Discoidin-1 subunit A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• carbohydrate binding Source: dictyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Developmentally regulated, carbohydrate-binding protein in Dictyostelium discoideum."
    Rosen S.D., Kafka J.A., Simpson D.L., Barondes S.H.
    Proc Natl Acad Sci U S A 70:2554-2557(1973) [PubMed] [Europe PMC] [Abstract]
• lipooligosaccharide binding Source: dictyBaseInferred from direct assayⁱ
  • "Lectins modulate the microbiota of social amoebae."
    Dinh C., Farinholt T., Hirose S., Zhuchenko O., Kuspa A.
    Science 361:402-406(2018) [PubMed] [Europe PMC] [Abstract]
• N-acetylgalactosamine binding Source: dictyBaseInferred from direct assayⁱ
  • "Discoidin-binding polysaccharide from Dictyostelium discoideum."
    Cooper D.N., Lee S.C., Barondes S.H.
    J Biol Chem 258:8745-8750(1983) [PubMed] [Europe PMC] [Abstract]
• oligosaccharide binding Source: dictyBaseInferred from direct assayⁱ
  • "Discoidin I from Dictyostelium discoideum and Interactions with oligosaccharides: specificity, affinity, crystal structures, and comparison with discoidin II."
    Mathieu S.V., Aragao K.S., Imberty A., Varrot A.
    J Mol Biol 400:540-554(2010) [PubMed] [Europe PMC] [Abstract]
• polysaccharide binding Source: dictyBaseInferred from direct assayⁱ
  • "Discoidin-binding polysaccharide from Dictyostelium discoideum."
    Cooper D.N., Lee S.C., Barondes S.H.
    J Biol Chem 258:8745-8750(1983) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell adhesion Source: dictyBaseInferred from direct assayⁱ
  • "Developmentally regulated, carbohydrate-binding protein in Dictyostelium discoideum."
    Rosen S.D., Kafka J.A., Simpson D.L., Barondes S.H.
    Proc Natl Acad Sci U S A 70:2554-2557(1973) [PubMed] [Europe PMC] [Abstract]
• cell-cell adhesion Source: dictyBaseInferred from direct assayⁱ
  • "Discoidin-binding polysaccharide from Dictyostelium discoideum."
    Cooper D.N., Lee S.C., Barondes S.H.
    J Biol Chem 258:8745-8750(1983) [PubMed] [Europe PMC] [Abstract]
• cell-substrate adhesion Source: dictyBaseInferred from direct assayⁱ
  • Ref.6

    "Discoidin I is implicated in cell-substratum attachment and ordered cell migration of Dictyostelium discoideum and resembles fibronectin."
    Springer W.R., Cooper D.N.W., Barondes S.H.
    Cell 39:557-564(1984) [PubMed] [Europe PMC] [Abstract]

    Cited for: CELL ATTACHMENT SITE.
• cytoskeleton organization Source: dictyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Discoidin proteins of Dictyostelium are necessary for normal cytoskeletal organization and cellular morphology during aggregation."
    Alexander S., Sydow L.M., Wessels D., Soll D.R.
    Differentiation 51:149-161(1992) [PubMed] [Europe PMC] [Abstract]
• lectin-induced modified bacterial internalization Source: dictyBaseInferred from direct assayⁱ
  • "Lectins modulate the microbiota of social amoebae."
    Dinh C., Farinholt T., Hirose S., Zhuchenko O., Kuspa A.
    Science 361:402-406(2018) [PubMed] [Europe PMC] [Abstract]
• response to bacterium Source: dictyBaseInferred from high throughput expression patternⁱ
  • "Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium."
    Shevchuk O., Batzilla C., Haegele S., Kusch H., Engelmann S., Hecker M., Haas A., Heuner K., Gloeckner G., Steinert M.
    Int. J. Med. Microbiol. 299:489-508(2009) [PubMed] [Europe PMC] [Abstract]
• response to catechin Source: dictyBaseInferred from direct assayⁱ
  • "The green tea catechin epigallocatechin gallate (EGCG) blocks cell motility, chemotaxis and development in Dictyostelium discoideum."
    McQuade K.J., Nakajima A., Ilacqua A.N., Shimada N., Sawai S.
    PLoS One 8:e59275-e59275(2013) [PubMed] [Europe PMC] [Abstract]
• response to curcumin Source: dictyBaseInferred from direct assayⁱ
  • "Curcumin inhibits development and cell adhesion in Dictyostelium discoideum: Implications for YakA signaling and GST enzyme function."
    Garige M., Walters E.
    Biochem Biophys Res Commun 467:275-281(2015) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MSTQGLVQLL ANAQCHLRTS TNYNGVHTQF NSALNYKNNG TNTIDGSEAW 
        60         70         80         90        100
CSSIVDTNQY IVAGCEVPRT FMCVALQGRG DADQWVTSYK IRYSLDNVSW 
       110        120        130        140        150
FEYRNGAAVT GVTDRNTVVN HFFDTPIRAR SIAIHPLTWN GHISLRCEFY 
       160        170        180        190        200
TQPVQSSVTQ VGADIYTGDN CALNTGSGKR EVVVPVKFQF EFATLPKVAL 
       210        220        230        240        250
NFDQIDCTDA TNQTRIGVQP RNITTKGFDC VFYTWNENKV YSLRADYIAT 

ALE                                                    

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Dictyostelium discoideum
   Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references