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Protein

Homeobox protein Hox-A3

Gene

Hoxa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 251HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: MGI
  • HMG box domain binding Source: UniProtKB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A3
Alternative name(s):
Homeobox protein Hox-1.5
Homeobox protein MO-10
Gene namesi
Name:Hoxa3
Synonyms:Hox-1.5, Hoxa-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96175 Hoxa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000441 – 443Homeobox protein Hox-A3Add BLAST443

Proteomic databases

MaxQBiP02831
PaxDbiP02831
PRIDEiP02831

PTM databases

iPTMnetiP02831
PhosphoSitePlusiP02831

Expressioni

Developmental stagei

Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000079560 Expressed in 214 organ(s), highest expression level in ascending aorta
CleanExiMM_HOXA3
ExpressionAtlasiP02831 baseline and differential
GenevisibleiP02831 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200368, 1 interactor
STRINGi10090.ENSMUSP00000110077

Structurei

3D structure databases

ProteinModelPortaliP02831
SMRiP02831
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi156 – 161Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 138Pro-richAdd BLAST60

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP02831
KOiK09303
OMAiYNASQQP
OrthoDBiEOG091G0PFO
PhylomeDBiP02831
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02831-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA
60 70 80 90 100
CSLQSPASAG GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP
110 120 130 140 150
PAPQPPQPPP QPPAPTPAAP PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP
160 170 180 190 200
TVGKQIFPWM KESRQNTKQK TSGSSSGESC AGDKSPPGQA SSKRARTAYT
210 220 230 240 250
SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF QNRRMKYKKD
260 270 280 290 300
QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK
310 320 330 340 350
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL
360 370 380 390 400
QGNGSYGTPH LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG
410 420 430 440
TGPLGSGHHH GPGPGEPHPT YTDLTAHHPS QGRIQEAPKL THL
Length:443
Mass (Da):46,430
Last modified:November 1, 1997 - v2
Checksum:i6C0E184B0F6F2D40
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YV38D3YV38_MOUSE
Homeobox protein Hox-A3
Hoxa3
26Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185S → G (Ref. 4) Curated1
Sequence conflicti185S → G (PubMed:6091896).Curated1
Sequence conflicti195A → G (Ref. 4) Curated1
Sequence conflicti195A → G (PubMed:6091896).Curated1
Sequence conflicti201 – 202SA → RP (Ref. 4) Curated2
Sequence conflicti201 – 202SA → RP (PubMed:6091896).Curated2
Sequence conflicti218C → M (Ref. 4) Curated1
Sequence conflicti218C → M (PubMed:6091896).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11717 mRNA Translation: CAA72404.1
BC096612 mRNA Translation: AAH96612.1
U56399 mRNA Translation: AAC52778.1
K02591 Genomic DNA Translation: AAA37822.1
CCDSiCCDS20140.1
PIRiI49746
RefSeqiNP_034582.1, NM_010452.3
XP_011239527.1, XM_011241225.2
XP_017176891.1, XM_017321402.1
XP_017176892.1, XM_017321403.1
XP_017176893.1, XM_017321404.1
UniGeneiMm.483277
Mm.71533

Genome annotation databases

EnsembliENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560
GeneIDi15400
KEGGimmu:15400
UCSCiuc009bya.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11717 mRNA Translation: CAA72404.1
BC096612 mRNA Translation: AAH96612.1
U56399 mRNA Translation: AAC52778.1
K02591 Genomic DNA Translation: AAA37822.1
CCDSiCCDS20140.1
PIRiI49746
RefSeqiNP_034582.1, NM_010452.3
XP_011239527.1, XM_011241225.2
XP_017176891.1, XM_017321402.1
XP_017176892.1, XM_017321403.1
XP_017176893.1, XM_017321404.1
UniGeneiMm.483277
Mm.71533

3D structure databases

ProteinModelPortaliP02831
SMRiP02831
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200368, 1 interactor
STRINGi10090.ENSMUSP00000110077

PTM databases

iPTMnetiP02831
PhosphoSitePlusiP02831

Proteomic databases

MaxQBiP02831
PaxDbiP02831
PRIDEiP02831

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560
GeneIDi15400
KEGGimmu:15400
UCSCiuc009bya.2 mouse

Organism-specific databases

CTDi3200
MGIiMGI:96175 Hoxa3

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP02831
KOiK09303
OMAiYNASQQP
OrthoDBiEOG091G0PFO
PhylomeDBiP02831
TreeFamiTF315938

Miscellaneous databases

PROiPR:P02831
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079560 Expressed in 214 organ(s), highest expression level in ascending aorta
CleanExiMM_HOXA3
ExpressionAtlasiP02831 baseline and differential
GenevisibleiP02831 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA3_MOUSE
AccessioniPrimary (citable) accession number: P02831
Secondary accession number(s): Q4V9Z8, Q61197
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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