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Protein

Salivary acidic proline-rich phosphoprotein 1/2

Gene

PRH1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P02810

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Salivary acidic proline-rich phosphoprotein 1/2
Alternative name(s):
Db-s
PRP-1/PRP-2
Parotid acidic protein
Short name:
Pa
Parotid double-band protein
Parotid isoelectric focusing variant protein
Short name:
PIF-S
Parotid proline-rich protein 1/2
Pr1/Pr2
Protein C
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRH1
AND
Name:PRH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134551.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9366 PRH1
HGNC:9367 PRH2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
168730 gene
168790 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02810

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24S → A: Decreased phosphorylation by FAM20C; when associated with A-38. 1 Publication1
Mutagenesisi38S → A: Decreased phosphorylation by FAM20C; when associated with A-24. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5554
5555

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33738

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRH1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
131008

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 167 PublicationsAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002213717 – 166Salivary acidic proline-rich phosphoprotein 1/2Add BLAST150
ChainiPRO_000002213817 – 122Salivary acidic proline-rich phosphoprotein 3/4Add BLAST106
ChainiPRO_0000022139123 – 166Peptide P-CAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17Pyrrolidone carboxylic acid1 Publication1
Modified residuei24Phosphoserine; by FAM20C3 Publications1
Modified residuei33Phosphoserine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33O-linked (GlcA) serine; alternate1 Publication1
Modified residuei38Phosphoserine; by FAM20C; alternate4 Publications1
Glycosylationi38O-linked (GlcA) serine; alternate1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.1 Publication
An hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P02810

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02810

PeptideAtlas

More...
PeptideAtlasi
P02810

PRoteomics IDEntifications database

More...
PRIDEi
P02810

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51603

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P02810

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02810

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02810

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134551 Expressed in 82 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_PRH2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02810 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111545, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P02810, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371271

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P02810

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 46Inhibits hydroxyapatite formation, binds to hydroxyapatite and calciumAdd BLAST30

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUYX Eukaryota
ENOG4110PRV LUCA

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02810

KEGG Orthology (KO)

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KOi
K13910

Database of Orthologous Groups

More...
OrthoDBi
1645809at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026086 Pro-rich

The PANTHER Classification System

More...
PANTHERi
PTHR23203 PTHR23203, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15240 Pro-rich, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01412 Pro-rich, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P02810-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLILLSVAL LAFSSAQDLD EDVSQEDVPL VISDGGDSEQ FIDEERQGPP
60 70 80 90 100
LGGQQSQPSA GDGNQDDGPQ QGPPQQGGQQ QQGPPPPQGK PQGPPQQGGH
110 120 130 140 150
PPPPQGRPQG PPQQGGHPRP PRGRPQGPPQ QGGHQQGPPP PPPGKPQGPP
160
PQGGRPQGPP QGQSPQ
Length:166
Mass (Da):17,016
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7DF62BF94E3C3EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV42A0A087WV42_HUMAN
Salivary acidic proline-rich phosph...
PRH1
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYT0A0A087WYT0_HUMAN
Salivary acidic proline-rich phosph...
PRH1
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYF5A0A087WYF5_HUMAN
Salivary acidic proline-rich phosph...
PRH1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI28193 differs from that shown. Reason: Erroneous termination at position 167. Translated as stop.Curated
The sequence AAI41917 differs from that shown. Reason: Erroneous termination at position 167. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41F → P AA sequence (Ref. 11) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Sequence shown is that of allele PRH2-2, also known as PR-2; Allele PRH2-1 is also known as PR-1 or protein C, and allele PRH2-3 as PR-1'. The PRH1-DB allele (about 16% of the population) has an insertion of 21 repeated amino acids compared to the more frequent PRH1-PIF allele (68%). In contrast to all other PRH1 and PRH2 alleles, the PRH1-PA allele (16%) is not proteolytically cleaved.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00556320D → N in allele PRH1-PIF, allele PRH1-PA and allele PRH1-DB. Corresponds to variant dbSNP:rs1130404Ensembl.1
Natural variantiVAR_02324042I → L in allele PRH1-PA and allele PRH1-DB. Corresponds to variant dbSNP:rs2923234Ensembl.1
Natural variantiVAR_00556466D → N in allele PRH2-1. 1 PublicationCorresponds to variant dbSNP:rs1049112Ensembl.1
Natural variantiVAR_02324197Q → QGGQQQQGPPPPQGKPQGPP QQ in allele PRH1-DB. 1
Natural variantiVAR_023242119R → C in allele PRH1-PA; interferes with proteolytic cleavage at Arg-122. 1
Natural variantiVAR_005565163Q → K in allele PRH2-3. 1 PublicationCorresponds to variant dbSNP:rs74062407Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K03202 mRNA Translation: AAA60183.1
K03203 mRNA Translation: AAA60184.1
M13057 Genomic DNA Translation: AAA98807.1
M13058 Genomic DNA Translation: AAA98808.1
BX641094 mRNA Translation: CAE46044.1
CH471094 Genomic DNA Translation: EAW96214.1
CH471094 Genomic DNA Translation: EAW96219.1
BC095488 mRNA Translation: AAH95488.1
BC128192 mRNA Translation: AAI28193.1 Sequence problems.
BC133676 mRNA Translation: AAI33677.1
BC136499 mRNA Translation: AAI36500.1
BC141916 mRNA Translation: AAI41917.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8636.1

Protein sequence database of the Protein Information Resource

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PIRi
A25372 PIHUSC
B25372

NCBI Reference Sequences

More...
RefSeqi
NP_001103683.1, NM_001110213.1
NP_001278243.1, NM_001291314.1
NP_001278244.1, NM_001291315.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.408153
Hs.656965
Hs.731575

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381847; ENSP00000371271; ENSG00000134551
ENST00000396400; ENSP00000379682; ENSG00000134551
ENST00000572141; ENSP00000458690; ENSG00000272803
ENST00000575657; ENSP00000461041; ENSG00000272803
ENST00000622570; ENSP00000481810; ENSG00000275679
ENST00000622848; ENSP00000483458; ENSG00000275679

Database of genes from NCBI RefSeq genomes

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GeneIDi
5554
5555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5554
hsa:5555

UCSC genome browser

More...
UCSCi
uc001qzi.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03202 mRNA Translation: AAA60183.1
K03203 mRNA Translation: AAA60184.1
M13057 Genomic DNA Translation: AAA98807.1
M13058 Genomic DNA Translation: AAA98808.1
BX641094 mRNA Translation: CAE46044.1
CH471094 Genomic DNA Translation: EAW96214.1
CH471094 Genomic DNA Translation: EAW96219.1
BC095488 mRNA Translation: AAH95488.1
BC128192 mRNA Translation: AAI28193.1 Sequence problems.
BC133676 mRNA Translation: AAI33677.1
BC136499 mRNA Translation: AAI36500.1
BC141916 mRNA Translation: AAI41917.1 Sequence problems.
CCDSiCCDS8636.1
PIRiA25372 PIHUSC
B25372
RefSeqiNP_001103683.1, NM_001110213.1
NP_001278243.1, NM_001291314.1
NP_001278244.1, NM_001291315.1
UniGeneiHs.408153
Hs.656965
Hs.731575

3D structure databases

ProteinModelPortaliP02810
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111545, 1 interactor
IntActiP02810, 4 interactors
STRINGi9606.ENSP00000371271

PTM databases

iPTMnetiP02810
PhosphoSitePlusiP02810

Polymorphism and mutation databases

BioMutaiPRH1
DMDMi131008

Proteomic databases

MaxQBiP02810
PaxDbiP02810
PeptideAtlasiP02810
PRIDEiP02810
ProteomicsDBi51603
TopDownProteomicsiP02810

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5554
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381847; ENSP00000371271; ENSG00000134551
ENST00000396400; ENSP00000379682; ENSG00000134551
ENST00000572141; ENSP00000458690; ENSG00000272803
ENST00000575657; ENSP00000461041; ENSG00000272803
ENST00000622570; ENSP00000481810; ENSG00000275679
ENST00000622848; ENSP00000483458; ENSG00000275679
GeneIDi5554
5555
KEGGihsa:5554
hsa:5555
UCSCiuc001qzi.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5554
5555
DisGeNETi5554
5555
EuPathDBiHostDB:ENSG00000134551.12

GeneCards: human genes, protein and diseases

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GeneCardsi
PRH1
PRH2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0026359
HIX0026397
HIX0079411
HGNCiHGNC:9366 PRH1
HGNC:9367 PRH2
MIMi168730 gene
168790 gene
neXtProtiNX_P02810
PharmGKBiPA33738

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IUYX Eukaryota
ENOG4110PRV LUCA
InParanoidiP02810
KOiK13910
OrthoDBi1645809at2759

Enzyme and pathway databases

SIGNORiP02810

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PRH1

Protein Ontology

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PROi
PR:P02810

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134551 Expressed in 82 organ(s), highest expression level in lung
CleanExiHS_PRH2
GenevisibleiP02810 HS

Family and domain databases

InterProiView protein in InterPro
IPR026086 Pro-rich
PANTHERiPTHR23203 PTHR23203, 1 hit
PfamiView protein in Pfam
PF15240 Pro-rich, 1 hit
SMARTiView protein in SMART
SM01412 Pro-rich, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRPC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02810
Secondary accession number(s): A2VCM0
, A3KN66, A5D902, B2RMW2, Q4VBP2, Q53XA2, Q6P2F6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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