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Protein

Larval cuticle protein 1

Gene

Lcp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the larval cuticle.

GO - Molecular functioni

  • structural constituent of chitin-based larval cuticle Source: FlyBase

GO - Biological processi

  • chitin-based cuticle development Source: FlyBase
  • larval chitin-based cuticle development Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Larval cuticle protein 1
Alternative name(s):
Larval cuticle protein I
Gene namesi
Name:Lcp1
ORF Names:CG11650
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002531 Lcp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000000638717 – 130Larval cuticle protein 1Add BLAST114

Proteomic databases

PaxDbiP02839

Expressioni

Gene expression databases

BgeeiFBgn0002531
ExpressionAtlasiP02839 baseline and differential
GenevisibleiP02839 DM

Interactioni

Protein-protein interaction databases

BioGridi61670, 7 interactors
DIPiDIP-18177N
IntActiP02839, 7 interactors
STRINGi7227.FBpp0305735

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 104Chitin-binding type R&RPROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 108Pro-rich7

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JPG1 Eukaryota
ENOG41119AX LUCA
GeneTreeiENSGT00900000141325
InParanoidiP02839
OMAiIAMICAV
OrthoDBiEOG091G0KRD
PhylomeDBiP02839

Family and domain databases

InterProiView protein in InterPro
IPR031311 CHIT_BIND_RR_consensus
IPR000618 Insect_cuticle
PfamiView protein in Pfam
PF00379 Chitin_bind_4, 1 hit
PROSITEiView protein in PROSITE
PS00233 CHIT_BIND_RR_1, 1 hit
PS51155 CHIT_BIND_RR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKFVMICAV LGLAVANPPV PHSLGRSEDV HADVLSQSDD VRADGFDSSL
60 70 80 90 100
HTSNGIEQAA SGDAHGNIHG NFGWISPEGE HVEVKYVANE NGYQPSGAWI
110 120 130
PTPPPIPEAI ARAVAWLESH PPAPEHPRHH
Length:130
Mass (Da):13,921
Last modified:November 2, 2001 - v3
Checksum:i0A20F5B9D2DC3F4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Q → R in CAA23487 (PubMed:6817923).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00202 Genomic DNA Translation: CAA23487.1
AE013599 Genomic DNA Translation: AAF59096.1
PIRiA03328 UCFF1L
A25299
RefSeqiNP_001260801.1, NM_001273872.2
NP_476619.1, NM_057271.4

Genome annotation databases

EnsemblMetazoaiFBtr0088763; FBpp0087841; FBgn0002531
FBtr0333557; FBpp0305735; FBgn0002531
GeneIDi35817
KEGGidme:Dmel_CG11650

Similar proteinsi

Entry informationi

Entry nameiLCP1_DROME
AccessioniPrimary (citable) accession number: P02839
Secondary accession number(s): Q24290, Q9V4S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 2, 2001
Last modified: July 18, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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