Hoxa3

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	192 – 251	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 21170035
HMG box domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16582099
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
animal organ formation
Source: MGI
Inferred from mutant phenotypeⁱ
- 7635047
animal organ morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 15100241
anterior/posterior pattern specification
Source: MGI
Inferred from genetic interactionⁱ
- 7913519
- 9441667
blood vessel remodeling
Source: MGI
Inferred from mutant phenotypeⁱ
- 15714286
bone mineralization
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
calcium ion homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
calcium ion transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
cartilage development
Source: MGI
Inferred from genetic interactionⁱ
- 9441667
embryonic skeletal system development
Source: MGI
Inferred from genetic interactionⁱ
- 7913519
embryonic skeletal system morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 9441667
gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
glossopharyngeal nerve morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 9441667
magnesium ion homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
negative regulation of calcium ion transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
parathyroid gland development
Source: MGI
Inferred from genetic interactionⁱ
- 11476574
phosphate ion homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
positive regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15714286
positive regulation of receptor binding
Source: MGI
Inferred from mutant phenotypeⁱ
- 19968565
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
specification of animal organ position
Source: MGI
Inferred from genetic interactionⁱ
- 9520319
thymus development
Source: MGI
Inferred from mutant phenotypeⁱ
- 7635047
thyroid gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 7635047
- 9520319

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-A3 Alternative name(s): Homeobox protein Hox-1.5 Homeobox protein MO-10
Gene namesⁱ	Name:Hoxa3 Synonyms:Hox-1.5, Hoxa-3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:96175 Hoxa3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200044	1 – 443	Homeobox protein Hox-A3Add BLAST		443

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02831
PaxDbⁱ	P02831
PRIDEⁱ	P02831

PTM databases

iPTMnetⁱ	P02831
PhosphoSitePlusⁱ	P02831

Expressionⁱ

Developmental stageⁱ

Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000079560 Expressed in 214 organ(s), highest expression level in ascending aorta
CleanExⁱ	MM_HOXA3
ExpressionAtlasⁱ	P02831 baseline and differential
Genevisibleⁱ	P02831 MM

Interactionⁱ

GO - Molecular functionⁱ

HMG box domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16582099

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200368, 1 interactor
STRINGⁱ	10090.ENSMUSP00000110077

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P02831
SMRⁱ	P02831
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	156 – 161	Antp-type hexapeptide		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	79 – 138	Pro-richAdd BLAST		60

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144005
HOGENOMⁱ	HOG000252944
HOVERGENⁱ	HBG107984
InParanoidⁱ	P02831
KEGG Orthology (KO) More...KOⁱ	K09303
OMAⁱ	YNASQQP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PFO
PhylomeDBⁱ	P02831
TreeFamⁱ	TF315938

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR025281 DUF4074 IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13293 DUF4074, 1 hit PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P02831-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA 
        60         70         80         90        100
CSLQSPASAG GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP 
       110        120        130        140        150
PAPQPPQPPP QPPAPTPAAP PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP 
       160        170        180        190        200
TVGKQIFPWM KESRQNTKQK TSGSSSGESC AGDKSPPGQA SSKRARTAYT 
       210        220        230        240        250
SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF QNRRMKYKKD 
       260        270        280        290        300
QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK 
       310        320        330        340        350
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL 
       360        370        380        390        400
QGNGSYGTPH LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG 
       410        420        430        440 
TGPLGSGHHH GPGPGEPHPT YTDLTAHHPS QGRIQEAPKL THL

