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Protein

Prolactin-inducible protein homolog

Gene

Pip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-inducible protein homolog
Alternative name(s):
14 kDa submandibular gland protein
Short name:
SMGP
Gross cystic disease fluid protein 15
Short name:
GCDFP-15
Prolactin-induced protein
Gene namesi
Name:Pip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:102696 Pip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000002429027 – 146Prolactin-inducible protein homologAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi65 ↔ 91By similarity
Disulfide bondi89 ↔ 123By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP02816
PRIDEiP02816

PTM databases

PhosphoSitePlusiP02816

Expressioni

Tissue specificityi

Lacrimal and submaxillary glands.

Gene expression databases

BgeeiENSMUSG00000058499 Expressed in 32 organ(s), highest expression level in parotid gland
CleanExiMM_PIP
ExpressionAtlasiP02816 baseline and differential
GenevisibleiP02816 MM

Interactioni

Subunit structurei

Monomer. Interacts with AZGP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074818

Structurei

3D structure databases

ProteinModelPortaliP02816
SMRiP02816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZUS Eukaryota
ENOG41116UQ LUCA
GeneTreeiENSGT00390000002099
HOGENOMiHOG000253013
HOVERGENiHBG065978
InParanoidiP02816
OMAiIRELGIC
OrthoDBiEOG091G0YJ1
PhylomeDBiP02816
TreeFamiTF336919

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR007990 PIP
PANTHERiPTHR15096 PTHR15096, 1 hit
PfamiView protein in Pfam
PF05326 SVA, 1 hit
PIRSFiPIRSF002572 PIP-GCDFP-15, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021604 SV_autoAg, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P02816-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGLSFTFSA VTLFLVLCLQ LGIIESQDDE NVRKPLLIEI DVPSTAQENQ
60 70 80 90 100
EITVQVTVET QYRECMVIKA YLVSNEPMEG AFNYVQTRCL CNDHPIRFFW
110 120 130 140
DIIITRTVTF ATVIDIVREK NICPNDMAVV PITANRYYTY NTVRMN
Length:146
Mass (Da):16,823
Last modified:April 26, 2004 - v3
Checksum:iB2257D1772C64531
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV85A0A0N4SV85_MOUSE
Prolactin induced protein, isoform ...
Pip mCG_4986
107Annotation score:
A0A0N4SV27A0A0N4SV27_MOUSE
Prolactin-inducible protein homolog
Pip
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 21MQGLS…LCLQL → MSAA (PubMed:6546617).CuratedAdd BLAST21
Sequence conflicti2Q → K in BAA75745 (Ref. 3) Curated1
Sequence conflicti2Q → K in BAA75747 (Ref. 3) Curated1
Sequence conflicti135N → S in AAB31990 (PubMed:7925123).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73282 mRNA Translation: AAB31990.2
X02510 mRNA Translation: CAA26346.1
AB017907 mRNA Translation: BAA75745.1
AB017918 Genomic DNA Translation: BAA75747.1
BC028889 mRNA Translation: AAH28889.1
CCDSiCCDS39469.1
PIRiA03299 WMMS14
RefSeqiNP_032869.2, NM_008843.3
UniGeneiMm.214755

Genome annotation databases

EnsembliENSMUST00000075351; ENSMUSP00000074818; ENSMUSG00000058499
GeneIDi18716
KEGGimmu:18716
UCSCiuc009bqh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73282 mRNA Translation: AAB31990.2
X02510 mRNA Translation: CAA26346.1
AB017907 mRNA Translation: BAA75745.1
AB017918 Genomic DNA Translation: BAA75747.1
BC028889 mRNA Translation: AAH28889.1
CCDSiCCDS39469.1
PIRiA03299 WMMS14
RefSeqiNP_032869.2, NM_008843.3
UniGeneiMm.214755

3D structure databases

ProteinModelPortaliP02816
SMRiP02816
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074818

PTM databases

PhosphoSitePlusiP02816

Proteomic databases

PaxDbiP02816
PRIDEiP02816

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075351; ENSMUSP00000074818; ENSMUSG00000058499
GeneIDi18716
KEGGimmu:18716
UCSCiuc009bqh.1 mouse

Organism-specific databases

CTDi5304
MGIiMGI:102696 Pip

Phylogenomic databases

eggNOGiENOG410IZUS Eukaryota
ENOG41116UQ LUCA
GeneTreeiENSGT00390000002099
HOGENOMiHOG000253013
HOVERGENiHBG065978
InParanoidiP02816
OMAiIRELGIC
OrthoDBiEOG091G0YJ1
PhylomeDBiP02816
TreeFamiTF336919

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Miscellaneous databases

PROiPR:P02816
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058499 Expressed in 32 organ(s), highest expression level in parotid gland
CleanExiMM_PIP
ExpressionAtlasiP02816 baseline and differential
GenevisibleiP02816 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR007990 PIP
PANTHERiPTHR15096 PTHR15096, 1 hit
PfamiView protein in Pfam
PF05326 SVA, 1 hit
PIRSFiPIRSF002572 PIP-GCDFP-15, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021604 SV_autoAg, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIP_MOUSE
AccessioniPrimary (citable) accession number: P02816
Secondary accession number(s): Q64013, Q8K127, Q9QUG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 26, 2004
Last modified: September 12, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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