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Protein

Statherin

Gene

STATH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiomineralization

Protein family/group databases

TCDBi1.C.79.1.2 the channel-forming histatin antimicrobial peptide (histatin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Statherin
Gene namesi
Name:STATH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000126549.9
HGNCiHGNC:11369 STATH
MIMi184470 gene
neXtProtiNX_P02808

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6779
OpenTargetsiENSG00000126549
PharmGKBiPA36187

Polymorphism and mutation databases

BioMutaiSTATH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000002242220 – 62StatherinAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Phosphoserine1 Publication1
Modified residuei22Phosphoserine1 Publication1
Cross-linki25 ↔ 58Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-39
Cross-linki25 ↔ 56Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-37

Post-translational modificationi

Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5% is cyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva.1 Publication
Sulfated on tyrosine residues.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Sulfation

Proteomic databases

EPDiP02808
MaxQBiP02808
PaxDbiP02808
PeptideAtlasiP02808
PRIDEiP02808
ProteomicsDBi51602
TopDownProteomicsiP02808-1 [P02808-1]
P02808-2 [P02808-2]

PTM databases

iPTMnetiP02808
PhosphoSitePlusiP02808

Expressioni

Tissue specificityi

Secreted by parotid and submandibular glands.

Gene expression databases

BgeeiENSG00000126549 Expressed in 91 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_STATH
GenevisibleiP02808 HS

Organism-specific databases

HPAiHPA044569

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MUC7Q8TAX72EBI-738687,EBI-738582

Protein-protein interaction databases

BioGridi112656, 4 interactors
IntActiP02808, 22 interactors
STRINGi9606.ENSP00000246895

Structurei

3D structure databases

ProteinModelPortaliP02808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 25Hydroxyapatite-binding; inhibits crystal growth6
Regioni38 – 62Hydrophobic; inhibits precipitation of calcium phosphate saltsAdd BLAST25

Sequence similaritiesi

Belongs to the histatin/statherin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KCI1 Eukaryota
ENOG4110NY1 LUCA
GeneTreeiENSGT00390000011757
HOGENOMiHOG000293326
InParanoidiP02808
KOiK13914
OMAiGPYQPFV
OrthoDBiEOG091G1BYD
PhylomeDBiP02808
TreeFamiTF341588

Family and domain databases

InterProiView protein in InterPro
IPR030773 Histatin/statherin
IPR005575 Statherin
PANTHERiPTHR15057 PTHR15057, 1 hit
PfamiView protein in Pfam
PF03875 Statherin, 1 hit
PIRSFiPIRSF002565 Statherin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Both isoforms can occur with the Phe-62 deletion.
Isoform 1 (identifier: P02808-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKFLVFAFIL ALMVSMIGAD SSEEKFLRRI GRFGYGYGPY QPVPEQPLYP
60
QPYQPQYQQY TF
Length:62
Mass (Da):7,304
Last modified:July 1, 1989 - v2
Checksum:iCFE32EC235CA3A22
GO
Isoform 2 (identifier: P02808-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-34: Missing.

Show »
Length:52
Mass (Da):6,073
Checksum:iC94F2FE112DAA733
GO

Mass spectrometryi

Molecular mass is 5380.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22.1 Publication
Molecular mass is 5363.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22 and transglutamine cross-link.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06906562Missing 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04574425 – 34Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18078 mRNA Translation: AAA60594.1
M18371 mRNA Translation: AAA60600.1
M32639 Genomic DNA Translation: AAA60593.1
AK311812 mRNA Translation: BAG34755.1
AC063956 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05604.1
CH471057 Genomic DNA Translation: EAX05605.1
BC067219 mRNA Translation: AAH67219.1
CCDSiCCDS33998.1 [P02808-2]
CCDS3533.1 [P02808-1]
PIRiJH0153 SBHUP
RefSeqiNP_001009181.1, NM_001009181.1 [P02808-2]
NP_003145.1, NM_003154.2 [P02808-1]
UniGeneiHs.654495

