEYRKHLE
310 320 330 340 350
IFYKILTNTD PNDDVERRNA DNKEDLTSAD PEGQIMREYA ADPEYRKHLE
360 370 380 390 400
VFHKILTNTD PNDEVERRNA DNKEDLTSAD PEGQIMREYA ADPEYRKHLE
410 420 430 440 450
IFHKILTNTD PNDEVERRNA DNKEDLTSAD PEGQIMREYA ADPEYRKHLE
460 470 480 490 500
VFHKILTNTD PNDEVERRNA DNKELTSSDP EGQIMREYAA DPEYRKHLEI
510 520 530 540 550
FHKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEI
560 570 580 590 600
FYKILTNTDP NDEVERRNAD NKEELTSSDP EGQIMREYAA DPEYRKHLEI
610 620 630 640 650
FHKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEI
660 670 680 690 700
FYKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAS DPEYRKHLEI
710 720 730 740 750
FYKILTNTDP NDDVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEI
760 770
FHKILTNTDP NDEVERQNAD NNEA
Length:774
Mass (Da):90,018
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16B795D08C0C1798
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti556T → A in AAA29607 (PubMed:3883491).Curated1
Sequence conflicti563E → D in AAA29607 (PubMed:3883491).Curated1
Sequence conflicti570D → E in AAA29607 (PubMed:3883491).Curated1
Sequence conflicti640A → V in AAA29607 (PubMed:3883491).Curated1
Sequence conflicti690S → P in AAA29607 (PubMed:3883491).Curated1
Sequence conflicti747H → D in AAA29607 (PubMed:3883491).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M12897 Genomic DNA Translation: AAA29608.1
M10985 mRNA Translation: AAA29607.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A03390, ZOZQMF
A24057

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12897 Genomic DNA Translation: AAA29608.1
M10985 mRNA Translation: AAA29607.1
PIRiA03390, ZOZQMF
A24057

3D structure databases

SMRiP02895
ModBaseiSearch...

Proteomic databases

PRIDEiP02895

Family and domain databases

InterProiView protein in InterPro
IPR003681, Glycophorin-bd
PfamiView protein in Pfam
PF02526, GBP_repeat, 11 hits
PROSITEiView protein in PROSITE
PS51069, GBP, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBP_PLAFG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02895
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: April 22, 2020
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
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