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Entry version 199 (16 Oct 2019)
Sequence version 1 (13 Aug 1987)
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Protein

Heat shock protein 83

Gene

Hsp83

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39ATPBy similarity1
Binding sitei81ATPBy similarity1
Binding sitei100ATPBy similarity1
Binding sitei126ATP; via amide nitrogenBy similarity1
Binding sitei385ATPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-203615 eNOS activation
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-3371511 HSF1 activation
R-DME-3371568 Attenuation phase
R-DME-3371571 HSF1-dependent transactivation
R-DME-399954 Sema3A PAK dependent Axon repulsion
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-6798695 Neutrophil degranulation
R-DME-844456 The NLRP3 inflammasome
R-DME-8863795 Downregulation of ERBB2 signaling
R-DME-8937144 Aryl hydrocarbon receptor signalling
R-DME-8939211 ESR-mediated signaling
R-DME-9009391 Extra-nuclear estrogen signaling
R-DME-9018519 Estrogen-dependent gene expression
R-DME-9613829 Chaperone Mediated Autophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat shock protein 83
Alternative name(s):
HSP 82
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hsp83
Synonyms:Hsp82
ORF Names:CG1242
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001233 Hsp83

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000629301 – 717Heat shock protein 83Add BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei219Phosphoserine1 Publication1
Modified residuei294Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02828

PRoteomics IDEntifications database

More...
PRIDEi
P02828

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02828

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In contrast to other major heat shock proteins, this one is also expressed at normal growth temperatures. It is also developmentally expressed during oogenesis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0001233 Expressed in 65 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02828 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02828 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Forms a complex with Hop and piwi; probably Hop mediates the interaction between piwi and Hsp83 (PubMed:21186352).

Interacts with shu (PubMed:22902557).

Interacts with Nup358 (via TPR repeats); the interaction is required for the nuclear import of the sesquiterpenoid juvenile hormone receptor Met (PubMed:27979731).

Forms a complex with Dpit47 and Hsp70aa (PubMed:11493638).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P922042EBI-136814,EBI-194490

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
63886, 77 interactors

Database of interacting proteins

More...
DIPi
DIP-17366N

Protein interaction database and analysis system

More...
IntActi
P02828, 5 interactors

Molecular INTeraction database

More...
MINTi
P02828

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305095

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02828

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi713 – 717TPR repeat-binding5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0020 Eukaryota
COG0326 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182747

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000263872

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02828

KEGG Orthology (KO)

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KOi
K04079

Identification of Orthologs from Complete Genome Data

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OMAi
VKRHSEF

Database of Orthologous Groups

More...
OrthoDBi
924636at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02828

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.790, 1 hit
3.30.565.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00505 HSP90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold

The PANTHER Classification System

More...
PANTHERi
PTHR11528 PTHR11528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002583 Hsp90, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00775 HEATSHOCK90

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00387 HATPase_c, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00298 HSP90, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02828-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEEAETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNA SDALDKIRYE
60 70 80 90 100
SLTDPSKLDS GKELYIKLIP NKTAGTLTII DTGIGMTKSD LVNNLGTIAK
110 120 130 140 150
SGTKAFMEAL QAGADISMIG QFGVGFYSAY LVADKVTVTS KNNDDEQYVW
160 170 180 190 200
ESSAGGSFTV RADNSEPLGR GTKIVLYIKE DQTDYLEESK IKEIVNKHSQ
210 220 230 240 250
FIGYPIKLLV EKEREKEVSD DEADDEKKEG DEKKEMETDE PKIEDVGEDE
260 270 280 290 300
DADKKDKDAK KKKTIKEKYT EDEELNKTKP IWTRNPDDIS QEEYGEFYKS
310 320 330 340 350
LTNDWEDHLA VKHFSVEGQL EFRALLFIPR RTPFDLFENQ KKRNNIKLYV
360 370 380 390 400
RRVFIMDNCE DLIPEYLNFM KGVVDSEDLP LNISREMLQQ NKVLKVIRKN
410 420 430 440 450
LVKKTMELIE ELTEDKENYK KFYDQFSKNL KLGVHEDSNN RAKLADFLRF
460 470 480 490 500
HTSASGDDFC SLADYVSRMK DNQKHVYFIT GESKDQVSNS AFVERVKARG
510 520 530 540 550
FEVVYMTEPI DEYVIQHLKE YKGKQLVSVT KEGLELPEDE SEKKKREEDK
560 570 580 590 600
AKFESLCKLM KSILDNKVEK VVVSNRLVDS PCCIVTSQFG WSANMERIMK
610 620 630 640 650
AQALRDTATM GYMAGKKQLE INPDHPIVET LRQKADADKN DKAVKDLVIL
660 670 680 690 700
LFETSLLSSG FSLDSPQVHA SRIYRMIKLG LGIDEDEPMT TDDAQSAGDA
710
PSLVEDTEDA SHMEEVD
Length:717
Mass (Da):81,865
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA71B96B2FE1684E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PBL3M9PBL3_DROME
Heat shock protein 83, isoform B
Hsp83 143198_at, 4C, 83, 83K HSP, anon-EST:Liang-2.53
717Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti234Missing in strain: MA-10.2, DPF-13, DPF-82.1, EM-10, 178.7, 709.6 and MA-4.4. 1
Natural varianti368N → K in strain: DPF-2, DPF-30, DPF-62, MA-10.2, DPF-82.1, 178.7, DPF-13, MA-4.4, EM-10, VC-805, MA-4.2, DPF-46, DPF-77, VC-815 and 709.6. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X03810 Genomic DNA Translation: CAA27435.1
X00065 Genomic DNA Translation: CAA24938.1
AE014296 Genomic DNA Translation: AAF47734.1
AY122080 mRNA Translation: AAM52592.1
U57459 Genomic DNA Translation: AAB46677.1
U57460 Genomic DNA Translation: AAB46678.1
U57461 Genomic DNA Translation: AAB46679.1
U57462 Genomic DNA Translation: AAB46680.1
U57463 Genomic DNA Translation: AAB46681.1
U57464 Genomic DNA Translation: AAB46682.1
U57465 Genomic DNA Translation: AAB46683.1
U57466 Genomic DNA Translation: AAB46684.1
U57467 Genomic DNA Translation: AAB46685.1
U57468 Genomic DNA Translation: AAB46686.1
U57469 Genomic DNA Translation: AAB46687.1
U57470 Genomic DNA Translation: AAB46688.1
U57471 Genomic DNA Translation: AAB46689.1
U57472 Genomic DNA Translation: AAB46690.1
U57473 Genomic DNA Translation: AAB46691.1

