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Protein

Submaxillary gland androgen-regulated protein 3B

Gene

SMR3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Submaxillary gland androgen-regulated protein 3B
Alternative name(s):
Proline-rich peptide P-B
Proline-rich protein 3
Cleaved into the following 2 chains:
Gene namesi
Name:SMR3B
Synonyms:PBII, PRL3, PROL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000171201.10
HGNCiHGNC:17326 SMR3B
MIMi611593 gene
neXtProtiNX_P02814

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10879
OpenTargetsiENSG00000171201
PharmGKBiPA33805

Polymorphism and mutation databases

BioMutaiSMR3B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002211223 – 79Submaxillary gland androgen-regulated protein 3BAdd BLAST57
PeptideiPRO_000002211330 – 43Peptide D1AAdd BLAST14
PeptideiPRO_000002211442 – 79Peptide P-AAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acid1 Publication1

Post-translational modificationi

P-A and D1A are probably degradation products of P-B.

Keywords - PTMi

Pyrrolidone carboxylic acid

Proteomic databases

EPDiP02814
MaxQBiP02814
PaxDbiP02814
PeptideAtlasiP02814
PRIDEiP02814
ProteomicsDBi51605
TopDownProteomicsiP02814

Expressioni

Tissue specificityi

Secreted into saliva by submaxillary gland. Not expressed in heart, brain, lung, liver, skeletal muscle, Kidney, pancreas or placenta.1 Publication

Gene expression databases

BgeeiENSG00000171201
CleanExiHS_SMR3B
GenevisibleiP02814 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116087, 8 interactors
IntActiP02814, 7 interactors
STRINGi9606.ENSP00000302400

Structurei

3D structure databases

ProteinModelPortaliP02814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 79Pro-richAdd BLAST54
Compositional biasi47 – 53Poly-Pro7
Compositional biasi60 – 66Poly-Pro7
Compositional biasi73 – 79Poly-Pro7

Sequence similaritiesi

Belongs to the PROL1/PROL3 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00860000134093
HOVERGENiHBG093969
InParanoidiP02814
OMAiPYGPGIF

Family and domain databases

InterProiView protein in InterPro
IPR026288 SMR-like
PANTHERiPTHR14179 PTHR14179, 1 hit
PfamiView protein in Pfam
PF15621 PROL5-SMR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPQP FGPGFVPPPP
60 70
PPPYGPGRIP PPPPAPYGPG IFPPPPPQP
Length:79
Mass (Da):8,188
Last modified:May 27, 2002 - v2
Checksum:i7B10AE90E95BCB61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29833 mRNA Translation: BAA06213.1
AB031740 Genomic DNA Translation: BAA88517.1
CH471057 Genomic DNA Translation: EAX05619.1
BC015327 mRNA Translation: AAH15327.1
BC144529 mRNA Translation: AAI44530.1
CCDSiCCDS3540.1
PIRiJX0321 PJHUSB
RefSeqiNP_006676.1, NM_006685.3
UniGeneiHs.650650

Genome annotation databases

EnsembliENST00000304915; ENSP00000302400; ENSG00000171201
ENST00000504825; ENSP00000423138; ENSG00000171201
ENST00000614072; ENSP00000481313; ENSG00000171201
GeneIDi10879
KEGGihsa:10879
UCSCiuc003hfh.3 human

Similar proteinsi

Entry informationi

Entry nameiSMR3B_HUMAN
AccessioniPrimary (citable) accession number: P02814
Secondary accession number(s): B7ZMG7, Q9UBN0, Q9UCT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 27, 2002
Last modified: June 20, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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