Genome annotation databases

EnsembliENST00000246895; ENSP00000246895; ENSG00000126549 [P02808-1]
ENST00000381060; ENSP00000370448; ENSG00000126549 [P02808-2]
ENST00000615994; ENSP00000484341; ENSG00000126549 [P02808-1]
ENST00000634727; ENSP00000489107; ENSG00000282891 [P02808-2]
ENST00000635437; ENSP00000489569; ENSG00000282891 [P02808-1]
ENST00000635686; ENSP00000489243; ENSG00000282891 [P02808-1]
GeneIDi6779
KEGGihsa:6779
UCSCiuc003heu.2 human [P02808-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18078 mRNA Translation: AAA60594.1
M18371 mRNA Translation: AAA60600.1
M32639 Genomic DNA Translation: AAA60593.1
AK311812 mRNA Translation: BAG34755.1
AC063956 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05604.1
CH471057 Genomic DNA Translation: EAX05605.1
BC067219 mRNA Translation: AAH67219.1
CCDSiCCDS33998.1 [P02808-2]
CCDS3533.1 [P02808-1]
PIRiJH0153 SBHUP
RefSeqiNP_001009181.1, NM_001009181.1 [P02808-2]
NP_003145.1, NM_003154.2 [P02808-1]
UniGeneiHs.654495

3D structure databases

ProteinModelPortaliP02808
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112656, 4 interactors
IntActiP02808, 22 interactors
STRINGi9606.ENSP00000246895

Protein family/group databases

TCDBi1.C.79.1.2 the channel-forming histatin antimicrobial peptide (histatin) family

PTM databases

iPTMnetiP02808
PhosphoSitePlusiP02808

Polymorphism and mutation databases

BioMutaiSTATH

Proteomic databases

EPDiP02808
MaxQBiP02808
PaxDbiP02808
PeptideAtlasiP02808
PRIDEiP02808
ProteomicsDBi51602
TopDownProteomicsiP02808-1 [P02808-1]
P02808-2 [P02808-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246895; ENSP00000246895; ENSG00000126549 [P02808-1]
ENST00000381060; ENSP00000370448; ENSG00000126549 [P02808-2]
ENST00000615994; ENSP00000484341; ENSG00000126549 [P02808-1]
ENST00000634727; ENSP00000489107; ENSG00000282891 [P02808-2]
ENST00000635437; ENSP00000489569; ENSG00000282891 [P02808-1]
ENST00000635686; ENSP00000489243; ENSG00000282891 [P02808-1]
GeneIDi6779
KEGGihsa:6779
UCSCiuc003heu.2 human [P02808-1]

Organism-specific databases

CTDi6779
DisGeNETi6779
EuPathDBiHostDB:ENSG00000126549.9
GeneCardsiSTATH
HGNCiHGNC:11369 STATH
HPAiHPA044569
MIMi184470 gene
neXtProtiNX_P02808
OpenTargetsiENSG00000126549
PharmGKBiPA36187
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCI1 Eukaryota
ENOG4110NY1 LUCA
GeneTreeiENSGT00390000011757
HOGENOMiHOG000293326
InParanoidiP02808
KOiK13914
OMAiGPYQPFV
OrthoDBiEOG091G1BYD
PhylomeDBiP02808
TreeFamiTF341588

Miscellaneous databases

ChiTaRSiSTATH human
GeneWikiiSTATH
GenomeRNAii6779
PROiPR:P02808
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126549 Expressed in 91 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_STATH
GenevisibleiP02808 HS

Family and domain databases

InterProiView protein in InterPro
IPR030773 Histatin/statherin
IPR005575 Statherin
PANTHERiPTHR15057 PTHR15057, 1 hit
PfamiView protein in Pfam
PF03875 Statherin, 1 hit
PIRSFiPIRSF002565 Statherin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAT_HUMAN
AccessioniPrimary (citable) accession number: P02808
Secondary accession number(s): A6NKE9, B2R4F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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