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UniProtKB - P02886 (DIS1A_DICDI)
Functioni
Galactose- and N-acetylgalactosamine-binding lectin. May play a role in cell-substratum adhesion rather than in cell-cell adhesion. May be necessary for the maintenance of normal elongate morphology during aggregation.
Caution
The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated
GO - Molecular functioni
- carbohydrate binding Source: dictyBase
- lipooligosaccharide binding Source: dictyBase
- N-acetylgalactosamine binding Source: dictyBase
- oligosaccharide binding Source: dictyBase
- polysaccharide binding Source: dictyBase
GO - Biological processi
- cell adhesion Source: dictyBase
- cell-cell adhesion Source: dictyBase
- cell-substrate adhesion Source: dictyBase
- cytoskeleton organization Source: dictyBase
- lectin-induced modified bacterial internalization Source: dictyBase
- response to bacterium Source: dictyBase
- response to catechin Source: dictyBase
- response to curcumin Source: dictyBase
Keywordsi
Biological process | Cell adhesion |
Ligand | Lectin |
Protein family/group databases
UniLectini | P02886 |
Names & Taxonomyi
Protein namesi | Recommended name: Discoidin-1 subunit AAlternative name(s): Discoidin-1 subunit alpha Short name: Discoidin I chain A |
Gene namesi | Name:dscA-1 ORF Names:DDB_G0273063 AND Name:dscA-2 ORF Names:DDB_G0273919 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0273063, dscA-1 DDB_G0273919, dscA-2 |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cell surface Source: dictyBase
- cytoplasm Source: dictyBase
- extracellular matrix Source: dictyBase
- intracellular vesicle Source: dictyBase
- phagocytic vesicle Source: dictyBase
- protein complex involved in cell adhesion Source: dictyBase
- symbiont cell surface Source: dictyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000079915 | 2 – 253 | Discoidin-1 subunit AAdd BLAST | 252 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P02886 |
Expressioni
Tissue specificityi
Stalk cells.
Interactioni
Subunit structurei
Tetramer of four different chains (A to D).
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P02886 |
SMRi | P02886 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02886 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 152 | F5/8 type CPROSITE-ProRule annotationAdd BLAST | 151 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 79 – 81 | Cell attachment site | 3 |
Phylogenomic databases
eggNOGi | KOG3516, Eukaryota |
HOGENOMi | CLU_1100181_0_0_1 |
InParanoidi | P02886 |
OMAi | GHISLRC |
PhylomeDBi | P02886 |
Family and domain databases
CDDi | cd00057, FA58C, 1 hit |
Gene3Di | 2.60.40.2080, 1 hit |
InterProi | View protein in InterPro IPR000421, FA58C IPR008979, Galactose-bd-like_sf IPR037221, H-type_lectin_dom_sf IPR019019, H-type_lectin_domain |
Pfami | View protein in Pfam PF00754, F5_F8_type_C, 1 hit PF09458, H_lectin, 1 hit |
SUPFAMi | SSF141086, SSF141086, 1 hit SSF49785, SSF49785, 1 hit |
PROSITEi | View protein in PROSITE PS01285, FA58C_1, 1 hit PS50022, FA58C_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02886-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTQGLVQLL ANAQCHLRTS TNYNGVHTQF NSALNYKNNG TNTIDGSEAW
60 70 80 90 100
CSSIVDTNQY IVAGCEVPRT FMCVALQGRG DADQWVTSYK IRYSLDNVSW
110 120 130 140 150
FEYRNGAAVT GVTDRNTVVN HFFDTPIRAR SIAIHPLTWN GHISLRCEFY
160 170 180 190 200
TQPVQSSVTQ VGADIYTGDN CALNTGSGKR EVVVPVKFQF EFATLPKVAL
210 220 230 240 250
NFDQIDCTDA TNQTRIGVQP RNITTKGFDC VFYTWNENKV YSLRADYIAT
ALE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 98 | V → L in AAA33197 (PubMed:6279874).Curated | 1 | |
Sequence conflicti | 107 | A → P in AAA33197 (PubMed:6279874).Curated | 1 | |
Sequence conflicti | 130 | R → P in AAA33197 (PubMed:6279874).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01282 Genomic DNA Translation: AAA33197.1 AAFI02000011 Genomic DNA Translation: EAL70650.1 AAFI02000009 Genomic DNA Translation: EAL70749.1 |
RefSeqi | XP_644576.1, XM_639484.1 XP_644675.1, XM_639583.1 |
Genome annotation databases
EnsemblProtistsi | EAL70650; EAL70650; DDB_G0273919 EAL70749; EAL70749; DDB_G0273063 |
GeneIDi | 8618769 8619207 |
KEGGi | ddi:DDB_G0273063 ddi:DDB_G0273919 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01282 Genomic DNA Translation: AAA33197.1 AAFI02000011 Genomic DNA Translation: EAL70650.1 AAFI02000009 Genomic DNA Translation: EAL70749.1 |
RefSeqi | XP_644576.1, XM_639484.1 XP_644675.1, XM_639583.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2W94 | X-ray | 1.80 | A/B/C | 1-253 | [»] | |
2W95 | X-ray | 1.75 | A/B/C | 1-253 | [»] | |
2WN2 | X-ray | 1.82 | A/B/C | 1-253 | [»] | |
2WN3 | X-ray | 1.59 | A/B/C | 1-253 | [»] | |
AlphaFoldDBi | P02886 | |||||
SMRi | P02886 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
UniLectini | P02886 |
Proteomic databases
PaxDbi | P02886 |
Protocols and materials databases
ABCDi | P02886, 1 sequenced antibody |
Genome annotation databases
EnsemblProtistsi | EAL70650; EAL70650; DDB_G0273919 EAL70749; EAL70749; DDB_G0273063 |
GeneIDi | 8618769 8619207 |
KEGGi | ddi:DDB_G0273063 ddi:DDB_G0273919 |
Organism-specific databases
dictyBasei | DDB_G0273063, dscA-1 DDB_G0273919, dscA-2 |
Phylogenomic databases
eggNOGi | KOG3516, Eukaryota |
HOGENOMi | CLU_1100181_0_0_1 |
InParanoidi | P02886 |
OMAi | GHISLRC |
PhylomeDBi | P02886 |
Miscellaneous databases
EvolutionaryTracei | P02886 |
PROi | PR:P02886 |
Family and domain databases
CDDi | cd00057, FA58C, 1 hit |
Gene3Di | 2.60.40.2080, 1 hit |
InterProi | View protein in InterPro IPR000421, FA58C IPR008979, Galactose-bd-like_sf IPR037221, H-type_lectin_dom_sf IPR019019, H-type_lectin_domain |
Pfami | View protein in Pfam PF00754, F5_F8_type_C, 1 hit PF09458, H_lectin, 1 hit |
SUPFAMi | SSF141086, SSF141086, 1 hit SSF49785, SSF49785, 1 hit |
PROSITEi | View protein in PROSITE PS01285, FA58C_1, 1 hit PS50022, FA58C_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DIS1A_DICDI | |
Accessioni | P02886Primary (citable) accession number: P02886 Secondary accession number(s): Q556P5, Q86AL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | December 4, 2007 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references