UniProtKB - P02831 (HXA3_MOUSE)
Protein
Homeobox protein Hox-A3
Gene
Hoxa3
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 192 – 251 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- HMG box domain binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- angiogenesis Source: Ensembl
- animal organ formation Source: MGI
- animal organ morphogenesis Source: MGI
- anterior/posterior pattern specification Source: MGI
- blood vessel remodeling Source: MGI
- cartilage development Source: MGI
- embryonic skeletal system development Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- gene expression Source: MGI
- glossopharyngeal nerve morphogenesis Source: MGI
- parathyroid gland development Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of receptor binding Source: MGI
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- specification of animal organ position Source: MGI
- thymus development Source: MGI
- thyroid gland development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-A3Alternative name(s): Homeobox protein Hox-1.5 Homeobox protein MO-10 |
Gene namesi | Name:Hoxa3 Synonyms:Hox-1.5, Hoxa-3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96175, Hoxa3 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200044 | 1 – 443 | Homeobox protein Hox-A3Add BLAST | 443 |
Proteomic databases
MaxQBi | P02831 |
PaxDbi | P02831 |
PRIDEi | P02831 |
PTM databases
iPTMneti | P02831 |
PhosphoSitePlusi | P02831 |
Expressioni
Developmental stagei
Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000079560, Expressed in ascending aorta and 230 other tissues |
ExpressionAtlasi | P02831, baseline and differential |
Genevisiblei | P02831, MM |
Interactioni
GO - Molecular functioni
- HMG box domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 200368, 1 interactor |
STRINGi | 10090.ENSMUSP00000110077 |
Miscellaneous databases
RNActi | P02831, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 156 – 161 | Antp-type hexapeptide | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 79 – 138 | Pro-richAdd BLAST | 60 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000159522 |
HOGENOMi | CLU_051508_1_0_1 |
InParanoidi | P02831 |
OMAi | GNYGTHM |
OrthoDBi | 934469at2759 |
PhylomeDBi | P02831 |
TreeFami | TF315938 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR025281, DUF4074 IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF13293, DUF4074, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P02831-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA
60 70 80 90 100
CSLQSPASAG GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP
110 120 130 140 150
PAPQPPQPPP QPPAPTPAAP PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP
160 170 180 190 200
TVGKQIFPWM KESRQNTKQK TSGSSSGESC AGDKSPPGQA SSKRARTAYT
210 220 230 240 250
SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF QNRRMKYKKD
260 270 280 290 300
QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK
310 320 330 340 350
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL
360 370 380 390 400
QGNGSYGTPH LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG
410 420 430 440
TGPLGSGHHH GPGPGEPHPT YTDLTAHHPS QGRIQEAPKL THL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YV38 | D3YV38_MOUSE | Homeobox protein Hox-A3 | Hoxa3 | 26 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 185 | S → G (Ref. 4) Curated | 1 | |
Sequence conflicti | 185 | S → G (PubMed:6091896).Curated | 1 | |
Sequence conflicti | 195 | A → G (Ref. 4) Curated | 1 | |
Sequence conflicti | 195 | A → G (PubMed:6091896).Curated | 1 | |
Sequence conflicti | 201 – 202 | SA → RP (Ref. 4) Curated | 2 | |
Sequence conflicti | 201 – 202 | SA → RP (PubMed:6091896).Curated | 2 | |
Sequence conflicti | 218 | C → M (Ref. 4) Curated | 1 | |
Sequence conflicti | 218 | C → M (PubMed:6091896).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11717 mRNA Translation: CAA72404.1 BC096612 mRNA Translation: AAH96612.1 U56399 mRNA Translation: AAC52778.1 K02591 Genomic DNA Translation: AAA37822.1 |
CCDSi | CCDS20140.1 |
PIRi | I49746 |
RefSeqi | NP_034582.1, NM_010452.3 XP_011239527.1, XM_011241225.2 XP_017176891.1, XM_017321402.1 XP_017176892.1, XM_017321403.1 XP_017176893.1, XM_017321404.1 |
Genome annotation databases
Ensembli | ENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560 |
GeneIDi | 15400 |
KEGGi | mmu:15400 |
UCSCi | uc009bya.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11717 mRNA Translation: CAA72404.1 BC096612 mRNA Translation: AAH96612.1 U56399 mRNA Translation: AAC52778.1 K02591 Genomic DNA Translation: AAA37822.1 |
CCDSi | CCDS20140.1 |
PIRi | I49746 |
RefSeqi | NP_034582.1, NM_010452.3 XP_011239527.1, XM_011241225.2 XP_017176891.1, XM_017321402.1 XP_017176892.1, XM_017321403.1 XP_017176893.1, XM_017321404.1 |
3D structure databases
SMRi | P02831 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200368, 1 interactor |
STRINGi | 10090.ENSMUSP00000110077 |
PTM databases
iPTMneti | P02831 |
PhosphoSitePlusi | P02831 |
Proteomic databases
MaxQBi | P02831 |
PaxDbi | P02831 |
PRIDEi | P02831 |
Protocols and materials databases
Antibodypediai | 12366, 192 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560 |
GeneIDi | 15400 |
KEGGi | mmu:15400 |
UCSCi | uc009bya.2, mouse |
Organism-specific databases
CTDi | 3200 |
MGIi | MGI:96175, Hoxa3 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000159522 |
HOGENOMi | CLU_051508_1_0_1 |
InParanoidi | P02831 |
OMAi | GNYGTHM |
OrthoDBi | 934469at2759 |
PhylomeDBi | P02831 |
TreeFami | TF315938 |
Miscellaneous databases
BioGRID-ORCSi | 15400, 6 hits in 17 CRISPR screens |
ChiTaRSi | Hoxa3, mouse |
PROi | PR:P02831 |
RNActi | P02831, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000079560, Expressed in ascending aorta and 230 other tissues |
ExpressionAtlasi | P02831, baseline and differential |
Genevisiblei | P02831, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR025281, DUF4074 IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF13293, DUF4074, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXA3_MOUSE | |
Accessioni | P02831Primary (citable) accession number: P02831 Secondary accession number(s): Q4V9Z8, Q61197 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries