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UniProtKB - P02835 (FTZ_DROME)
Protein
Segmentation protein fushi tarazu
Gene
ftz
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May play a role in determining neuronal identity, may be directly involved in specifying identity of individual neurons. Required during embryogenesis for the process of body segmentation. Homeotic protein, required in alternating segment primordia, it specifies the correct number of segments.
3 PublicationsMiscellaneous
'Fushi tarazu' means 'segment deficient' in Japanese. Flies lacking ftz exhibit embryos with half the usual number of body segments.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 254 – 313 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: FlyBase
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: FlyBase
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- cell fate specification Source: FlyBase
- central nervous system development Source: FlyBase
- germ cell migration Source: FlyBase
- gonadal mesoderm development Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- periodic partitioning by pair rule gene Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of transcription, DNA-templated Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
- segmentation Source: FlyBase
Keywordsi
Molecular function | Developmental protein, DNA-binding, Pair-rule protein |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
SignaLinki | P02835 |
Names & Taxonomyi
Protein namesi | Recommended name: Segmentation protein fushi tarazu |
Gene namesi | Name:ftz ORF Names:CG2047 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0001077, ftz |
VEuPathDBi | VectorBase:FBgn0001077 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 208 | P → L in allele Ual2; half-life is increased. 1 Publication | 1 | |
Mutagenesisi | 212 | P → L in allele Ual1; half-life is increased. 1 Publication | 1 | |
Mutagenesisi | 212 | P → S in allele Ual3; half-life is increased. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049062 | 1 – 410 | Segmentation protein fushi tarazuAdd BLAST | 410 |
Post-translational modificationi
Phosphorylated at as many as 16 sites.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P02835 |
PTM databases
iPTMneti | P02835 |
Expressioni
Tissue specificityi
Expressed early in development in a striped pattern at the blastoderm stage. Later expressed in a specific subset of neuronal precursor cells, neurons and glia in the developing CNS. Between 5 and 6 hours of development, found in the midline precursor-2 cells in a segmentally repeating pattern. Expression in many other neuronal precursors follows and reaches a second peak of abundance at 9 hours of development. Expressed in the hindgut between 11-15 hours of development.
Developmental stagei
Expressed during embryonic development.1 Publication
Gene expression databases
Bgeei | FBgn0001077, Expressed in embryo and 32 other tissues |
Genevisiblei | P02835, DM |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 66032, 29 interactors |
DIPi | DIP-18500N |
IntActi | P02835, 14 interactors |
STRINGi | 7227.FBpp0081139 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P02835 |
SMRi | P02835 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02835 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 71 – 93 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 138 – 157 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 175 – 221 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 175 – 192 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 193 – 207 | Pro residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000175004 |
HOGENOMi | CLU_589608_0_0_1 |
InParanoidi | P02835 |
OMAi | CKDSKRT |
OrthoDBi | 858478at2759 |
PhylomeDBi | P02835 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
IDEALi | IID50242 |
InterProi | View protein in InterPro IPR005567, FTZ_N IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF03867, FTZ, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P02835-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTNSQSHY SYADNMNMYN MYHPHSLPPT YYDNSGSNAY YQNTSNYQGY
60 70 80 90 100
YPQESYSESC YYYNNQEQVT TQTVPPVQPT TPPPKATKRK AEDDAASIIA
110 120 130 140 150
AVEERPSTLR ALLTNPVKKL KYTPDYFYTT VEQVKKAPAV STKVTASPAP
160 170 180 190 200
SYDQEYVTVP TPSASEDVDY LDVYSPQSQT QKLKNGDFAT PPPTTPTSLP
210 220 230 240 250
PLEGISTPPQ SPGEKSSSAV SQEINHRIVT APNGAGDFNW SHIEETLASD
260 270 280 290 300
CKDSKRTRQT YTRYQTLELE KEFHFNRYIT RRRRIDIANA LSLSERQIKI
310 320 330 340 350
WFQNRRMKSK KDRTLDSSPE HCGAGYTAML PPLEATSTAT TGAPSVPVPM
360 370 380 390 400
YHHHQTTAAY PAYSHSHSHG YGLLNDYPQQ QTHQQYDAYP QQYQHQCSYQ
410
QHPQDLYHLS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | Y → YHSY in CAA25408 (PubMed:6330566).Curated | 1 | |
Sequence conflicti | 141 | S → T in CAA25408 (PubMed:6330566).Curated | 1 | |
Sequence conflicti | 247 – 249 | LAS → MLT in AAA28372 (PubMed:6327065).Curated | 3 | |
Sequence conflicti | 395 | H → Q in CAA25408 (PubMed:6330566).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00854 Genomic DNA Translation: CAA25408.1 AE014297 Genomic DNA Translation: AAF54081.1 BT022173 mRNA Translation: AAY51567.1 AE001572 Genomic DNA Translation: AAD19794.1 X78905 Genomic DNA Translation: CAA55518.1 K01947 Genomic DNA Translation: AAA28372.1 |
PIRi | A93334, WJFFFT |
RefSeqi | NP_477498.1, NM_058150.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0081625; FBpp0081139; FBgn0001077 |
GeneIDi | 40834 |
KEGGi | dme:Dmel_CG2047 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00854 Genomic DNA Translation: CAA25408.1 AE014297 Genomic DNA Translation: AAF54081.1 BT022173 mRNA Translation: AAY51567.1 AE001572 Genomic DNA Translation: AAD19794.1 X78905 Genomic DNA Translation: CAA55518.1 K01947 Genomic DNA Translation: AAA28372.1 |
PIRi | A93334, WJFFFT |
RefSeqi | NP_477498.1, NM_058150.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FTZ | NMR | - | A | 253-321 | [»] | |
2XHS | X-ray | 2.80 | B | 107-115 | [»] | |
AlphaFoldDBi | P02835 | |||||
SMRi | P02835 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 66032, 29 interactors |
DIPi | DIP-18500N |
IntActi | P02835, 14 interactors |
STRINGi | 7227.FBpp0081139 |
PTM databases
iPTMneti | P02835 |
Proteomic databases
PaxDbi | P02835 |
Protocols and materials databases
DNASUi | 40834 |
Genome annotation databases
EnsemblMetazoai | FBtr0081625; FBpp0081139; FBgn0001077 |
GeneIDi | 40834 |
KEGGi | dme:Dmel_CG2047 |
Organism-specific databases
CTDi | 40834 |
FlyBasei | FBgn0001077, ftz |
VEuPathDBi | VectorBase:FBgn0001077 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000175004 |
HOGENOMi | CLU_589608_0_0_1 |
InParanoidi | P02835 |
OMAi | CKDSKRT |
OrthoDBi | 858478at2759 |
PhylomeDBi | P02835 |
Enzyme and pathway databases
SignaLinki | P02835 |
Miscellaneous databases
BioGRID-ORCSi | 40834, 0 hits in 1 CRISPR screen |
EvolutionaryTracei | P02835 |
GenomeRNAii | 40834 |
PROi | PR:P02835 |
Gene expression databases
Bgeei | FBgn0001077, Expressed in embryo and 32 other tissues |
Genevisiblei | P02835, DM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
IDEALi | IID50242 |
InterProi | View protein in InterPro IPR005567, FTZ_N IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF03867, FTZ, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FTZ_DROME | |
Accessioni | P02835Primary (citable) accession number: P02835 Secondary accession number(s): O96929, Q4V6Y3, Q9V3W3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 25, 2002 | |
Last modified: | May 25, 2022 | |
This is version 212 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families