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Protein

Salivary acidic proline-rich phosphoprotein 1/2

Gene

PRH1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

Enzyme and pathway databases

SIGNORiP02810

Names & Taxonomyi

Protein namesi
Recommended name:
Salivary acidic proline-rich phosphoprotein 1/2
Alternative name(s):
Db-s
PRP-1/PRP-2
Parotid acidic protein
Short name:
Pa
Parotid double-band protein
Parotid isoelectric focusing variant protein
Short name:
PIF-S
Parotid proline-rich protein 1/2
Pr1/Pr2
Protein C
Cleaved into the following 3 chains:
Gene namesi
Name:PRH1
AND
Name:PRH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134551.12
HGNCiHGNC:9366 PRH1
HGNC:9367 PRH2
MIMi168730 gene
168790 gene
neXtProtiNX_P02810

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24S → A: Decreased phosphorylation by FAM20C; when associated with A-38. 1 Publication1
Mutagenesisi38S → A: Decreased phosphorylation by FAM20C; when associated with A-24. 1 Publication1

Organism-specific databases

DisGeNETi5554
5555
PharmGKBiPA33738

Polymorphism and mutation databases

BioMutaiPRH1
DMDMi131008

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 167 PublicationsAdd BLAST16
ChainiPRO_000002213717 – 166Salivary acidic proline-rich phosphoprotein 1/2Add BLAST150
ChainiPRO_000002213817 – 122Salivary acidic proline-rich phosphoprotein 3/4Add BLAST106
ChainiPRO_0000022139123 – 166Peptide P-CAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Pyrrolidone carboxylic acid1 Publication1
Modified residuei24Phosphoserine; by FAM20C3 Publications1
Modified residuei33Phosphoserine; alternate1 Publication1
Glycosylationi33O-linked (GlcA) serine; alternate1 Publication1
Modified residuei38Phosphoserine; by FAM20C; alternate4 Publications1
Glycosylationi38O-linked (GlcA) serine; alternate1 Publication1

Post-translational modificationi

Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.1 Publication
An hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP02810
PaxDbiP02810
PeptideAtlasiP02810
PRIDEiP02810
ProteomicsDBi51603
TopDownProteomicsiP02810

PTM databases

iPTMnetiP02810
PhosphoSitePlusiP02810

Expressioni

Gene expression databases

BgeeiENSG00000134551
CleanExiHS_PRH2
GenevisibleiP02810 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111545, 1 interactor
IntActiP02810, 4 interactors
STRINGi9606.ENSP00000371271

Structurei

3D structure databases

ProteinModelPortaliP02810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 46Inhibits hydroxyapatite formation, binds to hydroxyapatite and calciumAdd BLAST30

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IUYX Eukaryota
ENOG4110PRV LUCA
InParanoidiP02810
KOiK13910
OrthoDBiEOG091G1ACT

Family and domain databases

InterProiView protein in InterPro
IPR026086 Pro-rich
PANTHERiPTHR23203 PTHR23203, 1 hit
PfamiView protein in Pfam
PF15240 Pro-rich, 1 hit
SMARTiView protein in SMART
SM01412 Pro-rich, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLILLSVAL LAFSSAQDLD EDVSQEDVPL VISDGGDSEQ FIDEERQGPP
60 70 80 90 100
LGGQQSQPSA GDGNQDDGPQ QGPPQQGGQQ QQGPPPPQGK PQGPPQQGGH
110 120 130 140 150
PPPPQGRPQG PPQQGGHPRP PRGRPQGPPQ QGGHQQGPPP PPPGKPQGPP
160
PQGGRPQGPP QGQSPQ
Length:166
Mass (Da):17,016
Last modified:July 1, 1989 - v2
Checksum:iA7DF62BF94E3C3EF
GO

Sequence cautioni

The sequence AAI28193 differs from that shown. Reason: Erroneous termination at position 167. Translated as stop.Curated
The sequence AAI41917 differs from that shown. Reason: Erroneous termination at position 167. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41F → P AA sequence (Ref. 11) Curated1

Polymorphismi

Sequence shown is that of allele PRH2-2, also known as PR-2; Allele PRH2-1 is also known as PR-1 or protein C, and allele PRH2-3 as PR-1'. The PRH1-DB allele (about 16% of the population) has an insertion of 21 repeated amino acids compared to the more frequent PRH1-PIF allele (68%). In contrast to all other PRH1 and PRH2 alleles, the PRH1-PA allele (16%) is not proteolytically cleaved.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00556320D → N in allele PRH1-PIF, allele PRH1-PA and allele PRH1-DB. Corresponds to variant dbSNP:rs1130404Ensembl.1
Natural variantiVAR_02324042I → L in allele PRH1-PA and allele PRH1-DB. Corresponds to variant dbSNP:rs2923234Ensembl.1
Natural variantiVAR_00556466D → N in allele PRH2-1. 1 PublicationCorresponds to variant dbSNP:rs1049112Ensembl.1
Natural variantiVAR_02324197Q → QGGQQQQGPPPPQGKPQGPP QQ in allele PRH1-DB. 1
Natural variantiVAR_023242119R → C in allele PRH1-PA; interferes with proteolytic cleavage at Arg-122. 1
Natural variantiVAR_005565163Q → K in allele PRH2-3. 1 PublicationCorresponds to variant dbSNP:rs74062407Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03202 mRNA Translation: AAA60183.1
K03203 mRNA Translation: AAA60184.1
M13057 Genomic DNA Translation: AAA98807.1
M13058 Genomic DNA Translation: AAA98808.1
BX641094 mRNA Translation: CAE46044.1
CH471094 Genomic DNA Translation: EAW96214.1
CH471094 Genomic DNA Translation: EAW96219.1
BC095488 mRNA Translation: AAH95488.1
BC128192 mRNA Translation: AAI28193.1 Sequence problems.
BC133676 mRNA Translation: AAI33677.1
BC136499 mRNA Translation: AAI36500.1
BC141916 mRNA Translation: AAI41917.1 Sequence problems.
CCDSiCCDS8636.1
PIRiA25372 PIHUSC
B25372
RefSeqiNP_001103683.1, NM_001110213.1
NP_001278243.1, NM_001291314.1
NP_001278244.1, NM_001291315.1
UniGeneiHs.408153
Hs.656965
Hs.731575

Genome annotation databases

EnsembliENST00000381847; ENSP00000371271; ENSG00000134551
ENST00000396400; ENSP00000379682; ENSG00000134551
ENST00000572141; ENSP00000458690; ENSG00000272803
ENST00000575657; ENSP00000461041; ENSG00000272803
ENST00000622570; ENSP00000481810; ENSG00000275679
ENST00000622848; ENSP00000483458; ENSG00000275679
GeneIDi5554
5555
KEGGihsa:5554
hsa:5555
UCSCiuc001qzi.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRPC_HUMAN
AccessioniPrimary (citable) accession number: P02810
Secondary accession number(s): A2VCM0
, A3KN66, A5D902, B2RMW2, Q4VBP2, Q53XA2, Q6P2F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: July 18, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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