Homeobox protein Hox-A3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "HoxA3 is an apical regulator of haemogenic endothelium."
    Iacovino M., Chong D., Szatmari I., Hartweck L., Rux D., Caprioli A., Cleaver O., Kyba M.
    Nat. Cell Biol. 13:72-78(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
• HMG box domain binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res. 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis Source: Ensembl
• animal organ formation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The role of Hoxa-3 in mouse thymus and thyroid development."
    Manley N.R., Capecchi M.R.
    Development 121:1989-2003(1995) [PubMed] [Europe PMC] [Abstract]
• animal organ morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The role of Hoxa3 gene in parathyroid gland organogenesis of the mouse."
    Kameda Y., Arai Y., Nishimaki T., Chisaka O.
    J. Histochem. Cytochem. 52:641-651(2004) [PubMed] [Europe PMC] [Abstract]
• anterior/posterior pattern specification Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions."
    Condie B.G., Capecchi M.R.
    Nature 370:304-307(1994) [PubMed] [Europe PMC] [Abstract]
  • "Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures."
    Manley N.R., Capecchi M.R.
    Dev. Biol. 192:274-288(1997) [PubMed] [Europe PMC] [Abstract]
• blood vessel remodeling Source: MGIInferred from mutant phenotypeⁱ
  • "Hoxa3 regulates the proliferation and differentiation of the third pharyngeal arch mesenchyme in mice."
    Chisaka O., Kameda Y.
    Cell Tissue Res. 320:77-89(2005) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: MGIInferred from genetic interactionⁱ
  • "Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures."
    Manley N.R., Capecchi M.R.
    Dev. Biol. 192:274-288(1997) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system development Source: MGIInferred from genetic interactionⁱ
  • "Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions."
    Condie B.G., Capecchi M.R.
    Nature 370:304-307(1994) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures."
    Manley N.R., Capecchi M.R.
    Dev. Biol. 192:274-288(1997) [PubMed] [Europe PMC] [Abstract]
• gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Parathyroid hormone regulates fetal-placental mineral homeostasis."
    Simmonds C.S., Karsenty G., Karaplis A.C., Kovacs C.S.
    J. Bone Miner. Res. 25:594-605(2010) [PubMed] [Europe PMC] [Abstract]
• glossopharyngeal nerve morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures."
    Manley N.R., Capecchi M.R.
    Dev. Biol. 192:274-288(1997) [PubMed] [Europe PMC] [Abstract]
• parathyroid gland development Source: MGIInferred from genetic interactionⁱ
  • "Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis."
    Su D., Ellis S., Napier A., Lee K., Manley N.R.
    Dev. Biol. 236:316-329(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Hoxa3 regulates the proliferation and differentiation of the third pharyngeal arch mesenchyme in mice."
    Chisaka O., Kameda Y.
    Cell Tissue Res. 320:77-89(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor binding Source: MGIInferred from mutant phenotypeⁱ
  • "Parathyroid hormone regulates fetal-placental mineral homeostasis."
    Simmonds C.S., Karsenty G., Karaplis A.C., Kovacs C.S.
    J. Bone Miner. Res. 25:594-605(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• specification of animal organ position Source: MGIInferred from genetic interactionⁱ
  • "Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands."
    Manley N.R., Capecchi M.R.
    Dev. Biol. 195:1-15(1998) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: MGIInferred from mutant phenotypeⁱ
  • "The role of Hoxa-3 in mouse thymus and thyroid development."
    Manley N.R., Capecchi M.R.
    Development 121:1989-2003(1995) [PubMed] [Europe PMC] [Abstract]
• thyroid gland development Source: MGIInferred from mutant phenotypeⁱ
  • "The role of Hoxa-3 in mouse thymus and thyroid development."
    Manley N.R., Capecchi M.R.
    Development 121:1989-2003(1995) [PubMed] [Europe PMC] [Abstract]
  • "Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands."
    Manley N.R., Capecchi M.R.
    Dev. Biol. 195:1-15(1998) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• HMG box domain binding Source: UniProtKBInferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res. 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA 
        60         70         80         90        100
CSLQSPASAG GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP 
       110        120        130        140        150
PAPQPPQPPP QPPAPTPAAP PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP 
       160        170        180        190        200
TVGKQIFPWM KESRQNTKQK TSGSSSGESC AGDKSPPGQA SSKRARTAYT 
       210        220        230        240        250
SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF QNRRMKYKKD 
       260        270        280        290        300
QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK 
       310        320        330        340        350
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL 
       360        370        380        390        400
QGNGSYGTPH LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG 
       410        420        430        440 
TGPLGSGHHH GPGPGEPHPT YTDLTAHHPS QGRIQEAPKL THL        

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families
3. Vertebrate homeotic Hox proteins
   Nomenclature of vertebrate homeotic Hox proteins and list of entries