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Protein

Pro-hevein

Gene

HEV1

Organism
Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

N-acetyl-D-glucosamine / N-acetyl-D-neuraminic acid binding lectin. Can inhibit fungal growth.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandChitin-binding

Protein family/group databases

CAZyiCBM18 Carbohydrate-Binding Module Family 18
UniLectiniP02877

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-hevein
Alternative name(s):
Major hevein
Cleaved into the following 2 chains:
Alternative name(s):
Allergen: Hev b 6
Gene namesi
Name:HEV1
OrganismiHevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Taxonomic identifieri3981 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeCrotonoideaeMicrandreaeHevea

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei390 Hev b 6
391 Hev b 6.01
392 Hev b 6.02
393 Hev b 6.03

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 173 PublicationsAdd BLAST17
ChainiPRO_000000528018 – 204Pro-heveinAdd BLAST187
ChainiPRO_000000528118 – 60HeveinAdd BLAST43
PropeptideiPRO_000000528261 – 661 Publication6
ChainiPRO_000000528367 – 204Win-like proteinAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 35PROSITE-ProRule annotation1 Publication
Disulfide bondi29 ↔ 41PROSITE-ProRule annotation1 Publication
Disulfide bondi34 ↔ 48PROSITE-ProRule annotation1 Publication
Disulfide bondi54 ↔ 58PROSITE-ProRule annotation1 Publication
Disulfide bondi96 ↔ 128PROSITE-ProRule annotation
Disulfide bondi117 ↔ 151PROSITE-ProRule annotation
Disulfide bondi131 ↔ 187PROSITE-ProRule annotation

Post-translational modificationi

Proteolytically processed to yield the two chains of the mature protein.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP02877

Expressioni

Tissue specificityi

Laticifer.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 24Combined sources3
Helixi30 – 32Combined sources3
Beta strandi37 – 39Combined sources3
Beta strandi41 – 44Combined sources4
Helixi45 – 48Combined sources4
Helixi50 – 52Combined sources3

3D structure databases

ProteinModelPortaliP02877
SMRiP02877
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02877

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 60Chitin-binding type-1PROSITE-ProRule annotationAdd BLAST43
Domaini68 – 189BarwinPROSITE-ProRule annotationAdd BLAST122

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.40.10, 1 hit
3.30.60.10, 1 hit
InterProiView protein in InterPro
IPR018226 Barwin_CS
IPR001153 Barwin_dom
IPR001002 Chitin-bd_1
IPR018371 Chitin-binding_1_CS
IPR036861 Endochitinase-like_sf
IPR036908 RlpA-like_sf
PfamiView protein in Pfam
PF00967 Barwin, 1 hit
PF00187 Chitin_bind_1, 1 hit
PRINTSiPR00602 BARWIN
PR00451 CHITINBINDNG
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004535 Barwin, 1 hit
PD000609 Chitin_bd_1, 1 hit
SMARTiView protein in SMART
SM00270 ChtBD1, 1 hit
SUPFAMiSSF50685 SSF50685, 1 hit
SSF57016 SSF57016, 1 hit
PROSITEiView protein in PROSITE
PS00771 BARWIN_1, 1 hit
PS00772 BARWIN_2, 1 hit
PS51174 BARWIN_3, 1 hit
PS00026 CHIT_BIND_I_1, 1 hit
PS50941 CHIT_BIND_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFIVVLLC LTGVAIAEQC GRQAGGKLCP NNLCCSQWGW CGSTDEYCSP
60 70 80 90 100
DHNCQSNCKD SGEGVGGGSA SNVLATYHLY NSQDHGWDLN AASAYCSTWD
110 120 130 140 150
ANKPYSWRSK YGWTAFCGPV GAHGQSSCGK CLSVTNTGTG AKTTVRIVDQ
160 170 180 190 200
CSNGGLDLDV NVFRQLDTDG KGYERGHITV NYQFVDCGDS FNPLFSVMKS

SVIN
Length:204
Mass (Da):21,859
Last modified:November 1, 1990 - v2
Checksum:iFBCEE57CDFC80569
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti31N → D Possible deamidation. 1
Natural varianti73V → M. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36986 mRNA Translation: AAA33357.1
PIRiA38288 HVHV

Similar proteinsi

Entry informationi

Entry nameiHEVE_HEVBR
AccessioniPrimary (citable) accession number: P02877
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: July 18, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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