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Protein

Galactose-binding lectin

Gene
N/A
Organism
Arachis hypogaea (Peanut)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

D-galactose specific lectin.

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi144Manganese1
Metal bindingi146Calcium1
Metal bindingi146Manganese1
Metal bindingi148Calcium; via carbonyl oxygen1
Metal bindingi150Calcium1
Metal bindingi155Calcium1
Metal bindingi155Manganese1
Metal bindingi160Manganese1

GO - Molecular functioni

Keywordsi

LigandCalcium, Lectin, Manganese, Metal-binding

Protein family/group databases

UniLectiniP02872

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-binding lectin
Alternative name(s):
Agglutinin
PNA
OrganismiArachis hypogaea (Peanut)
Taxonomic identifieri3818 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladedalbergioids sensu latoDalbergieaePterocarpus cladeArachis

Pathology & Biotechi

Protein family/group databases

Allergomei1050 Ara h Agglutinin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001758324 – 273Galactose-binding lectinAdd BLAST250

Proteomic databases

PRIDEiP02872

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

IntActiP02872, 1 interactor

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02872
SMRiP02872
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02872

Family & Domainsi

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd06899 lectin_legume_LecRK_Arcelin_Co, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR016363 L-lectin
IPR000985 Lectin_LegA_CS
IPR019825 Lectin_legB_Mn/Ca_BS
IPR001220 Legume_lectin_dom
PfamiView protein in Pfam
PF00139 Lectin_legB, 1 hit
PIRSFiPIRSF002690 L-type_lectin_plant, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00308 LECTIN_LEGUME_ALPHA, 1 hit
PS00307 LECTIN_LEGUME_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02872-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPFCVFLTF FLLLAASSKK VDSAETVSFN FNSFSEGNPA INFQGDVTVL
60 70 80 90 100
SNGNIQLTNL NKVNSVGRVL YAMPVRIWSS ATGNVASFLT SFSFEMKDIK
110 120 130 140 150
DYDPADGIIF FIAPEDTQIP AGSIGGGTLG VSDTKGAGHF VGVEFDTYSN
160 170 180 190 200
SEYNDPPTDH VGIDVNSVDS VKTVPWNSVS GAVVKVTVIY DSSTKTLSVA
210 220 230 240 250
VTNDNGDITT IAQVVDLKAK LPERVKFGFS ASGSLGGRQI HLIRSWSFTS
260 270
TLITTTRRSI DNNEKKIMNM ASA
Length:273
Mass (Da):29,325
Last modified:October 1, 1996 - v3
Checksum:i05A0B1A8FAC7B159
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti115E → V in minor form. 1
Natural varianti172K → A in minor form. 1
Natural varianti185K → I in minor form. 1
Natural varianti235 – 236LG → RA in minor form. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42352 mRNA Translation: AAB22817.1
PIRiA03364 LNNPG
S24044

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42352 mRNA Translation: AAB22817.1
PIRiA03364 LNNPG
S24044

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZWX-ray2.70A/B/C/D24-255[»]
1CIWX-ray2.70A/B/C/D24-259[»]
1CQ9X-ray3.50A/B/C/D24-259[»]
1CR7X-ray2.60A/B/C/D/E/F/G/H24-259[»]
1QF3X-ray2.80A/B/C/D24-259[»]
1RIRX-ray2.90A/B/C/D24-259[»]
1RITX-ray2.85A/B/C/D24-259[»]
1V6IX-ray2.15A/B/C/D24-255[»]
1V6JX-ray2.90A/B/C/D24-255[»]
1V6KX-ray2.40A/B/C/D24-255[»]
1V6LX-ray2.50A/B/C/D24-255[»]
1V6MX-ray2.70A/B/C/D/E/F/G/H24-255[»]
1V6NX-ray3.50A/B/C/D/E/F/G/H24-255[»]
1V6OX-ray3.00A/B/C/D/E/F/G/H24-255[»]
2DH1X-ray7.65A/B/C/D24-259[»]
2DV9X-ray2.48A/B/C/D24-259[»]
2DVAX-ray2.20A/B/C/D24-259[»]
2DVBX-ray2.25A/B/C/D24-259[»]
2DVDX-ray2.25A/B/C/D24-259[»]
2DVFX-ray2.74A/B/C/D24-259[»]
2DVGX-ray2.78A/B/C/D24-259[»]
2PELX-ray2.25A/B/C/D24-259[»]
2TEPX-ray2.50A/B/C/D24-259[»]
ProteinModelPortaliP02872
SMRiP02872
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02872, 1 interactor

Protein family/group databases

Allergomei1050 Ara h Agglutinin
UniLectiniP02872

Proteomic databases

PRIDEiP02872

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02872

Family and domain databases

CDDicd06899 lectin_legume_LecRK_Arcelin_Co, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR016363 L-lectin
IPR000985 Lectin_LegA_CS
IPR019825 Lectin_legB_Mn/Ca_BS
IPR001220 Legume_lectin_dom
PfamiView protein in Pfam
PF00139 Lectin_legB, 1 hit
PIRSFiPIRSF002690 L-type_lectin_plant, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00308 LECTIN_LEGUME_ALPHA, 1 hit
PS00307 LECTIN_LEGUME_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLECG_ARAHY
AccessioniPrimary (citable) accession number: P02872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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