Length:443

Mass (Da):46,430

Last modified:November 1, 1997 - v2

Checksum:ⁱ6C0E184B0F6F2D40

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3YV38	D3YV38_MOUSE		Homeobox protein Hox-A3 Homeobox protein Hox-A3	Hoxa3	26	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	185	S → G (Ref. 4) Curated	1
Sequence conflictⁱ	185	S → G (PubMed:6091896).Curated	1
Sequence conflictⁱ	195	A → G (Ref. 4) Curated	1
Sequence conflictⁱ	195	A → G (PubMed:6091896).Curated	1
Sequence conflictⁱ	201 – 202	SA → RP (Ref. 4) Curated	2
Sequence conflictⁱ	201 – 202	SA → RP (PubMed:6091896).Curated	2
Sequence conflictⁱ	218	C → M (Ref. 4) Curated	1
Sequence conflictⁱ	218	C → M (PubMed:6091896).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11717 mRNA Translation: CAA72404.1 BC096612 mRNA Translation: AAH96612.1 U56399 mRNA Translation: AAC52778.1 K02591 Genomic DNA Translation: AAA37822.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20140.1
PIRⁱ	I49746
NCBI Reference Sequences More...RefSeqⁱ	NP_034582.1, NM_010452.3 XP_011239527.1, XM_011241225.2 XP_017176891.1, XM_017321402.1 XP_017176892.1, XM_017321403.1 XP_017176893.1, XM_017321404.1
UniGeneⁱ	Mm.483277 Mm.71533

Genome annotation databases

Ensemblⁱ	ENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560
GeneIDⁱ	15400
KEGGⁱ	mmu:15400
UCSC genome browser More...UCSCⁱ	uc009bya.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02831	Homeobox protein Hox-A3		HUMAN		443	UniRef90_P02831
homeobox protein Hox-A3		MESAU		445
homeobox protein Hox-A3		ERIEU		444
Homeobox A3		CAVPO		444
Uncharacterized protein		PROCO		444
+78

Protein	Similar proteins		Species	Score	Length	Source
P02831	Homeobox protein Hox-A3		HUMAN		443	UniRef50_P02831
Homeobox protein Hox-A3		BOVIN		442
Homeobox protein Hox-A3		HETFR		410
homeobox protein Hox-A3		MESAU		445
Uncharacterized protein		Cebus capucinus imitator		444
+154

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11717 mRNA Translation: CAA72404.1 BC096612 mRNA Translation: AAH96612.1 U56399 mRNA Translation: AAC52778.1 K02591 Genomic DNA Translation: AAA37822.1
CCDSⁱ	CCDS20140.1
PIRⁱ	I49746
RefSeqⁱ	NP_034582.1, NM_010452.3 XP_011239527.1, XM_011241225.2 XP_017176891.1, XM_017321402.1 XP_017176892.1, XM_017321403.1 XP_017176893.1, XM_017321404.1
UniGeneⁱ	Mm.483277 Mm.71533

3D structure databases

ProteinModelPortalⁱ	P02831
SMRⁱ	P02831
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200368, 1 interactor
STRINGⁱ	10090.ENSMUSP00000110077

PTM databases

iPTMnetⁱ	P02831
PhosphoSitePlusⁱ	P02831

Proteomic databases

MaxQBⁱ	P02831
PaxDbⁱ	P02831
PRIDEⁱ	P02831

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560
GeneIDⁱ	15400
KEGGⁱ	mmu:15400
UCSCⁱ	uc009bya.2 mouse

Organism-specific databases

CTDⁱ	3200
MGIⁱ	MGI:96175 Hoxa3

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000144005
HOGENOMⁱ	HOG000252944
HOVERGENⁱ	HBG107984
InParanoidⁱ	P02831
KOⁱ	K09303
OMAⁱ	YNASQQP
OrthoDBⁱ	EOG091G0PFO
PhylomeDBⁱ	P02831
TreeFamⁱ	TF315938

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P02831
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000079560 Expressed in 214 organ(s), highest expression level in ascending aorta
CleanExⁱ	MM_HOXA3
ExpressionAtlasⁱ	P02831 baseline and differential
Genevisibleⁱ	P02831 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR025281 DUF4074 IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF13293 DUF4074, 1 hit PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXA3_MOUSE
Accessionⁱ	P02831Primary (citable) accession number: P02831 Secondary accession number(s): Q4V9Z8, Q61197
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Supporting data

UniProtKB - P02831 (HXA3_MOUSE)

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Homeobox protein Hox-A3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