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Protein

Metallothionein-1

Gene
N/A
Organism
Scylla serrata (Mud crab)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi4Divalent metal cation; cluster B1
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi9Divalent metal cation; cluster B1
Metal bindingi11Divalent metal cation; cluster B1
Metal bindingi16Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster B1
Metal bindingi22Divalent metal cation; cluster B1
Metal bindingi25Divalent metal cation; cluster B1
Metal bindingi27Divalent metal cation; cluster B1
Metal bindingi30Divalent metal cation; cluster A1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi39Divalent metal cation; cluster A1
Metal bindingi45Divalent metal cation; cluster A1
Metal bindingi49Divalent metal cation; cluster A1
Metal bindingi53Divalent metal cation; cluster A1
Metal bindingi55Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
OrganismiScylla serrata (Mud crab)
Taxonomic identifieri6761 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeScylla

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973401 – 58Metallothionein-1Add BLAST58

Structurei

3D structure databases

ProteinModelPortaliP02805
SMRiP02805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28BetaAdd BLAST28
Regioni29 – 58AlphaAdd BLAST30

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits

Sequencei

Sequence statusi: Complete.

P02805-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PGPCCNDKCV CKEGGCKEGC QCTSCRCSPC EKCSSGCKCA NKEECSKTCS

KACSCCPT
Length:58
Mass (Da):6,001
Last modified:July 21, 1986 - v1
Checksum:iCE8A24C590B027B8
GO

Sequence databases

PIRiA03283 SMKD1S

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA03283 SMKD1S

3D structure databases

ProteinModelPortaliP02805
SMRiP02805
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_SCYSE
AccessioniPrimary (citable) accession number: P02805
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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Main funding by: National Institutes of Health

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