Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major heat shock 70 kDa protein Ab

Gene

Hsp70Ab

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two copies of the gene coding for this protein at chromosome locus 87A7.

GO - Molecular functioni

GO - Biological processi

  • heat shock-mediated polytene chromosome puffing Source: FlyBase
  • response to heat Source: FlyBase
  • response to hypoxia Source: FlyBase
  • response to unfolded protein Source: UniProtKB

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Ab
Short name:
Heat shock protein 70Ab
Alternative name(s):
HSP70-87A7
Gene namesi
Name:Hsp70Ab
Synonyms:Hsp70A
ORF Names:CG18743
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013276 Hsp70Ab

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783301 – 642Major heat shock 70 kDa protein AbAdd BLAST642

Proteomic databases

PRIDEiP02825

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

BgeeiFBgn0013275
GenevisibleiP02825 DM

Interactioni

Protein-protein interaction databases

BioGridi69381, 46 interactors
71511, 57 interactors
IntActiP02825, 44 interactors

Structurei

3D structure databases

ProteinModelPortaliP02825
SMRiP02825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
InParanoidiP02825
KOiK03283
OrthoDBiEOG091G03SF
PhylomeDBiP02825

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P02825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA DEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQD
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYA DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQA
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNDTIRWLDS NTTAEKEEFD HKLEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAGAGGPG ANCGQQAGGF GGYSGPTVEE VD
Length:642
Mass (Da):70,160
Last modified:April 13, 2004 - v3
Checksum:iEC08E94412E27F84
GO

Sequence cautioni

The sequence CAA23495 differs from that shown. Reason: Frameshift at positions 31, 58, 91 and 99.Curated
The sequence CAA23495 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA23496 differs from that shown. Reason: Frameshift at position 506.Curated
The sequence CAA23496 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50D → E in AAA28640 (PubMed:6795353).Curated1
Sequence conflicti128A → AA in AAA28640 (PubMed:6795353).Curated1
Sequence conflicti128A → AA in CAA23495 (PubMed:6255408).Curated1
Sequence conflicti530H → R in AAA28640 (PubMed:6795353).Curated1
Sequence conflicti530H → R in CAA23496 (PubMed:6255408).Curated1
Sequence conflicti534I → V in AAA28640 (PubMed:6795353).Curated1
Sequence conflicti534I → V in CAA23496 (PubMed:6255408).Curated1
Sequence conflicti543 – 545YVF → HVL in AAA28640 (PubMed:6795353).Curated3
Sequence conflicti543 – 545YVF → HVL in CAA23496 (PubMed:6255408).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti189E → G in strain: B28. 1 Publication1
Natural varianti194I → N in strain: Z(H)1. 1 Publication1
Natural varianti262R → G in strain: 122. 1 Publication1
Natural varianti489K → R in strain: FrV3-1. 1 Publication1
Natural varianti567V → D in strain: 56H8. 1 Publication1
Natural varianti573D → G in strain: 122. 1 Publication1
Natural varianti636P → R in strain: B28. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01103 Genomic DNA Translation: AAA28640.1
AF295939 Genomic DNA Translation: AAG26893.1
AF295940 Genomic DNA Translation: AAG26894.1
AF295941 Genomic DNA Translation: AAG26895.1
AF295942 Genomic DNA Translation: AAG26896.1
AF295943 Genomic DNA Translation: AAG26897.1
AF295944 Genomic DNA Translation: AAG26898.1
AF295945 Genomic DNA Translation: AAG26899.1
AF350460 Genomic DNA Translation: AAK30217.1
AF350461 Genomic DNA Translation: AAK30218.1
AF350462 Genomic DNA Translation: AAK30219.1
AF350463 Genomic DNA Translation: AAK30220.1
AF350464 Genomic DNA Translation: AAK30221.1
AF350465 Genomic DNA Translation: AAK30222.1
AF350466 Genomic DNA Translation: AAK30223.1
AF350467 Genomic DNA Translation: AAK30224.1
AE014297 Genomic DNA Translation: AAG22148.2
V00213 Genomic DNA Translation: CAA23495.1 Sequence problems.
V00214 Genomic DNA Translation: CAA23496.1 Sequence problems.
PIRiA03308
RefSeqiNP_524798.2, NM_080059.3
NP_731651.1, NM_169441.2
UniGeneiDm.23375
Dm.31247

Genome annotation databases

EnsemblMetazoaiFBtr0082482; FBpp0081956; FBgn0013276
FBtr0082512; FBpp0081986; FBgn0013275
GeneIDi44920
48581
KEGGidme:Dmel_CG18743
dme:Dmel_CG31366

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHSP71_DROME
AccessioniPrimary (citable) accession number: P02825
Secondary accession number(s): Q95NG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 13, 2004
Last modified: July 18, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health