We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P02873 (LEA1_PHAVU)
Protein
Alpha-amylase inhibitor 1
Gene
LLP
Organism
Phaseolus vulgaris (Kidney bean) (French bean)
Status
Functioni
Lectin and alpha-amylase inhibitor. Acts as a defensive protein against insects.
1 PublicationGO - Molecular functioni
- alpha-amylase inhibitor activity Source: UniProtKB-KW
- carbohydrate binding Source: UniProtKB-KW
Keywordsi
Molecular function | Alpha-amylase inhibitor |
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-amylase inhibitor 1Short name: Alpha-AI-1 Short name: Alpha-AI1 Alternative name(s): Lectin Cleaved into the following 2 chains: |
Gene namesi | Name:LLP Synonyms:Alpha-AI1 |
Organismi | Phaseolus vulgaris (Kidney bean) (French bean) |
Taxonomic identifieri | 3885 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › NPAAA clade › indigoferoid/millettioid clade › Phaseoleae › Phaseolus |
Pathology & Biotechi
Biotechnological usei
Sold as a diet aid under the name of 'Phaseolamin' or 'Phase 2'.
Protein family/group databases
Allergomei | 2946, Pha v aAI 8208, Pha v aAI.0101 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 3 PublicationsAdd BLAST | 23 | |
ChainiPRO_0000017627 | 24 – 100 | Alpha-amylase inhibitor 1 chain 1Add BLAST | 77 | |
ChainiPRO_0000017628 | 101 – 239 | Alpha-amylase inhibitor 1 chain 2Add BLAST | 139 | |
PropeptideiPRO_0000017629 | 240 – 246 | 7 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 35 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 88 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Proteolytic processing yields active form.1 Publication
Keywords - PTMi
GlycoproteinPTM databases
GlyConnecti | 26, 7 N-Linked glycans 27, 8 N-Linked glycans |
iPTMneti | P02873 |
Interactioni
Subunit structurei
Heterodimer of chain 1 and chain 2.
1 PublicationProtein-protein interaction databases
MINTi | P02873 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02873 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02873 |
Family & Domainsi
Sequence similaritiesi
Belongs to the leguminous lectin family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd06899, lectin_legume_LecRK_Arcelin_ConA, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR016363, L-lectin IPR000985, Lectin_LegA_CS IPR019825, Lectin_legB_Mn/Ca_BS IPR001220, Legume_lectin_dom |
Pfami | View protein in Pfam PF00139, Lectin_legB, 1 hit |
PIRSFi | PIRSF002690, L-type_lectin_plant, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00308, LECTIN_LEGUME_ALPHA, 1 hit PS00307, LECTIN_LEGUME_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02873-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIMASSKLLS LALFLALLSH ANSATETSFI IDAFNKTNLI LQGDATVSSN
60 70 80 90 100
GNLQLSYNSY DSMSRAFYSA PIQIRDSTTG NVASFDTNFT MNIRTHRQAN
110 120 130 140 150
SAVGLDFVLV PVQPESKGDT VTVEFDTFLS RISIDVNNND IKSVPWDVHD
160 170 180 190 200
YDGQNAEVRI TYNSSTKVFS VSLSNPSTGK SNNVSTTVEL EKEVYDWVSV
210 220 230 240
GFSATSGAYQ WSYETHDVLS WSFSSKFINL KDQKSERSNI VLNKIL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | I → N AA sequence (PubMed:7763497).Curated | 1 | |
Sequence conflicti | 73 | Q → R in CAD28835 (Ref. 3) Curated | 1 | |
Sequence conflicti | 142 | K → E in CAD28835 (Ref. 3) Curated | 1 | |
Sequence conflicti | 196 | D → N (PubMed:6897567).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01261 Genomic DNA Translation: AAA33769.1 AJ439614 Genomic DNA Translation: CAD28835.1 |
PIRi | A03365, LNFB |
Genome annotation databases
EnsemblPlantsi | ESW24764; ESW24764; PHAVU_004G158100g |
Gramenei | ESW24764; ESW24764; PHAVU_004G158100g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01261 Genomic DNA Translation: AAA33769.1 AJ439614 Genomic DNA Translation: CAD28835.1 |
PIRi | A03365, LNFB |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DHK | X-ray | 1.85 | B | 24-246 | [»] | |
1VIW | X-ray | 3.00 | B | 24-228 | [»] | |
SMRi | P02873 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | P02873 |
Protein family/group databases
Allergomei | 2946, Pha v aAI 8208, Pha v aAI.0101 |
PTM databases
GlyConnecti | 26, 7 N-Linked glycans 27, 8 N-Linked glycans |
iPTMneti | P02873 |
Genome annotation databases
EnsemblPlantsi | ESW24764; ESW24764; PHAVU_004G158100g |
Gramenei | ESW24764; ESW24764; PHAVU_004G158100g |
Miscellaneous databases
EvolutionaryTracei | P02873 |
Family and domain databases
CDDi | cd06899, lectin_legume_LecRK_Arcelin_ConA, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR016363, L-lectin IPR000985, Lectin_LegA_CS IPR019825, Lectin_legB_Mn/Ca_BS IPR001220, Legume_lectin_dom |
Pfami | View protein in Pfam PF00139, Lectin_legB, 1 hit |
PIRSFi | PIRSF002690, L-type_lectin_plant, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00308, LECTIN_LEGUME_ALPHA, 1 hit PS00307, LECTIN_LEGUME_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LEA1_PHAVU | |
Accessioni | P02873Primary (citable) accession number: P02873 Secondary accession number(s): Q8RVY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families