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Protein

Osteocalcin

Gene

BGLAP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Calcium 11 Publication1
Metal bindingi72Calcium 21 Publication1
Metal bindingi75Calcium 21 Publication1
Metal bindingi75Calcium 31 Publication1
Metal bindingi81Calcium 31 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiomineralization
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
PropeptideiPRO_000001108424 – 511 PublicationAdd BLAST28
ChainiPRO_000001108552 – 100Osteocalcin1 PublicationAdd BLAST49

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei604-hydroxyproline1 Publication1
Modified residuei684-carboxyglutamatePROSITE-ProRule annotation2 Publications1
Modified residuei724-carboxyglutamatePROSITE-ProRule annotation2 Publications1
Disulfide bondi74 ↔ 80PROSITE-ProRule annotation1 Publication
Modified residuei754-carboxyglutamatePROSITE-ProRule annotation2 Publications1

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation2 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Proteomic databases

PaxDbiP02820
PRIDEiP02820

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047703

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 75Combined sources7
Helixi78 – 87Combined sources10
Helixi89 – 97Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3MNMR-A52-100[»]
4MZZX-ray1.88A/B68-100[»]
ProteinModelPortaliP02820
SMRiP02820
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02820

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 98GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z Eukaryota
ENOG410ZS6W LUCA
HOGENOMiHOG000115820
InParanoidiP02820
KOiK22609

Family and domain databases

InterProiView protein in InterPro
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR002384 Osteocalcin/MGP
PRINTSiPR00002 GLABONE
SMARTiView protein in SMART
SM00069 GLA, 1 hit
SUPFAMiSSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPMLLALL ALATLCLAGR ADAKPGDAES GKGAAFVSKQ EGSEVVKRLR
60 70 80 90 100
RYLDHWLGAP APYPDPLEPK REVCELNPDC DELADHIGFQ EAYRRFYGPV
Length:100
Mass (Da):11,042
Last modified:August 1, 1990 - v2
Checksum:i73015D1681B26219
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53699 mRNA Translation: CAA37737.1
X51700 mRNA Translation: CAA35997.1
EF673278 Genomic DNA Translation: ABU88822.1
PIRiS12653 GEBO
RefSeqiNP_776674.1, NM_174249.2
UniGeneiBt.4055

Genome annotation databases

GeneIDi281646
KEGGibta:281646

Similar proteinsi

Entry informationi

Entry nameiOSTCN_BOVIN
AccessioniPrimary (citable) accession number: P02820
Secondary accession number(s): A7YEW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: June 20, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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