Protein sequence database of the Protein Information Resource

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PIRi
A24827 HHFF83

NCBI Reference Sequences

More...
RefSeqi
NP_001261362.1, NM_001274433.1
NP_523899.1, NM_079175.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073040; FBpp0072904; FBgn0001233
FBtr0332873; FBpp0305095; FBgn0001233

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1242

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03810 Genomic DNA Translation: CAA27435.1
X00065 Genomic DNA Translation: CAA24938.1
AE014296 Genomic DNA Translation: AAF47734.1
AY122080 mRNA Translation: AAM52592.1
U57459 Genomic DNA Translation: AAB46677.1
U57460 Genomic DNA Translation: AAB46678.1
U57461 Genomic DNA Translation: AAB46679.1
U57462 Genomic DNA Translation: AAB46680.1
U57463 Genomic DNA Translation: AAB46681.1
U57464 Genomic DNA Translation: AAB46682.1
U57465 Genomic DNA Translation: AAB46683.1
U57466 Genomic DNA Translation: AAB46684.1
U57467 Genomic DNA Translation: AAB46685.1
U57468 Genomic DNA Translation: AAB46686.1
U57469 Genomic DNA Translation: AAB46687.1
U57470 Genomic DNA Translation: AAB46688.1
U57471 Genomic DNA Translation: AAB46689.1
U57472 Genomic DNA Translation: AAB46690.1
U57473 Genomic DNA Translation: AAB46691.1
PIRiA24827 HHFF83
RefSeqiNP_001261362.1, NM_001274433.1
NP_523899.1, NM_079175.4

3D structure databases

SMRiP02828
ModBaseiSearch...

Protein-protein interaction databases

BioGridi63886, 77 interactors
DIPiDIP-17366N
IntActiP02828, 5 interactors
MINTiP02828
STRINGi7227.FBpp0305095

PTM databases

iPTMnetiP02828

Proteomic databases

PaxDbiP02828
PRIDEiP02828

Genome annotation databases

EnsemblMetazoaiFBtr0073040; FBpp0072904; FBgn0001233
FBtr0332873; FBpp0305095; FBgn0001233
GeneIDi38389
KEGGidme:Dmel_CG1242

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38389
FlyBaseiFBgn0001233 Hsp83

Phylogenomic databases

eggNOGiKOG0020 Eukaryota
COG0326 LUCA
GeneTreeiENSGT00950000182747
HOGENOMiHOG000263872
InParanoidiP02828
KOiK04079
OMAiVKRHSEF
OrthoDBi924636at2759
PhylomeDBiP02828

Enzyme and pathway databases

ReactomeiR-DME-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-203615 eNOS activation
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-3371511 HSF1 activation
R-DME-3371568 Attenuation phase
R-DME-3371571 HSF1-dependent transactivation
R-DME-399954 Sema3A PAK dependent Axon repulsion
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-6798695 Neutrophil degranulation
R-DME-844456 The NLRP3 inflammasome
R-DME-8863795 Downregulation of ERBB2 signaling
R-DME-8937144 Aryl hydrocarbon receptor signalling
R-DME-8939211 ESR-mediated signaling
R-DME-9009391 Extra-nuclear estrogen signaling
R-DME-9018519 Estrogen-dependent gene expression
R-DME-9613829 Chaperone Mediated Autophagy

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hsp83 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
38389

Protein Ontology

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PROi
PR:P02828

Gene expression databases

BgeeiFBgn0001233 Expressed in 65 organ(s), highest expression level in oocyte
ExpressionAtlasiP02828 baseline and differential
GenevisibleiP02828 DM

Family and domain databases

Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSP83_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02828
Secondary accession number(s): P92174, P92202, Q9VZT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: October 16, 2019
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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